Hybrid modeling for quality by design and PAT-benefits and challenges of applications in biopharmaceutical industry

Fast development of Pichia pastoris GS115 Mut+ cultures employing batch-to-batch control and hybrid semi-parametric modeling

(2013) A. R. Ferreira et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Hybrid semi-parametric modeling in process systems engineering: Past, present and future

(2013) Moritz von Stosch et al.   COMPUTERS & CHEMICAL ENGINEERING

What matters most in commercial success: first-in-class or best-in-class?

(2013) Ulrik Schulze et al.   NATURE REVIEWS DRUG DISCOVERY

Inferential monitoring and optimization of crude separation units via hybrid models

(2012) Vladimir Mahalec et al.   COMPUTERS & CHEMICAL ENGINEERING

A general hybrid semi-parametric process control framework

(2012) Moritz von Stosch et al.   JOURNAL OF PROCESS CONTROL

Batch-to-batch control of particle size distribution in cobalt oxalate synthesis process based on hybrid model

(2012) Shuning Zhang et al.   POWDER TECHNOLOGY

Process analytical technology (PAT) for biopharmaceuticals

(2011) Jarka Glassey et al.   Biotechnology Journal

Hybrid modeling framework for process analytical technology: Application to Bordetella pertussis cultures

(2011) M. von Stosch et al.   BIOTECHNOLOGY PROGRESS

Trends in process analytical technology

(2010) Wee Chew et al.   Analytical Methods

Control of a Batch Polymerization System Using Hybrid Neural Network - First Principle Model

(2010) Ng Cheah Wei et al.   CANADIAN JOURNAL OF CHEMICAL ENGINEERING

A model-based systems approach to pharmaceutical product-process design and analysis

(2010) Krist V. Gernaey et al.   CHEMICAL ENGINEERING SCIENCE

Population Balance Model-Based Hybrid Neural Network for a Pharmaceutical Milling Process

(2010) Pavan Kumar Akkisetty et al.   Journal of Pharmaceutical Innovation

Quality-by-Design for biotechnology-related pharmaceuticals

(2009) Carl-Fredrik Mandenius et al.   Biotechnology Journal

Bioprocess hybrid parametric/nonparametric modelling based on the concept of mixture of experts

(2007) J. Peres et al.   BIOCHEMICAL ENGINEERING JOURNAL