Controlling the time evolution of mAb N-linked glycosylation - Part II: Model-based predictions

High-throughput profiling of nucleotides and nucleotide sugars to evaluate their impact on antibody N-glycosylation

(2016) Thomas K. Villiger et al.   JOURNAL OF BIOTECHNOLOGY

Understanding of alteredN-glycosylation-related gene expression in recombinant Chinese hamster ovary cells subjected to elevated ammonium concentration by digital mRNA counting

(2015) Tae Kwang Ha et al.   BIOTECHNOLOGY AND BIOENGINEERING

Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture

(2015) Daniel Baur et al.   Biotechnology Journal

Analysis of site-specificN-glycan remodeling in the endoplasmic reticulum and the Golgi

(2015) Ivan Hang et al.   GLYCOBIOLOGY

Optimal model-based design of the twin-column CaptureSMB process improves capacity utilization and productivity in protein A affinity capture

(2015) Daniel Baur et al.   Biotechnology Journal

Identification of manipulated variables for a glycosylation control strategy

(2014) Melissa M. St. Amand et al.   BIOTECHNOLOGY AND BIOENGINEERING

High-throughput nucleoside phosphate monitoring in mammalian cell fed-batch cultivation using quantitative matrix-assisted laser desorption/ionization time-of-flight mass spectrometry

(2014) Robert F. Steinhoff et al.   Biotechnology Journal

Hybrid modeling for quality by design and PAT-benefits and challenges of applications in biopharmaceutical industry

(2014) Moritz von Stosch et al.   Biotechnology Journal

High-throughput miniaturized bioreactors for cell culture process development: Reproducibility, scalability, and control

(2014) Shahid Rameez et al.   BIOTECHNOLOGY PROGRESS

Modulation of mAb quality attributes using microliter scale fed-batch cultures

(2014) Yolande Rouiller et al.   BIOTECHNOLOGY PROGRESS

Towards Controlling the Glycoform: A Model Framework Linking Extracellular Metabolites to Antibody Glycosylation

(2014) Philip Jedrzejewski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Galactosyltransferase 4 is a major control point for glycan branching in N-linked glycosylation

(2014) A. G. McDonald et al.   JOURNAL OF CELL SCIENCE

Controllability Analysis of Protein Glycosylation in Cho Cells

(2014) Melissa M. St. Amand et al.   PLoS One

An automated robotic platform for rapid profiling oligosaccharide analysis of monoclonal antibodies directly from cell culture

(2013) Margaret Doherty et al.   ANALYTICAL BIOCHEMISTRY

Automated, High-Throughput IgG-Antibody Glycoprofiling Platform

(2013) Henning Stöckmann et al.   ANALYTICAL CHEMISTRY

Glycosylation characterization of recombinant human erythropoietin produced in glycoengineeredPichia pastorisby mass spectrometry

(2013) Bing Gong et al.   JOURNAL OF MASS SPECTROMETRY

High-throughput work flow for IgG Fc-glycosylation analysis of biotechnological samples

(2012) Dietmar Reusch et al.   ANALYTICAL BIOCHEMISTRY

Quality attributes of recombinant therapeutic proteins: An assessment of impact on safety and efficacy as part of a quality by design development approach

(2012) Alex Eon-Duval et al.   BIOTECHNOLOGY PROGRESS

Advanced microscale bioreactor system: a representative scale-down model for bench-top bioreactors

(2012) Wei-Ting Hsu et al.   CYTOTECHNOLOGY

Differences in the glycosylation of recombinant proteins expressed in HEK and CHO cells

(2012) Amelie Croset et al.   JOURNAL OF BIOTECHNOLOGY

Modulation of antibody galactosylation through feeding of uridine, manganese chloride, and galactose

(2011) Michael J. Gramer et al.   BIOTECHNOLOGY AND BIOENGINEERING

A dynamic mathematical model for monoclonal antibody N-linked glycosylation and nucleotide sugar donor transport within a maturing Golgi apparatus

(2011) Ioscani Jimenez del Val et al.   BIOTECHNOLOGY PROGRESS

Understanding dynamics using sensitivity analysis: caveat and solution

(2011) Thanneer M Perumal et al.   BMC Systems Biology

Characterization of glycosylation sites for a recombinant IgG1 monoclonal antibody and a CTLA4-Ig fusion protein by liquid chromatography–mass spectrometry peptide mapping

(2011) Jacob Bongers et al.   JOURNAL OF CHROMATOGRAPHY A

Glycosylation and post-translational modification gene expression analysis by DNA microarrays for cultured mammalian cells

(2011) Arthur Nathan Brodsky et al.   METHODS

Production of non-fucosylated antibodies by co-expression of heterologous GDP-6-deoxy-D-lyxo-4-hexulose reductase

(2010) H. H. von Horsten et al.   GLYCOBIOLOGY

Inhibition of Golgi Apparatus Glycosylation Causes Endoplasmic Reticulum Stress and Decreased Protein Synthesis

(2010) Yu-Xin Xu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of cell culture conditions to controlN-glycosylation site-occupancy of recombinant glycoproteins expressed in CHO cells

(2009) Martin Gawlitzek et al.   BIOTECHNOLOGY AND BIOENGINEERING

A mathematical model to derive N-glycan structures and cellular enzyme activities from mass spectrometric data

(2009) Frederick J Krambeck et al.   GLYCOBIOLOGY

Elevated Golgi pH impairs terminalN-glycosylation by inducing mislocalization of Golgi glycosyltransferases

(2009) Antti Rivinoja et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Glycosylation as a strategy to improve antibody-based therapeutics

(2009) Roy Jefferis   NATURE REVIEWS DRUG DISCOVERY

Roadmap for implementation of quality by design (QbD) for biotechnology products

(2009) Anurag S. Rathore   TRENDS IN BIOTECHNOLOGY

Influence of intracellular nucleotide and nucleotide sugar contents on recombinant interferon-γ glycosylation during batch and fed-batch cultures of CHO cells

(2008) N. Kochanowski et al.   BIOTECHNOLOGY AND BIOENGINEERING

Glycosyltransferases: Structures, Functions, and Mechanisms

(2007) L.L. Lairson et al.   Annual Review of Biochemistry