Simvastatin as a Potential Disease-Modifying Therapy for Patients with Parkinson’s Disease: Rationale for Clinical Trial, and Current Progress

Impact of high cholesterol in a Parkinson’s disease model: Prevention of lysosomal leakage versus stimulation of α-synuclein aggregation

(2017) Ida Eriksson et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Targeting low-density lipoprotein cholesterol with PCSK9 inhibitors

(2017) Daniel J. Scherer et al.   INTERNAL MEDICINE JOURNAL

Expression Patterns of Nrf2 and Keap1 in Ovarian Cancer Cells and their Prognostic Role in Disease Recurrence and Patient Survival

(2017) Hye-yon Cho et al.   INTERNATIONAL JOURNAL OF GYNECOLOGICAL CANCER

Identification of a novel series of anti-inflammatory and anti-oxidative phospholipid oxidation products containing the cyclopentenone moietyin vitroandin vivo: Implication in atherosclerosis

(2017) Jianhong Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chitosan conduits filled with simvastatin/Pluronic F-127 hydrogel promote peripheral nerve regeneration in rats

(2017) Qi Guo et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS

Effect of high-dose simvastatin on cognitive, neuropsychiatric, and health-related quality-of-life measures in secondary progressive multiple sclerosis: secondary analyses from the MS-STAT randomised, placebo-controlled trial

(2017) Dennis Chan et al.   LANCET NEUROLOGY

The beneficial effects of HMG-CoA reductase inhibitors in the processes of neurodegeneration

(2017) Seyed Soheil Saeedi Saravi et al.   METABOLIC BRAIN DISEASE

Statins may facilitate Parkinson's disease: Insight gained from a large, national claims database

(2017) Guodong Liu et al.   MOVEMENT DISORDERS

Autophagic modulation by rosuvastatin prevents rotenone-induced neurotoxicity in an in vitro model of Parkinson’s disease

(2017) Seo Young Kang et al.   NEUROSCIENCE LETTERS

Geranylgeraniol prevents the simvastatin-induced PCSK9 expression: Role of the small G protein Rac1

(2017) Nicola Ferri et al.   PHARMACOLOGICAL RESEARCH

Preventive and therapeutic effect of simvastatin on secondary inflammatory damage of rats with cerebral hemorrhage

(2017) Hong-Xia Zhou et al.   Asian Pacific Journal of Tropical Medicine

Simvastatin protects ischemic spinal cord injury from cell death and cytotoxicity through decreasing oxidative stress: in vitro primary cultured rat spinal cord model under oxygen and glucose deprivation-reoxygenation conditions

(2017) Hye-Min Sohn et al.   Journal of Orthopaedic Surgery and Research

Statins and Cognition in Parkinson’s Disease

(2017) Benjamin L. Deck et al.   Journal of Parkinsons Disease

Statin adherence and the risk of Parkinson's disease: A population-based cohort study

(2017) Violetta Rozani et al.   PLoS One

Statin use and risk of Parkinson’s disease: A meta-analysis

(2016) Zhiguo Sheng et al.   BEHAVIOURAL BRAIN RESEARCH

An Update on the Role of Nitric Oxide in the Neurodegenerative Processes of Parkinson's Disease

(2016) Félix Jiménez-Jiménez et al.   CURRENT MEDICINAL CHEMISTRY

How strong is the evidence that Parkinsonʼs disease is a prion disorder?

(2016) Patrik Brundin et al.   CURRENT OPINION IN NEUROLOGY

Atorvastatin treatment is associated with increased BDNF level and improved functional recovery after atherothrombotic stroke

(2016) Jingmiao Zhang et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Statin Use for the Primary Prevention of Cardiovascular Disease in Adults

(2016) et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

3-Methylcholanthrene/Aryl-Hydrocarbon Receptor-Mediated Hypertension Through eNOS Inactivation

(2016) Chih-Cheng Chang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Widespread transneuronal propagation of α-synucleinopathy triggered in olfactory bulb mimics prodromal Parkinson’s disease

(2016) Nolwen L. Rey et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The ROCK/GGTase Pathway Are Essential to the Proliferation and Differentiation of Neural Stem Cells Mediated by Simvastatin

(2016) Chan Zhang et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Simvastatin inhibits neural cell apoptosis and promotes locomotor recovery via activation of Wnt/β-catenin signaling pathway after spinal cord injury

(2016) Kai Gao et al.   JOURNAL OF NEUROCHEMISTRY

Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death

(2016) Tian-Ya Liu et al.   JOURNAL OF NEUROCHEMISTRY

Statins are underused in recent-onset Parkinson's disease with increased vascular risk: findings from the UK Tracking Parkinson's and Oxford Parkinson's Disease Centre (OPDC) discovery cohorts

(2016) Diane M A Swallow et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Distinct Nrf2 Signaling Mechanisms of Fumaric Acid Esters and Their Role in Neuroprotection against 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine-Induced Experimental Parkinson's-Like Disease

(2016) M. Ahuja et al.   JOURNAL OF NEUROSCIENCE

A novel Nrf2 activator from microbial transformation inhibits radiation-induced dermatitis in mice

(2016) Yasuhiro Nakagami et al.   JOURNAL OF RADIATION RESEARCH

The epidemiology of Parkinson's disease: risk factors and prevention

(2016) Alberto Ascherio et al.   LANCET NEUROLOGY

A comprehensive map of molecular drug targets

(2016) Rita Santos et al.   NATURE REVIEWS DRUG DISCOVERY

Pleiotropic effects of statins: new therapeutic targets in drug design

(2016) Onkar Bedi et al.   NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY

The Incidence of Parkinson's Disease: A Systematic Review and Meta-Analysis

(2016) Lauren Hirsch et al.   NEUROEPIDEMIOLOGY

Particulate matter cytotoxicity in cultured SH-SY5Y cells is modulated by simvastatin: Toxicological assessment for oxidative damage

(2016) S.A. Ferraro et al.   NEUROTOXICOLOGY

Confounding of the association between statins and Parkinson disease: systematic review and meta-analysis

(2016) Katsiaryna Bykov et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Inflammatory Stress Sensitizes the Liver to Atorvastatin-Induced Injury in ApoE-/- Mice

(2016) Wei Wu et al.   PLoS One

Harnessing the trophic and modulatory potential of statins in a dopaminergic cell line

(2016) Mathieu Schmitt et al.   SYNAPSE

Lipid-lowering drugs prevent neurovascular and cognitive consequences of cardiopulmonary bypass

(2016) Thavarak Ouk et al.   VASCULAR PHARMACOLOGY

Simvastatin induces heme oxygenase-1 via NF-E2-related factor 2 (Nrf2) activation through ERK and PI3K/Akt pathway in colon cancer

(2016) Hyun Joo Jang et al.   Oncotarget

A Polymorphic Antioxidant Response Element Links NRF2/sMAF Binding to Enhanced MAPT Expression and Reduced Risk of Parkinsonian Disorders

(2016) Xuting Wang et al.   Cell Reports

Time Trends in the Incidence of Parkinson Disease

(2016) Rodolfo Savica et al.   JAMA Neurology

The cost-effectiveness of delayed-release dimethyl fumarate for the treatment of relapsing-remitting multiple sclerosis in Canada

(2016) Wenqing Su et al.   JOURNAL OF MEDICAL ECONOMICS

The cost-effectiveness of disease-modifying therapies for the treatment of relapsing-remitting multiple sclerosis

(2016) Duygu Bozkaya et al.   JOURNAL OF MEDICAL ECONOMICS

The novel triterpenoid RTA 408 protects human retinal pigment epithelial cells against H2O2-induced cell injury via NF-E2-related factor 2 (Nrf2) activation

(2016) Xiaobin Liu et al.   Redox Biology

Statin Use and the Risk of Parkinson's Disease: An Updated Meta-Analysis

(2016) Shuang Bai et al.   PLoS One

New CETP inhibitor K-312 reduces PCSK9 expression: a potential effect on LDL cholesterol metabolism

(2015) Katsutoshi Miyosawa et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The spatiotemporal regulation of the Keap1–Nrf2 pathway and its importance in cellular bioenergetics

(2015) Albena T. Dinkova-Kostova et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

HMG-CoA Reductase Inhibitors Bind to PPARα to Upregulate Neurotrophin Expression in the Brain and Improve Memory in Mice

(2015) Avik Roy et al.   Cell Metabolism

Beyond antioxidant genes in the ancient Nrf2 regulatory network

(2015) Sarah E. Lacher et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antagonistic pleiotropic effects of nitric oxide in the pathophysiology of Parkinson's disease

(2015) D. Tripathy et al.   FREE RADICAL RESEARCH

Evidence for a role of adaptive immune response in the disease pathogenesis of the MPTP mouse model of Parkinson's disease

(2015) Heather L. Martin et al.   GLIA

Pathways to Parkinsonism Redux: convergent pathobiological mechanisms in genetics of Parkinson's disease

(2015) Ravindran Kumaran et al.   HUMAN MOLECULAR GENETICS

Statin reduces persistent coronary arterial inflammation evaluated by serial 18fluorodeoxyglucose positron emission tomography imaging long after Kawasaki disease

(2015) Kenji Suda et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Simvastatin inhibits ischemia/reperfusion injury-induced apoptosis of retinal cells via downregulation of the tumor necrosis factor-α/nuclear factor-κB pathway

(2015) YU ZHANG et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Effects of simvastatin on the expression of inducible nitric oxide synthase and brain-derived neurotrophic factor in a lipopolysaccharide-induced rat model of Parkinson disease

(2015) Wang Tan et al.   INTERNATIONAL JOURNAL OF NEUROSCIENCE

Rosuvastatin suppresses atrial tachycardia-induced cellular remodeling via Akt/Nrf2/heme oxygenase-1 pathway

(2015) Yung-Hsin Yeh et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Neuroprotective effects of vildagliptin in rat rotenone Parkinson's disease model: role of RAGE-NFκB and Nrf2-antioxidant signaling pathways

(2015) Rania M. Abdelsalam et al.   JOURNAL OF NEUROCHEMISTRY

A Perspective on Roles Played by Innate and Adaptive Immunity in the Pathobiology of Neurodegenerative Disorders

(2015) Howard E. Gendelman et al.   Journal of Neuroimmune Pharmacology

Selective VIP Receptor Agonists Facilitate Immune Transformation for Dopaminergic Neuroprotection in MPTP-Intoxicated Mice

(2015) K. E. Olson et al.   JOURNAL OF NEUROSCIENCE

Statins, plasma cholesterol, and risk of Parkinson's disease: A prospective study

(2015) Xuemei Huang et al.   MOVEMENT DISORDERS

Plasma apolipoprotein A1 associates with age at onset and motor severity in early Parkinson's disease patients

(2015) Christine R. Swanson et al.   MOVEMENT DISORDERS

Glial activation is associated with l-DOPA induced dyskinesia and blocked by a nitric oxide synthase inhibitor in a rat model of Parkinson's disease

(2015) Mariza Bortolanza et al.   NEUROBIOLOGY OF DISEASE

Nitric oxide synthase inhibition decreases l-DOPA-induced dyskinesia and the expression of striatal molecular markers in Pitx3−/− aphakia mice

(2015) Oscar Solís et al.   NEUROBIOLOGY OF DISEASE

Cholesterol – A putative endogenous contributor towards Parkinson's disease

(2015) Rajib Paul et al.   NEUROCHEMISTRY INTERNATIONAL

Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of l-DOPA-induced dyskinesia in 6-OHDA-lesioned rats

(2015) Fernando Eduardo Padovan-Neto et al.   NEUROPHARMACOLOGY

Simvastatin prevents β-amyloid25–35-impaired neurogenesis in hippocampal dentate gyrus through α7nAChR-dependent cascading PI3K-Akt and increasing BDNF via reduction of farnesyl pyrophosphate

(2015) Conghui Wang et al.   NEUROPHARMACOLOGY

Neuroprotective Effect of Simvastatin via Inducing the Autophagy on Spinal Cord Injury in the Rat Model

(2015) Kai Gao et al.   Biomed Research International

RTA 408, A Novel Synthetic Triterpenoid with Broad Anticancer and Anti-Inflammatory Activity

(2015) Brandon L. Probst et al.   PLoS One

Simvastatin Attenuates Oxidative Stress, NF-κB Activation, and Artery Calcification in LDLR-/- Mice Fed with High Fat Diet via Down-regulation of Tumor Necrosis Factor-α and TNF Receptor 1

(2015) Chih-Pei Lin et al.   PLoS One

Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases

(2014) Li Gan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Alteration in the expression of exon IIC transcripts of brain-derived neurotrophic factor gene by simvastain in chronic mild stress in mice: a possible link with dopaminergic pathway

(2014) Digvijay G. Rana et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Simvastatin Inhibits Inflammation in Ischemia-Reperfusion Injury

(2014) Yilin Zhao et al.   INFLAMMATION

Inhibition of i-NOS but not n-NOS protects rat primary cell cultures against MPP+-induced neuronal toxicity

(2014) Monika J. Brzozowski et al.   JOURNAL OF NEURAL TRANSMISSION

Simvastatin prevents neuroinflammation by inhibiting N-methyl-D-aspartic acid receptor 1 in 6-hydroxydopamine-treated PC12 cells

(2014) Junqiang Yan et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Innate and Adaptive Inflammation as a Therapeutic Target in Vascular Disease

(2014) Dimitris Tousoulis et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Effect of high-dose simvastatin on brain atrophy and disability in secondary progressive multiple sclerosis (MS-STAT): a randomised, placebo-controlled, phase 2 trial

(2014) Jeremy Chataway et al.   LANCET

Statins and Neuroprotection: Basic Pharmacology Needed

(2014) W. Gibson Wood et al.   MOLECULAR NEUROBIOLOGY

Evaluation of Lovastatin Effects on Expression of Anti-apoptotic Nrf2 and PGC-1α Genes in Neural Stem Cells Treated with Hydrogen Peroxide

(2014) Alireza Abdanipour et al.   MOLECULAR NEUROBIOLOGY

Simvastatin reverses the downregulation of M1/4 receptor binding in 6-hydroxydopamine-induced parkinsonian rats: The association with improvements in long-term memory

(2014) Q. Wang et al.   NEUROSCIENCE

Role of statins in the treatment of multiple sclerosis

(2014) Rosella Ciurleo et al.   PHARMACOLOGICAL RESEARCH

Caveolin Contributes to the Modulation of Basal and β-Adrenoceptor Stimulated Function of the Adult Rat Ventricular Myocyte by Simvastatin: A Novel Pleiotropic Effect

(2014) Sara D. Pugh et al.   PLoS One

Effect of pravastatin on endothelial dysfunction in children with medium to giant coronary aneurysms due to Kawasaki disease

(2014) Chao Duan et al.   World Journal of Pediatrics

Statin treatment affects cytokine release and phagocytic activity in primary cultured microglia through two separable mechanisms

(2014) Matthew A Churchward et al.   Molecular Brain

α-Synuclein: The Long Distance Runner

(2013) Sonia George et al.   BRAIN PATHOLOGY

Atorvastatin improves cognitive, emotional and motor impairments induced by intranasal 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in rats, an experimental model of Parkinson's disease

(2013) Adalberto A. Castro et al.   BRAIN RESEARCH

Continuous oral administration of atorvastatin ameliorates brain damage after transient focal ischemia in rats

(2013) Tomonari Saito et al.   LIFE SCIENCES

An economic model of Parkinson's disease: Implications for slowing progression in the United States

(2013) Scott J. Johnson et al.   MOVEMENT DISORDERS

The current and projected economic burden of Parkinson's disease in the United States

(2013) Stacey L. Kowal et al.   MOVEMENT DISORDERS

Holding on to statins in Parkinson disease

(2013) E.-K. Tan et al.   NEUROLOGY

Discontinuation of statin therapy associates with Parkinson disease: A population-based study

(2013) Y.-C. Lee et al.   NEUROLOGY

Evidence from a Randomized Trial That Simvastatin, but Not Ezetimibe, Upregulates Circulating PCSK9 Levels

(2013) Heiner K. Berthold et al.   PLoS One

Prospective Study of Statin Use and Risk of Parkinson Disease

(2012) Xiang Gao   ARCHIVES OF NEUROLOGY

Neuroprotective potential of atorvastatin and simvastatin (HMG-CoA reductase inhibitors) against 6-hydroxydopamine (6-OHDA) induced Parkinson-like symptoms

(2012) Anil Kumar et al.   BRAIN RESEARCH

Nitric Oxide Modulation of the Basal Ganglia Circuitry: Therapeutic Implication for Parkinson's Disease and Other Motor Disorders

(2012) Massimo Pierucci et al.   CNS & Neurological Disorders-Drug Targets

Simvastatin Induces Neuroprotection in 6-OHDA-Lesioned PC12 via the PI3K/AKT/Caspase 3 Pathway and Anti-Inflammatory Responses

(2012) Yun-Qi Xu et al.   CNS Neuroscience & Therapeutics

Simvastatin inhibits secretion of Th17-polarizing cytokines and antigen presentation by DCs in patients with relapsing remitting multiple sclerosis

(2012) Xin Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Essential Role of MicroRNA-155 in Regulating Endothelium-Dependent Vasorelaxation by Targeting Endothelial Nitric Oxide Synthase

(2012) Hai-Xiang Sun et al.   HYPERTENSION

Cochrane review on ‘Statins for the treatment of dementia’

(2012) Bernadette McGuinness et al.   INTERNATIONAL JOURNAL OF GERIATRIC PSYCHIATRY

Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice

(2012) Kelvin C. Luk et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Anti-inflammatory effect of simvastatin in an experimental model of spinal cord trauma: involvement of PPAR-α

(2012) Emanuela Esposito et al.   Journal of Neuroinflammation

Statin use and risk of Parkinson’s disease: a meta-analysis of observational studies

(2012) Krishna Undela et al.   JOURNAL OF NEUROLOGY

Astrocyte-Specific Overexpression of Nrf2 Delays Motor Pathology and Synuclein Aggregation throughout the CNS in the Alpha-Synuclein Mutant (A53T) Mouse Model

(2012) L. Gan et al.   JOURNAL OF NEUROSCIENCE

Atorvastatin and pitavastatin reduce senile plaques and inflammatory responses in a mouse model of Alzheimer’s disease

(2012) Tomoko Kurata et al.   NEUROLOGICAL RESEARCH

Simvastatin decreases levodopa-induced dyskinesia in monkeys, but not in a randomized, placebo-controlled, multiple cross-over (“n-of-1”) exploratory trial of simvastatin against levodopa-induced dyskinesia in Parkinson's disease patients

(2012) François Tison et al.   PARKINSONISM & RELATED DISORDERS

 -Synuclein-Induced Down-Regulation of Nurr1 Disrupts GDNF Signaling in Nigral Dopamine Neurons

(2012) M. Decressac et al.   Science Translational Medicine

PPARαmediates the anti-inflammatory effect of simvastatin in an experimental model of zymosan-induced multiple organ failure

(2011) Barbara Rinaldi et al.   BRITISH JOURNAL OF PHARMACOLOGY

Pathways towards an effective immunotherapy for Parkinson’s disease

(2011) Jessica AL Hutter-Saunders et al.   Expert Review of Neurotherapeutics

Healthy User and Related Biases in Observational Studies of Preventive Interventions: A Primer for Physicians

(2011) William H. Shrank et al.   JOURNAL OF GENERAL INTERNAL MEDICINE

Retinoic Acid Isomers Up-Regulate ATP Binding Cassette A1 and G1 and Cholesterol Efflux in Rat Astrocytes: Implications for Their Therapeutic and Teratogenic Effects

(2011) J. Chen et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Prospects of Statins in Parkinson Disease

(2011) Avik Roy et al.   NEUROSCIENTIST

Simvastatin Prevents Dopaminergic Neurodegeneration in Experimental Parkinsonian Models: The Association with Anti-Inflammatory Responses

(2011) Junqiang Yan et al.   PLoS One

Serum Cholesterol and the Progression of Parkinson's Disease: Results from DATATOP

(2011) Xuemei Huang et al.   PLoS One

Lipopolysaccharide and Tumor Necrosis Factor Regulate Parkin Expression via Nuclear Factor-Kappa B

(2011) Thi A. Tran et al.   PLoS One

Genome-Wide Association Study Confirms SNPs inSNCAand theMAPTRegion as Common Risk Factors for Parkinson Disease

(2010) Todd L. Edwards et al.   ANNALS OF HUMAN GENETICS

Statins and neuroprotection

(2010) W. Gibson Wood et al.   Annals of the New York Academy of Sciences

Effects of Atorvastatin and Lisinopril on Endothelial Dysfunction in Patients with Behçet's Disease

(2010) Mehmet Tugrul Inanc et al.   ECHOCARDIOGRAPHY-A JOURNAL OF CARDIOVASCULAR ULTRASOUND AND ALLIED TECHNIQUES

Lovastatin decreases the synthesis of inflammatory mediators in the hippocampus and blocks the hyperthermia of rats submitted to long-lasting status epilepticus

(2010) Telma Luciana Furtado Gouveia et al.   EPILEPSY & BEHAVIOR

Myelin Basic Protein Priming Reduces the Expression of Foxp3 in T Cells via Nitric Oxide

(2010) Saurav Brahmachari et al.   JOURNAL OF IMMUNOLOGY

Regulatory T Cells Attenuate Th17 Cell-Mediated Nigrostriatal Dopaminergic Neurodegeneration in a Model of Parkinson’s Disease

(2010) Ashley D. Reynolds et al.   JOURNAL OF IMMUNOLOGY

Simvastatin treatment improves functional recovery after experimental spinal cord injury by upregulating the expression of BDNF and GDNF

(2010) Xiaoguang Han et al.   NEUROSCIENCE LETTERS

Microglia Acquire Distinct Activation Profiles Depending on the Degree of α-Synuclein Neuropathology in a rAAV Based Model of Parkinson's Disease

(2010) Vanesa Sanchez-Guajardo et al.   PLoS One

Stress-Activated Cap'n'collar Transcription Factors in Aging and Human Disease

(2010) G. P. Sykiotis et al.   Science Signaling

A Nurr1/CoREST Pathway in Microglia and Astrocytes Protects Dopaminergic Neurons from Inflammation-Induced Death

(2009) Kaoru Saijo et al.   CELL

Zocor Forte® (simvastatin) has a neuroprotective effect against LPS striatal dopaminergic terminals injury, whereas against MPP+ does not

(2009) Marti Santiago et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Lovastatin ameliorates α-synuclein accumulation and oxidation in transgenic mouse models of α-synucleinopathies

(2009) Andrew O. Koob et al.   EXPERIMENTAL NEUROLOGY

Neuronal NOS and cyclooxygenase-2 contribute to DNA damage in a mouse model of Parkinson disease

(2009) Tuan Hoang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Simvastatin Inhibits the Activation of p21ras and Prevents the Loss of Dopaminergic Neurons in a Mouse Model of Parkinson's Disease

(2009) A. Ghosh et al.   JOURNAL OF NEUROSCIENCE

Simvastatin improves cerebrovascular function and counters soluble amyloid-beta, inflammation and oxidative stress in aged APP mice

(2009) Xin-Kang Tong et al.   NEUROBIOLOGY OF DISEASE

Lipid-lowering drugs are associated with delayed onset and slower course of Parkinson's disease

(2009) Eugénie Mutez et al.   PHARMACOLOGICAL RESEARCH

Statins: Mechanisms of neuroprotection

(2009) Peter J. van der Most et al.   PROGRESS IN NEUROBIOLOGY

Use of Statins and the Risk of Parkinson???s Disease

(2008) Claudia Becker et al.   DRUG SAFETY

Simvastatin prevents the inflammatory process and the dopaminergic degeneration induced by the intranigral injection of lipopolysaccharide

(2008) María del Carmen Hernández-Romero et al.   JOURNAL OF NEUROCHEMISTRY

Statins reduce neuronal α-synuclein aggregation in in vitro models of Parkinson’s disease

(2008) Pazit Bar-On et al.   JOURNAL OF NEUROCHEMISTRY

The 3-Hydroxy-3-Methylglutaryl-CoA Reductase Inhibitor Lovastatin Reduces Severity of L-DOPA-Induced Abnormal Involuntary Movements in Experimental Parkinson's Disease

(2008) S. Schuster et al.   JOURNAL OF NEUROSCIENCE

Simvastatin-Mediated Upregulation of VEGF and BDNF, Activation of the PI3K/Akt Pathway, and Increase of Neurogenesis Are Associated with Therapeutic Improvement after Traumatic Brain Injury

(2008) Hongtao Wu et al.   JOURNAL OF NEUROTRAUMA

Association of MAPT haplotype-tagging SNPs with sporadic Parkinson's disease

(2008) Jana Vandrovcova et al.   NEUROBIOLOGY OF AGING

Statin use and the risk of Parkinson disease

(2008) A. D. Wahner et al.   NEUROLOGY

Total cholesterol and the risk of Parkinson disease

(2008) G. Hu et al.   NEUROLOGY

Nitrated α–Synuclein Immunity Accelerates Degeneration of Nigral Dopaminergic Neurons

(2008) Eric J. Benner et al.   PLoS One

Deficiency of Inducible Nitric Oxide Synthase Protects Against MPTP Toxicity In Vivo

(2003) Thomas Dehmer et al.   JOURNAL OF NEUROCHEMISTRY