Review
Immunology
Hayder M. M. Al-Kuraishy, Ali I. I. Al-Gareeb, Hebatallah M. M. Saad, Gaber El-Saber Batiha
Summary: Multiple sclerosis (MS) is a chronic progressive disease characterized by demyelination and neuronal injury. Dyslipidemia is an important risk factor in MS pathogenesis, and chronic inflammation in MS can lead to dyslipidemia. This review explores the effects of statins on MS, finding that while statins can have protective effects in the acute phase through anti-inflammatory and antioxidant mechanisms, they may have detrimental effects in the chronic phase by reducing brain cholesterol and inhibiting remyelination.
INFLAMMOPHARMACOLOGY
(2023)
Article
Clinical Neurology
Thijs R. J. Landman, Yvonne Schoon, Michiel C. Warle, Frederick J. A. Meijer, Frank-Erik De Leeuw, Dick H. J. Thijssen
Summary: This study found no significant improvement in infarct size or clinical outcome in patients with an acute ischemic stroke who were treated with repeated remote ischemic postconditioning.
INTERNATIONAL JOURNAL OF STROKE
(2023)
Review
Clinical Neurology
Nicolas Collongues, Guillaume Becker, Valerie Jolivel, Estelle Ayme-Dietrich, Jerome de Seze, Fabien Biname, Christine Patte-Mensah, Laurent Monassier, Ayikoe Guy Mensah-Nyagan
Summary: Multiple sclerosis is a chronic inflammatory disease with no neuroprotective drugs available. Research has identified potential targets for protecting axons from degeneration, offering hope for patients.
NEUROLOGY AND THERAPY
(2022)
Article
Medicine, Research & Experimental
Jack P. Antel, Timothy E. Kennedy, Tanja Kuhlmann
Summary: In this study, the authors investigate the potential of targeting the neuron-oligodendrocyte potassium shuttling as a neuroprotective strategy in multiple sclerosis. They examine disease models, evaluate the impact of pharmacologic intervention, and assess the status in tissues from MS patients. These findings serve as a template for defining a potential protective pathway.
JOURNAL OF CLINICAL INVESTIGATION
(2023)
Article
Clinical Neurology
Dylan R. Rice, Tamara B. Kaplan, Gladia C. Hotan, Andre C. Vogel, Marcelo Matiello, Rebecca L. Gillani, Spencer K. Hutto, Andrew S. Ham, Eric C. Klawiter, Ilena C. George, Kristin Galetta, Farrah J. Mateen
Summary: This randomized trial found that multiple sclerosis patients who received medication reminders had higher optimal adherence to oral disease modifying therapy. Younger age and taking more daily prescription pills were associated with lower optimal adherence. Strategies to improve adherence remain important in longitudinal MS care.
JOURNAL OF THE NEUROLOGICAL SCIENCES
(2021)
Article
Rehabilitation
Juan de Dios Perez-Bruzon, Cesar Fernandez-de-las-Penas, Joshua A. Cleland, Gustavo Plaza-Manzano, Ricardo Ortega-Santiago
Summary: The study demonstrates that incorporating neural mobilization into a multimodal management approach can reduce pressure sensitivity, decrease pain, and improve sensitivity to light touch and manual dexterity in individuals with multiple sclerosis.
Review
Immunology
M. J. Mansilla, S. Presas-Rodriguez, A. Teniente-Serra, I. Gonzalez-Larreategui, B. Quirant-Sanchez, F. Fondelli, N. Djedovic, D. Iwaszkiewicz-Grzes, K. Chwojnicki, D. Miljkovic, P. Trzonkowski, C. Ramo-Tello, E. M. Martinez-Caceres
Summary: Multiple sclerosis (MS) is a leading cause of chronic neurological disability in young to middle-aged adults, and current drug therapies are unable to halt or reverse the disease. Cell-based therapies have been proposed as a potential approach for treating MS.
CELLULAR & MOLECULAR IMMUNOLOGY
(2021)
Article
Clinical Neurology
Weili Li, Zhifeng Qi, Qingfeng Ma, Jiayue Ding, Chuanjie Wu, Haiqing Song, Qi Yang, Jiangang Duan, Lan Liu, Huining Kang, Longfei Wu, Kangxiang Ji, Wenbo Zhao, Chuanhui Li, Chenghe Sun, Na Li, Marc Fisher, Xunming Ji, Ke Jian Liu
Summary: The combination of NBO with EVT in patients with AIS shows promising results in reducing infarct volume, improving short-term neurobehavioral test scores, and enhancing clinical outcomes at 90 days compared to EVT alone. Although the NBO + EVT group had lower incidence rates of symptomatic intracranial hemorrhage, mortality, and adverse events compared to the EVT group, these differences were not statistically significant.
Review
Biochemistry & Molecular Biology
Daniel Sandi, Zsanett Fricska-Nagy, Krisztina Bencsik, Laszlo Vecsei
Summary: Neurodegeneration plays a crucial role in the pathogenesis of multiple sclerosis, leading to progression, pathopsychological disturbances, and optic neuropathy. The kynurenine pathway has been highlighted as a potential therapeutic target for neuroprotective drugs in MS, with promising data emerging from clinical evaluations. Further research on the pathway is expected to provide concrete results for everyday medicine in the future.
Article
Medicine, General & Internal
Antonio Avallone, Maria C. Piccirillo, Guglielmo Nasti, Gerardo Rosati, Chiara Carlomagno, Elena Di Gennaro, Carmela Romano, Fabiana Tatangelo, Vincenza Granata, Antonino Cassata, Lucrezia Silvestro, Alfonso De Stefano, Luigi Aloj, Valeria Vicario, Anna Nappi, Alessandra Leone, Domenico Bilancia, Laura Arenare, Antonella Petrillo, Secondo Lastoria, Ciro Gallo, Gerardo Botti, Paolo Delrio, Francesco Izzo, Franco Perrone, Alfredo Budillon
Summary: In this study, sequential administration of bevacizumab with chemotherapy did not improve the objective response rate as expected, but did show an advantage in overall survival, reduced adverse effects, and improved quality of life, suggesting potential for further exploration of antiangiogenic combination treatments.
Article
Clinical Neurology
Nancy D. Chiaravalloti, Silvana L. Costa, Nancy B. Moore, Kristen Costanza, John DeLuca
Summary: This study demonstrates the effectiveness of speed of processing training in improving processing speed deficits in individuals with multiple sclerosis. The training showed significant effects on the useful field of view and neuropsychological evaluation, with the number of completed training levels correlating with greater benefits.
JOURNAL OF NEUROLOGY
(2022)
Review
Immunology
Seyyed Mostafa Arabi, Leila Sadat Bahrami, Mahsa MalekAhmadi, Mahla Chambari, Narges Milkarizi, Alexander N. Orekhov, Amirhossein Sahebkar
Summary: This systematic review and meta-analysis evaluates the impact of combination therapy with statins and ezetimibe on proinflammatory cytokines. The results indicate that the combination therapy does not significantly reduce IL-1 beta, TNF-alpha, and MCP-1, but shows significant reductions in IL-6 and IFN-gamma levels. Furthermore, the reduction in IL-6 is particularly significant among individuals aged >= 60 years and the Asian population.
INTERNATIONAL IMMUNOPHARMACOLOGY
(2022)
Review
Medicine, General & Internal
Maria Teresa Gentile, Gianluca Muto, Giacomo Lus, Karl-Olof Lovblad, Asa Fex Svenningsen, Luca Colucci-D'Amato
Summary: This article reviews the role of angiogenesis in the onset and development of multiple sclerosis, including the molecular mechanisms, current therapeutic approaches, and potential therapeutic strategies with natural compounds as multi-target drugs with neuroprotective and anti-angiogenic properties.
JOURNAL OF CLINICAL MEDICINE
(2022)
Article
Clinical Neurology
Brian J. Loyd, Annie Fangman, Daniel S. Peterson, Eduard Gappmaier, Anne Thackeray, Michael C. Schubert, Leland E. Dibble
Summary: This study compared the efficacy of gaze and postural stability (GPS) retraining intervention to strength and endurance (SAE) intervention in individuals with multiple sclerosis (PwMS) who experienced dizziness or imbalance. The results showed that both GPS and SAE interventions resulted in significant improvements in dizziness handicap and balance from baseline to 6 weeks, with no significant difference between the two groups.
NEUROREHABILITATION AND NEURAL REPAIR
(2022)
Article
Clinical Neurology
Ludwig Kappos, Anthony Traboulsee, David K. B. Li, Amit Bar-Or, Frederik Barkhof, Xavier Montalban, David Leppert, Anna Baldinotti, Hans-Martin Schneble, Harold Koendgen, Annette Sauter, Qing Wang, Stephen L. Hauser
Summary: This study provides the longest follow-up to date of ocrelizumab-treated patients with RRMS, demonstrating sustained efficacy and reduced disease activity following interruption of 6-month dosing cycles without evidence of rebound.
JOURNAL OF NEUROLOGY
(2023)
Article
Health Care Sciences & Services
Rosaria De Luca, Carmela Rifici, Patrizia Pollicino, Marcella Di Cara, Sabrina Miceli, Giuseppina Sergi, Luisa Sorrenti, Michela Romano, Antonino Naro, Luana Billeri, Paola Lauria, Angelo Caminiti, Placido Bramanti, Michele Torrisi
Summary: This study aimed to investigate the effectiveness of online Skype therapy (OLST) in promoting cognitive and sensory-motor recovery in patients with severe acquired brain injury (SABI) and reducing caregiver distress. The results showed that OLST significantly reduced caregiver anxiety and burden, while improving trunk control, functional independence, cognitive functioning, and behavioral responsiveness in patients. The study also found significant changes in brain connectivity during the therapy. OLST could be a useful and complementary treatment for SABI patients and caregivers in the COVID-19 era.
JOURNAL OF TELEMEDICINE AND TELECARE
(2023)
Article
Clinical Neurology
Clara G. Chisari, Giancarlo Comi, Massimo Filippi, Damiano Paolicelli, Pietro Iaffaldano, Mauro Zaffaroni, Vincenzo Brescia Morra, Eleonora Cocco, Girolama Alessandra Marfia, Luigi Maria Grimaldi, Matilde Inglese, Simona Bonavita, Alessandra Lugaresi, Giuseppe Salemi, Giovanna De Luca, Salvatore Cottone, Antonella Conte, Patrizia Sola, Umberto Aguglia, Giorgia Teresa Maniscalco, Claudio Gasperini, Maria Teresa Ferro, Ilaria Pesci, Maria Pia Amato, Marco Rovaris, Claudio Solaro, Giacomo Lus, Davide Maimone, Roberto Bergamaschi, Franco Granella, Alessia Di Sapio, Antonio Bertolotto, Rocco Totaro, Marika Vianello, Paola Cavalla, Paolo Bellantonio, Vito Lepore, Francesco Patti
Summary: Approximately 60% of MS patients in Italy continued NTZ treatment during the observation period. Those who required discontinuation did so mainly due to concerns about PML.
JOURNAL OF NEUROLOGY
(2022)
Article
Public, Environmental & Occupational Health
Francesco Corallo, Carmela Rifici, Lilla Bonanno, Marcella Di Cara, Viviana Lo Buono, Giuseppe Venuti, Silvia Marino, Rosella Ciurleo, Viviana Torre, Giangaetano D'Aleo, Placido Bramanti, Edoardo Sessa
Summary: The study found that teriflunomide can potentially slow down the accumulation of microstructural tissue damage in Gray Matter and White Matter, better preserving cognitive profiles, particularly benefiting memory.
PSYCHOLOGY HEALTH & MEDICINE
(2022)
Article
Medicine, Research & Experimental
Viviana Lo Buono, Lilla Bonanno, Rosanna Palmeri, Simona Cammaroto, Rosa Morabito, Maria Cristina De Cola, Edoardo Sessa, Silvia Marino, Placido Bramanti, Francesco Corallo
Summary: Autoimmune limbic encephalitis is a brain inflammatory process that involves the medial temporal lobe and is mediated by antibodies. Diagnosing antibody-negative limbic encephalitis is challenging as it relies on excluding other causes. This case report describes a patient with typical radiological changes of limbic encephalitis, but with no identifiable antibodies and neuropsychological impairment.
JOURNAL OF INTERNATIONAL MEDICAL RESEARCH
(2022)
Correction
Clinical Neurology
Marcella Di Cara, Denise Grezzo, Rosanna Palmeri, Viviana Lo Buono, Emanuele Cartella, Katia Micchia, Caterina Formica, Carmela Rifici, Edoardo Sessa, Giangaetano D'Aleo, Giuseppa Maresca, Placido Bramanti, Francesco Corallo
NEUROLOGICAL SCIENCES
(2022)
Review
Clinical Neurology
Di Cara Marcella, Grezzo Denise, Palmeri Rosanna, Lo Buono Viviana, Cartella Emanuele, Micchia Katia, Formica Caterina, Rifici Carmela, Sessa Edoardo, D. 'Aleo Giangaetano, Maresca Giuseppa, Bramanti Placido, Corallo Francesco
Summary: Multiple sclerosis causes various psychosocial problems, with common symptoms being anxiety, depression, stress, fatigue, and pain. Studies have shown that mindfulness treatment can reduce depressive symptoms, improve quality of life, and decrease fatigue.
NEUROLOGICAL SCIENCES
(2022)
Review
Medicine, General & Internal
Katia Micchia, Caterina Formica, Simona De Salvo, Nunzio Muscara, Placido Bramanti, Fabrizia Caminiti, Silvia Marino, Francesco Corallo
Summary: Idiopathic normal pressure hydrocephalus (NPH) is a common syndrome in elderly people, characterized by excessive accumulation of cerebrospinal fluid in the brain. Diagnosis is based on clinical symptoms, including gait disturbances, cognitive impairment, and urinary incontinence. However, these symptoms do not always occur together, making diagnosis challenging. This review presents neurophysiological and neuropsychological approaches to assist in the diagnosis and differential diagnosis of NPH and other neurodegenerative disorders such as dementia.
Review
Medicine, General & Internal
Valentina Puglisi, Elisabetta Morini, Fiammetta Biasini, Luisa Vinciguerra, Giuseppe Lanza, Placido Bramanti
Summary: This is a case report on giant pituitary tumor apoplexy, presenting a rare case of an 81-year-old female with this condition. The authors highlight the importance of prompt diagnosis and multidisciplinary management in achieving significant improvement in symptoms.
JOURNAL OF CLINICAL MEDICINE
(2022)
Review
Biochemistry & Molecular Biology
Maria Sofia Basile, Placido Bramanti, Emanuela Mazzon
Summary: Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, and multiple sclerosis, are major medical needs that require novel therapeutic strategies. Inosine, known for its antioxidant properties, shows potential for use in these diseases. Its antioxidant action, ability to raise urate levels and increase ATP availability make it a promising candidate. Inosine appears to be safe and well tolerated, but the formation of kidney stones needs to be monitored. Further studies are needed to explore its effectiveness and safety, as well as its use as a complementary therapy with other approved drugs.
Article
Clinical Neurology
Roberto Bergamaschi, Ettore Beghi, Cristina Bosetti, Michela Ponzio, Claudia Santucci, Vito Lepore, Paola Mosconi, U. Aguglia, M. P. Amato, A. L. Ancona, B. Ardito, C. Avolio, R. Balgera, P. Banfi, V. Barcella, P. Barone, P. Bellantonio, A. Berardinelli, R. Bergamaschi, P. Bertora, M. Bianchi, P. Bramanti, V. Brescia Morra, G. Brichetto, A. M. Brioschi, M. Buccafusca, S. Bucello, V. Busillo, B. Calchetti, R. Cantello, M. Capobianco, F. Capone, L. Capone, D. Cargnelutti, M. Carrozzi, E. Cartechini, G. Cavaletti, P. Cavalla, M. G. Celani, R. Clerici, M. Clerico, E. Cocco, P. Confalonieri, M. G. Coniglio, A. Conte, F. Corea, S. Cottone, P. Crociani, F. D'Andrea, M. C. Danni, G. De Luca, D. de Pascalis, M. De Riz, F. De Robertis, G. De Rosa, N. De Stefano, M. Della Corte, A. Di Sapio, R. Docimo, M. Falcini, N. Falcone, S. Fermi, E. Ferraro, M. T. Ferro, M. Fortunato, M. Foschi, A. Gajofatto, A. Gallo, P. Gallo, M. Gatto, P. Gazzola, A. Giordano, F. Granella, M. F. Grasso, M. G. Grasso, L. M. E. Grimaldi, P. Iaffaldano, D. Imperiale, M. Inglese, R. Iodice, S. Leva, V. Luezzi, A. Lugaresi, G. Lus, D. Maimone, L. Mancinelli, G. T. Maniscalco, G. A. Marfia, B. Marini, A. Marson, N. Mascoli, L. Massacesi, F. Melani, M. Merello, G. Meucci, M. Mirabella, S. Montepietra, D. Nasuelli, P. Nicolao, F. Passantino, F. Patti, M. Peresson, I. Pesci, C. Piantadosi, M. L. Piras, M. Pizzorno, K. Plewnia, C. Pozzilli, A. Protti, R. Quatrale, S. Realmuto, G. Ribizzi, S. Rinalduzzi, A. Rini, S. Romano, M. Romeo, M. Ronzoni, P. Rossi, M. Rovaris, G. Salemi, G. Santangelo, M. Santangelo, G. Santuccio, P. Sarchielli, L. Sinisi, P. Sola, C. Solaro, D. Spitaleri, S. Strumia, T. Tassinari, S. Tonietti, C. Tortorella, R. Totaro, A. Tozzo, G. Trivelli, M. Ulivelli, P. Valentino, S. Venturi, M. Vianello, M. Zaffaroni, R. Zarbo, Maria Trojano, Mario Alberto Battaglia, Marco Capobianco, Maura Pugliatti, Monica Ulivelli, Paola Mosconi, Claudio Gasperini, Francesco Patti
Summary: The phenotypical heterogeneity of MS patients seen for the first time in Italian centers can only be partly explained by differences in the centers' characteristics, while the demographic and socio-economic characteristics of the patients seem to be the main determinants of the phenotypes at first referral.
NEUROLOGICAL SCIENCES
(2022)
Retraction
Integrative & Complementary Medicine
Sabrina Giacoppo, Renato Iori, Patrick Rollin, Placido Bramanti, Emanuela Mazzon
BMC COMPLEMENTARY MEDICINE AND THERAPIES
(2023)
Review
Integrative & Complementary Medicine
Giuseppa Maresca, Vanessa Nocito, Viviana Lo Buono, Desiree Latella, Marcella Di Cara, Caterina Formica, Lara Carnazza, Edoardo Sessa, Placido Bramanti, Francesco Corallo
Summary: This study conducted a systematic review on the symptoms of people with multiple sclerosis (MS), and found that hypnosis therapy has positive impacts on reducing pain, improving psychological well-being, and relieving fatigue in MS patients. Other nonpharmacological techniques did not have the same effects.
ALTERNATIVE THERAPIES IN HEALTH AND MEDICINE
(2023)
Article
Medicine, General & Internal
Roberta Cellini, Giuseppe Paladina, Giacomo Mascaro, Maria Antonietta Lembo, Antonino Lombardo Facciale, Maria Cristina Ferrera, Bartolo Fonti, Luca Pergolizzi, Piero Buonasera, Placido Bramanti, Emanuela Mazzon
Summary: Various studies have shown that immersive virtual reality can improve neuromuscular and cognitive outcomes in neurological diseases. This case study demonstrates the benefits of using advanced VR technology for neurorehabilitation in juvenile Huntington's disease patients.
MEDICINA-LITHUANIA
(2022)
Article
Medicine, General & Internal
Rosanna Palmeri, Francesco Corallo, Lilla Bonanno, Simona Curro, Paola Merlino, Giuseppe Di Lorenzo, Placido Bramanti, Silvia Marino, Viviana Lo Buono
Summary: Apathy and impulsiveness are common non-motor symptoms in Parkinson disease. This study aimed to investigate the presence of these symptoms, as well as other neuropsychiatric symptoms, in Parkinson disease patients. The results show that education and depression are important predictors of impulsiveness and apathy. This study highlights the importance of apathy and impulsiveness in Parkinson disease and suggests that future research should explore the role of other variables.
