Review
Biochemistry & Molecular Biology
Antonella Galeone, Maria Grano, Giacomina Brunetti
Summary: Ischemic heart disease, including myocardial infarction, stable angina, and ischemic cardiomyopathy, is a leading cause of death worldwide. Revascularization can reduce myocardial loss and improve clinical outcomes, but it also carries the risk of ischemia-reperfusion injury. This article reviews the role of tumor necrosis factor family members, such as TNF-alpha, CD95L/CD95, TRAIL, and the RANK/RANKL/OPG axis, in myocardial tissue damage and their potential as therapeutic targets.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Qian Zhang, Meng Jia, YunFu Wang, Qun Wang, Jianping Wu
Summary: Ischemic stroke is a major cause of morbidity and mortality worldwide. Various cell death mechanisms, including apoptosis, necrosis, autophagy, etc., play a role in brain tissue injury after cerebral ischemia-reperfusion. Understanding these mechanisms and their interactions is crucial.
NEUROCHEMICAL RESEARCH
(2022)
Article
Ophthalmology
Zongyuan Li, Feijia Xie, Ning Yang, Jiayi Yang, Jinyuan Luo, Dihao Hua, Tao He, Yiqiao Xing
Summary: The study demonstrated that overexpression of KLF7 can prevent the loss of RGCs and preserve electrophysiological function. Additionally, overexpression of KLF7 can ameliorate retinal dysfunction after RIR injury and improve the visual acuity of mice. The activation of Akt pathway and the suppression of the mitochondrial apoptotic pathway contribute to the neuroprotection of KLF7.
EXPERIMENTAL EYE RESEARCH
(2021)
Article
Biochemistry & Molecular Biology
Dandan Xu, Tingting Kong, Ziqi Shao, Minghui Liu, Rumin Zhang, Shengnan Zhang, Qingxia Kong, Jing Chen, Baohua Cheng, Chunmei Wang
Summary: Orexin-A has been shown to protect against cerebral ischemia/reperfusion injury by reducing inflammation, inhibiting astrocyte activation, and promoting apoptosis. Through the inhibition of specific signaling pathways, Orexin-A can improve neurological function in this context.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
(2021)
Article
Oncology
Qian-Lan Xu, Jie Wu
Summary: This study explores the role of Txk in ischemic stroke and suggests that Txk potentially regulates apoptosis, neurological deficit, and oxidative stress after I/R by entering the nucleus. NF-kappa B may be the downstream target factor of Txk in this process.
MOLECULAR MEDICINE REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Reda F. A. Abdelhameed, Amany K. Ibrahim, Mahmoud A. Elfaky, Eman S. Habib, Mayada Mahamed, Eman T. Mehanna, Khaled M. Darwish, Dina M. Khodeer, Safwat A. Ahmed, Sameh S. Elhady
Summary: Cynanchum acutum L. is a climbing vine in the Apocynaceae family, and seven compounds were isolated from its methanolic extract, including six flavonoids with anti-inflammatory and antioxidant properties. Among them, quercetin-3-O-galactoside and quercetin demonstrated superior anti-inflammatory activity compared to other bioactive metabolites.
Article
Pharmacology & Pharmacy
Hai-Jun Li, Dan-Qing Li, Yu-Liang Zhang, Xiao-Fei Ding, Hai-Tao Gao, Ya Zhu, Jun Liu, Li-Xia Zhang, Jie Chen, Guang Chen, Ying Yu
Summary: The modulation of the gut microbiota has been proposed as a potential therapeutic strategy for cerebral ischemia/reperfusion injury (CIRI). This study investigated the changes in the gut microbiota after CIRI and the effects of fecal microbiota transplant (FMT) on the brain. The findings suggest that FMT can attenuate CIRI in rats by inhibiting microglial M1 polarization through the ERK and NF-kappa B pathways.
FRONTIERS IN PHARMACOLOGY
(2023)
Article
Medicine, Research & Experimental
Akiko Inujima, Keiichi Koizumi, Naotoshi Shibahara
Summary: Research on bioactive components of herbal medicines has traditionally focused on secondary metabolites of herbal plants, with limited information on primary metabolites. This study highlights the immunostimulatory effects of heat-resistant RNA in a decoction of Glycyrrhizae Radix, suggesting nucleic acids as a new research field in the bioactive components of herbal medicines. By activating specific pathways and inducing cytokine production, the RNA demonstrated potential for therapeutic applications.
BIOMEDICINE & PHARMACOTHERAPY
(2022)
Article
Immunology
Yiqiu Zhang, Chenlu Song, Wei Ni, Qing Pei, Caixia Wang, Youguo Ying, Min Yao
Summary: This study demonstrates the protective effect of HSP70 on septic AKI by inhibiting inflammation and apoptosis through interaction with TRAF6.
JOURNAL OF INFLAMMATION RESEARCH
(2022)
Article
Ophthalmology
Ran Zhang, Yuqing Feng, Jinfang Lu, Yanni Ge, Huiling Li
Summary: The study revealed that lncRNA Ttc3-209 plays a proapoptotic role in RGCs during ischemia reperfusion-induced apoptosis, by competitively binding to miR-484 through a ceRNA mechanism to promote apoptosis in RGCs. Reducing the expression of lncRNA Ttc3-209 had a protective effect against apoptosis in RGCs, providing a potential therapeutic option for preventing RGC apoptosis in response to RIR injury.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)
Article
Oncology
Bo Liao, Xiaoyuan Tian
Summary: This study found that CTRP12 may mitigate inflammation and apoptosis in cardiomyocytes induced by hypoxia-reoxygenation (H/R) through the regulation of KLF15.
MOLECULAR MEDICINE REPORTS
(2022)
Article
Cardiac & Cardiovascular Systems
Holger Loerchner, Laia Canes Esteve, Maria Elisa Goes, Roxanne Harzenetter, Nathalie Brachmann, Praveen Gajawada, Stefan Guenther, Nicolas Doll, Jochen Poeling, Thomas Braun
Summary: This study reveals that TNF alpha recruits VEGFA-expressing neutrophils for muscle tissue revascularization through the CCL20-CCR6 axis. This finding provides a promising approach for revascularization, especially in diabetic conditions.
CIRCULATION RESEARCH
(2023)
Article
Multidisciplinary Sciences
Simin Deng, Yifeng Zhang, Ying Xin, Xinqun Hu
Summary: VNS may improve hepatic I/R injury-induced AKI by suppressing inflammation, oxidative stress, and apoptosis, possibly through activating the Nrf2/HO-1 signaling pathway.
SCIENTIFIC REPORTS
(2022)
Article
Ophthalmology
Yixuan Yao, Yujuan Cai, Ailing Sui, Yiyun Yao, Ting Su, Yanji Zhu, Bing Xie, Xi Shen
Summary: Through in vivo and in vitro experiments, it was found that etanercept regulates the expression of pro/anti-inflammatory factors, reduces the expression of pro-angiogenic factors, and decreases RNV formation by inhibiting NF-κB phosphorylation.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2021)
Article
Cardiac & Cardiovascular Systems
Dongze Qin, Xiaotong F. Jia, Anis Hanna, Jaehoon Lee, Ryan Pekson, John W. Elrod, John W. Calvert, Nikolaos G. Frangogiannis, Richard N. Kitsis
Summary: At least seven cell death programs are activated during myocardial infarction (MI), but the importance of each program in causing heart damage is not fully understood. In this study, the researchers focused on the role of BAK, a pro-cell death protein, in cardiomyocyte apoptosis and necrosis during MI/reperfusion (MI/R) and non-reperfused MI. They found that the absence of BAK significantly reduced infarct size and necrosis in vivo and in isolated cardiomyocytes. However, the complete deletion of BAK did not affect acute infarct size or long-term scar size, post-infarct remodeling, cardiac dysfunction, or mortality in non-reperfused MI. These results suggest that BAK may be a potential therapeutic target for MI/R.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
(2023)
Article
Environmental Sciences
Anqi Shan, Xi Chen, Xueli Yang, Baoqun Yao, Fengchao Liang, Ze Yang, Fangchao Liu, Song Chen, Xiaochang Yan, Jianfeng Huang, Shaoye Bo, Nai-Jun Tang, Dongfeng Gu, Hua Yan
Summary: The study found that long-term exposure to high levels of PM2.5 was associated with an increased risk of diabetic retinopathy among rural diabetic patients in China, with a stronger effect observed in participants who reported alcohol consumption.
ENVIRONMENT INTERNATIONAL
(2021)
Article
Ophthalmology
Yan Ren, Shufang Du, Dongping Zheng, Yanyun Shi, Luping Pan, Hua Yan
Summary: The study showed that intravitreal 3 mg triamcinolone acetonide injection during phacoemulsification in uveitic cataract patients can effectively reduce postoperative inflammation, improve visual acuity, shorten corticosteroid use, and lower the occurrence of complications.
Article
Ophthalmology
Mengyu Liao, Yunli Huang, Jiaxing Wang, Xiangda Meng, Yuanyuan Liu, Jinguo Yu, Hua Yan
Summary: Intravitreal triamcinolone acetonide (TA) administration after posterior vitreous detachment (PVD) during pars plana vitrectomy (PPV) can effectively improve the final visual outcomes and prevent postoperative complications in patients with severe proliferative diabetic retinopathy (PDR).
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Review
Ophthalmology
Sean Ming Sheng Ng, Rebecca Low, Annette K. Hoskin, Andres Rousselot, Dinesh Visva Gunasekeran, Sundaram Natarajan, Gangadhara Sundar, Caroline Ka Lin Chee, Chitaranjan Mishra, Parveen Sen, Eli Pradhan, Yunia Irawati, Tengku Ain Kamalden, Mehul Shah, Hua Yan, Fasika A. Woreta, Prem S. Subramanian, Ferenc Kuhn, Stephanie L. Watson, Rupesh Agrawal
Summary: Ophthalmic trauma is a leading cause of preventable monocular blindness globally, with varying prevalence based on factors such as geographic location and cultural practices. Clinical registries are valuable in guiding diagnosis, management, and prognostication, but there is currently a lack of a centralized international data repository for ophthalmic trauma.
GRAEFES ARCHIVE FOR CLINICAL AND EXPERIMENTAL OPHTHALMOLOGY
(2022)
Article
Biotechnology & Applied Microbiology
Zhuhong Zhang, Laien Zhao, Yuanyuan Ma, Jia Liu, Yanmei Huang, Xiaoxuan Fu, Shengjun Peng, Xiaojie Wang, Yun Yang, Xiaoyan Zhang, Wanru Ding, Jinguo Yu, Yanping Zhu, Hua Yan, Shubin Yang
Summary: The 15-nm silica nanoparticles induce size-dependent retinal toxicity, with glial cell activation and ROS generation contributing to this toxicity.
JOURNAL OF NANOBIOTECHNOLOGY
(2022)
Editorial Material
Medicine, General & Internal
Haoyu Chen, Vishal Jhanji, Rupesh Agrawal, Hua Yan
FRONTIERS IN MEDICINE
(2022)
Article
Ophthalmology
Yuanyuan Liu, Baoqun Yao, Xi Chen, Xueli Yang, Yong Liu, Zhenggao Xie, Xiaofeng Chen, Zhigang Yuan, Xingrong Wang, Dan Hu, Xiang Ma, Weiqi Gao, Ruifeng Wang, Yuzhong Yang, Song Chen, Jingkai Zhang, Zuoqing Song, Junsu Wang, Jing Wang, Jinyun Pei, Weijuan Wang, Meiyan Wang, Jun Gao, Hongwen Zhang, Lian Tan, Wei Du, Xuehui Pan, Gang Liu, Xiujuan Du, Xu Hou, Xin Gao, Zhen Zhang, Zhansheng Shen, Changfu Wu, Xiaochang Yan, Shaoye Bo, Xinghuai Sun, Nai-jun Tang, Chun Zhang, Hua Yan
Summary: This study investigated the prevalence of glaucoma and associated factors in rural populations in 10 provinces in China. The results showed a high prevalence of glaucoma in rural areas, with primary angle-closure glaucoma being the most common type. Increasing age, smoking, cerebral stroke, type 2 diabetes, higher education, and higher personal income were identified as significant risk factors for glaucoma. A family history of glaucoma was also associated with the prevalence of glaucoma and blindness.
BRITISH JOURNAL OF OPHTHALMOLOGY
(2023)
Article
Ophthalmology
Yan Wu, Xueliang Feng, Junhong Li, Min Chang, Jingjing Wang, Hua Yan
Summary: Prismatic treatment in a step-by-step manner can effectively reduce the angle of esotropia and improve binocular function in patients with acute acquired concomitant esotropia (AACE) of 25 prism diopters or less. Patients who have a shorter time from onset to treatment, smaller deviation at near and distant fixations, and good cooperation tend to eliminate esotropia and discontinue the use of press-on prisms within 1 year.
Article
Biochemistry & Molecular Biology
Ruotian Xie, Bei Wang, Shengkai Zuo, Mei Du, Xiaohong Wang, Ying Yu, Hua Yan
Summary: CRTH2 plays an important role in AMD. Inhibiting CRTH2 can protect RPE from apoptosis, reduce retinal degeneration area, and prevent loss of photoreceptor cells. This suggests that CRTH2 may be a promising therapeutic target for treating AMD.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
(2022)
Article
Medicine, General & Internal
Hua Yan, Kehu Yang, Zhizhong Ma, Ferenc Kuhn, Wenfang Zhang, ZhiJun Wang, Yuntao Hu, Hai Lu, Yoshida Shigeo, Gungor Sobaci, Sengul Ozdek, Matteo Forlini, Bo Huang, Yannian Hui, Ming Zhang, Gezhi Xu, Wenbin Wei, Yanrong Jiang, DongHo Park, RodrigoAntonio Brant Fernandes, Yuguang He, Andres Rousselot, Annette Hoskin, Gangadhara Sundar, Yong Liu, Yusheng Wang, Lijun Shen, Haoyu Chen, Huijin Chen, Gezhi Han, Rui Jiang, Xuemin Jin, Jijian Lin, Jing Luo, Zhaoyang Wang, Yong Wei, Ying Wen, Zhenggao Xie, Yi Wang, Xun Yang, Wenzhen Yu, Zhi Zheng, Xiaodong Sun, Jianhong Liang, Qin Liu, Jinguo Yu, Shihui Wei, Zhengxiang Li, Lu Chen, Xiufen Wang, Lili Wei, Haokun Zhang, Siyue Chen, Yuming Liu, Xu Guo, Siyuan Liu, Xinhua Xu, Yibo Tao, Yixuan Chen, Yaolong Chen
Summary: This article aims to establish evidence-based medical guidelines for the diagnosis, treatment, and prognosis of mechanical ocular trauma with no light perception. By reaching a consensus and providing detailed explanations, it hopes to address the current lack of unified standards in treatment.
JOURNAL OF EVIDENCE BASED MEDICINE
(2022)
Article
Biochemistry & Molecular Biology
Miao Guo, Yanfang Zhu, Ying Shi, Xiangda Meng, Xue Donga, Haokun Zhang, Xiaohong Wang, Mei Du, Hua Yan
Summary: Ferroptosis, a form of programmed cell death characterized by iron-dependent lethal lipid peroxides accumulation, plays a crucial role in RGC death in glaucoma and optic nerve crush models.
Article
Ophthalmology
Mingxue Zhang, Zhiyong Sun, Xinlei Zhu, Haokun Zhang, Yun Zhu, Hua Yan
Summary: In young sports-related groups in Tianjin, China, engaging in outdoor sports was associated with a lower prevalence of myopia. However, the use of electronic screens, training time, and family history of myopia were factors that contributed to a higher prevalence of myopia.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Article
Ophthalmology
Yinting Song, Haokun Zhang, Yanfang Zhu, Xiao Zhao, Yi Lei, Wei Zhou, Jinguo Yu, Xue Dong, Xiaohong Wang, Mei Du, Hua Yan
Summary: This study investigated the effects of lysozyme on SARS-CoV-2 infection and analyzed the susceptibility of corneal epithelial cells to the virus. The results showed that lysozyme can protect against SARS-CoV-2 infection and mitigate the inflammatory response in corneal epithelial cells.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2022)
Review
Biochemistry & Molecular Biology
Xiaohua Li, Binyun Ma, Mengyu Liao, Lingke Li, Xiaodan Zhang, Mei Du, Jinguo Yu, Shikun He, Hua Yan
Summary: This review discusses the role of N6-methyladenosine (m6A) methylation in eye diseases and explores its relevance to precision medicine, stem cell differentiation, and biomarkers for eye diseases.
FRONTIERS IN BIOSCIENCE-LANDMARK
(2022)
Article
Ophthalmology
Han Han, Xiao Zhao, Mengyu Liao, Yinting Song, Caiyun You, Xue Dong, Xueli Yang, Xiaohong Wang, Bo Huang, Mei Du, Hua Yan
Summary: The study revealed the profibrotic effects of FXa in PVR eyes, with mechanisms involving RPE activation.
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
(2021)