Rotenone and elevated extracellular potassium concentration induce cell-specific fibrillation of α-synuclein in axons of cholinergic enteric neurons in the guinea-pig ileum

New insights into cellular α-synuclein homeostasis in health and disease

(2016) Ulf Dettmer et al.   CURRENT OPINION IN NEUROBIOLOGY

ɑ-Synuclein strains and the variable pathologies of synucleinopathies

(2016) Wouter Peelaerts et al.   JOURNAL OF NEUROCHEMISTRY

Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance

(2016) Dena G. Hernandez et al.   JOURNAL OF NEUROCHEMISTRY

Review: Sporadic Parkinson's disease: development and distribution ofα-synuclein pathology

(2016) K. Del Tredici et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Constipation preceding Parkinson's disease: a systematic review and meta-analysis

(2015) Kerala L Adams-Carr et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Gastrointestinal dysfunction in Parkinson's disease

(2015) Alfonso Fasano et al.   LANCET NEUROLOGY

Alpha-synuclein in gastric and colonic mucosa in Parkinson's disease: Limited role as a biomarker

(2015) Sun Ju Chung et al.   MOVEMENT DISORDERS

Generation and characterization of novel conformation-specific monoclonal antibodies for α-synuclein pathology

(2015) Nishant N. Vaikath et al.   NEUROBIOLOGY OF DISEASE

Colonic mucosal  -synuclein lacks specificity as a biomarker for Parkinson disease

(2015) N. P. Visanji et al.   NEUROLOGY

Alpha-synuclein immunoreactivity patterns in the enteric nervous system

(2015) Iban Aldecoa et al.   NEUROSCIENCE LETTERS

Constipation is reduced by beta-blockers and increased by dopaminergic medications in Parkinson's disease

(2015) Gennaro Pagano et al.   PARKINSONISM & RELATED DISORDERS

Mitochondrial Dysfunction in Parkinson's Disease

(2015) Hyo Eun Moon et al.   Experimental Neurobiology

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats

(2014) Staffan Holmqvist et al.   ACTA NEUROPATHOLOGICA

Accumulation of oligomer-prone α-synuclein exacerbates synaptic and neuronal degeneration in vivo

(2014) Edward Rockenstein et al.   BRAIN

α-Synuclein assembles into higher-order multimers upon membrane binding to promote SNARE complex formation

(2014) Jacqueline Burré et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intramuscular injection of  -synuclein induces CNS  -synuclein pathology and a rapid-onset motor phenotype in transgenic mice

(2014) A. N. Sacino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Levels of cerebrospinal fluid α-synuclein oligomers are increased in Parkinson’s disease with dementia and dementia with Lewy bodies compared to Alzheimer’s disease

(2014) Oskar Hansson et al.   Alzheimers Research & Therapy

Mitochondrial reactive oxygen species: A double edged sword in ischemia/reperfusion vs preconditioning

(2014) Theodore Kalogeris et al.   Redox Biology

Accumulation of α-synuclein in the bowel of patients in the pre-clinical phase of Parkinson’s disease

(2013) David Hilton et al.   ACTA NEUROPATHOLOGICA

Selective coexpression of synaptic proteins, α-synuclein, cysteine string protein-α, synaptophysin, synaptotagmin-1, and synaptobrevin-2 in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig ileum

(2013) Dale F. Sharrad et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Effects of oral administration of rotenone on gastrointestinal functions in mice

(2013) M. Tasselli et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Physiological Phenotype and Vulnerability in Parkinson's Disease

(2013) D. J. Surmeier et al.   Cold Spring Harbor Perspectives in Medicine

Knock out of neuronal nitric oxide synthase exacerbates intestinal ischemia/reperfusion injury in mice

(2012) Leni R. Rivera et al.   CELL AND TISSUE RESEARCH

Selective expression of α-synuclein-immunoreactivity in vesicular acetylcholine transporter-immunoreactive axons in the guinea pig rectum and human colon

(2012) Dale F. Sharrad et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Alpha-synuclein overexpressing transgenic mice show internal organ pathology and autonomic deficits

(2012) Penelope J. Hallett et al.   NEUROBIOLOGY OF DISEASE

Expression pattern and localization of alpha-synuclein in the human enteric nervous system

(2012) Martina Böttner et al.   NEUROBIOLOGY OF DISEASE

Mice overexpressing wild-type human alpha-synuclein display alterations in colonic myenteric ganglia and defecation

(2012) L. Wang et al.   NEUROGASTROENTEROLOGY AND MOTILITY

A comparison between colonic submucosa and mucosa to detect Lewy pathology in Parkinson’s disease

(2012) H. Pouclet et al.   NEUROGASTROENTEROLOGY AND MOTILITY

Potassium Depolarization and Raised Calcium Induces α-Synuclein Aggregates

(2012) Jordan Follett et al.   NEUROTOXICITY RESEARCH

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

A soluble  -synuclein construct forms a dynamic tetramer

(2011) W. Wang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MPTP-induced parkinsonism extends to a subclass of TH-positive neurons in the gut

(2010) Gianfranco Natale et al.   BRAIN RESEARCH

Extensive enteric nervous system abnormalities in mice transgenic for artificial chromosomes containing Parkinson disease-associated α-synuclein gene mutations precede central nervous system changes

(2010) Yien-Ming Kuo et al.   HUMAN MOLECULAR GENETICS

CSPα promotes SNARE-complex assembly by chaperoning SNAP-25 during synaptic activity

(2010) Manu Sharma et al.   NATURE CELL BIOLOGY

Detection of elevated levels of  -synuclein oligomers in CSF from patients with Parkinson disease

(2010) T. Tokuda et al.   NEUROLOGY

Progression of Parkinson's Disease Pathology Is Reproduced by Intragastric Administration of Rotenone in Mice

(2010) Francisco Pan-Montojo et al.   PLoS One

 -Synuclein Promotes SNARE-Complex Assembly in Vivo and in Vitro

(2010) J. Burre et al.   SCIENCE

Rotenone Damages Striatal Organotypic Slice Culture

(2009) Rudolf Moldzio et al.   Annals of the New York Academy of Sciences

Delayed gastric emptying and enteric nervous system dysfunction in the rotenone model of Parkinson's disease

(2009) James G. Greene et al.   EXPERIMENTAL NEUROLOGY

Chronic rotenone exposure reproduces Parkinson's disease gastrointestinal neuropathology

(2009) Robert E. Drolet et al.   NEUROBIOLOGY OF DISEASE

Rotenone Induces Cell Death of Cholinergic Neurons in an Organotypic Co-Culture Brain Slice Model

(2009) Celine Ullrich et al.   NEUROCHEMICAL RESEARCH

A timeline for Parkinson's disease

(2009) Christopher H. Hawkes et al.   PARKINSONISM & RELATED DISORDERS

Pathological lesions in colonic biopsies during Parkinson's disease

(2008) T Lebouvier et al.   GUT