Entanglement of UPRER in Aging Driven Neurodegenerative Diseases

Tracking Effects of SIL1 Increase: Taking a Closer Look Beyond the Consequences of Elevated Expression Level

(2017) Thomas Labisch et al.   MOLECULAR NEUROBIOLOGY

GRP78 at the Centre of the Stage in Cancer and Neuroprotection

(2017) Caty Casas   Frontiers in Neuroscience

Endoplasmic Reticulum Stress, Unfolded Protein Response, and Cancer Cell Fate

(2017) Marco Corazzari et al.   Frontiers in Oncology

The Endoplasmic Reticulum Chaperone GRP78/BiP Modulates Prion Propagation in vitro and in vivo

(2017) Kyung-Won Park et al.   Scientific Reports

Repurposing the NRF2 Activator Dimethyl Fumarate as Therapy Against Synucleinopathy in Parkinson's Disease

(2016) Isabel Lastres-Becker et al.   ANTIOXIDANTS & REDOX SIGNALING

Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions

(2016) Natarajan Suganthy et al.   BIOMEDICINE & PHARMACOTHERAPY

Adaptive preconditioning in neurological diseases – therapeutic insights from proteostatic perturbations

(2016) B. Mollereau et al.   BRAIN RESEARCH

An update on potential therapeutic strategies for Parkinson’s disease based on pathogenic mechanisms

(2016) Ting Shen et al.   Expert Review of Neurotherapeutics

Alternative Selection of β-Site APP-Cleaving Enzyme 1 (BACE1) Cleavage Sites in Amyloid β-Protein Precursor (APP) Harboring Protective and Pathogenic Mutations within the Aβ Sequence

(2016) Ayano Kimura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Overview of Alzheimer’s Disease and Some Therapeutic Approaches Targeting Aβby Using Several Synthetic and Herbal Compounds

(2016) Sandeep Kumar Singh et al.   Oxidative Medicine and Cellular Longevity

Mitofusin-mediated ER stress triggers neurodegeneration in pink1/parkin models of Parkinson’s disease

(2016) I Celardo et al.   Cell Death & Disease

Regulation of Memory Formation by the Transcription Factor XBP1

(2016) Gabriela Martínez et al.   Cell Reports

An update on potential therapeutic strategies for Parkinson’s disease based on pathogenic mechanisms

(2016) Ting Shen et al.   Expert Review of Neurotherapeutics

Distinct Cell Stress Responses Induced by ATP Restriction in Quiescent Human Fibroblasts

(2016) Nirupama Yalamanchili et al.   Frontiers in Genetics

Therapeutic Targeting of Autophagy

(2016) Christina G. Towers et al.   EBioMedicine

PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia

(2015) Helois Radford et al.   ACTA NEUROPATHOLOGICA

HTT/Huntingtin in selective autophagy and Huntington disease: A foe or a friend within?

(2015) Yan-Ning Rui et al.   Autophagy

Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease

(2015) Merja H. Voutilainen et al.   FEBS LETTERS

Endoplasmic Reticulum Stress Interacts With Inflammation in Human Diseases

(2015) Stewart Siyan Cao et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Role of the unfolded protein response, GRP78 and GRP94 in organ homeostasis

(2015) Genyuan Zhu et al.   JOURNAL OF CELLULAR PHYSIOLOGY

ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress

(2015) Huikyong Lee et al.   MOLECULAR NEUROBIOLOGY

SIL1 Rescued Bip Elevation-Related Tau Hyperphosphorylation in ER Stress

(2015) Zan-Chao Liu et al.   MOLECULAR NEUROBIOLOGY

Unfolded Protein Response and Macroautophagy in Alzheimer’s, Parkinson’s and Prion Diseases

(2015) Irina Milisav et al.   MOLECULES

Integrated stress response is critical for gemcitabine resistance in pancreatic ductal adenocarcinoma

(2015) L R Palam et al.   Cell Death & Disease

The small molecule ISRIB reverses the effects of eIF2α phosphorylation on translation and stress granule assembly

(2015) Carmela Sidrauski et al.   eLife

Synaptic activity and Alzheimer's disease: a critical update

(2015) Davide Tampellini   Frontiers in Neuroscience

Hexosamine Pathway Metabolites Enhance Protein Quality Control and Prolong Life

(2014) Martin S. Denzel et al.   CELL

Protein kinase R-like endoplasmic reticulum kinase and glycogen synthase kinase-3α/β regulate foam cell formation

(2014) Cameron S. McAlpine et al.   JOURNAL OF LIPID RESEARCH

Selective mRNA translation during eIF2 phosphorylation induces expression of IBTKα

(2014) Thomas D. Baird et al.   MOLECULAR BIOLOGY OF THE CELL

ER Stress-Induced eIF2-alpha Phosphorylation Underlies Sensitivity of Striatal Neurons to Pathogenic Huntingtin

(2014) Julia Leitman et al.   PLoS One

Control of dopaminergic neuron survival by the unfolded protein response transcription factor XBP1

(2014) P. Valdes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Intracellular Accumulation of Toxic Turn Amyloid-β is Associated with Endoplasmic Reticulum Stress in Alzheimer’s Disease

(2013) Naoko Soejima et al.   Current Alzheimer Research

Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both  -Amyloid Production and Clearance

(2013) Z. Zhu et al.   JOURNAL OF NEUROSCIENCE

ER stress inhibits neuronal death by promoting autophagy

(2012) Antoine Fouillet et al.   Autophagy

Targeting the UPR transcription factor XBP1 protects against Huntington's disease through the regulation of FoxO1 and autophagy

(2012) Rene L. Vidal et al.   HUMAN MOLECULAR GENETICS

XBP1mRNA Splicing Triggers an Autophagic Response in Endothelial Cells throughBECLIN-1Transcriptional Activation

(2012) Andriana Margariti et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum Stress Is Important for the Manifestations of  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

Pathogenesis of Parkinson's disease

(2012) Etienne C. Hirsch et al.   MOVEMENT DISORDERS

Tauroursodeoxycholic acid suppresses amyloid β-induced synaptic toxicity in vitro and in APP/PS1 mice

(2012) Rita M. Ramalho et al.   NEUROBIOLOGY OF AGING

Dantrolene ameliorates cognitive decline and neuropathology in Alzheimer triple transgenic mice

(2012) Jun Peng et al.   NEUROSCIENCE LETTERS

ATF6alpha Promotes Astroglial Activation and Neuronal Survival in a Chronic Mouse Model of Parkinson’s Disease

(2012) Koji Hashida et al.   PLoS One

Endoplasmic reticulum stress activates autophagy but not the proteasome in neuronal cells: implications for Alzheimer's disease

(2011) D A T Nijholt et al.   CELL DEATH AND DIFFERENTIATION

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux

(2011) Huikyong Lee et al.   HUMAN MOLECULAR GENETICS

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Autophagy is a protective mechanism in normal cartilage, and its aging-related loss is linked with cell death and osteoarthritis

(2010) Beatriz Caramés et al.   ARTHRITIS AND RHEUMATISM

Phenylbutyrate rescues dendritic spine loss associated with memory deficits in a mouse model of Alzheimer disease

(2010) Ana Ricobaraza et al.   HIPPOCAMPUS

The Endoplasmic Reticulum Stress Sensor, ATF6α, Protects against Neurotoxin-induced Dopaminergic Neuronal Death

(2010) Naohiro Egawa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Impaired ATF6α processing, decreased Rheb and neuronal cell cycle re-entry in Huntington's disease

(2010) Maria Rosario Fernandez-Fernandez et al.   NEUROBIOLOGY OF DISEASE

Activation of PERK Signaling Attenuates Aβ-Mediated ER Stress

(2010) Do Yeon Lee et al.   PLoS One

Insulin/IGF-1 signaling mutants reprogram ER stress response regulators to promote longevity

(2010) S. Henis-Korenblit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus

(2009) Jeroen J.M. Hoozemans et al.   AMERICAN JOURNAL OF PATHOLOGY

Role of the Unfolded Protein Response Regulator GRP78/BiP in Development, Cancer, and Neurological Disorders

(2009) Miao Wang et al.   ANTIOXIDANTS & REDOX SIGNALING

Rrs1 Is Involved in Endoplasmic Reticulum Stress Response in Huntington Disease

(2009) Alisia Carnemolla et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the Akt-NF- B Pathway by Subtilase Cytotoxin through the ATF6 Branch of the Unfolded Protein Response

(2009) H. Yamazaki et al.   JOURNAL OF IMMUNOLOGY

Hypoxic activation of the unfolded protein response (UPR) induces expression of the metastasis-associated gene LAMP3

(2009) Hilda Mujcic et al.   RADIOTHERAPY AND ONCOLOGY

HIF-1 Modulates Dietary Restriction-Mediated Lifespan Extension via IRE-1 in Caenorhabditis elegans

(2009) Di Chen et al.   PLoS Genetics

Aging Impairs the Unfolded Protein Response to Sleep Deprivation and Leads to Proapoptotic Signaling

(2008) N. Naidoo et al.   JOURNAL OF NEUROSCIENCE

ER stress is involved in Aβ‐induced GSK‐3β activation and tau phosphorylation

(2008) Rosa Resende et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Mutant huntingtin and mitochondrial dysfunction

(2008) Ella Bossy-Wetzel et al.   TRENDS IN NEUROSCIENCES

Decreased enzyme activities of chaperones PDI and BiP in aged mouse livers

(2007) Jonathan E. Nuss et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS