Therapeutic potential of the endoplasmic reticulum located and secreted CDNF/MANF family of neurotrophic factors in Parkinson's disease

Cerebral dopamine neurotrophic factor improves long-term memory in APP/PS1 transgenic mice modeling Alzheimer's disease as well as in wild-type mice

(2015) Susanna Kemppainen et al.   BEHAVIOURAL BRAIN RESEARCH

Prospects of Neurotrophic Factors for Parkinson's Disease: Comparison of Protein and Gene Therapy

(2015) Andrii Domanskyi et al.   HUMAN GENE THERAPY

High diagnostic yield of clinical exome sequencing in Middle Eastern patients with Mendelian disorders

(2015) Tarunashree Yavarna et al.   HUMAN GENETICS

The Solution Structure and Dynamics of Full-length Human Cerebral Dopamine Neurotrophic Factor and Its Neuroprotective Role against α-Synuclein Oligomers

(2015) Cristiane Latge et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Enhanced Efficacy of the CDNF/MANF Family by Combined Intranigral Overexpression in the 6-OHDA Rat Model of Parkinson's Disease

(2015) Óscar Cordero-Llana et al.   MOLECULAR THERAPY

GDNF is not required for catecholaminergic neuron survival in vivo

(2015) Jaakko Kopra et al.   NATURE NEUROSCIENCE

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Involved in Inflammation by Negatively Regulating the NF-κB Pathway

(2015) Lijian Chen et al.   Scientific Reports

Transient transfection of human CDNF gene reduces the 6-hydroxydopamine-induced neuroinflammation in the rat substantia nigra

(2014) Rasajna Nadella et al.   Journal of Neuroinflammation

Age-Dependent Decrease in Chaperone Activity Impairs MANF Expression, Leading to Purkinje Cell Degeneration in Inducible SCA17 Mice

(2014) Su Yang et al.   NEURON

Spatiotemporal Expression of MANF in the Developing Rat Brain

(2014) Haiping Wang et al.   PLoS One

MANF Is Indispensable for the Proliferation and Survival of Pancreatic β Cells

(2014) Maria Lindahl et al.   Cell Reports

AAV2-mediated striatum delivery of human CDNF prevents the deterioration of midbrain dopamine neurons in a 6-hydroxydopamine induced parkinsonian rat model

(2013) Xinmiao Ren et al.   EXPERIMENTAL NEUROLOGY

Mesencephalic Astrocyte-Derived Neurotrophic Factor Inhibits Oxygen–Glucose Deprivation-Induced Cell Damage and Inflammation by Suppressing Endoplasmic Reticulum Stress in Rat Primary Astrocytes

(2013) Hua Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Mechanisms of Anti-inflammatory Property of Conserved Dopamine Neurotrophic Factor: Inhibition of JNK Signaling in Lipopolysaccharide-Induced Microglia

(2013) Hua Zhao et al.   JOURNAL OF MOLECULAR NEUROSCIENCE

Characterization of the Structural and Functional Determinants of MANF/CDNF in Drosophila In Vivo Model

(2013) Riitta Lindström et al.   PLoS One

Gene therapy with AAV2-CDNF provides functional benefits in a rat model of Parkinson's disease

(2013) Susanne Bäck et al.   Brain and Behavior

MANF regulates dopaminergic neuron development in larval zebrafish

(2012) Y.-C. Chen et al.   DEVELOPMENTAL BIOLOGY

Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Secretion and Cell Surface Binding Are Modulated by KDEL Receptors

(2012) Mark J. Henderson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mesencephalic Astrocyte-derived Neurotrophic Factor Protects the Heart from Ischemic Damage and Is Selectively Secreted upon Sarco/endoplasmic Reticulum Calcium Depletion

(2012) Christopher C. Glembotski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Accumulation of Toxic  -Synuclein Oligomer within Endoplasmic Reticulum Occurs in  -Synucleinopathy In Vivo

(2012) E. Colla et al.   JOURNAL OF NEUROSCIENCE

GDNF fails to exert neuroprotection in a rat  -synuclein model of Parkinson's disease

(2011) M. Decressac et al.   BRAIN

CDNF Protects the Nigrostriatal Dopamine System and Promotes Recovery after MPTP Treatment in Mice

(2011) Mikko Airavaara et al.   CELL TRANSPLANTATION

Vascular endothelial growth factor C acts as a neurotrophic factor for dopamine neurons in vitro and in vivo

(2011) M. Piltonen et al.   NEUROSCIENCE

Neurorestoration

(2011) Mikko Airavaara et al.   PARKINSONISM & RELATED DISORDERS

The Unfolded Protein Response: From Stress Pathway to Homeostatic Regulation

(2011) P. Walter et al.   SCIENCE

Clinical progression in Parkinson disease and the neurobiology of axons

(2010) Hsiao-Chun Cheng et al.   ANNALS OF NEUROLOGY

The Expanding Universe of Neurotrophic Factors: Therapeutic Potential in Aging and Age-Associated Disorders

(2010) C. Lanni et al.   CURRENT PHARMACEUTICAL DESIGN

Widespread cortical expression of MANF by AAV serotype 7: Localization and protection against ischemic brain injury

(2010) Mikko Airavaara et al.   EXPERIMENTAL NEUROLOGY

Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease

(2010) Merja H. Voutilainen et al.   EXPERIMENTAL NEUROLOGY

Solution structure and dynamics of mouse ARMET

(2010) Jun Hoseki et al.   FEBS LETTERS

Mesencephalic Astrocyte-derived Neurotrophic Factor (MANF) Has a Unique Mechanism to Rescue Apoptotic Neurons

(2010) Maarit Hellman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Repairing the parkinsonian brain with neurotrophic factors

(2010) Liviu Aron et al.   TRENDS IN NEUROSCIENCES

Mesencephalic astrocyte-derived neurotrophic factor reduces ischemic brain injury and promotes behavioral recovery in rats

(2009) Mikko Airavaara et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is Neurorestorative in Rat Model of Parkinson's Disease

(2009) M. H. Voutilainen et al.   JOURNAL OF NEUROSCIENCE

Evidence that DmMANF is an invertebrate neurotrophic factor supporting dopaminergic neurons

(2009) M. Palgi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mesencephalic Astrocyte-Derived Neurotrophic Factor Is an Ischemia-Inducible Secreted Endoplasmic Reticulum Stress Response Protein in the Heart

(2008) Archana Tadimalla et al.   CIRCULATION RESEARCH

Signalling mechanisms underlying development and maintenance of dopamine neurons

(2008) Jaan-Olle Andressoo et al.   CURRENT OPINION IN NEUROBIOLOGY

Armet, a UPR-upregulated protein, inhibits cell proliferation and ER stress-induced cell death

(2008) A APOSTOLOU et al.   EXPERIMENTAL CELL RESEARCH

The Structure of the Glial Cell Line-derived Neurotrophic Factor-Coreceptor Complex

(2008) Vimal Parkash et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MANF is widely expressed in mammalian tissues and differently regulated after ischemic and epileptic insults in rodent brain

(2008) Päivi Lindholm et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Absolute requirement of GDNF for adult catecholaminergic neuron survival

(2008) Alberto Pascual et al.   NATURE NEUROSCIENCE