PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
Published 2015 View Full Article
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Title
PERK inhibition prevents tau-mediated neurodegeneration in a mouse model of frontotemporal dementia
Authors
Keywords
Unfolded Protein Response, Tau, Neurodegeneration, Dementia, PERK
Journal
ACTA NEUROPATHOLOGICA
Volume 130, Issue 5, Pages 633-642
Publisher
Springer Nature
Online
2015-10-08
DOI
10.1007/s00401-015-1487-z
References
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Note: Only part of the references are listed.- Preventing proteostasis diseases by selective inhibition of a phosphatase regulatory subunit
- (2015) I. Das et al. SCIENCE
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- (2014) Christoph Köhler et al. NEUROBIOLOGY OF DISEASE
- The unfolded protein response mediates reversible tau phosphorylation induced by metabolic stress
- (2014) J M van der Harg et al. Cell Death & Disease
- Resetting translational homeostasis restores myelination in Charcot-Marie-Tooth disease type 1B mice
- (2013) Maurizio D’Antonio et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Tau Accumulation Activates the Unfolded Protein Response by Impairing Endoplasmic Reticulum-Associated Degradation
- (2013) J. F. Abisambra et al. JOURNAL OF NEUROSCIENCE
- Suppression of eIF2α kinases alleviates Alzheimer's disease–related plasticity and memory deficits
- (2013) Tao Ma et al. NATURE NEUROSCIENCE
- Targeting the unfolded protein response in disease
- (2013) Claudio Hetz et al. NATURE REVIEWS DRUG DISCOVERY
- Active glycogen synthase kinase-3 and tau pathology-related tyrosine phosphorylation in pR5 human tau transgenic mice
- (2013) Christoph Köhler et al. NEUROBIOLOGY OF AGING
- Unfolded protein response activates glycogen synthase kinase-3 via selective lysosomal degradation
- (2013) Diana A.T. Nijholt et al. NEUROBIOLOGY OF AGING
- Oral Treatment Targeting the Unfolded Protein Response Prevents Neurodegeneration and Clinical Disease in Prion-Infected Mice
- (2013) J. A. Moreno et al. Science Translational Medicine
- Pharmacological brake-release of mRNA translation enhances cognitive memory
- (2013) Carmela Sidrauski et al. eLife
- The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer’s disease
- (2013) Lauren D Stutzbach et al. Acta Neuropathologica Communications
- Discovery of 7-Methyl-5-(1-{[3-(trifluoromethyl)phenyl]acetyl}-2,3-dihydro-1H-indol-5-yl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine (GSK2606414), a Potent and Selective First-in-Class Inhibitor of Protein Kinase R (PKR)-like Endoplasmic Reticulum Kinase (PERK)
- (2012) Jeffrey M. Axten et al. JOURNAL OF MEDICINAL CHEMISTRY
- The unfolded protein response is associated with early tau pathology in the hippocampus of tauopathies
- (2011) Diana AT Nijholt et al. JOURNAL OF PATHOLOGY
- The unfolded protein response in familial amyotrophic lateral sclerosis
- (2010) L. Wang et al. HUMAN MOLECULAR GENETICS
- The Unfolded Protein Response Is Activated in Pretangle Neurons in Alzheimer's Disease Hippocampus
- (2009) Jeroen J.M. Hoozemans et al. AMERICAN JOURNAL OF PATHOLOGY
- A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice
- (2009) Smita Saxena et al. NATURE NEUROSCIENCE
- A novel GSK-3β inhibitor reduces Alzheimer's pathology and rescues neuronal loss in vivo
- (2009) L. Serenó et al. NEUROBIOLOGY OF DISEASE
- Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis
- (2008) Julie D. Atkin et al. NEUROBIOLOGY OF DISEASE
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