ENC1 Modulates the Aggregation and Neurotoxicity of Mutant Huntingtin Through p62 Under ER Stress

Redox regulation of autophagy in healthy brain and neurodegeneration

(2015) Kenneth Hensley et al.   NEUROBIOLOGY OF DISEASE

Proteotoxic Stress Induces Phosphorylation of p62/SQSTM1 by ULK1 to Regulate Selective Autophagic Clearance of Protein Aggregates

(2015) Junghyun Lim et al.   PLoS Genetics

The Regulation of Autophagosome Dynamics by Huntingtin and HAP1 Is Disrupted by Expression of Mutant Huntingtin, Leading to Defective Cargo Degradation

(2014) Y. C. Wong et al.   JOURNAL OF NEUROSCIENCE

Phosphorylation of p62 Activates the Keap1-Nrf2 Pathway during Selective Autophagy

(2013) Yoshinobu Ichimura et al.   MOLECULAR CELL

Soluble forms of polyQ-expanded huntingtin rather than large aggregates cause endoplasmic reticulum stress

(2013) Julia Leitman et al.   Nature Communications

Assurance of mitochondrial integrity and mammalian longevity by the p62–Keap1–Nrf2–Nqo1 cascade

(2012) Jeongho Kwon et al.   EMBO REPORTS

GRP78 counteracts cell death and protein aggregation caused by mutant huntingtin proteins

(2012) Yufeng Jiang et al.   NEUROSCIENCE LETTERS

Converging Pathways in the Occurrence of Endoplasmic Reticulum (ER) Stress in Huntingtons Disease

(2011) R. Vidal et al.   CURRENT MOLECULAR MEDICINE

IRE1 plays an essential role in ER stress-mediated aggregation of mutant huntingtin via the inhibition of autophagy flux

(2011) Huikyong Lee et al.   HUMAN MOLECULAR GENETICS

Interplay between histone deacetylases and autophagy - from cancer therapy to neurodegeneration

(2011) Oliver Trüe et al.   IMMUNOLOGY AND CELL BIOLOGY

p62 Is a Key Regulator of Nutrient Sensing in the mTORC1 Pathway

(2011) Angeles Duran et al.   MOLECULAR CELL

Serine 403 Phosphorylation of p62/SQSTM1 Regulates Selective Autophagic Clearance of Ubiquitinated Proteins

(2011) Gen Matsumoto et al.   MOLECULAR CELL

Clearance of Mutant Proteins as a Therapeutic Target in Neurodegenerative Diseases

(2010) Dimitri Krainc   ARCHIVES OF NEUROLOGY

Nuclear Matrix Protein (NRP/B) Modulates the Nuclear Factor (Erythroid-derived 2)-related 2 (NRF2)-dependent Oxidative Stress Response

(2010) Seyha Seng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1

(2010) Masaaki Komatsu et al.   NATURE CELL BIOLOGY

Autophagy gone awry in neurodegenerative diseases

(2010) Esther Wong et al.   NATURE NEUROSCIENCE

Cargo recognition failure is responsible for inefficient autophagy in Huntington's disease

(2010) Marta Martinez-Vicente et al.   NATURE NEUROSCIENCE

Acetylation Targets Mutant Huntingtin to Autophagosomes for Degradation

(2009) Hyunkyung Jeong et al.   CELL

SCAMP5 Links Endoplasmic Reticulum Stress to the Accumulation of Expanded Polyglutamine Protein Aggregates via Endocytosis Inhibition

(2009) Jee-Yeon Noh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutant Huntingtin Impairs Post-Golgi Trafficking to Lysosomes by Delocalizing Optineurin/Rab8 Complex from the Golgi Apparatus

(2009) Daniel del Toro et al.   MOLECULAR BIOLOGY OF THE CELL

Ectodermal-Neural Cortex 1 Down-Regulates Nrf2 at the Translational Level

(2009) Xiao-Jun Wang et al.   PLoS One

Inhibition of endoplasmic reticulum stress counteracts neuronal cell death and protein aggregation caused by N-terminal mutant huntingtin proteins

(2008) Sami Reijonen et al.   EXPERIMENTAL CELL RESEARCH

Impaired ERAD and ER stress are early and specific events in polyglutamine toxicity

(2008) M. L. Duennwald et al.   GENES & DEVELOPMENT