Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites

Crystal Structures of Human GlyRα3 Bound to Ivermectin

(2017) Xin Huang et al.   STRUCTURE

De novoGABRA1mutations in Ohtahara and West syndromes

(2016) Hirofumi Kodera et al.   EPILEPSIA

X-ray structure of the human α4β2 nicotinic receptor

(2016) Claudio L. Morales-Perez et al.   NATURE

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

(2016) Xin Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators

(2016) Xin Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ff14SB: Improving the Accuracy of Protein Side Chain and Backbone Parameters from ff99SB

(2015) James A. Maier et al.   Journal of Chemical Theory and Computation

Crystal structure of human glycine receptor-α3 bound to antagonist strychnine

(2015) Xin Huang et al.   NATURE

Glycine receptor mechanism elucidated by electron cryo-microscopy

(2015) Juan Du et al.   NATURE

The GABAA Receptor as a Therapeutic Target for Neurodevelopmental Disorders

(2015) Sien Braat et al.   NEURON

Allosteric and hyperekplexic mutant phenotypes investigated on an α1glycine receptor transmembrane structure

(2015) Gustavo Moraga-Cid et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The desensitization gate of inhibitory Cys-loop receptors

(2015) Marc Gielen et al.   Nature Communications

Genuine open form of the pentameric ligand-gated ion channel GLIC

(2015) Zaineb Fourati et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

A Predicted Binding Site for Cholesterol on the GABAA Receptor

(2014) Jérôme Hénin et al.   BIOPHYSICAL JOURNAL

Lipid14: The Amber Lipid Force Field

(2014) Callum J. Dickson et al.   Journal of Chemical Theory and Computation

Crystal structure of a human GABAA receptor

(2014) Paul S. Miller et al.   NATURE

X-ray structures of GluCl in apo states reveal a gating mechanism of Cys-loop receptors

(2014) Thorsten Althoff et al.   NATURE

Decision making inxia2

(2013) Graeme Winter et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

GABAAReceptor Subtypes: Therapeutic Potential in Down Syndrome, Affective Disorders, Schizophrenia, and Autism

(2013) Uwe Rudolph et al.   Annual Review of Pharmacology and Toxicology

Structural basis for ion permeation mechanism in pentameric ligand-gated ion channels

(2013) Ludovic Sauguet et al.   EMBO JOURNAL

Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

(2013) Ludovic Sauguet et al.   Nature Communications

Desensitization Mechanism in Prokaryotic Ligand-gated Ion Channel

(2012) Phanindra Velisetty et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

LAMBADA and InflateGRO2: Efficient Membrane Alignment and Insertion of Membrane Proteins for Molecular Dynamics Simulations

(2012) Thomas H. Schmidt et al.   Journal of Chemical Information and Modeling

A neurosteroid potentiation site can be moved among GABAAreceptor subunits

(2012) John R. Bracamontes et al.   JOURNAL OF PHYSIOLOGY-LONDON

Structure and Pharmacology of Pentameric Receptor Channels: From Bacteria to Brain

(2012) Pierre-Jean Corringer et al.   STRUCTURE

Overview of theCCP4 suite and current developments

(2011) Martyn D. Winn et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PROPKA3: Consistent Treatment of Internal and Surface Residues in Empirical pKaPredictions

(2011) Mats H. M. Olsson et al.   Journal of Chemical Theory and Computation

Profound Desensitization by Ambient GABA Limits Activation of  -Containing GABAA Receptors during Spillover

(2011) D. P. Bright et al.   JOURNAL OF NEUROSCIENCE

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

(2011) R. J. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Bridging the Gap between Structural Models of Nicotinic Receptor Superfamily Ion Channels and Their Corresponding Functional States

(2010) Giovanni Gonzalez-Gutierrez et al.   JOURNAL OF MOLECULAR BIOLOGY

Binding, activation and modulation of Cys-loop receptors

(2010) Paul S. Miller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Neurosteroids Allosterically Modulate Binding of the Anesthetic Etomidate to γ-Aminobutyric Acid Type A Receptors

(2009) Guo-Dong Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Neurosteroid replacement therapy for catamenial epilepsy

(2009) Doodipala S. Reddy et al.   Neurotherapeutics

Making sense of nonsense GABAA receptor mutations associated with genetic epilepsies

(2009) Jing-Qiong Kang et al.   TRENDS IN MOLECULAR MEDICINE

Mutations of the GABA-A Receptor  1 Subunit M1 Domain Reveal Unexpected Complexity for Modulation by Neuroactive Steroids

(2008) G. Akk et al.   MOLECULAR PHARMACOLOGY

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

General anaesthesia: from molecular targets to neuronal pathways of sleep and arousal

(2008) Nicholas P. Franks   NATURE REVIEWS NEUROSCIENCE