Structural basis for potentiation by alcohols and anaesthetics in a ligand-gated ion channel

Identification of Propofol Binding Sites in a Nicotinic Acetylcholine Receptor with a Photoreactive Propofol Analog

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NMR structures of the transmembrane domains of the α4β2 nAChR

(2012) Vasyl Bondarenko et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Theory and Simulation of Ion Conduction in the Pentameric GLIC Channel

(2012) Fangqiang Zhu et al.   Journal of Chemical Theory and Computation

A locally closed conformation of a bacterial pentameric proton-gated ion channel

(2012) Marie S Prevost et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Microsecond Simulations Indicate that Ethanol Binds between Subunits and Could Stabilize an Open-State Model of a Glycine Receptor

(2011) Samuel Murail et al.   BIOPHYSICAL JOURNAL

Anesthetic sites and allosteric mechanisms of action on Cys-loop ligand-gated ion channels

(2011) Stuart A. Forman et al.   Canadian Journal of Anesthesia-Journal canadien d anesthesie

Global burden of disease in young people aged 10–24 years: a systematic analysis

(2011) Fiona M Gore et al.   LANCET

X-ray structures of general anaesthetics bound to a pentameric ligand-gated ion channel

(2011) Hugues Nury et al.   NATURE

Principles of activation and permeation in an anion-selective Cys-loop receptor

(2011) Ryan E. Hibbs et al.   NATURE

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel

(2011) R. J. Howard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family

(2011) G. Duret et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

XDS

(2010) Wolfgang Kabsch   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Improved Helix and Kink Characterization in Membrane Proteins Allows Evaluation of Kink Sequence Predictors

(2010) David N. Langelaan et al.   Journal of Chemical Information and Modeling

Structural basis of open channel block in a prokaryotic pentameric ligand-gated ion channel

(2010) Ricarda J C Hilf et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Binding, activation and modulation of Cys-loop receptors

(2010) Paul S. Miller et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Anesthetic Sensitivity of the Gloeobacter violaceus Proton-Gated Ion Channel

(2009) Yun Weng et al.   ANESTHESIA AND ANALGESIA

Blockade of Ethanol-Induced Potentiation of Glycine Receptors by a Peptide That Interferes with G   Binding

(2009) L. Guzman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

A discrete alcohol pocket involved in GIRK channel activation

(2009) Prafulla Aryal et al.   NATURE NEUROSCIENCE

The role of GABAA receptors in the acute and chronic effects of ethanol: a decade of progress

(2009) Sandeep Kumar et al.   PSYCHOPHARMACOLOGY

Physiology and pharmacology of alcohol: the imidazobenzodiazepine alcohol antagonist site on subtypes of GABAA receptors as an opportunity for drug development?

(2008) M Wallner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

X-ray structure of a pentameric ligand-gated ion channel in an apparently open conformation

(2008) Nicolas Bocquet et al.   NATURE

X-ray structure of a prokaryotic pentameric ligand-gated ion channel

(2008) Ricarda J. C. Hilf et al.   NATURE

GABRG1 and GABRA2 as Independent Predictors for Alcoholism in Two Populations

(2008) Mary-Anne Enoch et al.   NEUROPSYCHOPHARMACOLOGY

Ethanol's Molecular Targets

(2008) R. A. Harris et al.   Science Signaling

HOLLOW: Generating Accurate Representations of Channel and Interior Surfaces in Molecular Structures

(2008) Bosco K Ho et al.   BMC STRUCTURAL BIOLOGY