Prioritizing multiple therapeutic targets in parallel using automated DNA-encoded library screening

Chemical Biology Probes from Advanced DNA-encoded Libraries

(2016) Hazem Salamon et al.   ACS Chemical Biology

Cover Picture: Design of S -Allylcysteine in Situ Production and Incorporation Based on a Novel Pyrrolysyl-tRNA Synthetase Variant (ChemBioChem 1/2017)

(2016) Matthias P. Exner et al.   CHEMBIOCHEM

Quality guidelines for oral drug candidates: dose, solubility and lipophilicity

(2016) Martin K. Bayliss et al.   DRUG DISCOVERY TODAY

Discovery and Characterization of a Class of Pyrazole Inhibitors of Bacterial Undecaprenyl Pyrophosphate Synthase

(2016) Nestor Concha et al.   JOURNAL OF MEDICINAL CHEMISTRY

DNA tags help the hunt for drugs

(2016) Asher Mullard   NATURE

Antibacterial drug discovery in the resistance era

(2016) Eric D. Brown et al.   NATURE

Automated screening for small organic ligands using DNA-encoded chemical libraries

(2016) Willy Decurtins et al.   Nature Protocols

DNA-encoded chemistry: enabling the deeper sampling of chemical space

(2016) Robert A. Goodnow et al.   NATURE REVIEWS DRUG DISCOVERY

Discovery of cofactor-specific, bactericidalMycobacterium tuberculosisInhA inhibitors using DNA-encoded library technology

(2016) Holly H. Soutter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification of Structure-Activity Relationships from Screening a Structurally Compact DNA-Encoded Chemical Library

(2015) Raphael M. Franzini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Compatible Multistep Synthesis and Applications to DNA Encoded Libraries

(2015) Alexander Lee Satz et al.   BIOCONJUGATE CHEMISTRY

Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins

(2015) Raphael M. Franzini et al.   CHEMICAL COMMUNICATIONS

The promise and peril of chemical probes

(2015) Cheryl H Arrowsmith et al.   Nature Chemical Biology

Improving R&D productivity

(2015) Katarzyna Smietana et al.   NATURE REVIEWS DRUG DISCOVERY

The phenotypic screening pendulum swings

(2015) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Time for a change: addressing R&D and commercialization challenges for antibacterials

(2015) D. J. Payne et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)

(2015) Hongfang Yang et al.   ACS Medicinal Chemistry Letters

Discovery, SAR, and X-ray Binding Mode Study of BCATm Inhibitors from a Novel DNA-Encoded Library

(2015) Hongfeng Deng et al.   ACS Medicinal Chemistry Letters

A Structural and Energetic Model for the Slow-Onset Inhibition of the Mycobacterium tuberculosis Enoyl-ACP Reductase InhA

(2014) Huei-Jiun Li et al.   ACS Chemical Biology

Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists

(2014) Christopher S. Kollmann et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Time-Dependent Diaryl Ether Inhibitors of InhA: Structure-Activity Relationship Studies of Enzyme Inhibition, Antibacterial Activity, and in vivo Efficacy

(2014) Pan Pan et al.   ChemMedChem

Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA

(2014) Lourdes Encinas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction

(2014) Aidan G Gilmartin et al.   Nature Chemical Biology

Robust Suzuki–Miyaura Cross-Coupling on DNA-Linked Substrates

(2014) Yun Ding et al.   ACS Combinatorial Science

Discovery of 1-(1,3,5-triazin-2-yl)piperidine-4-carboxamides as inhibitors of soluble epoxide hydrolase

(2013) Reema K. Thalji et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of Thieno[3,2-d]pyrimidine-6-carboxamides as Potent Inhibitors of SIRT1, SIRT2, and SIRT3

(2013) Jeremy S. Disch et al.   JOURNAL OF MEDICINAL CHEMISTRY

Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

(2013) Eduardo Dominguez et al.   Nature Chemical Biology

Tracking 20 Years of Compound-to-Target Output from Literature and Patents

(2013) Christopher Southan et al.   PLoS One

5-Aryl-4-carboxamide-1,3-oxazoles: Potent and selective GSK-3 inhibitors

(2012) Gabriella Gentile et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Development of a Rule-Based Method for the Assessment of Protein Druggability

(2012) Emanuele Perola et al.   Journal of Chemical Information and Modeling

Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)

(2012) Hongfeng Deng et al.   JOURNAL OF MEDICINAL CHEMISTRY

Finding the sweet spot: the role of nature and nurture in medicinal chemistry

(2012) Michael M. Hann et al.   NATURE REVIEWS DRUG DISCOVERY

Diagnosing the decline in pharmaceutical R&D efficiency

(2012) Jack W. Scannell et al.   NATURE REVIEWS DRUG DISCOVERY

Small-molecule discovery from DNA-encoded chemical libraries

(2011) Ralph E. Kleiner et al.   CHEMICAL SOCIETY REVIEWS

Rapid Analysis of Pharmacology for Infectious Diseases

(2011) Andrew L. Hopkins et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Fragment screening to predict druggability (ligandability) and lead discovery success

(2011) Fredrik N.B. Edfeldt et al.   DRUG DISCOVERY TODAY

Too many roads not taken

(2011) Aled M. Edwards et al.   NATURE

Colistin Resistance in Acinetobacter baumannii Is Mediated by Complete Loss of Lipopolysaccharide Production

(2010) J. H. Moffatt et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Using protein-ligand docking to assess the chemical tractability of inhibiting a protein target

(2010) Richard A. Ward   JOURNAL OF MOLECULAR MODELING

A Yoctoliter-Scale DNA Reactor for Small-Molecule Evolution

(2009) Margit Haahr Hansen et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology

A structural biology view of target drugability

(2008) Ursula Egner et al.   Expert Opinion on Drug Discovery

Small molecules and chemical tools at the interface

(2008) Robert H Newman et al.   Nature Chemical Biology