Automated screening for small organic ligands using DNA-encoded chemical libraries

DNA Encoded Library Selections and Insights Provided by Computational Simulations

(2015) Alexander L. Satz   ACS Chemical Biology

Identification of Structure-Activity Relationships from Screening a Structurally Compact DNA-Encoded Chemical Library

(2015) Raphael M. Franzini et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

DNA Compatible Multistep Synthesis and Applications to DNA Encoded Libraries

(2015) Alexander Lee Satz et al.   BIOCONJUGATE CHEMISTRY

Interrogating target-specificity by parallel screening of a DNA-encoded chemical library against closely related proteins

(2015) Raphael M. Franzini et al.   CHEMICAL COMMUNICATIONS

Novel selection methods for DNA-encoded chemical libraries

(2015) Alix I Chan et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Fidelity by design: Yoctoreactor and binder trap enrichment for small-molecule DNA-encoded libraries and drug discovery

(2015) Peter Blakskjaer et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

PNA-encoded chemical libraries

(2015) Claudio Zambaldo et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Increasing the delivery of next generation therapeutics from high throughput screening libraries

(2015) Mark J Wigglesworth et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Active-learning strategies in computer-assisted drug discovery

(2015) Daniel Reker et al.   DRUG DISCOVERY TODAY

Tankyrase 1 Inhibitors with Drug-like Properties Identified by Screening a DNA-Encoded Chemical Library

(2015) Florent Samain et al.   JOURNAL OF MEDICINAL CHEMISTRY

The Discovery of Macrocyclic XIAP Antagonists from a DNA-Programmed Chemistry Library, and Their Optimization To Give Lead Compounds with in Vivo Antitumor Activity

(2015) Benjamin A. Seigal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Dual-display of small molecules enables the discovery of ligand pairs and facilitates affinity maturation

(2015) Moreno Wichert et al.   Nature Chemistry

DNA display of fragment pairs as a tool for the discovery of novel biologically active small molecules

(2015) J.-P. Daguer et al.   Chemical Science

“Cap-and-Catch” Purification for Enhancing the Quality of Libraries of DNA Conjugates

(2015) Raphael M. Franzini et al.   ACS Combinatorial Science

Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library

(2015) Alexander Litovchick et al.   Scientific Reports

DNA-Encoded Chemical Libraries: Advancing beyond Conventional Small-Molecule Libraries

(2014) Raphael M. Franzini et al.   ACCOUNTS OF CHEMICAL RESEARCH

Characterization of DNA-Conjugated Compounds Using a Regenerable Chip

(2014) Weilin Lin et al.   ANALYTICAL CHEMISTRY

Selection of DNA-Encoded Small Molecule Libraries Against Unmodified and Non-Immobilized Protein Targets

(2014) Peng Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Systematic Evaluation and Optimization of Modification Reactions of Oligonucleotides with Amines and Carboxylic Acids for the Synthesis of DNA-Encoded Chemical Libraries

(2014) Raphael M. Franzini et al.   BIOCONJUGATE CHEMISTRY

PNA-Encoded Synthesis (PES) of a 10 000-Member Hetero-Glycoconjugate Library and Microarray Analysis of Diverse Lectins

(2014) Alexandre Novoa et al.   CHEMBIOCHEM

Identification of Ligand–Target Pairs from Combined Libraries of Small Molecules and Unpurified Protein Targets in Cell Lysates

(2014) Lynn M. McGregor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Anti-diabetic activity of insulin-degrading enzyme inhibitors mediated by multiple hormones

(2014) Juan Pablo Maianti et al.   NATURE

Revealing the macromolecular targets of complex natural products

(2014) Daniel Reker et al.   Nature Chemistry

Photoaffinity Labeling of Small-Molecule-Binding Proteins by DNA-Templated Chemistry

(2013) Gang Li et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

mRNA display: from basic principles to macrocycle drug discovery

(2013) Kristopher Josephson et al.   DRUG DISCOVERY TODAY

Multistep DNA-Templated Synthesis Using a Universal Template

(2013) Yizhou Li et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Discovery of Small-Molecule Interleukin-2 Inhibitors from a DNA-Encoded Chemical Library

(2012) Markus Leimbacher et al.   CHEMISTRY-A EUROPEAN JOURNAL

Highly specific, bisubstrate-competitive Src inhibitors from DNA-templated macrocycles

(2012) George Georghiou et al.   Nature Chemical Biology

Highly Parallel Translation of DNA Sequences into Small Molecules

(2012) Rebecca M. Weisinger et al.   PLoS One

DNA as a Molecular Ruler: Interrogation of a Tandem SH2 Domain with Self-Assembled, Bivalent DNA-Peptide Complexes

(2011) Hendrik Eberhard et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Selection of a synthetic glycan oligomer from a library of DNA-templated fragments against DC-SIGN and inhibition of HIV gp120 binding to dendritic cells

(2011) Mihai Ciobanu et al.   CHEMICAL COMMUNICATIONS

20 years of DNA-encoded chemical libraries

(2011) Luca Mannocci et al.   CHEMICAL COMMUNICATIONS

Small-molecule discovery from DNA-encoded chemical libraries

(2011) Ralph E. Kleiner et al.   CHEMICAL SOCIETY REVIEWS

Impact of high-throughput screening in biomedical research

(2011) Ricardo Macarron et al.   NATURE REVIEWS DRUG DISCOVERY

Selection of Carbonic Anhydrase IX Inhibitors from One Million DNA-Encoded Compounds

(2010) Fabian Buller et al.   ACS Chemical Biology

Isolation of Potent and Specific Trypsin Inhibitors from a DNA-Encoded Chemical Library

(2010) Luca Mannocci et al.   BIOCONJUGATE CHEMISTRY

High-throughput sequencing for the identification of binding molecules from DNA-encoded chemical libraries

(2010) Fabian Buller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Isolation of a Small-Molecule Inhibitor of the Antiapoptotic Protein Bcl-xL from a DNA-Encoded Chemical Library

(2010) Samu Melkko et al.   ChemMedChem

In VitroSelection of a DNA-Templated Small-Molecule Library Reveals a Class of Macrocyclic Kinase Inhibitors

(2010) Ralph E. Kleiner et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Interaction-Dependent PCR: Identification of Ligand−Target Pairs from Libraries of Ligands and Libraries of Targets in a Single Solution-Phase Experiment

(2010) Lynn M. McGregor et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

DNA-Templated Homo- and Heterodimerization of Peptide Nucleic Acid Encoded Oligosaccharides that Mimick the Carbohydrate Epitope of HIV

(2009) Katarzyna Gorska et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Human monoclonal antibodies targeting carbonic anhydrase IX for the molecular imaging of hypoxic regions in solid tumours

(2009) J K J Ahlskog et al.   BRITISH JOURNAL OF CANCER

Discovery of TNF Inhibitors from a DNA-Encoded Chemical Library based on Diels-Alder Cycloaddition

(2009) Fabian Buller et al.   CHEMISTRY & BIOLOGY

Novel trends in high-throughput screening

(2009) Lorenz M Mayr et al.   CURRENT OPINION IN PHARMACOLOGY

Immobilization strategies for small molecule, peptide and protein microarrays

(2009) Maja Köhn   JOURNAL OF PEPTIDE SCIENCE

Design, synthesis and selection of DNA-encoded small-molecule libraries

(2009) Matthew A Clark et al.   Nature Chemical Biology

DNA-Encoded Chemical Libraries for the Discovery of MMP-3 Inhibitors

(2008) Jörg Scheuermann et al.   BIOCONJUGATE CHEMISTRY

Design and synthesis of a novel DNA-encoded chemical library using Diels-Alder cycloadditions

(2008) Fabian Buller et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Translation of DNA into a Library of 13 000 Synthetic Small-Molecule Macrocycles Suitable forin VitroSelection

(2008) Brian N. Tse et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Accurate whole human genome sequencing using reversible terminator chemistry

(2008) David R. Bentley et al.   NATURE

High-throughput sequencing allows the identification of binding molecules isolated from DNA-encoded chemical libraries

(2008) L. Mannocci et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA