Discovery of cofactor-specific, bactericidalMycobacterium tuberculosisInhA inhibitors using DNA-encoded library technology
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Discovery of cofactor-specific, bactericidalMycobacterium tuberculosisInhA inhibitors using DNA-encoded library technology
Authors
Keywords
-
Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 113, Issue 49, Pages E7880-E7889
Publisher
Proceedings of the National Academy of Sciences
Online
2016-11-19
DOI
10.1073/pnas.1610978113
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Chemical ligation methods for the tagging of DNA-encoded chemical libraries
- (2015) Anthony D Keefe et al. CURRENT OPINION IN CHEMICAL BIOLOGY
- Crystal structure of the enoyl-ACP reductase of Mycobacterium tuberculosis (InhA) in the apo-form and in complex with the active metabolite of isoniazid pre-formed by a biomimetic approach
- (2015) Aurélien Chollet et al. JOURNAL OF STRUCTURAL BIOLOGY
- Direct inhibitors of InhA are active against Mycobacterium tuberculosis
- (2015) U. H. Manjunatha et al. Science Translational Medicine
- Discovery of a Potent Class of PI3Kα Inhibitors with Unique Binding Mode via Encoded Library Technology (ELT)
- (2015) Hongfang Yang et al. ACS Medicinal Chemistry Letters
- Discovery of Potent and Selective Inhibitors for ADAMTS-4 through DNA-Encoded Library Technology (ELT)
- (2015) Yun Ding et al. ACS Medicinal Chemistry Letters
- Encoded Library Synthesis Using Chemical Ligation and the Discovery of sEH Inhibitors from a 334-Million Member Library
- (2015) Alexander Litovchick et al. Scientific Reports
- Application of encoded library technology (ELT) to a protein–protein interaction target: Discovery of a potent class of integrin lymphocyte function-associated antigen 1 (LFA-1) antagonists
- (2014) Christopher S. Kollmann et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Encoded Library Technology as a Source of Hits for the Discovery and Lead Optimization of a Potent and Selective Class of Bactericidal Direct Inhibitors of Mycobacterium tuberculosis InhA
- (2014) Lourdes Encinas et al. JOURNAL OF MEDICINAL CHEMISTRY
- Allosteric Wip1 phosphatase inhibition through flap-subdomain interaction
- (2014) Aidan G Gilmartin et al. Nature Chemical Biology
- Methyl-Thiazoles: A Novel Mode of Inhibition with the Potential to Develop Novel Inhibitors Targeting InhA in Mycobacterium tuberculosis
- (2013) Pravin S. Shirude et al. JOURNAL OF MEDICINAL CHEMISTRY
- Pyridomycin bridges the NADH- and substrate-binding pockets of the enoyl reductase InhA
- (2013) Ruben C Hartkoorn et al. Nature Chemical Biology
- Targeting InhA, the FASII Enoyl-ACP Reductase: SAR Studies on Novel Inhibitor Scaffolds
- (2012) Pan Pan et al. CURRENT TOPICS IN MEDICINAL CHEMISTRY
- Discovery of Highly Potent and Selective Small Molecule ADAMTS-5 Inhibitors That Inhibit Human Cartilage Degradation via Encoded Library Technology (ELT)
- (2012) Hongfeng Deng et al. JOURNAL OF MEDICINAL CHEMISTRY
- A Slow, Tight Binding Inhibitor of InhA, the Enoyl-Acyl Carrier Protein Reductase fromMycobacterium tuberculosis
- (2010) Sylvia R. Luckner et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Design, synthesis and selection of DNA-encoded small-molecule libraries
- (2009) Matthew A Clark et al. Nature Chemical Biology
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreDiscover Peeref hubs
Discuss science. Find collaborators. Network.
Join a conversation