Integrated phenotypic and activity-based profiling links Ces3 to obesity and diabetes

Mechanisms for Insulin Resistance: Common Threads and Missing Links

(2012) Varman T. Samuel et al.   CELL

FAT SIGNALS - Lipases and Lipolysis in Lipid Metabolism and Signaling

(2012) Rudolf Zechner et al.   Cell Metabolism

How Chemoproteomics Can Enable Drug Discovery and Development

(2012) Raymond E. Moellering et al.   CHEMISTRY & BIOLOGY

Liver specific inactivation of carboxylesterase 3/triacylglycerol hydrolase decreases blood lipids without causing severe steatosis in mice

(2012) Jihong Lian et al.   HEPATOLOGY

Deficiency of carboxylesterase 1/esterase-x results in obesity, hepatic steatosis, and hyperlipidemia

(2012) Ariel D. Quiroga et al.   HEPATOLOGY

Using transcriptome sequencing to identify mechanisms of drug action and resistance

(2012) Sarah A Wacker et al.   Nature Chemical Biology

The pharmacological landscape and therapeutic potential of serine hydrolases

(2012) Daniel A. Bachovchin et al.   NATURE REVIEWS DRUG DISCOVERY

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

Functional imaging of proteases: recent advances in the design and application of substrate-based and activity-based probes

(2011) Laura E Edgington et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Functional fat body proteomics and gene targeting reveal in vivo functions of Drosophila melanogaster α-Esterase-7

(2011) Ruth Birner-Gruenberger et al.   INSECT BIOCHEMISTRY AND MOLECULAR BIOLOGY

Adipocyte lipases and lipid droplet-associated proteins: insight from transgenic mouse models

(2011) A Girousse et al.   INTERNATIONAL JOURNAL OF OBESITY

Depot-Specific Expression of Lipolytic Genes in Human Adipose Tissues

(2011) Shuichi Nagashima et al.   Journal of Atherosclerosis and Thrombosis

Selective killing of cancer cells by a small molecule targeting the stress response to ROS

(2011) Lakshmi Raj et al.   NATURE

Chemical informatics and target identification in a zebrafish phenotypic screen

(2011) Christian Laggner et al.   Nature Chemical Biology

How were new medicines discovered?

(2011) David C. Swinney et al.   NATURE REVIEWS DRUG DISCOVERY

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Role of endoplasmic reticulum neutral lipid hydrolases

(2011) Ariel D. Quiroga et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Loss of TGH/Ces3 in Mice Decreases Blood Lipids, Improves Glucose Tolerance, and Increases Energy Expenditure

(2010) Enhui Wei et al.   Cell Metabolism

Activity-based probes: discovering new biology and new drug targets

(2010) William P. Heal et al.   CHEMICAL SOCIETY REVIEWS

The Role of Adipose Tissue and Lipotoxicity in the Pathogenesis of Type 2 Diabetes

(2010) Kenneth Cusi   Current Diabetes Reports

Functional Proteomic Analysis of Lipases and Esterases in Cultured Human Adipocytes

(2010) Maximilian Schicher et al.   JOURNAL OF PROTEOME RESEARCH

Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins

(2010) Roger S. Holmes et al.   MAMMALIAN GENOME

Rethinking screening

(2010) Thomas Kodadek   Nature Chemical Biology

A Dysregulation in CES1, APOE and Other Lipid Metabolism-Related Genes Is Associated to Cardiovascular Risk Factors Linked to Obesity

(2010) M. Pilar Marrades et al.   Obesity Facts

Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening

(2010) D. A. Bachovchin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulation of carboxylesterase 1 (CES1) in human adipose tissue

(2009) Margareta Jernås et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Proteomic and Genetic Approaches Identify Syk as an AML Target

(2009) Cynthia K. Hahn et al.   CANCER CELL

Differential activity-based gel electrophoresis for comparative analysis of lipolytic and esterolytic activities

(2009) Maria Morak et al.   JOURNAL OF LIPID RESEARCH

Target profiling of small molecules by chemical proteomics

(2009) Uwe Rix et al.   Nature Chemical Biology

Identifying the proteins to which small-molecule probes and drugs bind in cells

(2009) S.-E. Ong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activity-Based Protein Profiling: From Enzyme Chemistry to Proteomic Chemistry

(2008) Benjamin F. Cravatt et al.   Annual Review of Biochemistry

Dipeptidyl Peptidase-4 as a New Target of Action for Type 2 Diabetes Mellitus: A Systematic Review

(2008) Javaid H. Wani et al.   CARDIOLOGY CLINICS