Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Published 2017 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
Cannabinoid CB2 receptor ligand profiling reveals biased signalling and off-target activity
Authors
Keywords
-
Journal
Nature Communications
Volume 8, Issue -, Pages 13958
Publisher
Springer Nature
Online
2017-01-03
DOI
10.1038/ncomms13958
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Role of the endocannabinoid system in diabetes and diabetic complications
- (2015) G Gruden et al. BRITISH JOURNAL OF PHARMACOLOGY
- A natural substrate-based fluorescence assay for inhibitor screening on diacylglycerol lipase α
- (2015) Tom van der Wel et al. JOURNAL OF LIPID RESEARCH
- Cannabinoid receptor with an 'identity crisis' gets a second look
- (2015) Nala Rogers NATURE MEDICINE
- Correlating FAAH and anandamide cellular uptake inhibition using N-alkylcarbamate inhibitors: From ultrapotent to hyperpotent
- (2014) Simon Nicolussi et al. BIOCHEMICAL PHARMACOLOGY
- Policy: NIH plans to enhance reproducibility
- (2014) Francis S. Collins et al. NATURE
- Early phytocannabinoid chemistry to endocannabinoids and beyond
- (2014) Raphael Mechoulam et al. NATURE REVIEWS NEUROSCIENCE
- Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies
- (2014) Mauro Maccarrone et al. NATURE REVIEWS NEUROSCIENCE
- Guineensine is a novel inhibitor of endocannabinoid uptake showing cannabimimetic behavioral effects in BALB/c mice
- (2014) Simon Nicolussi et al. PHARMACOLOGICAL RESEARCH
- Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-α in Brain
- (2013) Marc P. Baggelaar et al. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
- Selective CB2 agonists with anti-pruritic activity: Discovery of potent and orally available bicyclic 2-pyridones
- (2013) Ken-ichi Kusakabe et al. BIOORGANIC & MEDICINAL CHEMISTRY
- Real-time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action
- (2013) Erin E Cawston et al. BRITISH JOURNAL OF PHARMACOLOGY
- Therapeutic Utility of Cannabinoid Receptor Type 2 (CB2) Selective Agonists
- (2013) Sangdon Han et al. JOURNAL OF MEDICINAL CHEMISTRY
- Signalling bias in new drug discovery: detection, quantification and therapeutic impact
- (2013) Terry Kenakin et al. NATURE REVIEWS DRUG DISCOVERY
- Functional monoclonal antibody acts as a biased agonist by inducing internalization of metabotropic glutamate receptor 7
- (2012) C Ullmer et al. BRITISH JOURNAL OF PHARMACOLOGY
- Organotypic liver culture models: Meeting current challenges in toxicity testing
- (2012) Edward L. LeCluyse et al. CRITICAL REVIEWS IN TOXICOLOGY
- Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design
- (2012) Li Di et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Why do cannabinoid receptors have more than one endogenous ligand?
- (2012) V. Di Marzo et al. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
- Improved accessibility to the desoxy analogues of Δ9-tetrahydrocannabinol and cannabidiol
- (2012) Shane M. Wilkinson et al. TETRAHEDRON LETTERS
- A Simple Method for Quantifying Functional Selectivity and Agonist Bias
- (2011) Terry Kenakin et al. ACS Chemical Neuroscience
- Decahydroquinoline amides as highly selective CB2 agonists: Role of selectivity on in vivo efficacy in a rodent model of analgesia
- (2011) Peter J. Manley et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Effects of palmitoylation of Cys415 in helix 8 of the CB1 cannabinoid receptor on membrane localization and signalling
- (2011) Sergio Oddi et al. BRITISH JOURNAL OF PHARMACOLOGY
- A new cannabinoid CB2 receptor agonist HU-910 attenuates oxidative stress, inflammation and cell death associated with hepatic ischaemia/reperfusion injury
- (2011) Bėla Horváth et al. BRITISH JOURNAL OF PHARMACOLOGY
- A Randomized, Controlled Study to Investigate the Analgesic Efficacy of Single Doses of the Cannabinoid Receptor-2 Agonist GW842166, Ibuprofen or Placebo in Patients With Acute Pain Following Third Molar Tooth Extraction
- (2011) Thor Ostenfeld et al. CLINICAL JOURNAL OF PAIN
- What makes a good drug target?
- (2011) Isabella Gashaw et al. DRUG DISCOVERY TODAY
- Discovery and Optimization of 1-(4-(Pyridin-2-yl)benzyl)imidazolidine-2,4-dione Derivatives As a Novel Class of Selective Cannabinoid CB2 Receptor Agonists
- (2011) Mario van der Stelt et al. JOURNAL OF MEDICINAL CHEMISTRY
- Validation of 96-well Equilibrium Dialysis with Non-radiolabeled Drug for Definitive Measurement of Protein Binding and Application to Clinical Development of Highly-Bound Drugs
- (2011) Maciej J. Zamek-Gliszczynski et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Is lipid signaling through cannabinoid 2 receptors part of a protective system?
- (2011) P. Pacher et al. PROGRESS IN LIPID RESEARCH
- Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: Implications for therapeutics
- (2010) Natasha L. Grimsey et al. BIOCHEMICAL PHARMACOLOGY
- Animal research: Reporting in vivo experiments: The ARRIVE guidelines
- (2010) Carol Kilkenny et al. BRITISH JOURNAL OF PHARMACOLOGY
- Enol Carbamates as Inhibitors of Fatty Acid Amide Hydrolase (FAAH) Endowed with High Selectivity for FAAH over the Other Targets of the Endocannabinoid System
- (2010) Sonia Gattinoni et al. ChemMedChem
- The endocannabinoid 2-arachidonylglycerol is a negative allosteric modulator of the human A3 adenosine receptor
- (2009) J. Robert Lane et al. BIOCHEMICAL PHARMACOLOGY
- Latest advances in cannabinoid receptor agonists
- (2009) Ganesh A Thakur et al. EXPERT OPINION ON THERAPEUTIC PATENTS
- Cannabinoid-2 receptor limits inflammation, oxidative/nitrosative stress, and cell death in nephropathy
- (2009) Partha Mukhopadhyay et al. FREE RADICAL BIOLOGY AND MEDICINE
- CB2 cannabinoid receptor activation is cardioprotective in a mouse model of ischemia/reperfusion
- (2009) Fabrizio Montecucco et al. JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY
- Cannabinoid CB2receptors: a therapeutic target for the treatment of inflammatory and neuropathic pain
- (2007) J Guindon et al. BRITISH JOURNAL OF PHARMACOLOGY
- In vitro pharmacological characterization of AM1241: a protean agonist at the cannabinoid CB2 receptor?
- (2006) B B Yao et al. BRITISH JOURNAL OF PHARMACOLOGY
Add your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload NowCreate your own webinar
Interested in hosting your own webinar? Check the schedule and propose your idea to the Peeref Content Team.
Create Now