Development of an Activity-Based Probe and In Silico Design Reveal Highly Selective Inhibitors for Diacylglycerol Lipase-α in Brain

Multiple Functions of Endocannabinoid Signaling in the Brain

(2012) István Katona et al.   Annual Review of Neuroscience

Assay and inhibition of diacylglycerol lipase activity

(2012) Meghan Johnston et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

A novel fluorophosphonate inhibitor of the biosynthesis of the endocannabinoid 2-arachidonoylglycerol with potential anti-obesity effects

(2012) Tiziana Bisogno et al.   BRITISH JOURNAL OF PHARMACOLOGY

How Chemoproteomics Can Enable Drug Discovery and Development

(2012) Raymond E. Moellering et al.   CHEMISTRY & BIOLOGY

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses

(2012) Ku-Lung Hsu et al.   Nature Chemical Biology

The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling

(2012) M. Reisenberg et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Development of Highly Potent Inhibitors of the Ras-Targeting Human Acyl Protein Thioesterases Based on Substrate Similarity Design

(2011) Christian Hedberg et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Identification of Acyl Protein Thioesterases 1 and 2 as the Cellular Targets of the Ras-Signaling Modulators Palmostatin B and M

(2011) Marion Rusch et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular characterization and identification of surrogate substrates for diacylglycerol lipase α

(2011) Donna L. Pedicord et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The molecular mechanism of human hormone-sensitive lipase inhibition by substituted 3-phenyl-5-alkoxy-1,3,4-oxadiazol-2-ones

(2011) Yassine Ben Ali et al.   BIOCHIMIE

The Metabolic Serine Hydrolases and Their Functions in Mammalian Physiology and Disease

(2011) Jonathan Z. Long et al.   CHEMICAL REVIEWS

Endocannabinoid Hydrolysis Generates Brain Prostaglandins That Promote Neuroinflammation

(2011) D. K. Nomura et al.   SCIENCE

Small-molecule inhibition of APT1 affects Ras localization and signaling

(2010) Frank J Dekker et al.   Nature Chemical Biology

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

Endocannabinoid signaling in the brain: biosynthetic mechanisms in the limelight

(2010) Vincenzo Di Marzo   NATURE NEUROSCIENCE

Synthesis and Pharmacological Activity of a Potent Inhibitor of the Biosynthesis of the Endocannabinoid 2-Arachidonoylglycerol

(2009) Tiziana Bisogno et al.   ChemMedChem

Activity-Based Proteome Profiling of Potential Cellular Targets of Orlistat − An FDA-Approved Drug with Anti-Tumor Activities

(2009) Peng-Yu Yang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

β-Lactones as Privileged Structures for the Active-Site Labeling of Versatile Bacterial Enzyme Classes

(2008) Thomas Böttcher et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Exploration of a fundamental substituent effect of α-ketoheterocycle enzyme inhibitors: Potent and selective inhibitors of fatty acid amide hydrolase

(2008) Jessica K. DeMartino et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

(2008) Heather S. Hoover et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Azido‐BODIPY Acid Reveals Quantitative Staudinger–Bertozzi Ligation in Two‐Step Activity‐Based Proteasome Profiling

(2008) Martijn Verdoes et al.   CHEMBIOCHEM

Tetrahydrolipstatin Analogues as Modulators of Endocannabinoid 2-Arachidonoylglycerol Metabolism

(2008) Giorgio Ortar et al.   JOURNAL OF MEDICINAL CHEMISTRY

β-Lactone probes identify a papain-like peptide ligase in Arabidopsis thaliana

(2008) Zheming Wang et al.   Nature Chemical Biology