Real-time characterization of cannabinoid receptor 1 (CB1) allosteric modulators reveals novel mechanism of action

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

(2013) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deciphering µ-opioid receptor phosphorylation and dephosphorylation in HEK293 cells

(2012) Christian Doll et al.   BRITISH JOURNAL OF PHARMACOLOGY

Allosteric Modulator ORG27569 Induces CB1 Cannabinoid Receptor High Affinity Agonist Binding State, Receptor Internalization, and GiProtein-independent ERK1/2 Kinase Activation

(2012) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Key Agonist-induced Conformational Change in the Cannabinoid Receptor CB1 Is Blocked by the Allosteric Ligand Org 27569

(2012) Jonathan F. Fay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein phosphatase 2A mediates resensitization of the neurokinin 1 receptor

(2011) Jane E. Murphy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Best of Both Worlds? Bitopic Orthosteric/Allosteric Ligands of G Protein–Coupled Receptors

(2011) Celine Valant et al.   Annual Review of Pharmacology and Toxicology

Guide to Receptors and Channels (GRAC), 5th edition

(2011) SPH Alexander et al.   BRITISH JOURNAL OF PHARMACOLOGY

Regulation of GPCR activity, trafficking and localization by GPCR-interacting proteins

(2011) Ana C Magalhaes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid Receptor 1 trafficking and the role of the intracellular pool: Implications for therapeutics

(2010) Natasha L. Grimsey et al.   BIOCHEMICAL PHARMACOLOGY

Neuroprotective potential of CB1 receptor agonists in an in vitro model of Huntington's disease

(2010) EL Scotter et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Multiplicity of Action of Cannabinoids: Implications for Treating Neurodegeneration

(2010) Aoife Gowran et al.   CNS Neuroscience & Therapeutics

Effects of the Allosteric Antagonist 1-(4-Chlorophenyl)-3-[3-(6-pyrrolidin-1-ylpyridin-2-yl)phenyl]urea (PSNCBAM-1) on CB1 Receptor Modulation in the Cerebellum

(2010) X. Wang et al.   MOLECULAR PHARMACOLOGY

Seven Transmembrane Receptors as Shapeshifting Proteins: The Impact of Allosteric Modulation and Functional Selectivity on New Drug Discovery

(2010) T. Kenakin et al.   PHARMACOLOGICAL REVIEWS

Dynamic Regulation of the Endocannabinoid System: Implications for Analgesia

(2009) Devi Rani Sagar et al.   Molecular Pain

A NOVEL HIGH-THROUGHPUT ASSAY FOR THE QUANTITATIVE ASSESSMENT OF RECEPTOR TRAFFICKING

(2008) Natasha L Grimsey et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Regulation of CB1 cannabinoid receptor trafficking by the adaptor protein AP-3

(2008) Raphael Rozenfeld et al.   FASEB JOURNAL

Noncompetitive Antagonism and Inverse Agonism as Mechanism of Action of Nonpeptidergic Antagonists at Primate and Rodent CXCR3 Chemokine Receptors

(2008) D. Verzijl et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

PSNCBAM-1, a novel allosteric antagonist at cannabinoid CB1 receptors with hypophagic effects in rats

(2007) J G Horswill et al.   BRITISH JOURNAL OF PHARMACOLOGY

Rapid CB1 cannabinoid receptor desensitization defines the time course of ERK1/2 MAP kinase signaling

(2007) Tanya L. Daigle et al.   NEUROPHARMACOLOGY