Programming of neural cells by (endo)cannabinoids: from physiological rules to emerging therapies

Neurogenesis in the Striatum of the Adult Human Brain

(2014) Aurélie Ernst et al.   CELL

Miswiring the brain:  9-tetrahydrocannabinol disrupts cortical development by inducing an SCG10/stathmin-2 degradation pathway

(2014) G. Tortoriello et al.   EMBO JOURNAL

Microglia Enhance Neurogenesis and Oligodendrogenesis in the Early Postnatal Subventricular Zone

(2014) Y. Shigemoto-Mogami et al.   JOURNAL OF NEUROSCIENCE

Parental THC Exposure Leads to Compulsive Heroin-Seeking and Altered Striatal Synaptic Plasticity in the Subsequent Generation

(2014) Henrietta Szutorisz et al.   NEUROPSYCHOPHARMACOLOGY

Adverse Health Effects of Marijuana Use

(2014) Nora D. Volkow et al.   NEW ENGLAND JOURNAL OF MEDICINE

Modulation of subventricular zone oligodendrogenesis: a role for hemopressin?

(2014) Sara Xapelli et al.   Frontiers in Cellular Neuroscience

Endocannabinoids modulate cortical development by configuring Slit2/Robo1 signalling

(2014) Alán Alpár et al.   Nature Communications

Long-term consequences of perinatal fatty acid amino hydrolase inhibition

(2013) Chia-Shan Wu et al.   BRITISH JOURNAL OF PHARMACOLOGY

Antibodies to cannabinoid type 1 receptor co-react with stomatin-like protein 2 in mouse brain mitochondria

(2013) Yury M. Morozov et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Distinct Roles of β-Arrestin 1 and β-Arrestin 2 in ORG27569-induced Biased Signaling and Internalization of the Cannabinoid Receptor 1 (CB1)

(2013) Kwang H. Ahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Prenatal exposure to the CB1and CB2cannabinoid receptor agonist WIN 55,212-2 alters migration of early-born glutamatergic neurons and GABAergic interneurons in the rat cerebral cortex

(2013) Trinidad M. M. Saez et al.   JOURNAL OF NEUROCHEMISTRY

Impact of omega-6 polyunsaturated fatty acid supplementation and γ-aminobutyric acid on astrogliogenesis through the endocannabinoid system

(2013) Noriko Shinjyo et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Alterations of prefrontal cortex GABAergic transmission in the complex psychotic-like phenotype induced by adolescent delta-9-tetrahydrocannabinol exposure in rats

(2013) Erica Zamberletti et al.   NEUROBIOLOGY OF DISEASE

Autism-Associated Neuroligin-3 Mutations Commonly Disrupt Tonic Endocannabinoid Signaling

(2013) Csaba Földy et al.   NEURON

Type-1 (CB1) Cannabinoid Receptor Promotes Neuronal Differentiation and Maturation of Neural Stem Cells

(2013) Claudia Compagnucci et al.   PLoS One

GPR55, a G-Protein Coupled Receptor for Lysophosphatidylinositol, Plays a Role in Motor Coordination

(2013) Chia-Shan Wu et al.   PLoS One

Activation of Type 1 Cannabinoid Receptor (CB1R) Promotes Neurogenesis in Murine Subventricular Zone Cell Cultures

(2013) Sara Xapelli et al.   PLoS One

Cannabinoid Receptor CB2 Modulates Axon Guidance

(2013) Gabriel Duff et al.   PLoS One

Transcriptional Basis for the Inhibition of Neural Stem Cell Proliferation and Migration by the TGFβ-Family Member GDF11

(2013) Gareth Williams et al.   PLoS One

Nerve growth factor scales endocannabinoid signaling by regulating monoacylglycerol lipase turnover in developing cholinergic neurons

(2013) E. Keimpema et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Obesity-driven synaptic remodeling affects endocannabinoid control of orexinergic neurons

(2013) L. Cristino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cannabinoid receptor signaling in progenitor/stem cell proliferation and differentiation

(2013) Ismael Galve-Roperh et al.   PROGRESS IN LIPID RESEARCH

Diacylglycerol lipase α manipulation reveals developmental roles for intercellular endocannabinoid signaling

(2013) Erik Keimpema et al.   Scientific Reports

Subventricular zone neural progenitors protect striatal neurons from glutamatergic excitotoxicity

(2012) Erica Butti et al.   BRAIN

WIN55, 212-2 promotes differentiation of oligodendrocyte precursor cells and improve remyelination through regulation of the phosphorylation level of the ERK 1/2 via cannabinoid receptor 1 after stroke-induced demyelination

(2012) Jing Sun et al.   BRAIN RESEARCH

Acute Cannabinoids Impair Working Memory through Astroglial CB1 Receptor Modulation of Hippocampal LTD

(2012) Jing Han et al.   CELL

The CB1 Cannabinoid Receptor Drives Corticospinal Motor Neuron Differentiation through the Ctip2/Satb2 Transcriptional Regulation Axis

(2012) J. Diaz-Alonso et al.   JOURNAL OF NEUROSCIENCE

The molecular basis of the cooperation between EGF, FGF and eCB receptors in the regulation of neural stem cell function

(2012) Philipp Sütterlin et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1

(2012) Kristin Stock et al.   NATURE MEDICINE

Mitochondrial CB1 receptors regulate neuronal energy metabolism

(2012) Giovanni Bénard et al.   NATURE NEUROSCIENCE

Estradiol Acutely Suppresses Inhibition in the Hippocampus through a Sex-Specific Endocannabinoid and mGluR-Dependent Mechanism

(2012) Guang Zhe Huang et al.   NEURON

Maternal Metabolic Conditions and Risk for Autism and Other Neurodevelopmental Disorders

(2012) P. Krakowiak et al.   PEDIATRICS

The diacylglycerol lipases: structure, regulation and roles in and beyond endocannabinoid signalling

(2012) M. Reisenberg et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

SCG10 is a JNK target in the axonal degeneration pathway

(2012) J. E. Shin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Uncoupling of the endocannabinoid signalling complex in a mouse model of fragile X syndrome

(2012) Kwang-Mook Jung et al.   Nature Communications

Maternal Cannabis Use Alters Ventral Striatal Dopamine D2 Gene Regulation in the Offspring

(2011) Jennifer A. DiNieri et al.   BIOLOGICAL PSYCHIATRY

Assessment of the pharmacology and tolerability of PF-04457845, an irreversible inhibitor of fatty acid amide hydrolase-1, in healthy subjects

(2011) Gai Ling Li et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

Cannabinoid receptor agonists modulate oligodendrocyte differentiation by activating PI3K/Akt and the mammalian target of rapamycin (mTOR) pathways

(2011) O Gomez et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid CB1 receptors transactivate multiple receptor tyrosine kinases and regulate serine/threonine kinases to activate ERK in neuronal cells

(2011) George D Dalton et al.   BRITISH JOURNAL OF PHARMACOLOGY

Stimulation of the midkine/ALK axis renders glioma cells resistant to cannabinoid antitumoral action

(2011) M Lorente et al.   CELL DEATH AND DIFFERENTIATION

Differential gene expression in migratory streams of cortical interneurons

(2011) Mary Antypa et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Genetic association between bipolar disorder and 524A>C (Leu133Ile) polymorphism of CNR2 gene, encoding for CB2 cannabinoid receptor

(2011) D. Minocci et al.   JOURNAL OF AFFECTIVE DISORDERS

CB2Cannabinoid Receptors Promote Neural Progenitor Cell Proliferation via mTORC1 Signaling

(2011) Javier Palazuelos et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Concerted Action of CB1 Cannabinoid Receptor and Deleted in Colorectal Cancer in Axon Guidance

(2011) A. Argaw et al.   JOURNAL OF NEUROSCIENCE

Endocannabinoids Regulate the Migration of Subventricular Zone-Derived Neuroblasts in the Postnatal Brain

(2011) M. J. Oudin et al.   JOURNAL OF NEUROSCIENCE

A Combined Preclinical Therapy of Cannabinoids and Temozolomide against Glioma

(2011) S. Torres et al.   MOLECULAR CANCER THERAPEUTICS

Corridors of migrating neurons in the human brain and their decline during infancy

(2011) Nader Sanai et al.   NATURE

A catalytically silent FAAH-1 variant drives anandamide transport in neurons

(2011) Jin Fu et al.   NATURE NEUROSCIENCE

Mutations in ABHD12 Cause the Neurodegenerative Disease PHARC: An Inborn Error of Endocannabinoid Metabolism

(2010) Torunn Fiskerstrand et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Regulation of neural progenitor cell fate by anandamide

(2010) John Soltys et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The COX-2 inhibitors, meloxicam and nimesulide, suppress neurogenesis in the adult mouse brain

(2010) Maria Beatriz Goncalves et al.   BRITISH JOURNAL OF PHARMACOLOGY

A role for L-α-lysophosphatidylinositol and GPR55 in the modulation of migration, orientation and polarization of human breast cancer cells

(2010) Lesley A Ford et al.   BRITISH JOURNAL OF PHARMACOLOGY

Cannabinoid receptor-dependent and -independent anti-proliferative effects of omega-3 ethanolamides in androgen receptor-positive and -negative prostate cancer cell lines

(2010) Iain Brown et al.   CARCINOGENESIS

Requirement of cannabinoid CB1 receptors in cortical pyramidal neurons for appropriate development of corticothalamic and thalamocortical projections

(2010) Chia-Shan Wu et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

A synthetic cannabinoid agonist promotes oligodendrogliogenesis during viral encephalitis in rats

(2010) Marylou V. Solbrig et al.   EXPERIMENTAL NEUROLOGY

The constitutive production of the endocannabinoid 2-arachidonoylglycerol participates in oligodendrocyte differentiation

(2010) Oscar Gomez et al.   GLIA

CB1Cannabinoid Receptors Increase Neuronal Precursor Proliferation through AKT/Glycogen Synthase Kinase-3β/β-Catenin Signaling

(2010) Stefania Trazzi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Subcellular Recruitment of Monoacylglycerol Lipase Generates Spatial Specificity of 2-Arachidonoyl Glycerol Signaling during Axonal Pathfinding

(2010) E. Keimpema et al.   JOURNAL OF NEUROSCIENCE

Loss of Retrograde Endocannabinoid Signaling and Reduced Adult Neurogenesis in Diacylglycerol Lipase Knock-out Mice

(2010) Y. Gao et al.   JOURNAL OF NEUROSCIENCE

An update on sphingosine-1-phosphate and other sphingolipid mediators

(2010) Henrik Fyrst et al.   Nature Chemical Biology

TRPV1 activation by endogenous anandamide triggers postsynaptic long-term depression in dentate gyrus

(2010) Andrés E Chávez et al.   NATURE NEUROSCIENCE

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

(2010) William R Marrs et al.   NATURE NEUROSCIENCE

Chronic monoacylglycerol lipase blockade causes functional antagonism of the endocannabinoid system

(2010) Joel E Schlosburg et al.   NATURE NEUROSCIENCE

Postsynaptic TRPV1 triggers cell type–specific long-term depression in the nucleus accumbens

(2010) Brad A Grueter et al.   NATURE NEUROSCIENCE

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

(2010) Wei Deng et al.   NATURE REVIEWS NEUROSCIENCE

The Endocannabinoid 2-Arachidonoylglycerol Produced by Diacylglycerol Lipase α Mediates Retrograde Suppression of Synaptic Transmission

(2010) Asami Tanimura et al.   NEURON

Endocannabinoids Potentiate Synaptic Transmission through Stimulation of Astrocytes

(2010) Marta Navarrete et al.   NEURON

Cannabinoid CB1 Receptor Immunoreactivity in the Prefrontal Cortex: Comparison of Schizophrenia and Major Depressive Disorder

(2010) Stephen M Eggan et al.   NEUROPSYCHOPHARMACOLOGY

The orphan G protein-coupled receptor GPR55 promotes cancer cell proliferation via ERK

(2010) C Andradas et al.   ONCOGENE

The putative cannabinoid receptor GPR55 defines a novel autocrine loop in cancer cell proliferation

(2010) R Piñeiro et al.   ONCOGENE

Investigation of CNR1 and FAAH endocannabinoid gene polymorphisms in bipolar disorder and major depression

(2010) Palmiero Monteleone et al.   PHARMACOLOGICAL RESEARCH

International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid Receptors and Their Ligands: Beyond CB1 and CB2

(2010) R. G. Pertwee et al.   PHARMACOLOGICAL REVIEWS

The Expression Level of CB1 and CB2 Receptors Determines Their Efficacy at Inducing Apoptosis in Astrocytomas

(2010) Eiron Cudaback et al.   PLoS One

The Cannabinoid WIN55212-2 Promotes Neural Repair After Neonatal Hypoxia–Ischemia

(2010) David Fernández-López et al.   STROKE

Brain Cannabinoid CB2 Receptor in Schizophrenia

(2009) Hiroki Ishiguro et al.   BIOLOGICAL PSYCHIATRY

Origin, Early Commitment, Migratory Routes, and Destination of Cannabinoid Type 1 Receptor-Containing Interneurons

(2009) Yury M. Morozov et al.   CEREBRAL CORTEX

Molecular Identification of Albumin and Hsp70 as Cytosolic Anandamide-Binding Proteins

(2009) Sergio Oddi et al.   CHEMISTRY & BIOLOGY

Changes in hippocampal morphology and neuroplasticity induced by adolescent THC treatment are associated with cognitive impairment in adulthood

(2009) Tiziana Rubino et al.   HIPPOCAMPUS

Characterization of the Endocannabinoid System in Human Neuronal Cells and Proteomic Analysis of Anandamide-induced Apoptosis

(2009) Nicoletta Pasquariello et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells

(2009) María Salazar et al.   JOURNAL OF CLINICAL INVESTIGATION

Developmental Alteration of Endocannabinoid Retrograde Signaling in the Hippocampus

(2009) Ping Jun Zhu et al.   JOURNAL OF NEUROPHYSIOLOGY

Selective CB2 Receptor Agonism Protects Central Neurons from Remote Axotomy-Induced Apoptosis through the PI3K/Akt Pathway

(2009) M. T. Viscomi et al.   JOURNAL OF NEUROSCIENCE

Ligand- and Heterodimer-Directed Signaling of the CB1 Cannabinoid Receptor

(2009) B. D. Hudson et al.   MOLECULAR PHARMACOLOGY

Endocannabinoid Signaling Is Required for Development and Critical Period Plasticity of the Whisker Map in Somatosensory Cortex

(2009) Lu Li et al.   NEURON

Activity-Dependent Regulation of Synapses by Retrograde Messengers

(2009) Wade G. Regehr et al.   NEURON

BDNF regulates neuronal sensitivity to endocannabinoids

(2009) Patrick Maison et al.   NEUROSCIENCE LETTERS

Altered regulation of glutamate release and decreased functional activity and expression of GLT1 and GLAST glutamate transporters in the hippocampus of adolescent rats perinatally exposed to Δ9-THC

(2009) Pasqualina Castaldo et al.   PHARMACOLOGICAL RESEARCH

Endocannabinoid-Mediated Control of Synaptic Transmission

(2009) Masanobu Kano et al.   PHYSIOLOGICAL REVIEWS

Identification of intracellular carriers for the endocannabinoid anandamide

(2009) M. Kaczocha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spinal Endocannabinoids and CB1 Receptors Mediate C-Fiber-Induced Heterosynaptic Pain Sensitization

(2009) A. J. Pernia-Andrade et al.   SCIENCE

Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond

(2008) Roger G. Pertwee   ADDICTION BIOLOGY

Reduced Cortical Cannabinoid 1 Receptor Messenger RNA and Protein Expression in Schizophrenia

(2008) Stephen M. Eggan et al.   ARCHIVES OF GENERAL PSYCHIATRY

Cannabinoids Inhibit Glioma Cell Invasion by Down-regulating Matrix Metalloproteinase-2 Expression

(2008) C. Blazquez et al.   CANCER RESEARCH

Mechanisms and Functional Implications of Adult Neurogenesis

(2008) Chunmei Zhao et al.   CELL

Evidence for the intracellular accumulation of anandamide in adiposomes

(2008) S. Oddi et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Enzymatic Pathways That Regulate Endocannabinoid Signaling in the Nervous System

(2008) Kay Ahn et al.   CHEMICAL REVIEWS

Wiring and firing neuronal networks: endocannabinoids take center stage

(2008) Tibor Harkany et al.   CURRENT OPINION IN NEUROBIOLOGY

The endocannabinoid system in obesity and type 2 diabetes

(2008) V. Di Marzo   DIABETOLOGIA

The type 1 cannabinoid receptor is highly expressed in embryonic cortical projection neurons and negatively regulates neurite growthin vitro

(2008) Tania Vitalis et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Modes and Mishaps of Neuronal Migration in the Mammalian Brain

(2008) C. Metin et al.   JOURNAL OF NEUROSCIENCE

A diacylglycerol lipase-CB2 cannabinoid pathway regulates adult subventricular zone neurogenesis in an age-dependent manner

(2008) Maria Beatriz Goncalves et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

The endocannabinoid receptor, CB1, is required for normal axonal growth and fasciculation

(2008) Sheona Watson et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

Endocannabinoid signaling as a synaptic circuit breaker in neurological disease

(2008) István Katona et al.   NATURE MEDICINE

Anandamide inhibits metabolism and physiological actions of 2-arachidonoylglycerol in the striatum

(2008) Mauro Maccarrone et al.   NATURE NEUROSCIENCE

Pyramidal Neurons Grow Up and Change Their Mind

(2008) Gord Fishell et al.   NEURON

DAG Lipase Activity Is Necessary for TRP Channel Regulation in Drosophila Photoreceptors

(2008) Hung-Tat Leung et al.   NEURON

Regulation of excitability and plasticity by endocannabinoids and PKA in developing hippocampus

(2008) H. Yasuda et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GPR55 is a cannabinoid receptor that increases intracellular calcium and inhibits M current

(2008) J. E. Lauckner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endocannabinoid signaling controls pyramidal cell specification and long-range axon patterning

(2008) J. Mulder et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Design Logic of a Cannabinoid Receptor Signaling Network That Triggers Neurite Outgrowth

(2008) K. D. Bromberg et al.   SCIENCE

Compartmentalization of endocannabinoids into lipid rafts in a dorsal root ganglion cell line

(2007) N Rimmerman et al.   BRITISH JOURNAL OF PHARMACOLOGY

Inhibition of Cancer Cell Invasion by Cannabinoids via Increased Expression of Tissue Inhibitor of Matrix Metalloproteinases-1

(2007) Robert Ramer et al.   JNCI-Journal of the National Cancer Institute