Interference of Apoptosis by Hepatitis B Virus

ROS signalling in the biology of cancer

(2018) Jennifer N. Moloney et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Virus-induced hepatocellular carcinoma with special emphasis on HBV

(2017) Ming Wang et al.   Hepatology International

Hepatitis B Virus X Protein Stimulates Proliferation, Wound Closure and Inhibits Apoptosis of HuH-7 Cells via CDC42

(2017) Yongru Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Racial/ethnic disparities in the prevalence and awareness of Hepatitis B virus infection and immunity in the United States

(2017) H. S. Kim et al.   JOURNAL OF VIRAL HEPATITIS

Recent advances in the use of PI3K inhibitors for glioblastoma multiforme: current preclinical and clinical development

(2017) Hua-fu Zhao et al.   Molecular Cancer

Reinvigorating exhausted T cells in hepatitis B infection

(2017) Megan Cully   NATURE REVIEWS DRUG DISCOVERY

Hepatitis B virus X protein-induced upregulation of CAT-1 stimulates proliferation and inhibits apoptosis in hepatocellular carcinoma cells

(2017) Rongjuan Dai et al.   Oncotarget

HBx promotes cell proliferation by disturbing the cross-talk between miR-181a and PTEN

(2017) Yi Tian et al.   Scientific Reports

Activation of apoptosis signalling pathways by reactive oxygen species

(2016) Maureen Redza-Dutordoir et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

A novel mutant 10Ala/Arg together with mutant 144Ser/Arg of hepatitis B virus X protein involved in hepatitis B virus-related hepatocarcinogenesis in HepG2 cell lines

(2016) Ying Shi et al.   CANCER LETTERS

HBxAg suppresses apoptosis of human placental trophoblastic cell lines via activation of the PI3K/Akt pathway

(2016) Weimin Wang et al.   CELL BIOLOGY INTERNATIONAL

Hepatitis B Virus X Protein Modulates Apoptosis in NRK-52E Cells and Activates Fas/FasL Through the MLK3-MKK7-JNK3 Signaling Pathway

(2016) Ping He et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Hepatitis B virus genotypes: epidemiological and clinical relevance in Asia

(2016) Qiuju Tian et al.   Hepatology International

Hepatitis B virus whole-X and X protein play distinct roles in HBV-related hepatocellular carcinoma progression

(2016) Yu Zhang et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Global strategies are required to cure and eliminate HBV infection

(2016) Peter Revill et al.   Nature Reviews Gastroenterology & Hepatology

Experimental models of hepatitis B and C — new insights and progress

(2016) Emmanuel Thomas et al.   Nature Reviews Gastroenterology & Hepatology

Hepatitis B virus X protein sensitizes HL-7702 cells to oxidative stress-induced apoptosis through modulation of the mitochondrial permeability transition pore

(2016) Wen-Yu Gao et al.   ONCOLOGY REPORTS

Hepatitis B Virus HBx Activates Notch Signaling via Delta-Like 4/Notch1 in Hepatocellular Carcinoma

(2016) Pornrat Kongkavitoon et al.   PLoS One

Structural and biochemical analysis of Bcl-2 interaction with the hepatitis B virus protein HBx

(2016) Tianyu Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation of AMPK/MnSOD signaling mediates anti-apoptotic effect of hepatitis B virus in hepatoma cells

(2016) Lei Li et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Cell Culture Models for the Investigation of Hepatitis B and D Virus Infection

(2016) Eloi Verrier et al.   Viruses-Basel

Genomic and oncogenic preference of HBV integration in hepatocellular carcinoma

(2016) Ling-Hao Zhao et al.   Nature Communications

Global burden of cancers attributable to infections in 2012: a synthetic analysis

(2016) Martyn Plummer et al.   Lancet Global Health

Protective Role of Sirtuin3 (SIRT3) in Oxidative Stress Mediated by Hepatitis B Virus X Protein Expression

(2016) Ji-Hua Ren et al.   PLoS One

Hepatitis B virus core protein inhibits Fas-mediated apoptosis of hepatoma cells via regulation of mFas/FasL and sFas expression

(2015) Wei Liu et al.   FASEB JOURNAL

Characterization of the genotype and integration patterns of hepatitis B virus in early- and late-onset hepatocellular carcinoma

(2015) Hongli Yan et al.   HEPATOLOGY

Hepatitis B virus X protein modifies invasion, proliferation and the inflammatory response in an HTR-8/SVneo cell model

(2015) HONG CUI et al.   ONCOLOGY REPORTS

Cellular inhibitor of apoptosis proteins prevent clearance of hepatitis B virus

(2015) Gregor Ebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Eliminating hepatitis B by antagonizing cellular inhibitors of apoptosis

(2015) Gregor Ebert et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Activation and Exhaustion of Adaptive Immune Cells in Hepatitis B Infection

(2015) Dimpu Gogoi et al.   VIRAL IMMUNOLOGY

The enhanced expression of death receptor 5 (DR5) mediated by HBV X protein through NF-kappaB pathway is associated with cell apoptosis induced by (TNF-α related apoptosis inducing ligand) TRAIL in hepatoma cells

(2015) Fanyun Kong et al.   Virology Journal

Hepatitis B and C virus-induced hepatitis: Apoptosis, autophagy, and unfolded protein response

(2015) Behzad Yeganeh   WORLD JOURNAL OF GASTROENTEROLOGY

Molecular mechanism of hepatitis B virus X protein function in hepatocarcinogenesis

(2015) Ming Geng   WORLD JOURNAL OF GASTROENTEROLOGY

HBx-related long non-coding RNA DBH-AS1 promotes cell proliferation and survival by activating MAPK signaling in hepatocellular carcinoma

(2015) Jin-lan Huang et al.   Oncotarget

Is mother-to-infant transmission the most important factor for persistent HBV infection?

(2015) Zixiong Li et al.   Emerging Microbes & Infections

Mo1946 HBsAg Inhibits the Translocation of Jtb Into Mitochondria in HEPG2 Cells and Potentially Plays a Role in HCC Progression

(2015) Bayasi Guleng et al.   GASTROENTEROLOGY

Hepatitis B Virus X Protein Sensitizes TRAIL-Induced Hepatocyte Apoptosis by Inhibiting the E3 Ubiquitin Ligase A20

(2015) Hang Zhang et al.   PLoS One

NTCP and Beyond: Opening the Door to Unveil Hepatitis B Virus Entry

(2014) Koichi Watashi et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Hepatitis B Virus Regulates Apoptosis and Tumorigenesis through the MicroRNA-15a-Smad7-Transforming Growth Factor Beta Pathway

(2014) Ningning Liu et al.   JOURNAL OF VIROLOGY

Hepatitis B Virus Core Protein Sensitizes Hepatocytes to Tumor Necrosis Factor-Induced Apoptosis by Suppression of the Phosphorylation of Mitogen-Activated Protein Kinase Kinase 7

(2014) Baosen Jia et al.   JOURNAL OF VIROLOGY

HBx protein-induced upregulation of microRNA-221 promotes aberrant proliferation in HBV-related hepatocellular carcinoma by targeting estrogen receptor-α

(2014) JUAN-JUAN CHEN et al.   ONCOLOGY REPORTS

MicroRNAs in cancer: biomarkers, functions and therapy

(2014) Josie Hayes et al.   TRENDS IN MOLECULAR MEDICINE

Hepatitis reactivation in patients with rheumatic diseases after immunosuppressive therapy—a report of long-term follow-up of serial cases and literature review

(2013) Dandan Xuan et al.   CLINICAL RHEUMATOLOGY

Hepatitis B and D Viruses Exploit Sodium Taurocholate Co-transporting Polypeptide for Species-Specific Entry into Hepatocytes

(2013) Yi Ni et al.   GASTROENTEROLOGY

Hepatitis B virus X protein modulates apoptosis in human renal proximal tubular epithelial cells by activating the JAK2/STAT3 signaling pathway

(2013) PING HE et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Hepatitis B virus x protein induces autophagyviaactivating death-associated protein kinase

(2013) H.-T Zhang et al.   JOURNAL OF VIRAL HEPATITIS

Hepatitis B Virus Inhibits Apoptosis of Hepatoma Cells by Sponging the MicroRNA 15a/16 Cluster

(2013) N. Liu et al.   JOURNAL OF VIROLOGY

Hepatitis B Virus Disrupts Mitochondrial Dynamics: Induces Fission and Mitophagy to Attenuate Apoptosis

(2013) Seong-Jun Kim et al.   PLoS Pathogens

Pro-apoptotic or anti-apoptotic property of X protein of hepatitis B virus is determined by phosphorylation at Ser31 by Akt

(2012) Wei-Ping Lee et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

miR-101 is down-regulated by the hepatitis B virus x protein and induces aberrant DNA methylation by targeting DNA methyltransferase 3A

(2012) Xufu Wei et al.   CELLULAR SIGNALLING

Hepatitis B Virus Encoded X Protein Suppresses Apoptosis by Inhibition of the Caspase-Independent Pathway

(2012) Haiying Liu et al.   JOURNAL OF PROTEOME RESEARCH

Hepatitis B virus X gene differentially modulates cell cycle progression and apoptotic protein expression in hepatocyte versus hepatoma cell lines

(2012) C. H. Yang et al.   JOURNAL OF VIRAL HEPATITIS

Altered Binding Site Selection of p53 Transcription Cassettes by Hepatitis B Virus X Protein

(2012) Cheryl Chan et al.   MOLECULAR AND CELLULAR BIOLOGY

Hepatitis B virus X protein targets the Bcl-2 protein CED-9 to induce intracellular Ca2+ increase and cell death in Caenorhabditis elegans

(2012) X. Geng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Global epidemiology of hepatitis B virus infection: New estimates of age-specific HBsAg seroprevalence and endemicity

(2012) J.J. Ott et al.   VACCINE

Expression of TRAIL in liver tissue from patients with different outcomes of HBV infection

(2012) Fan-wei Liu et al.   Clinics and Research in Hepatology and Gastroenterology

Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus

(2012) Huan Yan et al.   eLife

Hepatitis B virus X protein reduces starvation-induced cell death through activation of autophagy and inhibition of mitochondrial apoptotic pathway

(2011) Yi Mao et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

miR-29c targets TNFAIP3, inhibits cell proliferation and induces apoptosis in hepatitis B virus-related hepatocellular carcinoma

(2011) Chun-Mei Wang et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Hepatitis B Virus Large Surface Antigen Promotes Liver Carcinogenesis by Activating the Src/PI3K/Akt Pathway

(2011) H. Liu et al.   CANCER RESEARCH

Proinflammatory cytokine TNF-α increases the stability of hepatitis B virus X protein through NF-κB signaling

(2011) Ruchi Shukla et al.   CARCINOGENESIS

Dissection of cell context-dependent interactions between HBx and p53 family members in regulation of apoptosis: A role for HBV-induced HCC

(2011) Susanne Knoll et al.   CELL CYCLE

Cell line misidentification: The case of the Chang liver cell line

(2011) Qiang Gao et al.   HEPATOLOGY

Hepatitis B virus X protein induces IKKα nuclear translocation via Akt-Dependent phosphorylation to promote the motility of hepatocarcinoma cells

(2011) Wei-Chien Huang et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Involvement of the NF-κB pathway in multidrug resistance induced by HBx in a hepatoma cell line

(2011) Y. Liu et al.   JOURNAL OF VIRAL HEPATITIS

HBx Sensitizes Cells to Oxidative Stress-induced Apoptosis by Accelerating the Loss of Mcl-1 Protein via Caspase-3 Cascade

(2011) Liang Hu et al.   Molecular Cancer

Interaction of mutant hepatitis B X protein with p53 tumor suppressor protein affects both transcription and cell survival

(2011) Shoba Iyer et al.   MOLECULAR CARCINOGENESIS

Induction of Bcl-2 Expression by Hepatitis B Virus Pre-S2 Mutant Large Surface Protein Resistance to 5-Fluorouracil Treatment in Huh-7 Cells

(2011) Jui-Hsiang Hung et al.   PLoS One

Molecular biology of Bax and Bak activation and action

(2010) Dana Westphal et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Non-canonical NF-κB signaling pathway

(2010) Shao-Cong Sun   CELL RESEARCH

Cellular inhibitor of apoptosis 1 (cIAP-1) degradation by caspase 8 during TNF-related apoptosis-inducing ligand (TRAIL)-induced apoptosis

(2010) Maria Eugenia Guicciardi et al.   EXPERIMENTAL CELL RESEARCH

Carriers of Inactive Hepatitis B Virus Are Still at Risk for Hepatocellular Carcinoma and Liver-Related Death

(2010) Jin–De Chen et al.   GASTROENTEROLOGY

Modeling hepatitis B virus X-induced hepatocellular carcinoma in mice with the sleeping beauty transposon system

(2010) Vincent W. Keng et al.   HEPATOLOGY

Mitochondria and cell death: outer membrane permeabilization and beyond

(2010) Stephen W. G. Tait et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inhibition of NF- B Signaling by A20 Through Disruption of Ubiquitin Enzyme Complexes

(2010) N. Shembade et al.   SCIENCE

Hepatitis B virus X protein overcomes the growth-inhibitory potential of retinoic acid by downregulating retinoic acid receptor- 2 expression via DNA methylation

(2009) J. K. Jung et al.   JOURNAL OF GENERAL VIROLOGY

The replication cycle of hepatitis B virus

(2009) Stephan Urban et al.   JOURNAL OF HEPATOLOGY

Hepatitis B Virus X Protein Modulates Apoptosis in Primary Rat Hepatocytes by Regulating both NF- B and the Mitochondrial Permeability Transition Pore

(2009) A. J. Clippinger et al.   JOURNAL OF VIROLOGY

Bcl-2 complexed with Beclin-1 maintains full anti-apoptotic function

(2009) I A Ciechomska et al.   ONCOGENE

Hepatitis B virus HBx protein localized to the nucleus restores HBx-deficient virus replication in HepG2 cells and in vivo in hydrodynamically-injected mice

(2009) Victor V. Keasler et al.   VIROLOGY

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

(2008) Lai Wang et al.   CELL

TRAF2 and TRAF3 Signal Adapters Act Cooperatively to Control the Maturation and Survival Signals Delivered to B Cells by the BAFF Receptor

(2008) Sandra Gardam et al.   IMMUNITY

Hepatitis B virus X protein induces apoptosis by enhancing translocation of Bax to mitochondria

(2008) Hye Jin Kim et al.   IUBMB LIFE

c-IAP1 and c-IAP2 Are Critical Mediators of Tumor Necrosis Factor α (TNFα)-induced NF-κB Activation

(2008) Eugene Varfolomeev et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Both cIAP1 and cIAP2 regulate TNF -mediated NF- B activation

(2008) D. J. Mahoney et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of canonical NF- B activation through the NIK-IKK complex pathway

(2008) B. Zarnegar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hepatitis B viruses: Reverse transcription a different way

(2008) Michael Nassal   VIRUS RESEARCH

Viral Control of Mitochondrial Apoptosis

(2008) Lorenzo Galluzzi et al.   PLoS Pathogens