Review
Biochemistry & Molecular Biology
Caroline Lefeuvre, Helene Le Guillou-Guillemette, Alexandra Ducancelle
Summary: Chronic HBV infection is a common factor associated with HCC, with studies showing that the HBc protein plays a significant role in affecting pathways involved in HCC development, such as migration, proliferation, apoptosis, metabolism, and immune responses. HBc can also promote HCC metastasis by modulating host gene expression.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Biotechnology & Applied Microbiology
Yuan Zhang, Xiaorong Chen, Yajuan Cao, Zongguo Yang
Summary: APOBEC3 (A3) cytidine deaminases play important roles in inhibiting HBV infection, but their deaminated deoxycytidine activity can also cause cellular genetic mutations, affecting genomic stability and cancer development.
Review
Gastroenterology & Hepatology
Masataka Tsuge
Summary: Chronic hepatitis B virus (HBV) infection is a global health issue that can lead to severe liver dysfunction and hepatocellular carcinoma. Current antiviral therapies are effective in suppressing viral replication, but difficulty in complete virus elimination, along with alterations in intracellular metabolism and signaling pathways, contribute to the development of hepatocarcinogenesis in chronic HBV infection.
LIVER INTERNATIONAL
(2021)
Article
Medicine, General & Internal
Bangxiang Xie, Qian Hao, Xiang Zhou, Dexi Chen
Summary: The HBx protein of hepatitis B virus interacts with the TAp63 protein and inhibits its transcriptional activity, leading to the progression of hepatocellular carcinoma with defective p53.
CHINESE MEDICAL JOURNAL
(2022)
Review
Virology
Giacomo Emanuele Maria Rizzo, Giuseppe Cabibbo, Antonio Craxi
Summary: Hepatitis B virus (HBV) infection is associated with the risk of developing hepatocellular carcinoma (HCC), with or without liver cirrhosis, through various mechanisms. The molecular profile of HBV-HCC is constantly being studied, and it is the result of altered molecular pathways, changes in the microenvironment, and DNA damage. Proper management of HBV-related liver disease is crucial for prevention and treatment of HCC.
Review
Microbiology
Suchandrima Ghosh, Anannya Chakraborty, Soma Banerjee
Summary: HBV infection has a complex impact on the host, affecting immune response dynamics and increasing susceptibility to oncogenic factors. The virus exists in multiple forms, with viral DNA, cccDNA, pgRNA, and HBsAg being important therapeutic targets.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Oncology
Meng Xue, Xiaona Lin, Qiu-Xiong Lin, Xiaoyong Pu, Jiumin Liu, Xing-Fang Li, Jun Hou, Xudong Liu, Ren Chen
Summary: This study found that HBV infection was associated with an increased risk of HCC compared to HEV infection, and that HEV infection may mitigate the promoting impact of HBV on HCC development.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Genetics & Heredity
Gurbet Celik-Turgut, Nazmiye Olmez, Tugba Koc, Ozden Ozgun-Acar, Asli Semiz, Yavuz Dodurga, Naciye Lale Satiroglu-Tufan, Alaattin Sen
Summary: The aim of this study was to investigate the interaction between aryl hydrocarbon receptor (AHR), nuclear factor -kappa B (NF-kB), and cytochrome P4501A1 (CYP1A1) with hepatitis B virus X protein (HBX). The results showed that NF-kB and AHR genes interacted with HBX, but there was no interaction between CYP1A1 and HBX proteins. This suggests that AHR and NF-kB play a role in HBV mechanism mediated via HBX, while CYP1A1 has no effect on this interaction.
Review
Biochemistry & Molecular Biology
Nicholas Noverati, Rukaiya Bashir-Hamidu, Dina Halegoua-DeMarzio, Hie-Won Hann
Summary: Hepatitis B virus is a significant cause of hepatocellular carcinoma globally. The complex mechanisms of this virus include interactions with the host's immune system. Factors such as stress can amplify these mechanisms. Chronic stress, harmful to health, can suppress or activate the host's defense system, leading to tumor initiation and progression in liver cancer. Chronic stress, often overlooked, should be recognized as a potential risk factor.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Medicine, Research & Experimental
Wensheng Deng, Jiaoyu Ai, Wanlin Zhang, Zhenyu Zhou, Muqi Li, Likun Yan, Lidong Zhang, Zongjing Huang, Ziyi Wu, Junhua Ai, Hai Jiang
Summary: The HBx/PRMT9/HSPA8/CD44 axis was identified as a key signaling pathway regulating ferroptosis in HCC cells.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Review
Medicine, General & Internal
Mirjam B. Zeisel, Francesca Guerrieri, Massimo Levrero
Summary: Hepatocellular carcinoma (HCC) is the most common primary liver malignancy and is largely caused by chronic hepatitis B virus (HBV) infection. While antiviral therapies can suppress viral replication, there is currently no cure for chronic HBV infection. HBV contributes to liver carcinogenesis through direct and indirect effects on host epigenetic alterations, modulating gene expression.
JOURNAL OF CLINICAL MEDICINE
(2021)
Article
Cell Biology
Yiming Lei, Xuan Xu, Huiling Liu, Lingjun Chen, Haoxiong Zhou, Jie Jiang, Yidong Yang, Bin Wu
Summary: The protein ARBB1 plays a critical role in HBV-related hepatocellular carcinoma by modulating autophagy and the CDKN1B-CDK2-CCNE1-E2F1 axis, suggesting it may be a potential therapeutic target for HCC.
Article
Gastroenterology & Hepatology
Yongdong Niu, Shaohua Fan, Qin Luo, Liming Chen, Danmei Huang, Wenjun Chang, Wenxin Qin, Ganggang Shi
Summary: HBV infection increases hepatocellular sensitivity to carcinogenic xenobiotics and promotes hepatocellular carcinoma formation. The HBx-PXR-CYP3A4/GSTM1-KRAS-IL11:IL11RA signaling axis plays a crucial role in enhancing the toxicity of chemical carcinogens in HBV-associated hepatocarcinogenesis.
JOURNAL OF CLINICAL AND TRANSLATIONAL HEPATOLOGY
(2021)
Article
Gastroenterology & Hepatology
Hyun-seok Kim, Xian Yu, Jennifer Kramer, Aaron P. Thrift, Pete Richardson, Yao-Chun Hsu, Avegail Flores, Hashem B. El-Serag, Fasiha Kanwal
Summary: This study evaluated the performance of 10 HCC risk prediction models in patients with HBV, showing that most models performed well in predicting HCC risk and identified low-risk subsets for exclusion from HCC surveillance. Further research is needed to validate these findings.
JOURNAL OF HEPATOLOGY
(2022)
Review
Oncology
Xinhe Zhang, Lin Guan, Haoyu Tian, Zilu Zeng, Jiayu Chen, Die Huang, Ji Sun, Jiaqi Guo, Huipeng Cui, Yiling Li
Summary: HCC is a common cancer with increasing incidence caused by HBV and HCV infections, liver cirrhosis, and metabolic risk factors. Predictive factors can assess the risk of HCC, and prevention strategies include vaccination, antiviral treatment, and HCC management to reduce recurrence.
FRONTIERS IN ONCOLOGY
(2021)
