Article
Microbiology
Maria Bousali, Timokratis Karamitros
Summary: This study investigated the preferential integration of hepatitis B virus (HBV) into specific genes and evaluated their contribution to hepatocellular carcinoma (HCC) development. The results suggested that 15 genes are frequently affected by HBV integrations and significantly associated with HBV-HCC.
Review
Oncology
Sheng-Han Wang, Shiou-Hwei Yeh, Pei-Jer Chen
Summary: HBV infection is a major risk factor for HCC globally, with chronic hepatitis B generating an inflammatory microenvironment that leads to genetic mutations in hepatocytes predisposing them to cancer. Male dominance in HBV-related HCC highlights the interplay between sex hormones and viral factors influencing carcinogenesis.
Article
Cell Biology
Selena Y. Lin, Adam Zhang, Jessica Lian, Jeremy Wang, Ting-Tsung Chang, Yih-Jyh Lin, Wei Song, Ying-Hsiu Su
Summary: The study identified 396 recurrently targeted genes (RTGs) in HBV-associated HCC, with 23 of them associated with carcinogenesis. Among the top three RTGs, TERT, MLL4/KMT2B, and PLEKHG4B were identified as most frequently targeted. Comprehensive analysis of these genes provides insights for potential drug development and disease management in HCC.
Article
Medicine, General & Internal
Bangxiang Xie, Qian Hao, Xiang Zhou, Dexi Chen
Summary: The HBx protein of hepatitis B virus interacts with the TAp63 protein and inhibits its transcriptional activity, leading to the progression of hepatocellular carcinoma with defective p53.
CHINESE MEDICAL JOURNAL
(2022)
Article
Virology
Pranav P. Mathkar, Xun Chen, Arvis Sulovari, Dawei Li
Summary: Hepatocellular carcinoma (HCC) is a major cause of cancer-related mortality, with about half of cases associated with hepatitis B virus (HBV) infections. Accurate identification of HBV integration sites is crucial for understanding the landscape of HCC genome. Through pathway enrichment analysis, it was found that HBV integrations were linked to various metabolism pathways. The VIcaller method showed potential in identifying novel clonal integrations in cancer-related genes.
Article
Immunology
Ruonan Sun, Jiawei Li, Xianyi Lin, Yidong Yang, Bing Liu, Tianbi Lan, Shuang Xiao, Anyi Deng, Zhinan Yin, Yan Xu, Zheng Xiang, Bin Wu
Summary: This study aimed to explore the changes in peripheral immunity in patients with HBV-related hepatocellular carcinoma (HBV-HCC). The results showed that circulating lymphocytes in HBV-HCC patients exhibited features of immune exhaustion, especially in patients with persistent viral replication and in those with intermediate and advanced HBV-HCC. The combination of CD3(+) T cells and CD8(+)HLADR(+)CD38(+) T cells may serve as a potential diagnostic indicator for HBV-HCC.
FRONTIERS IN IMMUNOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Hiroaki Kanzaki, Tetsuhiro Chiba, Tatsuya Kaneko, Junjie Ao, Motoyasu Kan, Ryosuke Muroyama, Shingo Nakamoto, Tatsuo Kanda, Hitoshi Maruyama, Jun Kato, Yoh Zen, Ai Kotani, Kazuma Sekiba, Motoyuki Otsuka, Masayuki Ohtsuka, Naoya Kato
Summary: ELAVL1 protein is not only involved in the replication of hepatitis B virus, but also has an impact on the cell growth of hepatocellular carcinoma, making it a potential therapeutic target for HBV-related HCC treatment.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Virology
Arpita Kar, Abhisekh Samanta, Soumyadeep Mukherjee, Subhasis Barik, Avik Biswas
Summary: Hepatitis B virus (HBV) is a major cause of hepatocellular carcinoma (HCC), the most common primary liver malignancy. The study of HBV-host interactions has identified various mechanisms involved in the development and progression of HBV-associated HCC. This review provides a comprehensive summary of the existing knowledge on HBV-host interplay and highlights new therapeutic strategies for HBV-induced HCC.
JOURNAL OF MEDICAL VIROLOGY
(2023)
Article
Microbiology
Renxiang Xia, Jing Peng, Jian He, Ping Jiang, Chunyan Yuan, Xiaoli Liu, Yunqing Yao
Summary: This study investigated the clinical and virological characteristics of individuals in China with chronic occult hepatitis B virus infection (HBV) and their correlation with hepatocellular carcinoma (HCC). Findings revealed that there are at least 21 million individuals with occult HBV infection in China. The presence of HBcAb(+) indicated not only chronic HBV infection, but also a dangerous marker for surface antigen-negative patients. Regular check-ups every six months or one year are recommended for early detection of HCC in occult infection patients.
FRONTIERS IN MICROBIOLOGY
(2022)
Article
Virology
Xiazhen Xu, Lu Zhang, Guiying Ye, Jiajian Shi, Yibin Peng, Fan Xin, Yi Lin, Qiong Wu, Xu Lin, Wannan Chen
Summary: The study reveals that the 2.2-kb HBV spliced variants encoded protein, HBDSP, promotes apoptosis in wt-p53 hepatocytes and induces the activation of p53-dependent apoptotic signaling pathway. Additionally, HBDSP increases the production of HBV progeny and viral antigens through the transactivation of the p53 promoter in an ETS1-, GATA2-, and YY1-dependent manner.
JOURNAL OF VIROLOGY
(2023)
Article
Immunology
Ya Fu, Fengling Fang, Hongyan Guo, Xialin Xiao, Yuhai Hu, Yongbin Zeng, Tianbin Chen, Songhang Wu, Ni Lin, Jinlan Huang, Ling Jiang, Qishui Ou, Can Liu
Summary: This study investigates the evolutionary characteristics of HBV X gene in the hepatocellular carcinoma microenvironment, and finds lower heterogeneity in tumor tissues and a location bias in X gene mutations. Additionally, the study reveals that HBx harboring mutation T81P/S101P/L123S promotes cell proliferation and increases genomic instability.
EMERGING MICROBES & INFECTIONS
(2022)
Article
Oncology
Rui Wang, Zhijian Xu, Jiaping Tian, Qian Liu, Jingwen Dong, Lijuan Guo, Boning Hai, Xia Liu, Hangping Yao, Zhi Chen, Junjie Xu, Lijun Zhu, Haiyi Chen, Tingjun Hou, Weiliang Zhu, Jimin Shao
Summary: Pterostilbene is identified as a potent RR inhibitor targeting RRM2, which can effectively inhibit both HCC proliferation and HBV replication, showing potential for the treatment of HCC and HBV-related HCC.
AMERICAN JOURNAL OF CANCER RESEARCH
(2021)
Article
Medicine, Research & Experimental
Guangyuan Song, Xingxin Zhu, Zefeng Xuan, Long Zhao, Haijiang Dong, Jian Chen, Zequn Li, Wenfeng Song, Cheng Jin, Mengqiao Zhou, Haiyang Xie, Shusen Zheng, Penghong Song
Summary: In this study, we identified that GNA14 is downregulated in HCC and negatively correlated with HBV infection, vascular invasion, and prognosis. HBx regulates GNA14 through DNA methylation, affecting the Notch1 and JMJD6 pathways to inhibit tumor proliferation and metastasis. GNA14 shows potential as a biomarker and therapeutic target in HCC.
Article
Genetics & Heredity
Yaqun Li, Jianhua Li, Tianye He, Yun Song, Jian Wu, Bin Wang
Summary: Cirrhosis is a risk factor for hepatocellular carcinoma (HCC) development. Preventive surveillance for early HCC in cirrhosis patients can enhance prognosis and reduce mortality. Researching effective genetic biomarkers for HCC incidence is crucial for accurate diagnosis.
Article
Oncology
Yu-Chong Peng, Jing-Xuan Xu, Chuan-Fa Zeng, Xin-Hua Zhao, Xue-Mei You, Ping-Ping Xu, Le-Qun Li, Lu-Nan Qi
Summary: This study investigated the difference in gut microbiota in patients with operable HBV-HCC at different ages and explored the features and functions associated with different age groups. The findings are of significance in the development of novel treatment approaches for HCC at different ages.
ANNALS OF TRANSLATIONAL MEDICINE
(2022)
Article
Pharmacology & Pharmacy
Liangliang Li, Biyun Xue, Weiyao Sun, Guoqian Gu, Gaopeng Hou, Lu Zhang, Chunyan Wu, Qin Zhao, Yanjin Zhang, Gaiping Zhang, Julian A. Hiscox, Yuchen Nan, En-Min Zhou
ANTIVIRAL RESEARCH
(2018)
Article
Virology
Liping Yang, Rong Wang, Shixing Yang, Zexu Ma, Shaoli Lin, Yuchen Nan, Qisheng Li, Qiyi Tang, Yan-Jin Zhang
JOURNAL OF VIROLOGY
(2018)
Article
Virology
Rong Wang, Liping Yang, Yali Zhang, Junyan Li, Liran Xu, Yueqiang Xiao, Qian Zhang, Liang Bai, Sihai Zhao, Enqi Liu, Yan-Jin Zhang
Review
Virology
Yuchen Nan, Chunyan Wu, Yan-Jin Zhang
Article
Virology
Shaoli Lin, Shixing Yang, Jia He, Johnathan D. Guest, Zexu Ma, Liping Yang, Brian G. Pierce, Qiyi Tang, Yan-Jin Zhang
Article
Virology
Liping Yang, Jia He, Rong Wang, Xinheng Zhang, Shaoli Lin, Zexu Ma, Yanjin Zhang
JOURNAL OF VIROLOGY
(2019)
Article
Virology
Jie Wang, Jie Li, Nana Wang, Qi Ji, Mingshuo Li, Yuchen Nan, En-Min Zhou, Yanjin Zhang, Chunyan Wu
Article
Virology
Shaoli Lin, Yonglin Yang, Yuchen Nan, Zexu Ma, Liping Yang, Yan-Jin Zhang
Article
Biochemistry & Molecular Biology
Jingjing Lan, Ruihua Zhang, Honglei Yu, Jingyu Wang, Wenxiang Xue, Junhao Chen, Shaoli Lin, Yu Wang, Zhijing Xie, Shijin Jiang
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2019)
Article
Immunology
Ruihua Zhang, Yupeng Yang, Jingjing Lan, Shaoli Lin, Zhijing Xie, Xiansheng Zhang, Shijin Jiang
Article
Cell Biology
Jia He, Liping Yang, Peixi Chang, Shixing Yang, Shaoli Lin, Qiyi Tang, Xinping Wang, Yan-Jin Zhang
Review
Virology
Shaoli Lin, Yan-Jin Zhang
Summary: Hepatitis E virus (HEV) is a causative agent for liver inflammation globally, with human strains mainly classified into four genotypes. Genotypes 1 and 2 cause acute hepatitis, while genotype 3 may lead to chronic infection in immunocompromised individuals. Pregnant women infected with genotype 1 HEV are at higher risk for severe outcomes.
Article
Virology
Jia He, Liping Yang, Peixi Chang, Shixing Yang, Yu Wang, Shaoli Lin, Qiyi Tang, Yanjin Zhang
Summary: This study found that Zika virus can degrade the Numb protein, which plays an important role in neurogenesis. Zika virus infection reduces the level of Numb protein, but has minimal effect on its transcription. The capsid protein of Zika virus significantly reduces the level of Numb protein, indicating the interaction between these two proteins. These findings provide insights into the impact of Zika virus on neurogenesis.
