Carbon Nanotubes Disrupt Iron Homeostasis and Induce Anemia of Inflammation through Inflammatory Pathway as a Secondary Effect Distant to Their Portal-of-Entry

Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation

(2016) Ming Xu et al.   ACS Nano

Minihepcidin peptides as disease modifiers in mice affected by  -thalassemia and polycythemia vera

(2016) C. Casu et al.   BLOOD

Isocitrate treatment of acute anemia of inflammation in a mouse model

(2016) Airie Kim et al.   BLOOD CELLS MOLECULES AND DISEASES

Carbon Nanotube Properties Influence Adsorption of Phenanthrene and Subsequent Bioavailability and Toxicity to Pseudokirchneriella subcapitata

(2016) Berit Glomstad et al.   ENVIRONMENTAL SCIENCE & TECHNOLOGY

Human exposure to carbon-based fibrous nanomaterials: A review

(2016) Irina Guseva Canu et al.   INTERNATIONAL JOURNAL OF HYGIENE AND ENVIRONMENTAL HEALTH

Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses

(2016) Julie T.-W. Wang et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle–liver interactions: Cellular uptake and hepatobiliary elimination

(2016) Yi-Nan Zhang et al.   JOURNAL OF CONTROLLED RELEASE

Hepcidin

(2016) Jing Liu et al.   MEDICINE

Ion-doping as a strategy to modulate hydroxyapatite nanoparticle internalization

(2016) Z. Zhao et al.   Nanoscale

Carbon nanotubes stimulate synovial inflammation by inducing systemic pro-inflammatory cytokines

(2016) Juan Ma et al.   Nanoscale

Inhibition of the formation of benzo[a]pyrene adducts to DNA in A549 lung cells exposed to mixtures of polycyclic aromatic hydrocarbons

(2016) Camille Genies et al.   TOXICOLOGY IN VITRO

Crucial Role of Lateral Size for Graphene Oxide in Activating Macrophages and Stimulating Pro-inflammatory Responses in Cells and Animals

(2015) Juan Ma et al.   ACS Nano

Cellular iron uptake, trafficking and metabolism: Key molecules and mechanisms and their roles in disease

(2015) D.J.R. Lane et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Ironing out Ferroportin

(2015) Hal Drakesmith et al.   Cell Metabolism

Hepatocytes: a key cell type for innate immunity

(2015) Zhou Zhou et al.   Cellular & Molecular Immunology

Subchronic Toxicity and Cardiovascular Responses in Spontaneously Hypertensive Rats after Exposure to Multiwalled Carbon Nanotubes by Intratracheal Instillation

(2015) Rui Chen et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Polychlorinated biphenyls and polybrominated biphenyl ethers in adipose tissue and matched serum from an E-waste recycling area (Wenling, China)

(2015) Quan-Xia Lv et al.   ENVIRONMENTAL POLLUTION

Carboxylation of multiwalled carbon nanotube attenuated the cytotoxicity by limiting the oxidative stress initiated cell membrane integrity damage, cell cycle arrestment, and death receptor mediated apoptotic pathway

(2015) Zhenbao Liu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Redox nanoparticles as a novel treatment approach for inflammation and fibrosis associated with nonalcoholic steatohepatitis

(2015) Akiko Eguchi et al.   Nanomedicine

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Time to Say Goodbye to the 16 EPA PAHs? Toward an Up-to-Date Use of PACs for Environmental Purposes

(2015) Jan T. Andersson et al.   POLYCYCLIC AROMATIC COMPOUNDS

The Occurrence of 16 EPA PAHs in Food – A Review

(2015) Zuzana Zelinkova et al.   POLYCYCLIC AROMATIC COMPOUNDS

Hepcidin and Host Defense against Infectious Diseases

(2015) Kathryn Michels et al.   PLoS Pathogens

Tuning Cell Autophagy by Diversifying Carbon Nanotube Surface Chemistry

(2014) Ling Wu et al.   ACS Nano

Nanosilver Incurs an Adaptive Shunt of Energy Metabolism Mode to Glycolysis in Tumor and Nontumor Cells

(2014) Yue Chen et al.   ACS Nano

Recent advances in surface functionalization techniques on polymethacrylate materials for optical biosensor applications

(2014) Samira Hosseini et al.   ANALYST

Bone Morphogenetic Proteins as Regulators of Iron Metabolism

(2014) Nermi L. Parrow et al.   Annual Review of Nutrition

Biology of ferritin in mammals: an update on iron storage, oxidative damage and neurodegeneration

(2014) Dario Finazzi et al.   ARCHIVES OF TOXICOLOGY

C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia

(2014) R. Kapur et al.   BLOOD

The regulation of hepcidin expression by serum treatment: Requirements of the BMP response element and STAT- and AP-1-binding sites

(2014) Yohei Kanamori et al.   GENE

Anemia of Inflammation

(2014) Elizabeta Nemeth et al.   HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA

Influence of polyethylene glycol coating on biodistribution and toxicity of nanoscale graphene oxide in mice after intravenous injection

(2014) Bo Li et al.   International Journal of Nanomedicine

Macrophage heterogeneity in liver injury and fibrosis

(2014) Frank Tacke et al.   JOURNAL OF HEPATOLOGY

The effects of carbon nanotubes on lung and dermal cellular behaviors

(2014) Sudjit Luanpitpong et al.   Nanomedicine

In vivo detection of magnetic labeled oxidized multi-walled carbon nanotubes by magnetic resonance imaging

(2014) Ruibin Li et al.   NANOTECHNOLOGY

Identification of erythroferrone as an erythroid regulator of iron metabolism

(2014) Léon Kautz et al.   NATURE GENETICS

Functionalization of Graphene Oxide Generates a Unique Interface for Selective Serum Protein Interactions

(2013) Xiaofang Tan et al.   ACS Applied Materials & Interfaces

Graphene Oxide Induces Toll-like Receptor 4 (TLR4)-Dependent Necrosis in Macrophages

(2013) Guangbo Qu et al.   ACS Nano

Surface Charge and Cellular Processing of Covalently Functionalized Multiwall Carbon Nanotubes Determine Pulmonary Toxicity

(2013) Ruibin Li et al.   ACS Nano

A mouse model of anemia of inflammation: complex pathogenesis with partial dependence on hepcidin

(2013) A. Kim et al.   BLOOD

The effect of nanoparticle properties, detection method, delivery route and animal model on poly(lactic-co-glycolic) acid nanoparticles biodistribution in mice and rats

(2013) Lacey C. Simon et al.   DRUG METABOLISM REVIEWS

Investigation of the role of interleukin-6 and hepcidin antimicrobial peptide in the development of anemia with age

(2013) B. J. McCranor et al.   HAEMATOLOGICA

Ferritin: The Protein Nanocage and Iron Biomineral in Health and in Disease

(2013) Elizabeth C. Theil   INORGANIC CHEMISTRY

Carboxylation of multiwalled carbon nanotube enhanced its biocompatibility with L02 cells through decreased activation of mitochondrial apoptotic pathway

(2013) Zhenbao Liu et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Iron regulation by hepcidin

(2013) Ningning Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Effect of multi-walled carbon nanotube surface modification on bioactivity in the C57BL/6 mouse model

(2013) Tina M. Sager et al.   Nanotoxicology

Macrophage biology in development, homeostasis and disease

(2013) Thomas A. Wynn et al.   NATURE

Macrophages support pathological erythropoiesis in polycythemia vera and β-thalassemia

(2013) Pedro Ramos et al.   NATURE MEDICINE

Rapid formation of plasma protein corona critically affects nanoparticle pathophysiology

(2013) Stefan Tenzer et al.   Nature Nanotechnology

Extrapulmonary transport of MWCNT following inhalation exposure

(2013) Robert R Mercer et al.   Particle and Fibre Toxicology

Systemic Iron Homeostasis

(2013) Tomas Ganz   PHYSIOLOGICAL REVIEWS

Iron Metabolism: Interactions with Normal and Disordered Erythropoiesis

(2013) T. Ganz et al.   Cold Spring Harbor Perspectives in Medicine

Occupational Nanosafety Considerations for Carbon Nanotubes and Carbon Nanofibers

(2012) Vincent Castranova et al.   ACCOUNTS OF CHEMICAL RESEARCH

Hepcidin and iron homeostasis

(2012) Tomas Ganz et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Drug development: longer-lived proteins

(2012) Stephan Kontos et al.   CHEMICAL SOCIETY REVIEWS

Leucocyte recruitment in inflammation and novel endogenous negative regulators thereof

(2012) Triantafyllos Chavakis   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

STAT proteins – Key regulators of anti-viral responses, inflammation, and tumorigenesis in the liver

(2012) Bin Gao et al.   JOURNAL OF HEPATOLOGY

Macrophages and Systemic Iron Homeostasis

(2012) Tomas Ganz   Journal of Innate Immunity

Development of risk-based nanomaterial groups for occupational exposure control

(2012) E. D. Kuempel et al.   JOURNAL OF NANOPARTICLE RESEARCH

Innate Immune Cells in Liver Inflammation

(2012) Evaggelia Liaskou et al.   MEDIATORS OF INFLAMMATION

Pluronic F108 Coating Decreases the Lung Fibrosis Potential of Multiwall Carbon Nanotubes by Reducing Lysosomal Injury

(2012) Xiang Wang et al.   NANO LETTERS

DNA helicase and helicase-nuclease enzymes with a conserved iron-sulfur cluster

(2012) Y. Wu et al.   NUCLEIC ACIDS RESEARCH

Comparison of non-crystalline silica nanoparticles in IL-1β release from macrophages

(2012) Wiggo J Sandberg et al.   Particle and Fibre Toxicology

Perspectives on Raman spectroscopy of graphene-based systems: from the perfect two-dimensional surface to charcoal

(2012) Ado Jorio et al.   PHYSICAL CHEMISTRY CHEMICAL PHYSICS

Hepcidin Expression in Iron Overload Diseases Is Variably Modulated by Circulating Factors

(2012) Giulia Ravasi et al.   PLoS One

Functionalized multiwalled carbon nanotubes as ultrasound contrast agents

(2012) L. G. Delogu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Steering Carbon Nanotubes to Scavenger Receptor Recognition by Nanotube Surface Chemistry Modification Partially Alleviates NFκB Activation and Reduces Its Immunotoxicity

(2011) Ningning Gao et al.   ACS Nano

Fabrication of a Au Nanoporous Film by Self-Organization of Networked Ultrathin Nanowires and Its Application as a Surface-Enhanced Raman Scattering Substrate for Single-Molecule Detection

(2011) Rui Liu et al.   ANALYTICAL CHEMISTRY

Hepcidin regulation by innate immune and infectious stimuli

(2011) A. E. Armitage et al.   BLOOD

IL-6/IL-6 receptor system and its role in physiological and pathological conditions

(2011) Masahiko Mihara et al.   CLINICAL SCIENCE

Carbon nanotubes provoke inflammation by inducing the pro-inflammatory genes IL-1β and IL-6

(2011) Chen Qu et al.   GENE

Iron sensing and signalling

(2011) Rayko Evstatiev et al.   GUT

Evidence for distinct pathways of hepcidin regulation by acute and chronic iron loading in mice

(2011) Emilio Ramos et al.   HEPATOLOGY

Environmental chemical exposures and human epigenetics

(2011) Lifang Hou et al.   INTERNATIONAL JOURNAL OF EPIDEMIOLOGY

The molecular basis of iron overload disorders and iron-linked anemias

(2011) Jerry Kaplan et al.   INTERNATIONAL JOURNAL OF HEMATOLOGY

Erythropoiesis, anemia and the bone marrow microenvironment

(2011) Carl R. Walkley   INTERNATIONAL JOURNAL OF HEMATOLOGY

A new era of cancer treatment: carbon nanotubes as drug delivery tools

(2011) Alexander Seifalian   International Journal of Nanomedicine

Exposure of pregnant mice to carbon black by intratracheal instillation: Toxicogenomic effects in dams and offspring

(2011) Petra Jackson et al.   MUTATION RESEARCH-GENETIC TOXICOLOGY AND ENVIRONMENTAL MUTAGENESIS

In vivobiodistribution of nanoparticles

(2011) Joao Paulo Mattos Almeida et al.   Nanomedicine

Pulmonary exposure to carbon black by inhalation or instillation in pregnant mice: Effects on liver DNA strand breaks in dams and offspring

(2011) Petra Jackson et al.   Nanotoxicology

Sample preparation method for isolation of single-cell types from mouse liver for proteomic studies

(2011) Wei Liu et al.   PROTEOMICS

Spleen: A new role for an old player?

(2011) Giovanni Tarantino   WORLD JOURNAL OF GASTROENTEROLOGY

Quantitative Techniques for Assessing and Controlling the Dispersion and Biological Effects of Multiwalled Carbon Nanotubes in Mammalian Tissue Culture Cells

(2010) Xiang Wang et al.   ACS Nano

P-Glycoprotein Antibody Functionalized Carbon Nanotube Overcomes the Multidrug Resistance of Human Leukemia Cells

(2010) Ruibin Li et al.   ACS Nano

Hepcidin and Disorders of Iron Metabolism

(2010) Tomas Ganz et al.   Annual Review of Medicine

Antihepcidin antibody treatment modulates iron metabolism and is effective in a mouse model of inflammation-induced anemia

(2010) B. J. Sasu et al.   BLOOD

Iron-Export Ferroxidase Activity of β-Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease

(2010) James A. Duce et al.   CELL

Neutrophils, from Marrow to Microbes

(2010) Niels Borregaard   IMMUNITY

Advancement in carbon nanotubes: basics, biomedical applications and toxicity

(2010) Sarwar Beg et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

A critical review of the biological mechanisms underlying thein vivoandin vitrotoxicity of carbon nanotubes: The contribution of physico-chemical characteristics

(2010) Helinor J. Johnston et al.   Nanotoxicology

Repeated administrations of carbon nanotubes in male mice cause reversible testis damage without affecting fertility

(2010) Yuhong Bai et al.   Nature Nanotechnology

Asbestos, carbon nanotubes and the pleural mesothelium: a review and the hypothesis regarding the role of long fibre retention in the parietal pleura, inflammation and mesothelioma

(2010) Ken Donaldson et al.   Particle and Fibre Toxicology

Nanoparticle interaction with plasma proteins as it relates to particle biodistribution, biocompatibility and therapeutic efficacy

(2009) Parag Aggarwal et al.   ADVANCED DRUG DELIVERY REVIEWS

Biodegradation aspects of Polycyclic Aromatic Hydrocarbons (PAHs): A review

(2009) A.K. Haritash et al.   JOURNAL OF HAZARDOUS MATERIALS

In Vivo Imaging of Carbon Nanotube Biodistribution Using Magnetic Resonance Imaging

(2009) Achraf Al Faraj et al.   NANO LETTERS

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Inhaled carbon nanotubes reach the subpleural tissue in mice

(2009) Jessica P. Ryman-Rasmussen et al.   Nature Nanotechnology

Mouse pulmonary dose- and time course-responses induced by exposure to multi-walled carbon nanotubes

(2009) Dale W. Porter et al.   TOXICOLOGY

Iron metabolism in the anemia of chronic disease

(2008) Günter Weiss   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Erythroblastic islands: niches for erythropoiesis

(2008) J. A. Chasis et al.   BLOOD

Haem-regulated eIF2α kinase is necessary for adaptive gene expression in erythroid precursors under the stress of iron deficiency

(2008) Sijin Liu et al.   BRITISH JOURNAL OF HAEMATOLOGY

Scalable Functional Group Engineering of Carbon Nanotubes by Improved One-Step Nitrene Chemistry

(2008) Chao Gao et al.   CHEMISTRY OF MATERIALS

Monitoring Multiwalled Carbon Nanotube Exposure in Carbon Nanotube Research Facility

(2008) Jeong Hee Han et al.   INHALATION TOXICOLOGY

Exploring the Immunotoxicity of Carbon Nanotubes

(2008) Yanmei Yu et al.   Nanoscale Research Letters

Carbon nanotubes introduced into the abdominal cavity of mice show asbestos-like pathogenicity in a pilot study

(2008) Craig A. Poland et al.   Nature Nanotechnology

Biodistribution and clearance of instilled carbon nanotubes in rat lung

(2008) Dan Elgrabli et al.   Particle and Fibre Toxicology