Hepcidin and Host Defense against Infectious Diseases

Hepatic Hepcidin Protects against Polymicrobial Sepsis in Mice by Regulating Host Iron Status

(2015) CongLi Zeng et al.   ANESTHESIOLOGY

Hepcidin-Induced Hypoferremia Is a Critical Host Defense Mechanism against the Siderophilic Bacterium Vibrio vulnificus

(2015) João Arezes et al.   Cell Host & Microbe

BMP type II receptors have redundant roles in the regulation of hepatic hepcidin gene expression and iron metabolism

(2014) C. Mayeur et al.   BLOOD

Targeted disruption of hepcidin in the liver recapitulates the hemochromatotic phenotype

(2014) S. Zumerle et al.   BLOOD

Dual stimulation with bacterial and viral components increases the expression of hepcidin in human monocytes

(2014) Delia A. Ripley et al.   FEMS MICROBIOLOGY LETTERS

Attenuated Inflammatory Responses in Hemochromatosis Reveal a Role for Iron in the Regulation of Macrophage Cytokine Translation

(2014) L. Wang et al.   JOURNAL OF IMMUNOLOGY

Inverse agonist of estrogen-related receptor γ controls Salmonella typhimurium infection by modulating host iron homeostasis

(2014) Don-Kyu Kim et al.   NATURE MEDICINE

Interleukin-10 Regulates Hepcidin in Plasmodium falciparum Malaria

(2014) Honglei Huang et al.   PLoS One

Distinct patterns of hepcidin and iron regulation during HIV-1, HBV, and HCV infections

(2014) A. E. Armitage et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Leishmania-Mediated Inhibition of Iron Export Promotes Parasite Replication in Macrophages

(2014) Rym Ben-Othman et al.   PLoS Pathogens

Iron, anemia and hepcidin in malaria

(2014) Natasha Spottiswoode et al.   Frontiers in Pharmacology

Hepcidin Induction by Pathogens and Pathogen-Derived Molecules Is Strongly Dependent on Interleukin-6

(2013) Richard Rodriguez et al.   INFECTION AND IMMUNITY

Suppression of Hepcidin Expression and Iron Overload Mediate Salmonella Susceptibility in Ankyrin 1 ENU-Induced Mutant

(2013) Kyoko E. Yuki et al.   PLoS One

A Strong Anti-Inflammatory Signature Revealed by Liver Transcription Profiling of Tmprss6−/− Mice

(2013) Michela Riba et al.   PLoS One

Fungal Iron Availability during Deep Seated Candidiasis Is Defined by a Complex Interplay Involving Systemic and Local Events

(2013) Joanna Potrykus et al.   PLoS Pathogens

Targeting Iron Acquisition Blocks Infection with the Fungal Pathogens Aspergillus fumigatus and Fusarium oxysporum

(2013) Sixto M. Leal et al.   PLoS Pathogens

Beyond anemia: hepcidin, monocytes and inflammation

(2012) Xiaolan Zhang et al.   BIOLOGICAL CHEMISTRY

Molecular Mechanism of Hepcidin-Mediated Ferroportin Internalization Requires Ferroportin Lysines, Not Tyrosines or JAK-STAT

(2012) Sandra L. Ross et al.   Cell Metabolism

Iron Deficiency Protects Against Severe Plasmodium falciparum Malaria and Death in Young Children

(2012) M. Gwamaka et al.   CLINICAL INFECTIOUS DISEASES

Hepcidin demonstrates a biphasic association with anemia in acute Plasmodium falciparum malaria

(2012) C. Casals-Pascual et al.   HAEMATOLOGICA

Bacterial Cell Wall Constituents Induce Hepcidin Expression in Macrophages Through MyD88 Signaling

(2012) Antonio Layoun et al.   INFLAMMATION

The hemochromatosis proteins HFE, TfR2, and HJV form a membrane-associated protein complex for hepcidin regulation

(2012) Flavia D’Alessio et al.   JOURNAL OF HEPATOLOGY

Hepcidin protects against lipopolysaccharide-induced liver injury in a mouse model of obstructive jaundice

(2012) Ying-Hsien Huang et al.   PEPTIDES

Hepcidin Regulation by BMP Signaling in Macrophages Is Lipopolysaccharide Dependent

(2012) Xinggang Wu et al.   PLoS One

Blunted hepcidin response to inflammation in the absence of Hfe and transferrin receptor 2

(2011) D. F. Wallace et al.   BLOOD

Low hepcidin accounts for the proinflammatory status associated with iron deficiency

(2011) A. Pagani et al.   BLOOD

Hepcidin regulation by innate immune and infectious stimuli

(2011) A. E. Armitage et al.   BLOOD

A critical role for phagocytosis in resistance to malaria in iron-deficient mice

(2011) Chikako Matsuzaki-Moriya et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Iron Levels in Hepatocytes and Portal Tract Cells Predict Progression and Outcomes of Patients With Advanced Chronic Hepatitis C

(2011) Richard W. Lambrecht et al.   GASTROENTEROLOGY

Hepcidin Is Regulated during Blood-Stage Malaria and Plays a Protective Role in Malaria Infection

(2011) H.-Z. Wang et al.   JOURNAL OF IMMUNOLOGY

Host-mediated regulation of superinfection in malaria

(2011) Silvia Portugal et al.   NATURE MEDICINE

Role of Ferroportin in Macrophage-Mediated Immunity

(2010) E. E. Johnson et al.   INFECTION AND IMMUNITY

Hepcidin mediates transcriptional changes that modulate acute cytokine-induced inflammatory responses in mice

(2010) Ivana De Domenico et al.   JOURNAL OF CLINICAL INVESTIGATION

Hepatitis C virus core protein compromises iron-induced activation of antioxidants in mice and HepG2 cells

(2010) Kyoji Moriya et al.   JOURNAL OF MEDICAL VIROLOGY

Antimicrobial activity of human hepcidin 20 and 25 against clinically relevant bacterial strains: Effect of copper and acidic pH

(2010) Giuseppantonio Maisetta et al.   PEPTIDES

The Battle for Iron between Bacterial Pathogens and Their Vertebrate Hosts

(2010) Eric P. Skaar   PLoS Pathogens

Absence of functional Hfe protects mice from invasive Salmonella enterica Serovar Typhimurium infection via induction of lipocalin-2

(2009) M. Nairz et al.   BLOOD

Plasmodium falciparuminfected erythrocytes induce hepcidin (HAMP) mRNA synthesis by peripheral blood mononuclear cells

(2009) Andrew E. Armitage et al.   BRITISH JOURNAL OF HAEMATOLOGY

Reduced serum hepcidin levels in patients with chronic hepatitis C

(2009) Domenico Girelli et al.   JOURNAL OF HEPATOLOGY

Bone morphogenetic protein (BMP)-responsive elements located in the proximal and distal hepcidin promoter are critical for its response to HJV/BMP/SMAD

(2009) Guillem Casanovas et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

BMP6 is a key endogenous regulator of hepcidin expression and iron metabolism

(2009) Billy Andriopoulos Jr et al.   NATURE GENETICS

Iron availability and infection

(2008) Eugene D. Weinberg   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Iron depletion limits intracellular bacterial growth in macrophages

(2008) P. N. Paradkar et al.   BLOOD

HLA haplotype map of river valley populations with hemochromatosis traced through five centuries in Central Sweden

(2008) K. Sigvard Olsson et al.   EUROPEAN JOURNAL OF HAEMATOLOGY

Hepatitis C virus-induced oxidative stress suppresses hepcidin expression through increased histone deacetylase activity

(2008) Kouichi Miura et al.   HEPATOLOGY

Increased Susceptibility to Mycobacterium avium in Hemochromatosis Protein HFE-Deficient Mice

(2008) S. Gomes-Pereira et al.   INFECTION AND IMMUNITY

Decreased Susceptibility toPlasmodium falciparumInfection in Pregnant Women with Iron Deficiency

(2008) Edward R. Kabyemela et al.   JOURNAL OF INFECTIOUS DISEASES

Assessment of Urinary Concentrations of Hepcidin Provides Novel Insight into Disturbances in Iron Homeostasis during Malarial Infection

(2008) Quirijn de Mast et al.   JOURNAL OF INFECTIOUS DISEASES

The iron export protein ferroportin 1 is differentially expressed in mouse macrophage populations and is present in the mycobacterial-containing phagosome

(2008) Kristopher E. Van Zandt et al.   JOURNAL OF LEUKOCYTE BIOLOGY

The Serine Protease TMPRSS6 Is Required to Sense Iron Deficiency

(2008) X. Du et al.   SCIENCE

Hepatitis C Virus–Induced Reactive Oxygen Species Raise Hepatic Iron Level in Mice by Reducing Hepcidin Transcription

(2007) Sohji Nishina et al.   GASTROENTEROLOGY