Immunometabolism, pregnancy, and nutrition

Body mass index and the risk of infection - from underweight to obesity

(2018) J. Dobner et al.   CLINICAL MICROBIOLOGY AND INFECTION

The bioenergetics of inflammation: insights into obesity and type 2 diabetes

(2017) K N Keane et al.   EUROPEAN JOURNAL OF CLINICAL NUTRITION

Medical conditions associated with recurrent miscarriage—Is BMI the tip of the iceberg?

(2017) Mushi J. Matjila et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

Resistin and NGAL are associated with inflammatory response, endothelial activation and clinical outcomes in sepsis

(2017) Stephen P. J. Macdonald et al.   INFLAMMATION RESEARCH

Downregulation of L-arginine metabolism in dendritic cells induces tolerance to exogenous antigen

(2017) Patricia U Simioni et al.   INTERNATIONAL JOURNAL OF IMMUNOPATHOLOGY AND PHARMACOLOGY

The role of decidual NK cells in pregnancies with impaired vascular remodelling

(2017) Judith E. Cartwright et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Vitamin D endocrinology on the cross-road between immunity and metabolism

(2017) An-Sofie Vanherwegen et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Macrophage function in obesity-induced inflammation and insulin resistance

(2017) Mario A. R. Lauterbach et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Uterine NK cells and macrophages in pregnancy

(2017) Marijke M. Faas et al.   PLACENTA

Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy

(2017) Jan Broder Engler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association between vitamin D status and the risk of gestational diabetes mellitus: a meta-analysis

(2016) Min Lu et al.   ARCHIVES OF GYNECOLOGY AND OBSTETRICS

Vitamin D: not just the bone. Evidence for beneficial pleiotropic extraskeletal effects

(2016) Massimiliano Caprio et al.   Eating and Weight Disorders-Studies on Anorexia Bulimia and Obesity

Systematic review and meta-analysis on the association of prepregnancy underweight and miscarriage

(2016) Montserrat Balsells et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

The Proteomic Landscape of Human Ex Vivo Regulatory and Conventional T Cells Reveals Specific Metabolic Requirements

(2016) Claudio Procaccini et al.   IMMUNITY

Metabolic reprogramming of alloantigen-activated T cells after hematopoietic cell transplantation

(2016) Hung D. Nguyen et al.   JOURNAL OF CLINICAL INVESTIGATION

Metformin ameliorates the development of experimental autoimmune encephalomyelitis by regulating T helper 17 and regulatory T cells in mice

(2016) Yafei Sun et al.   JOURNAL OF NEUROIMMUNOLOGY

Specific deletion of the progesterone receptor on CD11c dendritic cells reveals a progesterone-DC-crosstalk necessary to sustain fetal development

(2016) K. Thiele et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The importance of being a regulatory T cell in pregnancy

(2016) David A. Clark   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Autophagy enforces functional integrity of regulatory T cells by coupling environmental cues and metabolic homeostasis

(2016) Jun Wei et al.   NATURE IMMUNOLOGY

Immunometabolism of regulatory T cells

(2016) Ryan Newton et al.   NATURE IMMUNOLOGY

Arginase 1 is an innate lymphoid-cell-intrinsic metabolic checkpoint controlling type 2 inflammation

(2016) Laurel A Monticelli et al.   NATURE IMMUNOLOGY

Interleukin-33-induced expression of PIBF1 by decidual B cells protects against preterm labor

(2016) Bihui Huang et al.   NATURE MEDICINE

Fertile ground: human endometrial programming and lessons in health and disease

(2016) Jemma Evans et al.   Nature Reviews Endocrinology

Metabolic pathways in T cell activation and lineage differentiation

(2016) Luís Almeida et al.   SEMINARS IN IMMUNOLOGY

Influenza pathogenicity during pregnancy in women and animal models

(2016) Debby van Riel et al.   Seminars in Immunopathology

Maternal nutrition, inadequate gestational weight gain and birth weight: results from a prospective birth cohort

(2016) Anke Diemert et al.   BMC Pregnancy and Childbirth

Organ-Specific Gene Expression Changes in the Fetal Liver and Placenta in Response to Maternal Folate Depletion

(2016) Jill McKay et al.   Nutrients

Role of the Placental Vitamin D Receptor in Modulating Feto-Placental Growth in Fetal Growth Restriction and Preeclampsia-Affected Pregnancies

(2016) Padma Murthi et al.   Frontiers in Physiology

Maternal high-fat diet is associated with impaired fetal lung development

(2015) Reina S. Mayor et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Superfertility is more prevalent in obese women with recurrent early pregnancy miscarriage

(2015) HM Bhandari et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

CD5L/AIM Regulates Lipid Biosynthesis and Restrains Th17 Cell Pathogenicity

(2015) Chao Wang et al.   CELL

Pyruvate Kinase M2 Regulates Hif-1α Activity and IL-1β Induction and Is a Critical Determinant of the Warburg Effect in LPS-Activated Macrophages

(2015) Eva M. Palsson-McDermott et al.   Cell Metabolism

Immunomodulatory role of vitamin D in the pathogenesis of preeclampsia

(2015) Tyler A Smith et al.   Expert Review of Clinical Immunology

Essential role of mitochondrial energy metabolism in Foxp3+ T-regulatory cell function and allograft survival

(2015) Ulf H. Beier et al.   FASEB JOURNAL

Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy

(2015) Ru-Juan Zuo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Immunological role of vitamin D at the maternal-fetal interface

(2015) J. A. Tamblyn et al.   JOURNAL OF ENDOCRINOLOGY

Helios-positive functional regulatory T cells are decreased in decidua of miscarriage cases with normal fetal chromosomal content

(2015) Kumiko Inada et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

From leptin to other adipokines in health and disease: Facts and expectations at the beginning of the 21st century

(2015) Matthias Blüher et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Prostate cancer: 4 big questions

(2015) Richard Hodson   NATURE

Treg cells require the phosphatase PTEN to restrain TH1 and TFH cell responses

(2015) Sharad Shrestha et al.   NATURE IMMUNOLOGY

Immune mechanisms at the maternal-fetal interface: perspectives and challenges

(2015) Mercy PrabhuDas et al.   NATURE IMMUNOLOGY

Amino acid auxotrophy as a system of immunological control nodes

(2015) Peter J Murray   NATURE IMMUNOLOGY

Control of PI(3) kinase in Treg cells maintains homeostasis and lineage stability

(2015) Alexandria Huynh et al.   NATURE IMMUNOLOGY

Review: hCGs: Different sources of production, different glycoforms and functions

(2015) T. Fournier et al.   PLACENTA

Preventing Allograft Rejection by Targeting Immune Metabolism

(2015) Chen-Fang Lee et al.   Cell Reports

B Cell Development Undergoes Profound Modifications and Adaptations During Pregnancy in Mice1

(2014) Damián O. Muzzio et al.   BIOLOGY OF REPRODUCTION

Adipsin Is an Adipokine that Improves β Cell Function in Diabetes

(2014) James C. Lo et al.   CELL

Memory CD8+ T Cells Use Cell-Intrinsic Lipolysis to Support the Metabolic Programming Necessary for Development

(2014) David O’Sullivan et al.   IMMUNITY

Metabolic programming and PDHK1 control CD4+ T cell subsets and inflammation

(2014) Valerie A. Gerriets et al.   JOURNAL OF CLINICAL INVESTIGATION

Evidence for a Selective Migration of Fetus-Specific CD4+CD25bright Regulatory T Cells from the Peripheral Blood to the Decidua in Human Pregnancy

(2014) T. Tilburgs et al.   JOURNAL OF IMMUNOLOGY

mTORC1-Dependent Metabolic Reprogramming Is a Prerequisite for NK Cell Effector Function

(2014) Raymond P. Donnelly et al.   JOURNAL OF IMMUNOLOGY

Sex, Immunity and Influenza

(2014) G. Gabriel et al.   JOURNAL OF INFECTIOUS DISEASES

Crosstalk between Adipocytes and Immune Cells in Adipose Tissue Inflammation and Metabolic Dysregulation in Obesity

(2014) Jin Young Huh et al.   MOLECULES AND CELLS

Identification of diverse innate lymphoid cells in human decidua

(2014) P Vacca et al.   Mucosal Immunology

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

De novo fatty acid synthesis controls the fate between regulatory T and T helper 17 cells

(2014) Luciana Berod et al.   NATURE MEDICINE

Metabolism via Arginase or Nitric Oxide Synthase: Two Competing Arginine Pathways in Macrophages

(2014) Meera Rath et al.   Frontiers in Immunology

Metabolic Regulation of T Lymphocytes

(2013) Nancie J. MacIver et al.   Annual Review of Immunology

M1 and M2 Macrophages: Oracles of Health and Disease

(2013) Charles Mills   CRITICAL REVIEWS IN IMMUNOLOGY

Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis

(2013) Laura Piccio et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY

Elevated Fetal Adipsin/Acylation-Stimulating Protein (ASP) in Obese Pregnancy: Novel Placental Secretion via Hofbauer Cells

(2013) K. Sivakumar et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Insulin Inhibits IL-10-Mediated Regulatory T Cell Function: Implications for Obesity

(2013) J. M. Han et al.   JOURNAL OF IMMUNOLOGY

Human Chorionic Gonadotropin as a Central Regulator of Pregnancy Immune Tolerance

(2013) A. Schumacher et al.   JOURNAL OF IMMUNOLOGY

Resistin concentration and gestational diabetes: a systematic review of the literature

(2013) Thalita Frutuoso Lobo et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Regulation of the expression of Th17 cells and regulatory T cells by IL-27 in patients with unexplained early recurrent miscarriage

(2013) Wen-Juan Wang et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Arginine supplementation for improving maternal and neonatal outcomes in hypertensive disorder of pregnancy: A systematic review

(2013) Shunping Gui et al.   JOURNAL OF THE RENIN-ANGIOTENSIN-ALDOSTERONE SYSTEM

The immune privilege of testis and gravid uterus: Same difference?

(2013) Petra Arck et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

mTORC1 couples immune signals and metabolic programming to establish Treg-cell function

(2013) Hu Zeng et al.   NATURE

Regulatory T cells in nonlymphoid tissues

(2013) Dalia Burzyn et al.   NATURE IMMUNOLOGY

Rapid effector function of memory CD8+ T cells requires an immediate-early glycolytic switch

(2013) Patrick M Gubser et al.   NATURE IMMUNOLOGY

Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

(2013) Petra C Arck et al.   NATURE MEDICINE

Folic acid supplementation during pregnancy protects against lipopolysaccharide-induced neural tube defects in mice

(2013) Mei Zhao et al.   TOXICOLOGY LETTERS

Acceleration of the Glycolytic Flux by Steroid Receptor Coactivator-2 Is Essential for Endometrial Decidualization

(2013) Ramakrishna Kommagani et al.   PLoS Genetics

Leptin-Induced mTOR Activation Defines a Specific Molecular and Transcriptional Signature Controlling CD4+ Effector T Cell Responses

(2012) C. Procaccini et al.   JOURNAL OF IMMUNOLOGY

Dietary Folic Acid Promotes Survival of Foxp3+ Regulatory T Cells in the Colon

(2012) M. Kinoshita et al.   JOURNAL OF IMMUNOLOGY

Impaired insulin and leptin sensitivity in the offspring of moderate caloric-restricted dams during gestation is early programmed

(2012) Mariona Palou et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

(2012) Jared H. Rowe et al.   NATURE

Mechanisms of implantation: strategies for successful pregnancy

(2012) Jeeyeon Cha et al.   NATURE MEDICINE

Chemokine Gene Silencing in Decidual Stromal Cells Limits T Cell Access to the Maternal-Fetal Interface

(2012) P. Nancy et al.   SCIENCE

Layers of dendritic cell-mediated T cell tolerance, their regulation and the prevention of autoimmunity

(2012) Christian T. Mayer et al.   Frontiers in Immunology

Is the adipose tissue a key target of developmental programming of adult adiposity by maternal undernutrition?

(2012) Marie-Amélie Lukaszewski et al.   Adipocyte

Inflammation and pregnancy: the role of the immune system at the implantation site

(2011) Gil Mor et al.   Annals of the New York Academy of Sciences

The mitochondrial citrate carrier: a new player in inflammation

(2011) Vittoria Infantino et al.   BIOCHEMICAL JOURNAL

Lipid synthesis in macrophages during inflammation in vivo: Effect of agonists of peroxisome proliferator activated receptors α and γ and of retinoid X receptors

(2011) E. N. Posokhova et al.   BIOCHEMISTRY-MOSCOW

Quantitative Analysis of Glucose Transporter mRNAs in Endometrial Stromal Cells Reveals Critical Role of GLUT1 in Uterine Receptivity

(2011) Antonina I. Frolova et al.   ENDOCRINOLOGY

Adiponectin is a negative regulator of antigen-activated T cells

(2011) Sabrina Wilk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

The Transcription Factor Myc Controls Metabolic Reprogramming upon T Lymphocyte Activation

(2011) Ruoning Wang et al.   IMMUNITY

Mitochondrial Respiratory Capacity Is a Critical Regulator of CD8+ T Cell Memory Development

(2011) Gerritje J.W. van der Windt et al.   IMMUNITY

HIF1α–dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Tregcells

(2011) Lewis Z. Shi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Cutting Edge: Distinct Glycolytic and Lipid Oxidative Metabolic Programs Are Essential for Effector and Regulatory CD4+ T Cell Subsets

(2011) R. D. Michalek et al.   JOURNAL OF IMMUNOLOGY

Dehydroepiandrosterone Inhibits Glucose Flux Through the Pentose Phosphate Pathway in Human and Mouse Endometrial Stromal Cells, Preventing Decidualization and Implantation

(2011) Antonina I. Frolova et al.   MOLECULAR ENDOCRINOLOGY

B cells promote insulin resistance through modulation of T cells and production of pathogenic IgG antibodies

(2011) Daniel A Winer et al.   NATURE MEDICINE

Paternal MHC expression on mouse trophoblast affects uterine vascularization and fetal growth

(2011) Z. Madeja et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Adipokines: A treasure trove for the discovery of biomarkers for metabolic disorders

(2011) Stefan Lehr et al.   Proteomics Clinical Applications

Glucose transporters in the uterus: an analysis of tissue distribution and proposed physiological roles

(2011) Antonina I Frolova et al.   REPRODUCTION

Manipulating the Bioenergetics of Alloreactive T Cells Causes Their Selective Apoptosis and Arrests Graft-Versus-Host Disease

(2011) E. Gatza et al.   Science Translational Medicine

Intracellular metabolic pathways control immune tolerance

(2011) Claudio Procaccini et al.   TRENDS IN IMMUNOLOGY

Toll-like receptor-induced changes in glycolytic metabolism regulate dendritic cell activation

(2010) C. M. Krawczyk et al.   BLOOD

Asthma and Allergic Inflammation

(2010) Richard M. Locksley   CELL

An Oscillatory Switch in mTOR Kinase Activity Sets Regulatory T Cell Responsiveness

(2010) Claudio Procaccini et al.   IMMUNITY

Obesity Increases the Production of Proinflammatory Mediators from Adipose Tissue T Cells and Compromises TCR Repertoire Diversity: Implications for Systemic Inflammation and Insulin Resistance

(2010) H. Yang et al.   JOURNAL OF IMMUNOLOGY

Substrate Fate in Activated Macrophages: A Comparison between Innate, Classic, and Alternative Activation

(2010) J.-C. Rodriguez-Prados et al.   JOURNAL OF IMMUNOLOGY

Glutamine Uptake and Metabolism Are Coordinately Regulated by ERK/MAPK during T Lymphocyte Activation

(2010) E. L. Carr et al.   JOURNAL OF IMMUNOLOGY

Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice

(2010) Tomoko Shima et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Sexual dimorphism in the lasting effects of moderate caloric restriction during gestation on energy homeostasis in rats is related with fetal programming of insulin and leptin resistance

(2010) Mariona Palou et al.   Nutrition & Metabolism

Everolimus: A Proliferation Signal Inhibitor with Clinical Applications in Organ Transplantation, Oncology, and Cardiology

(2010) Steven Gabardi et al.   PHARMACOTHERAPY

REVIEW ARTICLE: Inflammation and Implantation

(2009) Nava Dekel et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Arginase: an emerging key player in the mammalian immune system

(2009) Markus Munder   BRITISH JOURNAL OF PHARMACOLOGY

High resistin and interleukin-6 levels are associated with gestational diabetes mellitus

(2009) Mariusz Kuzmicki et al.   GYNECOLOGICAL ENDOCRINOLOGY

The mTOR Kinase Differentially Regulates Effector and Regulatory T Cell Lineage Commitment

(2009) Greg M. Delgoffe et al.   IMMUNITY

Transcriptional Profiling with a Pathway-Oriented Analysis Identifies Dysregulated Molecular Phenotypes in the Endometrium of Patients with Polycystic Ovary Syndrome

(2009) Jin Yeong Kim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Cross-Presentation of Male Seminal Fluid Antigens Elicits T Cell Activation to Initiate the Female Immune Response to Pregnancy

(2009) L. M. Moldenhauer et al.   JOURNAL OF IMMUNOLOGY

Human Chorionic Gonadotropin Attracts Regulatory T Cells into the Fetal-Maternal Interface during Early Human Pregnancy

(2009) A. Schumacher et al.   JOURNAL OF IMMUNOLOGY

Inhibition of Phenotypic and Functional Maturation of Dendritic Cells by Manassantin A

(2009) Jee Youn Kim et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

Fetal–maternal HLA-C mismatch is associated with decidual T cell activation and induction of functional T regulatory cells

(2009) Tamara Tilburgs et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Activating T regulatory cells for tolerance in early pregnancy — the contribution of seminal fluid

(2009) Sarah A. Robertson et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Lean, but not obese, fat is enriched for a unique population of regulatory T cells that affect metabolic parameters

(2009) Markus Feuerer et al.   NATURE MEDICINE

CD8+ effector T cells contribute to macrophage recruitment and adipose tissue inflammation in obesity

(2009) Satoshi Nishimura et al.   NATURE MEDICINE

Infectious tolerance via the consumption of essential amino acids and mTOR signaling

(2009) S. P. Cobbold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Arginine metabolism and nutrition in growth, health and disease

(2008) Guoyao Wu et al.   AMINO ACIDS

Folic acid supplements in pregnancy and early childhood respiratory health

(2008) S E Haberg et al.   ARCHIVES OF DISEASE IN CHILDHOOD

Interferon-γ, a Th1 Cytokine, Regulates Fat Inflammation

(2008) Viviane Zorzanelli Rocha et al.   CIRCULATION RESEARCH

Up-Regulation of Placental Leptin by Human Chorionic Gonadotropin

(2008) Julieta L. Maymó et al.   ENDOCRINOLOGY

Human leucocyte antigen (HLA) expression of primary trophoblast cells and placental cell lines, determined using single antigen beads to characterize allotype specificities of anti-HLA antibodies

(2008) Richard Apps et al.   IMMUNOLOGY

In vivo dendritic cell depletion reduces breeding efficiency, affecting implantation and early placental development in mice

(2008) Gesa Krey et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Hypovitaminosis D in obese children and adolescents: relationship with adiposity, insulin sensitivity, ethnicity, and season

(2008) Ramin Alemzadeh et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Effects of oral l-arginine on the pulsatility indices of umbilical artery and middle cerebral artery in preterm labor

(2007) Krzysztof Rytlewski et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology