Article
Medicine, General & Internal
Ksawery Golawski, Wojciech Giermaziak, Michal Ciebiera, Cezary Wojtyla
Summary: Adequate weight gain during pregnancy is important for a healthy pregnancy, but excessive weight gain is associated with adverse pregnancy outcomes. Based on a Polish national survey of 10,319 women and 6930 children, excessive gestational weight gain is associated with higher birthweight, increased risk of birthweight over 4500 g, cesarean section/assisted delivery, pregnancy induced hypertension, hospitalization during pregnancy, and lower Apgar score in the first minute of neonate's life. However, there was no significant difference in premature rupture of membranes and labor inductions. Our study highlights the increased risk of adverse pregnancy outcomes with excessive gestational weight gain.
JOURNAL OF CLINICAL MEDICINE
(2023)
Article
Medicine, General & Internal
Xiuling Zhao, Shi Wu Wen, Wei Ma, Pili Xu, Chunmei Zhang, Shan Jiang, Laura M. M. Gaudet, Jie Gao
Summary: This study explores the feasibility and usability of using resting energy expenditure (REE) to guide gestational weight gain (GWG) management in obese and overweight women. The findings suggest that using REE can significantly reduce daily total energy intake, overall GWG, and the percentage of excess-GWG.
Article
Biochemistry & Molecular Biology
Jin Dai, Nansi S. Boghossian, Mark A. Sarzynski, Feng Luo, Xiaoqian Sun, Jian Li, Oliver Fiehn, Jihong Liu, Liwei Chen
Summary: In this metabolome-wide association study, metabolomic markers associated with excessive gestational weight gain (GWG) were identified. Novel metabolites in the first and third trimesters were found to be associated with GWG, shedding light on the pathophysiology of GWG.
Article
Nutrition & Dietetics
Otilia Perichart-Perera, Jennifer Mier-Cabrera, Claudia Montserrat Flores-Robles, Nayeli Martinez-Cruz, Lidia Arce-Sanchez, Itzel Nallely Alvarado-Maldonado, Araceli Montoya-Estrada, Jose Romo-Yanez, Ameyalli Mariana Rodriguez-Cano, Guadalupe Estrada-Gutierrez, Salvador Sosa, Mario Guzman-Huerta, Rodrigo Ayala-Yanez, Enrique Reyes-Munoz
Summary: The addition of metformin to intensive medical nutrition therapy does not provide any benefit in preventing gestational diabetes mellitus among high-risk Mexican women.
Article
Obstetrics & Gynecology
Julia Schubert, Nina Timmesfeld, Kathrin Noever, Susann Behnam, Angela Vinturache, Birgit Arabin
Summary: This study aimed to contribute evidence to the appropriate gestational weight gain in twin pregnancies and found that nonoptimal maternal weight gain is strongly associated with adverse maternal and neonatal outcomes.
ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA
(2023)
Article
Nutrition & Dietetics
Nicola Heslehurst, Angela C. Flynn, Lem Ngongalah, Catherine McParlin, Kathryn V. Dalrymple, Kate E. Best, Judith Rankin, Elaine McColl
Summary: This study found that pregnant women living with obesity in high deprivation areas had suboptimal dietary intake and predominantly light intensity physical activity. Most women gained weight outside of guideline recommendations, with those in class 3 obesity most likely to have inadequate weight gain. Support is needed for this population to achieve guideline recommendations.
Article
Nutrition & Dietetics
Xue Liu, Huan Wang, Liu Yang, Min Zhao, Costan G. Magnussen, Bo Xi
Summary: The associations between gestational weight gain (GWG) and adverse birth outcomes are inconclusive. This study examined the associations between maternal GWG and six adverse birth outcomes in a large population. The results showed that pregnant women with GWG below or above guidelines had increased odds of adverse birth outcomes.
FRONTIERS IN NUTRITION
(2022)
Review
Nutrition & Dietetics
Shan Wu, Jiani Jin, Kai-Lun Hu, Yiqing Wu, Dan Zhang
Summary: This study aimed to evaluate the optimal intervention strategy to prevent gestational diabetes mellitus (GDM) and restrict gestational weight gain (GWG) among overweight/obese pregnant women. The results showed that PA and diet + PA interventions had a trend of preventing GDM, and interventions of diet, PA, and diet + PA were significant factors to restrict GWG. Overall, a combination of diet and physical activity intervention seemed to be the superior choice for both GDM prevention and excessive GWG.
Article
Obstetrics & Gynecology
Xiao-guang Yin, Peng Wang, Mei-ting Zhou, De-qin Li, Rui-xue Tao, Fang-biao Tao, Yang Wang, Peng Zhu
Summary: The timing of gestational diabetes mellitus (GDM) diagnosis and gestational weight gains (GWG) during pregnancy are associated with the growth trajectory of children from perinatal to early childhood. GDM diagnosed before 26 weeks increases the risk of fetal overgrowth and higher birth weight, as well as higher BMI peak within 48 months. Maternal early GDM diagnosis and excessive gestational weight gains have additive impacts on offspring overgrowth, with higher levels of hsCRP observed in the early EGWG group.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Obstetrics & Gynecology
Jiang-Feng Ke, Sheng Liu, Ri-Le Ge, Li Ma, Mei-Fang Li
Summary: In women with gestational diabetes mellitus (GDM), maternal pre-pregnancy body mass index (ppBMI) and gestational weight gain (GWG) are associated with adverse pregnancy outcomes (APOs). The study found that obese mothers and excessive GWG increase the risk of APOs, while inadequate GWG increases the risk of preterm birth.
BMC PREGNANCY AND CHILDBIRTH
(2023)
Article
Nutrition & Dietetics
Reyna Samano, Hugo Martinez-Rojano, Luis Ortiz-Hernandez, Oralia Najera-Medina, Gabriela Chico-Barba, Estela Godinez-Martinez, Ricardo Gamboa, Estefania Aguirre-Minutti
Summary: The study found that pregnant adolescents have inadequate diet and eating habits, with insufficient legumes intake, excessive cereal intake associated with GWG, and inadequate sugar-sweetened beverages intake and watching TV during meals linked to offspring's lower birth weight.
Article
Endocrinology & Metabolism
Li-hua Lin, Juan Lin, Jian-ying Yan
Summary: In women with gestational diabetes mellitus, pre-pregnancy overweight or obesity, excessive gestational weight gain, and abnormal items of oral glucose tolerance test parameters independently contribute to adverse pregnancy outcomes, and the combined effect between these three factors appears to be multiplicative.
FRONTIERS IN ENDOCRINOLOGY
(2022)
Article
Nutrition & Dietetics
Ella Muhli, Ella Koivuniemi, Kirsi Laitinen
Summary: This study examined the dietary quality and physical activity levels of 1034 pregnant women in different regions of Finland. The results showed that 53% of the women had poor dietary quality and 45% had low levels of physical activity. However, these lifestyle habits were not significantly impacted by a history of gestational diabetes (GDM), but rather by overweight status.
Article
Public, Environmental & Occupational Health
Sanna Mustaniemi, Hilkka Nikkinen, Aini Bloigu, Anneli Pouta, Risto Kaaja, Johan G. Eriksson, Hannele Laivuori, Mika Gissler, Eero Kajantie, Marja Vaarasmaki
Summary: The study showed that normal gestational weight gain is associated with a lower risk of large-for-gestational-age infants and lower birth weight standard deviation scores in the presence of gestational diabetes and maternal obesity.
FRONTIERS IN PUBLIC HEALTH
(2021)
Article
Nutrition & Dietetics
Martina Barchitta, Roberta Magnano San Lio, Maria Clara La Rosa, Claudia La Mastra, Giuliana Favara, Giuliana Ferrante, Fabiola Galvani, Elisa Pappalardo, Carla Ettore, Giuseppe Ettore, Antonella Agodi, Andrea Maugeri
Summary: Limited evidence exists on the effects of maternal dietary patterns on birth weight, and most studies conducted so far did not adjust their findings for gestational age and sex, leading to potentially biased conclusions. In this study, a novel method was applied to derive dietary patterns among pregnant women and evaluate the associations with birth weight for gestational age. The findings suggest that adherence to an unhealthy dietary pattern is associated with an increased likelihood of having a large for gestational age newborn.
Article
Immunology
Marie Albrecht, Mirja Pagenkemper, Christian Wiessner, Michael Spohn, Marc Luetgehetmann, Henning Jacobsen, Gulsah Gabriel, Dimitra E. Zazara, Christoph Haertel, Kurt Hecher, Anke Diemert, Petra Clara Arck
Summary: Neonatal passive immunity, derived from the transplacental transfer of IgG antibodies from mother to fetus during pregnancy, can reduce the risk of severe infections in the early postnatal period. Factors such as placental function and IgG levels in mothers play a crucial role in this process. Higher levels of anti-influenza A IgG in cord blood are associated with a reduced risk of respiratory tract infections in infants. Vaccination of pregnant women against influenza can increase neonatal antibody levels and protect against early life respiratory infections.
Article
Microbiology
Anna Both, Jiabin Huang, Minyue Qi, Christian Lausmann, Samira Weisselberg, Henning Buttner, Susanne Lezius, Antonio Virgilio Failla, Martin Christner, Marc Stegger, Thorsten Gehrke, Sharmin Baig, Mustafa Citak, Malik Alawi, Martin Aepfelbacher, Holger Rohde
Summary: S. epidermidis demonstrates multifactorial processes of infection adaptation, including intra-clonal heterogeneity, mutations and deletions in specific genes, and enhanced biofilm formation. This adaptive process allows invasive S. epidermidis to survive in hostile environments and progress to chronic implant-associated infections.
Article
Clinical Neurology
Louisa Niemann, Susanne Lezius, Aleksandra Maceski, David Leppert, Catrin Englisch, Edzard Schwedhelm, Tanja Zeller, Christian Gerloff, Jens Kuhle, Chi-un Choe
Summary: In advanced PD patients, serum NfL concentrations are associated with motor function, cognitive decline, and subclinical cardiac damage.
PARKINSONISM & RELATED DISORDERS
(2021)
Article
Pharmacology & Pharmacy
Claudia Langebrake, Carina Hohmann, Susanne Lezius, Michael Lueb, Gesine Picksak, Wencke Walter, Sandra Kaden, Heike Hilgarth, Angela Ihbe-Heffinger, Katja Leichenberg
Summary: Clinical pharmacy services in Germany are not yet widely available, but the intervention rate of pharmacists is increasing. Pharmacists are increasingly involved in proactive and early management of drug-related problems.
INTERNATIONAL JOURNAL OF CLINICAL PHARMACY
(2022)
Letter
Clinical Neurology
Carsten Buhmann, Susanne Lezius, Monika Poetter-Nerger, Christian Gerloff, Jens Kuhle, Chi-un Choe
MOVEMENT DISORDERS
(2022)
Review
Immunology
Dennis Yuezen, Petra Clara Arck, Kristin Thiele
Summary: The understanding of immune system organization has been challenged recently, as it was found that immune cells can reside in tissues instead of circulating. However, research on tissue-resident immunity in the female reproductive tract is lacking. This review focuses on the characteristics and functional roles of tissue-resident immune cells in the vagina, endometrium, decidua, and highlights their importance in reproductive health.
SEMINARS IN IMMUNOPATHOLOGY
(2022)
Article
Psychiatry
Susanne Mudra, Ariane Goebel, Eva Moehler, Lydia Yao Stuhrmann, Michael Schulte-Markwort, Petra Arck, Kurt Hecher, Anke Diemert
Summary: The study found that both infant and maternal factors are predictive of the development of behavioral inhibition in toddlerhood. Maternal pregnancy-related anxiety was associated with more overprotective parenting and infants with more distress to novelty, which in turn were related to greater behavioral inhibition. The stability of infant distress to novelty was also found to be a predictor of later behavioral inhibition.
FRONTIERS IN PSYCHIATRY
(2022)
Article
Immunology
Flaminia Olearo, Laura-Sophie Radmanesh, Nadine Felber, Ronald von Possel, Petra Emmerich, Neele Pekarek, Susanne Pfefferle, Dominik Noerz, Gudula Hansen, Anke Diemert, Martin Aepfelbacher, Kurt Hecher, Marc Luetgehetmann, Petra Clara Arck, Ann-Christin Tallarek
Summary: This study found a moderate positive correlation between antibody levels in maternal serum and breast milk, with significantly higher anti-RBD IgA/M/G transfer in breast milk of COVID-19 recovered women who were vaccinated during lactation. Breast milk antibodies had neutralization capacities against early pandemic and Omicron variants of SARS-CoV-2.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Multidisciplinary Sciences
Steven Schepanski, Mattia Chini, Veronika Sternemann, Christopher Urbschat, Kristin Thiele, Ting Sun, Yu Zhao, Mareike Poburski, Anna Woestemeier, Marie-Theres Thieme, Dimitra E. Zazara, Malik Alawi, Nicole Fischer, Joerg Heeren, Nikita Vladimirov, Andrew Woehler, Victor G. Puelles, Stefan Bonn, Nicola Gagliani, Ileana L. Hanganu-Opatz, Petra C. Arck
Summary: This study demonstrates the important role of maternal cells in fetal brain development. Maternal microchimeric cells (MMc) express specific markers, control microglia homeostasis, prevent excessive synaptic elimination, and support the maturation of behavioral abilities.
NATURE COMMUNICATIONS
(2022)
Article
Immunology
Anne Wisgalla, Caren Ramien, Mathias Streitz, Stephan Schlickeiser, Andreea-Roxana Lupu, Anke Diemert, Eva Tolosa, Petra C. Arck, Judith Bellmann-Strobl, Nadja Siebert, Christoph Heesen, Friedemann Paul, Manuel A. Friese, Carmen Infante-Duarte, Stefan M. Gold
Summary: During pregnancy, there are significant shifts in NK cell populations, with an increase in CD56(bright) NK cells and a decrease in CD56(dim) NK cells. These changes occur in both pregnant women with multiple sclerosis and healthy pregnant women, potentially contributing to disease amelioration in multiple sclerosis during pregnancy.
FRONTIERS IN IMMUNOLOGY
(2022)
Article
Immunology
Gabor A. Dunay, Madalena Barroso, Mathias Woidy, Marta K. Danecka, Geraldine Engels, Katharina Hermann, Friederike S. Neumann, Kevin Paul, Jan Beime, Gabriele Escherich, Kristin Fehse, Lev Grinstein, Franziska Haniel, Luka J. Haupt, Laura Hecher, Torben Kehl, Christoph Kemen, Markus J. Kemper, Robin Kobbe, Aloisa Kohl, Thomas Klokow, Dominik Noerz, Jakob Olfe, Friderike Schlenker, Jessica Schmiesing, Johanna Schrum, Freya Sibbertsen, Philippe Stock, Stephan Tiede, Eik Vettorazzi, Dimitra E. Zazara, Antonia Zapf, Marc Luetgehetmann, Jun Oh, Thomas S. Mir, Ania C. Muntau, Soren W. Gersting
Summary: This study investigates the long-term immune response of children to SARS-CoV-2. They found that children have higher antibody levels and lower seroprevalence in families with pediatric index cases in a low-incidence setting. Children show sustained antibody responses to SARS-CoV-2.
JOURNAL OF CLINICAL IMMUNOLOGY
(2023)
Article
Oncology
Anastasios D. Giannou, Joran Luecke, Dorte Kleinschmidt, Ahmad Mustafa Shiri, Babett Steglich, Mikolaj Nawrocki, Tao Zhang, Dimitra E. Zazara, Jan Kempski, Lilan Zhao, Olympia Giannou, Theodora Agalioti, Leonie Brockmann, Franziska Bertram, Morsal Sabihi, Marius Boettcher, Florian Ewald, Kornelius Schulze, Johann von Felden, Andres Machicote, Ioannis C. Maroulis, Petra C. Arck, Julia-Kristin Grass, Baris Mercanoglu, Matthias Reeh, Stefan Wolter, Michael Tachezy, Hannes Seese, Myrto Theodorakopoulou, Panagis M. Lykoudis, Asmus Heumann, Faik G. Uzunoglu, Tarik Ghadban, Oliver Mann, Jakob R. Izbicki, Jun Li, Anna Dupree, Nathaniel Melling, Nicola Gagliani, Samuel Huber
Summary: The study aimed to investigate the role and mechanisms of IL-22 and IL-22BP signaling in liver cancer. The results showed that IL-22 promoted HCC development, while IL-22BP reduced tumor growth. IL-22 was mainly produced by a subset of T cells in HCC, while IL-22BP was abundantly secreted by neutrophils. Hepatocytes were identified as a major target of this pathological IL-22 signaling.
Article
Medicine, General & Internal
Dennis Yuezen, Isabel Graf, Ann-Christin Tallarek, Bettina Hollwitz, Christian Wiessner, Ekkehard Schleussner, Detlef Stammer, Amy Padula, Kurt Hecher, Petra Clara Arck, Anke Diemert
Summary: Climate change, especially exposure to heat, has a negative impact on human health and can lead to diseases. This study conducted in Hamburg, Germany, reveals that extreme heat and prolonged heat exposure increase the risk of preterm birth in a temperate climate region. The critical period of heat exposure was found to be between gestational ages 34-37 weeks, and pregnancies with female fetuses were more susceptible to heat stress-induced preterm birth. These findings emphasize the importance of monitoring and providing appropriate care for pregnant women at risk in temperate climate regions.
Article
Biochemistry & Molecular Biology
Dennis Yuezen, Christopher Urbschat, Steven Schepanski, Kristin Thiele, Petra C. Arck, Hans-Willi Mittruecker
Summary: Neonatal health is influenced by maternal antibodies and cells that are transferred to the fetus. Maternal microchimeric cells (MMc) can persist in the offspring and promote neonatal immunity against infections. These cells can transfer immune memory between generations and have the potential to clear pathogen threats in the offspring.
Editorial Material
Immunology
Kristin Thiele, Petra Clara Arck
Summary: Pregnancy is a complex process of dynamic adaptations that occur at specific sites of the maternal body and unfold over a period of time. Spatially-resolved transcriptomic analyses now allow for a comprehensive decoding of these dynamic adaptations during the early stages of mammalian pregnancies and fetal development.
TRENDS IN IMMUNOLOGY
(2023)