Intracerebral transplantation of interleukin 13-producing mesenchymal stem cells limits microgliosis, oligodendrocyte loss and demyelination in the cuprizone mouse model

Immune remodelling of stromal cell grafts in the central nervous system: therapeutic inflammation or (harmless) side-effect?

(2016) Debbie Le Blon et al.   Journal of Tissue Engineering and Regenerative Medicine

Diffusion kurtosis imaging probes cortical alterations and white matter pathology following cuprizone induced demyelination and spontaneous remyelination

(2016) C. Guglielmetti et al.   NEUROIMAGE

In Vivo Interleukin-13-Primed Macrophages Contribute to Reduced Alloantigen-Specific T Cell Activation and Prolong Immunological Survival of Allogeneic Mesenchymal Stem Cell Implants

(2016) Chloé J. Hoornaert et al.   STEM CELLS

Mesenchymal stem cells do not exert direct beneficial effects on CNS remyelination in the absence of the peripheral immune system

(2015) Laura Salinas Tejedor et al.   BRAIN BEHAVIOR AND IMMUNITY

Distinct In Vitro Properties of Embryonic and Extraembryonic Fibroblast-Like Cells are Reflected in their in Vivo Behavior following Grafting in the Adult Mouse Brain

(2015) Roberta Costa et al.   CELL TRANSPLANTATION

Early Inflammatory Responses following Cell Grafting in the CNS Trigger Activation of the Subventricular Zone: A Proposed Model of Sequential Cellular Events

(2015) Jelle Praet et al.   CELL TRANSPLANTATION

Inefficient clearance of myelin debris by microglia impairs remyelinating processes

(2015) Antoine Lampron et al.   JOURNAL OF EXPERIMENTAL MEDICINE

CCR2 Antagonism Alters Brain Macrophage Polarization and Ameliorates Cognitive Dysfunction Induced by Traumatic Brain Injury

(2015) J. M. Morganti et al.   JOURNAL OF NEUROSCIENCE

Longitudinal monitoring of metabolic alterations in cuprizone mouse model of multiple sclerosis using 1H-magnetic resonance spectroscopy

(2015) Jasmien Orije et al.   NEUROIMAGE

Cuprizone-induced demyelination and demyelination-associated inflammation result in different proton magnetic resonance metabolite spectra

(2015) Jelle Praet et al.   NMR IN BIOMEDICINE

Macrophage Activation and Polarization: Nomenclature and Experimental Guidelines

(2014) Peter J. Murray et al.   IMMUNITY

Distinct spatial distribution of microglia and macrophages following mesenchymal stem cell implantation in mouse brain

(2014) Debbie Le Blon et al.   IMMUNOLOGY AND CELL BIOLOGY

Differential roles of microglia and monocytes in the inflamed central nervous system

(2014) Ryo Yamasaki et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Function of microglia and macrophages in secondary damage after spinal cord injury

(2014) Yi Ren et al.   Neural Regeneration Research

Cellular and molecular neuropathology of the cuprizone mouse model: Clinical relevance for multiple sclerosis

(2014) Jelle Praet et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Interleukin-4- and Interleukin-13-Mediated Alternatively Activated Macrophages: Roles in Homeostasis and Disease

(2013) Steven J. Van Dyken et al.   Annual Review of Immunology

Gene therapy and DNA delivery systems

(2013) D. Ibraheem et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

M2 microglia and macrophages drive oligodendrocyte differentiation during CNS remyelination

(2013) Veronique E Miron et al.   NATURE NEUROSCIENCE

Multimodal imaging of subventricular zone neural stem/progenitor cells in the cuprizone mouse model reveals increased neurogenic potential for the olfactory bulb pathway, but no contribution to remyelination of the corpus callosum

(2013) Caroline Guglielmetti et al.   NEUROIMAGE

Quantitative MRI and ultrastructural examination of the cuprizone mouse model of demyelination

(2013) Jonathan D. Thiessen et al.   NMR IN BIOMEDICINE

Effects of Murine and Human Bone Marrow-Derived Mesenchymal Stem Cells on Cuprizone Induced Demyelination

(2013) Jasmin Nessler et al.   PLoS One

Tackling the physiological barriers for successful mesenchymal stem cell transplantation into the central nervous system

(2013) Nathalie De Vocht et al.   Stem Cell Research & Therapy

Astrocytes regulate myelin clearance through recruitment of microglia during cuprizone-induced demyelination

(2012) Thomas Skripuletz et al.   BRAIN

Cell Type-Associated Differences in Migration, Survival, and Immunogenicity following Grafting in CNS Tissue

(2012) Jelle Praet et al.   CELL TRANSPLANTATION

Quantitative and phenotypic analysis of mesenchymal stromal cell graft survival and recognition by microglia and astrocytes in mouse brain

(2012) Nathalie De Vocht et al.   IMMUNOBIOLOGY

Harnessing monocyte-derived macrophages to control central nervous system pathologies: no longer ‘if’ but ‘how’

(2012) Ravid Shechter et al.   JOURNAL OF PATHOLOGY

Spatiotemporal evolution of early innate immune responses triggered by neural stem cell grafting

(2012) Kristien Reekmans et al.   Stem Cell Research & Therapy

Recognition of cellular implants by the brain's innate immune system

(2010) Irene Bergwerf et al.   IMMUNOLOGY AND CELL BIOLOGY

Reporter gene-expressing bone marrow-derived stromal cells are immune-tolerated following implantation in the central nervous system of syngeneic immunocompetent mice

(2009) Irene Bergwerf et al.   BMC BIOTECHNOLOGY

Allogeneic stromal cell implantation in brain tissue leads to robust microglial activation

(2009) Bart R Tambuyzer et al.   IMMUNOLOGY AND CELL BIOLOGY