Danger- and pathogen-associated molecular patterns recognition by pattern-recognition receptors and ion channels of the transient receptor potential family triggers the inflammasome activation in immune cells and sensory neurons

The pharmacology of TRP channels

(2014) Peter Holzer et al.   BRITISH JOURNAL OF PHARMACOLOGY

Calcitonin Gene-Related Peptide Biases Langerhans Cells toward Th2-Type Immunity

(2014) W. Ding et al.   JOURNAL OF IMMUNOLOGY

Inflammasomes in the CNS

(2014) John G. Walsh et al.   NATURE REVIEWS NEUROSCIENCE

Extracellular MicroRNAs Activate Nociceptor Neurons to Elicit Pain via TLR7 and TRPA1

(2014) Chul-Kyu Park et al.   NEURON

Effects of TRPC6 on invasibility of low-differentiated prostate cancer cells

(2014) Dong Wang et al.   Asian Pacific Journal of Tropical Medicine

TLR4 enhances histamine-mediated pruritus by potentiating TRPV1 activity

(2014) Hyunjung Min et al.   Molecular Brain

Transient Receptor Potential Ankyrin 1 Receptor Stimulation by Hydrogen Peroxide Is Critical to Trigger Pain During Monosodium Urate-Induced Inflammation in Rodents

(2013) Gabriela Trevisan et al.   ARTHRITIS AND RHEUMATISM

TRP Channels: New Potential Therapeutic Approaches in CNS Neuropathies

(2013) Maria Beatrice Morelli et al.   CNS & Neurological Disorders-Drug Targets

Targeting TRPs in Neurodegenerative Disorders

(2013) Yoshinori Takada et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Human astrocytes express a novel NLRP2 inflammasome

(2013) Julia Minkiewicz et al.   GLIA

Activation of NLRP3 and AIM2 Inflammasomes by Porphyromonas gingivalis Infection

(2013) Eunjoo Park et al.   INFECTION AND IMMUNITY

A sensory neuron–expressed IL-31 receptor mediates T helper cell–dependent itch: Involvement of TRPV1 and TRPA1

(2013) Ferda Cevikbas et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Extracellular Acidosis Is a Novel Danger Signal Alerting Innate Immunity via the NLRP3 Inflammasome

(2013) Kristiina Rajamäki et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient Receptor Potential Canonical Type 3 Channels—Their Evolving Role in Hypertension and Its Related Complications

(2013) Peijian Wang et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Gene Deletion of Gabarap Enhances Nlrp3 Inflammasome-Dependent Inflammatory Responses

(2013) Z. Zhang et al.   JOURNAL OF IMMUNOLOGY

PW02-035 - A role for thermo-TRP channels in innate immunity?

(2013) M Stoffels et al.   Pediatric Rheumatology

Participation of the TRPV1 receptor in the development of acute gout attacks

(2013) C. Hoffmeister et al.   RHEUMATOLOGY

Spreading Depression Triggers Headache by Activating Neuronal Panx1 Channels

(2013) H. Karatas et al.   SCIENCE

Rhinovirus upregulates transient receptor potential channels in a human neuronal cell line: implications for respiratory virus-induced cough reflex sensitivity

(2013) H Abdullah et al.   THORAX

TRPM2 links oxidative stress to NLRP3 inflammasome activation

(2013) Zhenyu Zhong et al.   Nature Communications

Ionotropic receptors and ion channels in ischemic neuronal death and dysfunction

(2012) Nicholas L Weilinger et al.   ACTA PHARMACOLOGICA SINICA

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

The role of TRPA1 in visceral inflammation and pain

(2012) Tamia K. Lapointe et al.   Channels

The roles of G proteins in the activation of TRPC4 and TRPC5 transient receptor potential channels

(2012) Hana Kim et al.   Channels

Cell Volume Regulation Modulates NLRP3 Inflammasome Activation

(2012) Vincent Compan et al.   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Porphyromonas gingivalisMediates Inflammasome Repression in Polymicrobial Cultures through a Novel Mechanism Involving Reduced Endocytosis

(2012) Debra J. Taxman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR4 activation of TRPC6-dependent calcium signaling mediates endotoxin-induced lung vascular permeability and inflammation

(2012) Mohammad Tauseef et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRs, inflammasomes, and viral infection

(2012) S. R. Jacobs et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Inflammasomes in health and disease

(2012) Till Strowig et al.   NATURE

Neurogenic inflammation and the peripheral nervous system in host defense and immunopathology

(2012) Isaac M Chiu et al.   NATURE NEUROSCIENCE

TRPA1 Has a Key Role in the Somatic Pro-Nociceptive Actions of Hydrogen Sulfide

(2012) David A. Andersson et al.   PLoS One

Critical role for calcium mobilization in activation of the NLRP3 inflammasome

(2012) T. Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-1β Signaling Promotes CNS-Intrinsic Immune Control of West Nile Virus Infection

(2012) Hilario J. Ramos et al.   PLoS Pathogens

TGF-β-activated kinase 1 mediates mechanical stress-induced IL-6 expression in osteoblasts

(2011) Naoto Fukuno et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Capsaicin promotes a more aggressive gene expression phenotype and invasiveness in null-TRPV1 urothelial cancer cells

(2011) Sara Caprodossi et al.   CARCINOGENESIS

Transient receptor potential melastatin 4 inhibition prevents lipopolysaccharide-induced endothelial cell death

(2011) Alvaro Becerra et al.   CARDIOVASCULAR RESEARCH

Mitochondrial ROS fuel the inflammasome

(2011) Matthew T Sorbara et al.   CELL RESEARCH

Inflammasome Activation in Reperfusion Injury

(2011) Sebastian Grundmann et al.   CIRCULATION

Intracellular acidification evoked by moderate extracellular acidosis attenuates transient receptor potential V1 (TRPV1) channel activity in rat dorsal root ganglion neurons

(2011) Seungsoo Chung et al.   EXPERIMENTAL PHYSIOLOGY

The inflammasome: an integrated view

(2011) Olaf Gross et al.   IMMUNOLOGICAL REVIEWS

LPS Sensitizes TRPV1 via Activation of TLR4 in Trigeminal Sensory Neurons

(2011) A. Diogenes et al.   JOURNAL OF DENTAL RESEARCH

Painful Pathways Induced by TLR Stimulation of Dorsal Root Ganglion Neurons

(2011) J. Qi et al.   JOURNAL OF IMMUNOLOGY

Characterization of TRPM8-Like Channels Activated by the Cooling Agent Icilin in the Macrophage Cell Line RAW 264.7

(2011) Sheng-Nan Wu et al.   JOURNAL OF MEMBRANE BIOLOGY

Expression of transient receptor potential vanilloid receptor 1 and toll-like receptor 4 in aggressive periodontitis and in chronic periodontitis

(2011) A. Öztürk et al.   JOURNAL OF PERIODONTAL RESEARCH

The NLRP3 inflammasome instigates obesity-induced inflammation and insulin resistance

(2011) Bolormaa Vandanmagsar et al.   NATURE MEDICINE

Inflammasome-Mediated Autoinflammatory Disorders

(2011) Shruti P. Wilson et al.   POSTGRADUATE MEDICINE

Transient Receptor Potential Melastatin 2 (TRPM2) ion channel is required for innate immunity against Listeria monocytogenes

(2011) H. Knowles et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The transient receptor potential family of ion channels

(2011) Bernd Nilius et al.   GENOME BIOLOGY

Role of transient receptor potential vanilloid 2 in LPS-induced cytokine production in macrophages

(2010) Kenji Yamashiro et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

Chemical probing reveals insights into the signaling mechanism of inflammasome activation

(2010) Yi-Nan Gong et al.   CELL RESEARCH

TRPV1 Function in Health and Disease

(2010) John P.M. White et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Listeria monocytogenes is sensed by the NLRP3 and AIM2 inflammasome

(2010) Sarah Kim et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Intracellular Toll-like Receptors

(2010) Amanda L. Blasius et al.   IMMUNITY

Zinc-induced Neurotoxicity Mediated by Transient Receptor Potential Melastatin 7 Channels

(2010) Koichi Inoue et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sodium Overload and Water Influx Activate the NALP3 Inflammasome

(2010) Christine Schorn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR-signaling Networks

(2010) J. Brown et al.   JOURNAL OF DENTAL RESEARCH

Lipopolysaccharide From Porphyromonas gingivalis Sensitizes Capsaicin-Sensitive Nociceptors

(2010) Caio Cezar Randi Ferraz et al.   JOURNAL OF ENDODONTICS

Interleukin 18 in the CNS

(2010) Silvia Alboni et al.   Journal of Neuroinflammation

Emerging concepts for the role of TRP channels in the cardiovascular system

(2010) Rudi Vennekens   JOURNAL OF PHYSIOLOGY-LONDON

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

TRPV2 has a pivotal role in macrophage particle binding and phagocytosis

(2010) Tiffany M Link et al.   NATURE IMMUNOLOGY

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

(2010) Kiichi Nakahira et al.   NATURE IMMUNOLOGY

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

Toll-like receptor 7 mediates pruritus

(2010) Tong Liu et al.   NATURE NEUROSCIENCE

Tumor necrosis factor-α induces sensitization of meningeal nociceptors mediated via local COX and p38 MAP kinase actions

(2010) Xi-Chun Zhang et al.   PAIN

Transient receptor potential channelopathies

(2010) Bernd Nilius et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Cooperation between Mast Cells and Neurons Is Essential for Antigen-Mediated Bronchoconstriction

(2009) J. M. Cyphert et al.   JOURNAL OF IMMUNOLOGY

The role of transient receptor potential channels in kidney disease

(2009) Titia E. Woudenberg-Vrenken et al.   Nature Reviews Nephrology

The NALP1 inflammasome controls cytokine production and nociception in a rat fracture model of complex regional pain syndrome

(2009) Wen-Wu Li et al.   PAIN

Physiology of Cell Volume Regulation in Vertebrates

(2009) Else K. Hoffmann et al.   PHYSIOLOGICAL REVIEWS

Toll-like receptors (TLRs) and Nod-like receptors (NLRs) in inflammatory disorders

(2009) Masayuki Fukata et al.   SEMINARS IN IMMUNOLOGY

Increased transcription of cytokine genes in human lung epithelial cells through activation of a TRPM8 variant by cold temperatures

(2008) Ashwini S. Sabnis et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Amyloid-β oligomers set fire to inflammasomes and induce Alzheimer's pathology

(2008) Antero Salminen et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

A Molecular Platform in Neurons Regulates Inflammation after Spinal Cord Injury

(2008) J. P. de Rivero Vaccari et al.   JOURNAL OF NEUROSCIENCE

Nociceptors Are Interleukin-1  Sensors

(2008) A. M. Binshtok et al.   JOURNAL OF NEUROSCIENCE

Cutaneous Nociception Evoked by 15-delta PGJ2 via Activation of Ion Channel TRPA1

(2008) Lillian Cruz-Orengo et al.   Molecular Pain

The NALP3 inflammasome is involved in the innate immune response to amyloid-β

(2008) Annett Halle et al.   NATURE IMMUNOLOGY

TRPM2-mediated Ca2+ influx induces chemokine production in monocytes that aggravates inflammatory neutrophil infiltration

(2008) Shinichiro Yamamoto et al.   NATURE MEDICINE

The Nalp3 inflammasome is essential for the development of silicosis

(2008) Suzanne L. Cassel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Association of transient receptor potential canonical type 3 (TRPC3) channel transcripts with proinflammatory cytokines

(2007) Florian Thilo et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Nod-like proteins in inflammation and disease

(2007) LAM Carneiro et al.   JOURNAL OF PATHOLOGY