Local Treatment with Lactate Prevents Intestinal Inflammation in the TNBS-Induced Colitis Model

From Dietary Fiber to Host Physiology: Short-Chain Fatty Acids as Key Bacterial Metabolites

(2016) Ara Koh et al.   CELL

Immunomodulation properties of multi-species fermented milks

(2016) Benoît Foligné et al.   FOOD MICROBIOLOGY

Immunoresponsive Gene 1 and Itaconate Inhibit Succinate Dehydrogenase to Modulate Intracellular Succinate Levels

(2016) Thekla Cordes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Intermediates of Metabolism: From Bystanders to Signalling Molecules

(2016) Robert Haas et al.   TRENDS IN BIOCHEMICAL SCIENCES

Human mesenchymal stromal cell-secreted lactate induces M2-macrophage differentiation by metabolic reprogramming

(2016) Silvia Selleri et al.   Oncotarget

Probiotic yeast Kluyveromyces marxianus CIDCA 8154 shows anti-inflammatory and anti-oxidative stress properties in in vivo models

(2016) D.E. Romanin et al.   Beneficial Microbes

Lactate Inhibits the Pro-Inflammatory Response and Metabolic Reprogramming in Murine Macrophages in a GPR81-Independent Manner

(2016) Agustina Errea et al.   PLoS One

Effects of glucagon-like peptide-2 on bacterial translocation in rat models of colitis

(2016) Bulent HALACLAR et al.   Turkish Journal of Gastroenterology

Lactic acid delays the inflammatory response of human monocytes

(2015) Katrin Peter et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Gut Microbiota as Potential Orchestrators of Irritable Bowel Syndrome

(2015) Sean M.P. Bennet et al.   Gut and Liver

Network Integration of Parallel Metabolic and Transcriptional Data Reveals Metabolic Modules that Regulate Macrophage Polarization

(2015) Abhishek K. Jha et al.   IMMUNITY

Lactate and short chain fatty acids produced by microbial fermentation downregulate proinflammatory responses in intestinal epithelial cells and myeloid cells

(2015) Carolina Iraporda et al.   IMMUNOBIOLOGY

Immunometabolism governs dendritic cell and macrophage function

(2015) Luke A.J. O’Neill et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Combining selected immunomodulatoryPropionibacterium freudenreichiiandLactobacillus delbrueckiistrains: Reverse engineering development of an anti-inflammatory cheese

(2015) Coline Plé et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Dual TNF-α/IL-12p40 Interference as a Strategy to Protect Against Colitis Based on miR-16 Precursors With Macrophage Targeting Vectors

(2015) Zhen Huang et al.   MOLECULAR THERAPY

The GPR55 antagonist CID16020046 protects against intestinal inflammation

(2015) A. Stančić et al.   NEUROGASTROENTEROLOGY AND MOTILITY

miR-19b downregulates intestinal SOCS3 to reduce intestinal inflammation in Crohn’s disease

(2015) Xiuqin Cheng et al.   Scientific Reports

Intrinsic Immunomodulatory Effects of Low-Digestible Carbohydrates Selectively Extend Their Anti-Inflammatory Prebiotic Potentials

(2015) Jérôme Breton et al.   Biomed Research International

Is lactate an undervalued functional component of fermented food products?

(2015) Graciela L. Garrote et al.   Frontiers in Microbiology

The role of lactate on the immunomodulatory properties of the nonbacterial fraction of kefir

(2014) Carolina Iraporda et al.   FOOD RESEARCH INTERNATIONAL

Lactate Reduces Liver and Pancreatic Injury in Toll-Like Receptor– and Inflammasome-Mediated Inflammation via GPR81-Mediated Suppression of Innate Immunity

(2014) Rafaz Hoque et al.   GASTROENTEROLOGY

The Monocarboxylate Transporter 4 Is Required for Glycolytic Reprogramming and Inflammatory Response in Macrophages

(2014) Zheng Tan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Deletion of Flagellin's Hypervariable Region Abrogates Antibody-Mediated Neutralization and Systemic Activation of TLR5-Dependent Immunity

(2014) C. Nempont et al.   JOURNAL OF IMMUNOLOGY

Functional polarization of tumour-associated macrophages by tumour-derived lactic acid

(2014) Oscar R. Colegio et al.   NATURE

TLR-driven early glycolytic reprogramming via the kinases TBK1-IKKɛ supports the anabolic demands of dendritic cell activation

(2014) Bart Everts et al.   NATURE IMMUNOLOGY

Immunopathology of inflammatory bowel disease

(2014) Kori L Wallace   WORLD JOURNAL OF GASTROENTEROLOGY

Gadolinium chloride improves the course of TNBS and DSS-induced colitis through protecting against colonic mucosal inflammation

(2014) Chao Du et al.   Scientific Reports

Effects of the Modulation of Microbiota on the Gastrointestinal Immune System and Bowel Function

(2013) Osamu Kanauchi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Role of commensal and probiotic bacteria in human health: a focus on inflammatory bowel disease

(2013) Rebeca Martín et al.   Microbial Cell Factories

Regulation of intestinal homeostasis and immunity with probiotic lactobacilli

(2013) Peter van Baarlen et al.   TRENDS IN IMMUNOLOGY

Microbiota-derived lactate accelerates colon epithelial cell turnover in starvation-refed mice

(2013) Toshihiko Okada et al.   Nature Communications

Probiotic and postbiotic activity in health and disease: comparison on a novel polarised ex-vivo organ culture model

(2012) Katerina Tsilingiri et al.   GUT

Butyricicoccus pullicaecorumin inflammatory bowel disease

(2012) Venessa Eeckhaut et al.   GUT

Exogenous alkaline phosphatase treatment complements endogenous enzyme protection in colonic inflammation and reduces bacterial translocation in rats

(2012) P. Martínez-Moya et al.   PHARMACOLOGICAL RESEARCH

Dysfunction of the intestinal microbiome in inflammatory bowel disease and treatment

(2012) Xochitl C Morgan et al.   GENOME BIOLOGY

Oral administration of sodium butyrate attenuates inflammation and mucosal lesion in experimental acute ulcerative colitis

(2011) Erica L.M. Vieira et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The Multifaceted Role of the Inflammasome in Inflammatory Bowel Diseases

(2011) Donata Lissner et al.   TheScientificWorldJOURNAL

Dysbiosis of fecal microbiota in Crohnʼs disease patients as revealed by a custom phylogenetic microarray

(2010) Seungha Kang et al.   INFLAMMATORY BOWEL DISEASES

Diet, gut microbiota and immune responses

(2010) Kendle M Maslowski et al.   NATURE IMMUNOLOGY

New prebiotics from rice bran ameliorate inflammation in murine colitis models through the modulation of intestinal homeostasis and the mucosal immune system

(2010) Yutaka Komiyama et al.   SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY

Lactic Acid and Acidification Inhibit TNF Secretion and Glycolysis of Human Monocytes

(2009) K. Dietl et al.   JOURNAL OF IMMUNOLOGY

Probiotics for Preventive Health

(2009) Anil Minocha   NUTRITION IN CLINICAL PRACTICE

Role of gut microbiota in Crohn’s disease

(2009) Phillip I Baker et al.   Expert Review of Gastroenterology & Hepatology

Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

(2008) H. Sokol et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ameliorative effects of bombesin and neurotensin on trinitrobenzene sulphonic acid-induced colitis, oxidative damage and apoptosis in rats

(2008) Alper Akcan et al.   WORLD JOURNAL OF GASTROENTEROLOGY