Ubiquitination and the Regulation of Membrane Proteins

Communication by Extracellular Vesicles: Where We Are and Where We Need to Go

(2016) Mercedes Tkach et al.   CELL

Ubiquitin modifications

(2016) Kirby N Swatek et al.   CELL RESEARCH

Drugging the undruggables: exploring the ubiquitin system for drug development

(2016) Xiaodong Huang et al.   CELL RESEARCH

Poly-ubiquitination in TNFR1-mediated necroptosis

(2016) Yves Dondelinger et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Aβ-Induced Synaptic Alterations Require the E3 Ubiquitin Ligase Nedd4-1

(2016) Elizabeth M. Rodrigues et al.   JOURNAL OF NEUROSCIENCE

System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes

(2016) Wei Zhang et al.   MOLECULAR CELL

Ndfip2 is a potential regulator of the iron transporter DMT1 in the liver

(2016) Natalie J. Foot et al.   Scientific Reports

Angelman Syndrome Protein Ube3a Regulates Synaptic Growth and Endocytosis by Inhibiting BMP Signaling in Drosophila

(2016) Wenhua Li et al.   PLoS Genetics

Genome-wide analysis of copy number variations identifies PARK2 as a candidate gene for autism spectrum disorder

(2016) Chia-Lin Yin et al.   Molecular Autism

The Ubiquitin-Proteasome System: Potential Therapeutic Targets for Alzheimer’s Disease and Spinal Cord Injury

(2016) Bing Gong et al.   Frontiers in Molecular Neuroscience

Regulation of the divalent metal ion transporter via membrane budding

(2016) KimberlyD Mackenzie et al.   Cell Discovery

Nedd4 family interacting protein 1 (Ndfip1) promotes death of pancreatic beta cells

(2015) Avital Beck et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Regulation of the human ether-a-go-go-related gene (hERG) potassium channel by Nedd4 family interacting proteins (Ndfips)

(2015) Y. Kang et al.   BIOCHEMICAL JOURNAL

Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR

(2015) Y.-Y. Chen et al.   CLINICAL SCIENCE

Regulation of amino acid transporter trafficking by mTORC1 in primary human trophoblast cells is mediated by the ubiquitin ligase Nedd4-2

(2015) F. J. Rosario et al.   CLINICAL SCIENCE

NEDD4-2 and salt-sensitive hypertension

(2015) Federica Rizzo et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Characterisation of the Cullin-3 mutation that causes a severe form of familial hypertension and hyperkalaemia

(2015) F.-R. Schumacher et al.   EMBO Molecular Medicine

Phosphorylation of ubiquitin at Ser65 affects its polymerization, targets, and proteome-wide turnover

(2015) D. L. Swaney et al.   EMBO REPORTS

NEDD4: The founding member of a family of ubiquitin-protein ligases

(2015) Natasha Anne Boase et al.   GENE

NEDD4-2 (NEDD4L): The ubiquitin ligase for multiple membrane proteins

(2015) Pranay Goel et al.   GENE

The E3 Ubiquitin Ligases, HUWE1 and NEDD4-1, Are Involved in the Post-translational Regulation of the ABCG1 and ABCG4 Lipid Transporters

(2015) Shereen M. Aleidi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Novel microduplications at Xp11.22 including HUWE1: clinical and molecular insights into these genomic rearrangements associated with intellectual disability

(2015) Cíntia Barros Santos-Rebouças et al.   JOURNAL OF HUMAN GENETICS

Identification of GDC-0810 (ARN-810), an Orally Bioavailable Selective Estrogen Receptor Degrader (SERD) that Demonstrates Robust Activity in Tamoxifen-Resistant Breast Cancer Xenografts

(2015) Andiliy Lai et al.   JOURNAL OF MEDICINAL CHEMISTRY

Membrane Protein Structure, Function, and Dynamics: a Perspective from Experiments and Theory

(2015) Zoe Cournia et al.   JOURNAL OF MEMBRANE BIOLOGY

Discovery of CLC transport proteins: cloning, structure, function and pathophysiology

(2015) Thomas J. Jentsch   JOURNAL OF PHYSIOLOGY-LONDON

The α-arrestin ARRDC3 mediates ALIX ubiquitination and G protein–coupled receptor lysosomal sorting

(2015) Michael R. Dores et al.   MOLECULAR BIOLOGY OF THE CELL

The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1

(2015) Begum G. Akkaya et al.   MOLECULAR MEMBRANE BIOLOGY

An Essential Role of Nedd4-2 in the Ubiquitination, Expression, and Function of Organic Anion Transporter-3

(2015) Da Xu et al.   MOLECULAR PHARMACEUTICS

Phosphorylation and linear ubiquitin direct A20 inhibition of inflammation

(2015) Ingrid E. Wertz et al.   NATURE

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

RING finger protein 121 facilitates the degradation and membrane localization of voltage-gated sodium channels

(2015) Kazutoyo Ogino et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Seizure-like activity in a juvenile Angelman syndrome mouse model is attenuated by reducingArcexpression

(2015) Caleigh Mandel-Brehm et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The demographics of the ubiquitin system

(2015) Michael J. Clague et al.   TRENDS IN CELL BIOLOGY

Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity

(2015) Toshiaki Fukushima et al.   Nature Communications

Genetic Inhibition Of The Ubiquitin Ligase Rnf5 Attenuates Phenotypes Associated To F508del Cystic Fibrosis Mutation

(2015) Valeria Tomati et al.   Scientific Reports

UBE3A Regulates Synaptic Plasticity and Learning and Memory by Controlling SK2 Channel Endocytosis

(2015) Jiandong Sun et al.   Cell Reports

Activity-Dependent Ubiquitination of GluA1 and GluA2 Regulates AMPA Receptor Intracellular Sorting and Degradation

(2015) Jocelyn Widagdo et al.   Cell Reports

Mutant Cbl proteins as oncogenic drivers in myeloproliferative disorders

(2015) Mayumi Naramura et al.   Oncotarget

A Critical Role of c-Cbl-Interacting Protein of 85 kDa in the Development and Progression of Head and Neck Squamous Cell Carcinomas through the Ras-ERK Pathway

(2015) Takahiro Wakasaki et al.   NEOPLASIA

Biogenesis, Secretion, and Intercellular Interactions of Exosomes and Other Extracellular Vesicles

(2014) Marina Colombo et al.   Annual Review of Cell and Developmental Biology

Lys11- and Lys48-linked ubiquitin chains interact with p97 during endoplasmic-reticulum-associated degradation

(2014) Matthew Locke et al.   BIOCHEMICAL JOURNAL

Parkin is activated by PINK1-dependent phosphorylation of ubiquitin at Ser65

(2014) Agne Kazlauskaite et al.   BIOCHEMICAL JOURNAL

Axotrophin/MARCH7 acts as an E3 ubiquitin ligase and ubiquitinates tau protein in vitro impairing microtubule binding

(2014) Katharina Flach et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular Pathways: Cbl Proteins in Tumorigenesis and Antitumor Immunity--Opportunities for Cancer Treatment

(2014) M. S. Liyasova et al.   CLINICAL CANCER RESEARCH

Ubiquitin Ser65 phosphorylation affects ubiquitin structure, chain assembly and hydrolysis

(2014) T. Wauer et al.   EMBO JOURNAL

RBR E3-ligases at work

(2014) J. J. Smit et al.   EMBO REPORTS

The E3 Ubiquitin Ligase AMFR and INSIG1 Bridge the Activation of TBK1 Kinase by Modifying the Adaptor STING

(2014) Qiang Wang et al.   IMMUNITY

Activation of 3-Phosphoinositide-dependent Kinase 1 (PDK1) and Serum- and Glucocorticoid-induced Protein Kinase 1 (SGK1) by Short-chain Sphingolipid C4-ceramide Rescues the Trafficking Defect of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (ΔF508-CFTR)

(2014) Hung Caohuy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

F-box Only Protein 2 (Fbxo2) Regulates Amyloid Precursor Protein Levels and Processing

(2014) Graham Atkin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Unique Regulation of Human Na+/H+Exchanger 3 (NHE3) by Nedd4-2 Ligase That Differs from Non-primate NHE3s

(2014) Yi Ran No et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endoplasmic Reticulum-associated Degradation of Niemann-Pick C1

(2014) Naoe Nakasone et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

 -Arrestins - new players in Notch and GPCR signaling pathways in mammals

(2014) L. Puca et al.   JOURNAL OF CELL SCIENCE

Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

(2014) James A. McCormick et al.   JOURNAL OF CLINICAL INVESTIGATION

In Vivo Regulation of NGF-Mediated Functions by Nedd4-2 Ubiquitination of TrkA

(2014) T. Yu et al.   JOURNAL OF NEUROSCIENCE

Synaptic Strength Is Bidirectionally Controlled by Opposing Activity-Dependent Regulation of Nedd4-1 and USP8

(2014) S. L. Scudder et al.   JOURNAL OF NEUROSCIENCE

Small-Molecule Probes Targeting the Viral PPxY-Host Nedd4 Interface Block Egress of a Broad Range of RNA Viruses

(2014) Z. Han et al.   JOURNAL OF VIROLOGY

Ubiquitin is phosphorylated by PINK1 to activate parkin

(2014) Fumika Koyano et al.   NATURE

Rsp5/Nedd4 is the main ubiquitin ligase that targets cytosolic misfolded proteins following heat stress

(2014) Nancy N. Fang et al.   NATURE CELL BIOLOGY

Cleaning up in the endoplasmic reticulum: ubiquitin in charge

(2014) John C Christianson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

RNF11 is a GGA protein cargo and acts as a molecular adaptor for GGA3 ubiquitination mediated by Itch

(2014) E Santonico et al.   ONCOGENE

Ubiquitin Ligase gp78 Targets Unglycosylated Prion Protein PrP for Ubiquitylation and Degradation

(2014) Jia Shao et al.   PLoS One

TMEM129 is a Derlin-1 associated ERAD E3 ligase essential for virus-induced degradation of MHC-I

(2014) D. J. H. van den Boomen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rer1 and calnexin regulate endoplasmic reticulum retention of a peripheral myelin protein 22 mutant that causes type 1A Charcot-Marie-Tooth disease

(2014) Taichi Hara et al.   Scientific Reports

Carfilzomib

(2013) K. M. Kortuem et al.   BLOOD

Role of β-arrestins and arrestin domain-containing proteins in G protein-coupled receptor trafficking

(2013) Dong Soo Kang et al.   CURRENT OPINION IN CELL BIOLOGY

The ubiquitin ligase RNF126 regulates the retrograde sorting of the cation-independent mannose 6-phosphate receptor

(2013) Christopher J. Smith et al.   EXPERIMENTAL CELL RESEARCH

Different dynamic movements of wild-type and pathogenic VCPs and their cofactors to damaged mitochondria in a Parkin-mediated mitochondrial quality control system

(2013) Yoko Kimura et al.   GENES TO CELLS

Ubiquitinations in the Notch Signaling Pathway

(2013) Julien Moretti et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Endoplasmic Reticulum-associated Degradation Controls Cell Surface Expression of γ-Aminobutyric Acid, Type B Receptors

(2013) Khaled Zemoura et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitination by the Membrane-associated RING-CH-8 (MARCH-8) Ligase Controls Steady-state Cell Surface Expression of Tumor Necrosis Factor-related Apoptosis Inducing Ligand (TRAIL) Receptor 1

(2013) Bert van de Kooij et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

UBE4B Protein Couples Ubiquitination and Sorting Machineries to Enable Epidermal Growth Factor Receptor (EGFR) Degradation

(2013) Natalie Sirisaengtaksin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RNF185 Is a Novel E3 Ligase of Endoplasmic Reticulum-associated Degradation (ERAD) That Targets Cystic Fibrosis Transmembrane Conductance Regulator (CFTR)

(2013) Elma El Khouri et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

From uncertain beginnings: Initiation mechanisms of clathrin-mediated endocytosis

(2013) Camilla Godlee et al.   JOURNAL OF CELL BIOLOGY

Extracellular vesicles: Exosomes, microvesicles, and friends

(2013) Graça Raposo et al.   JOURNAL OF CELL BIOLOGY

Reciprocal cross-regulation between RNF41 and USP8 controls cytokine receptor sorting and processing

(2013) L. De Ceuninck et al.   JOURNAL OF CELL SCIENCE

Dysregulation of voltage-gated sodium channels by ubiquitin ligase NEDD4-2 in neuropathic pain

(2013) Cédric J. Laedermann et al.   JOURNAL OF CLINICAL INVESTIGATION

Mutation of SIMPLE in Charcot–Marie–Tooth 1C alters production of exosomes

(2013) Hong Zhu et al.   MOLECULAR BIOLOGY OF THE CELL

Landscape of the PARKIN-dependent ubiquitylome in response to mitochondrial depolarization

(2013) Shireen A. Sarraf et al.   NATURE

Central role of E3 ubiquitin ligase MG53 in insulin resistance and metabolic disorders

(2013) Ruisheng Song et al.   NATURE

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

(2013) Nam Chul Kim et al.   NEURON

Nedd4 is a specific E3 ubiquitin ligase for the NMDA receptor subunit GluN2D

(2013) Vivek Gautam et al.   NEUROPHARMACOLOGY

Src-Like Adaptor Protein (SLAP) Binds to the Receptor Tyrosine Kinase Flt3 and Modulates Receptor Stability and Downstream Signaling

(2013) Julhash U. Kazi et al.   PLoS One

Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein Arc

(2013) S. Kuhnle et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Previously unknown role for the ubiquitin ligase Ubr1 in endoplasmic reticulum-associated protein degradation

(2013) A. Stolz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Yeast Reveal a "Druggable" Rsp5/Nedd4 Network that Ameliorates  -Synuclein Toxicity in Neurons

(2013) D. F. Tardiff et al.   SCIENCE

A Strategy for Modulation of Enzymes in the Ubiquitin System

(2013) A. Ernst et al.   SCIENCE

The ART-Rsp5 ubiquitin ligase network comprises a plasma membrane quality control system that protects yeast cells from proteotoxic stress

(2013) Yingying Zhao et al.   eLife

Ubiquitin and Membrane Protein Turnover: From Cradle to Grave

(2012) Jason A. MacGurn et al.   Annual Review of Biochemistry

Isoform specific regulation of divalent metal (ion) transporter (DMT1) by proteasomal degradation

(2012) Michael D. Garrick et al.   BIOMETALS

Regulation of Endocytic Clathrin Dynamics by Cargo Ubiquitination

(2012) Anastasia G. Henry et al.   DEVELOPMENTAL CELL

Cargo ubiquitination is essential for multivesicular body intralumenal vesicle formation

(2012) Chris MacDonald et al.   EMBO REPORTS

Distinct roles for β-arrestin2 and arrestin-domain-containing proteins in β2 adrenergic receptor trafficking

(2012) Sang-Oh Han et al.   EMBO REPORTS

Synergistical effect of 20-HETE and high salt on NKCC2 protein and blood pressure via ubiquitin–proteasome pathway

(2012) Jingjing Wu et al.   HUMAN GENETICS

Ubiquitylation of the chemokine receptor CCR7 enables efficient receptor recycling and cell migration

(2012) K. Schaeuble et al.   JOURNAL OF CELL SCIENCE

CIN85 phosphorylation is essential for EGFR ubiquitination and sorting into multivesicular bodies

(2012) Barbara Schroeder et al.   MOLECULAR BIOLOGY OF THE CELL

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

Prion propagation, toxicity and degradation

(2012) Adriano Aguzzi et al.   NATURE NEUROSCIENCE

Pharmacogenomics of the heptahelical receptor regulators G-protein-coupled receptor kinases and arrestins: the known and the unknown

(2012) Anastasios Lymperopoulos et al.   PHARMACOGENOMICS

Ezrin Ubiquitylation by the E3 Ubiquitin Ligase, WWP1, and Consequent Regulation of Hepatocyte Growth Factor Receptor Activity

(2012) Rania F. Zaarour et al.   PLoS One

Rsp5 Ubiquitin Ligase Is Required for Protein Trafficking in Saccharomyces cerevisiae COPI Mutants

(2012) Katarzyna Jarmoszewicz et al.   PLoS One

Mammalian Alpha Arrestins Link Activated Seven Transmembrane Receptors to Nedd4 Family E3 Ubiquitin Ligases and Interact with Beta Arrestins

(2012) Fortune F. Shea et al.   PLoS One

Ubiquitin ligase RNF167 regulates AMPA receptor-mediated synaptic transmission

(2012) M. P. Lussier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Formation and release of arrestin domain-containing protein 1-mediated microvesicles (ARMMs) at plasma membrane by recruitment of TSG101 protein

(2012) J. F. Nabhan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Tumor Suppressor PTEN Is Exported in Exosomes and Has Phosphatase Activity in Recipient Cells

(2012) U. Putz et al.   Science Signaling

Mitochondrial Quality Control Mediated by PINK1 and Parkin: Links to Parkinsonism

(2012) D. Narendra et al.   Cold Spring Harbor Perspectives in Biology

USP8 Promotes Smoothened Signaling by Preventing Its Ubiquitination and Changing Its Subcellular Localization

(2012) Ruohan Xia et al.   PLOS BIOLOGY

Hedgehog-Regulated Ubiquitination Controls Smoothened Trafficking and Cell Surface Expression in Drosophila

(2012) Shuang Li et al.   PLOS BIOLOGY

Molecular Mechanisms of Ubiquitin-Dependent Membrane Traffic

(2011) James H. Hurley et al.   Annual Review of Biophysics

In Vitro and In Vivo Selective Antitumor Activity of a Novel Orally Bioavailable Proteasome Inhibitor MLN9708 against Multiple Myeloma Cells

(2011) Dharminder Chauhan et al.   CLINICAL CANCER RESEARCH

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Nedd4-1 binds and ubiquitylates activated FGFR1 to control its endocytosis and function

(2011) Avinash Persaud et al.   EMBO JOURNAL

Misfolded PrP impairs the UPS by interaction with the 20S proteasome and inhibition of substrate entry

(2011) Pelagia Deriziotis et al.   EMBO JOURNAL

Broad activation of the ubiquitin–proteasome system by Parkin is critical for mitophagy

(2011) Nickie C. Chan et al.   HUMAN MOLECULAR GENETICS

Novel, orally active, proteasome inhibitor, delanzomib (CEP-18770), ameliorates disease symptoms and glomerulonephritis in two preclinical mouse models of SLE

(2011) Matthew M. Seavey et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Parkin Mediates Proteasome-dependent Protein Degradation and Rupture of the Outer Mitochondrial Membrane

(2011) Saori R. Yoshii et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fbxw7-dependent Degradation of Notch Is Required for Control of “Stemness” and Neuronal-Glial Differentiation in Neural Stem Cells

(2011) Akinobu Matsumoto et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The E3 Ligase Smurf1 Regulates Wolfram Syndrome Protein Stability at the Endoplasmic Reticulum

(2011) Xing Guo et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Engagement of S1P1-degradative mechanisms leads to vascular leak in mice

(2011) Myat Lin Oo et al.   JOURNAL OF CLINICAL INVESTIGATION

Ubiquitination of CD86 Is a Key Mechanism in Regulating Antigen Presentation by Dendritic Cells

(2011) G. Baravalle et al.   JOURNAL OF IMMUNOLOGY

Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking

(2011) Amy Lin et al.   JOURNAL OF NEUROCHEMISTRY

Activity-Dependent Ubiquitination of the AMPA Receptor Subunit GluA2

(2011) M. P. Lussier et al.   JOURNAL OF NEUROSCIENCE

Nedd4-2 Modulates Renal Na+-Cl- Cotransporter via the Aldosterone-SGK1-Nedd4-2 Pathway

(2011) J. P. Arroyo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

A Proteome-wide, Quantitative Survey of In Vivo Ubiquitylation Sites Reveals Widespread Regulatory Roles

(2011) Sebastian A. Wagner et al.   MOLECULAR & CELLULAR PROTEOMICS

MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation

(2011) Craig A. Eyster et al.   MOLECULAR BIOLOGY OF THE CELL

Systematic and Quantitative Assessment of the Ubiquitin-Modified Proteome

(2011) Woong Kim et al.   MOLECULAR CELL

A direct role for Met endocytosis in tumorigenesis

(2011) Carine Joffre et al.   NATURE CELL BIOLOGY

Deubiquitination of EGFR by Cezanne-1 contributes to cancer progression

(2011) F Pareja et al.   ONCOGENE

D-Cbl Binding to Drk Leads to Dose-Dependent Down-Regulation of EGFR Signaling and Increases Receptor-Ligand Endocytosis

(2011) Pei-Yu Wang et al.   PLoS One

Ubiquitin ligase Nedd4 promotes  -synuclein degradation by the endosomal-lysosomal pathway

(2011) G. K. Tofaris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Basis for ESCRT-III CHMP3 Recruitment of AMSH

(2011) Julianna Solomons et al.   STRUCTURE

The Role of EGF Receptor Ubiquitination in Regulating Its Intracellular Traffic

(2011) Emily R. Eden et al.   TRAFFIC

Respiratory distress and perinatal lethality in Nedd4-2-deficient mice

(2011) Natasha A. Boase et al.   Nature Communications

Ubiquitination in Postsynaptic Function and Plasticity

(2010) Angela M. Mabb et al.   Annual Review of Cell and Developmental Biology

Parkin-mediated ubiquitin signalling in aggresome formation and autophagy

(2010) Lih-Shen Chin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Ndfip1-deficient mice have impaired DMT1 regulation and iron homeostasis

(2010) N. J. Foot et al.   BLOOD

Spartin activates atrophin-1-interacting protein 4 (AIP4) E3 ubiquitin ligase and promotes ubiquitination of adipophilin on lipid droplets

(2010) Christopher Hooper et al.   BMC BIOLOGY

Myeloid Leukemia Development in c-Cbl RING Finger Mutant Mice Is Dependent on FLT3 Signaling

(2010) Chozhavendan Rathinam et al.   CANCER CELL

The Angelman Syndrome Protein Ube3A Regulates Synapse Development by Ubiquitinating Arc

(2010) Paul L. Greer et al.   CELL

Cell Signaling by Receptor Tyrosine Kinases

(2010) Mark A. Lemmon et al.   CELL

Drosophila Ndfip is a novel regulator of Notch signaling

(2010) H E Dalton et al.   CELL DEATH AND DIFFERENTIATION

Balanced ubiquitylation and deubiquitylation of Frizzled regulate cellular responsiveness to Wg/Wnt

(2010) Akiko Mukai et al.   EMBO JOURNAL

Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the β2-adrenergic receptor

(2010) Joseph F Nabhan et al.   EMBO REPORTS

Activated Inositol 1,4,5-Trisphosphate Receptors Are Modified by Homogeneous Lys-48- and Lys-63-linked Ubiquitin Chains, but Only Lys-48-linked Chains Are Required for Degradation

(2010) Danielle A. Sliter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Deubiquitinating Enzyme USP8 Promotes Trafficking and Degradation of the Chemokine Receptor 4 at the Sorting Endosome

(2010) Ilana Berlin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Direct Ubiquitination of β-Catenin by Siah-1 and Regulation by the Exchange Factor TBL1

(2010) Yoana N. Dimitrova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Proteasome and p97 mediate mitophagy and degradation of mitofusins induced by Parkin

(2010) Atsushi Tanaka et al.   JOURNAL OF CELL BIOLOGY

Wolfram syndrome 1 gene negatively regulates ER stress signaling in rodent and human cells

(2010) Sonya G. Fonseca et al.   JOURNAL OF CLINICAL INVESTIGATION

Activity-Dependent Ubiquitination of GluA1 Mediates a Distinct AMPA Receptor Endocytosis and Sorting Pathway

(2010) L. A. Schwarz et al.   JOURNAL OF NEUROSCIENCE

The Rab11 Pathway Is Required for Influenza A Virus Budding and Filament Formation

(2010) E. A. Bruce et al.   JOURNAL OF VIROLOGY

Role of extracellular membrane vesicles in the pathogenesis of various diseases, including cancer, renal diseases, atherosclerosis and arthritis

(2010) H Clarke Anderson et al.   LABORATORY INVESTIGATION

Neuralized Promotes Basal to Apical Transcytosis of Delta in Epithelial Cells

(2010) Najate Benhra et al.   MOLECULAR BIOLOGY OF THE CELL

Isoform-Specific Degradation of PR-B by E6-AP Is Critical for Normal Mammary Gland Development

(2010) Sivapriya Ramamoorthy et al.   MOLECULAR ENDOCRINOLOGY

APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity

(2010) Amy K Y Fu et al.   NATURE NEUROSCIENCE

Fbw7 controls neural stem cell differentiation and progenitor apoptosis via Notch and c-Jun

(2010) Joerg D Hoeck et al.   NATURE NEUROSCIENCE

Neuralized1 causes apoptosis and downregulates Notch target genes in medulloblastoma

(2010) Natalia Teider et al.   NEURO-ONCOLOGY

CBL Is Frequently Altered in Lung Cancers: Its Relationship to Mutations in MET and EGFR Tyrosine Kinases

(2010) Yi-Hung Carol Tan et al.   PLoS One

Regulation of Trafficking of Activated TrkA Is Critical for NGF-Mediated Functions

(2010) Tao Yu et al.   TRAFFIC

TARPs differentially decorate AMPA receptors to specify neuropharmacology

(2010) Akihiko S. Kato et al.   TRENDS IN NEUROSCIENCES

COP9-Associated CSN5 Regulates Exosomal Protein Deubiquitination and Sorting

(2009) Yuelong Liu et al.   AMERICAN JOURNAL OF PATHOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

Nedd4 and Nedd4-2: closely related ubiquitin-protein ligases with distinct physiological functions

(2009) B Yang et al.   CELL DEATH AND DIFFERENTIATION

Control of the activity of WW-HECT domain E3 ubiquitin ligases by NDFIP proteins

(2009) Thomas Mund et al.   EMBO REPORTS

Differential regulation of CFTRΔF508 degradation by ubiquitin ligases gp78 and Hrd1

(2009) Petek Ballar et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Regulation of Endoplasmic Reticulum-associated Degradation by RNF5-dependent Ubiquitination of JNK-associated Membrane Protein (JAMP)

(2009) Marianna Tcherpakov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

(2009) Helen R. Stagg et al.   JOURNAL OF CELL BIOLOGY

Molecular mechanisms of clathrin-independent endocytosis

(2009) C. G. Hansen et al.   JOURNAL OF CELL SCIENCE

The E3 Ligase Axotrophin/MARCH-7: Protein Expression Profiling of Human Tissues Reveals Links to Adult Stem Cells

(2009) Cristina A. Szigyarto et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Discrete Domains of MARCH1 Mediate Its Localization, Functional Interactions, and Posttranscriptional Control of Expression

(2009) M. Jabbour et al.   JOURNAL OF IMMUNOLOGY

Regulation of Synaptic Structure by Ubiquitin C-Terminal Hydrolase L1

(2009) A. E. Cartier et al.   JOURNAL OF NEUROSCIENCE

The HECT-Type E3 Ubiquitin Ligase AIP2 Inhibits Activation-Induced T-Cell Death by Catalyzing EGR2 Ubiquitination

(2009) A. Chen et al.   MOLECULAR AND CELLULAR BIOLOGY

The ESCRT machinery in endosomal sorting of ubiquitylated membrane proteins

(2009) Camilla Raiborg et al.   NATURE

Physiological functions of the HECT family of ubiquitin ligases

(2009) Daniela Rotin et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

(2009) Y Li et al.   ONCOGENE

Divalent metal transporter 1 (DMT1) regulation by Ndfip1 prevents metal toxicity in human neurons

(2009) J. Howitt et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

 -Arrestin-dependent signaling and trafficking of 7-transmembrane receptors is reciprocally regulated by the deubiquitinase USP33 and the E3 ligase Mdm2

(2009) S. K. Shenoy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sorting of MHC Class II Molecules into Exosomes through a Ubiquitin-Independent Pathway

(2009) Marie-Élaine Gauvreau et al.   TRAFFIC

Enhanced cell-surface stability of rescued ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) by pharmacological chaperones

(2008) Karoly Varga et al.   BIOCHEMICAL JOURNAL

Regulation of the divalent metal ion transporter DMT1 and iron homeostasis by a ubiquitin-dependent mechanism involving Ndfips and WWP2

(2008) N. J. Foot et al.   BLOOD

On the origins of arrestin and rhodopsin

(2008) Carlos E Alvarez   BMC EVOLUTIONARY BIOLOGY

Mind bomb 2, a founder myoblast-specific protein, regulates myoblast fusion and muscle stability

(2008) M. Carrasco-Rando et al.   DEVELOPMENT

Exon 8 splice site mutations in the gene encoding the E3-ligase CBL are associated with core binding factor acute myeloid leukemias

(2008) S. Abbas et al.   HAEMATOLOGICA

Negative regulation of lymphocyte development and function by the Cbl family of proteins

(2008) Fang Huang et al.   IMMUNOLOGICAL REVIEWS

Nedd4 Family-interacting Protein 1 (Ndfip1) Is Required for the Exosomal Secretion of Nedd4 Family Proteins

(2008) Ulrich Putz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nedd4 Mediates Agonist-dependent Ubiquitination, Lysosomal Targeting, and Degradation of the β2-Adrenergic Receptor

(2008) Sudha K. Shenoy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Grb10/Nedd4-mediated multiubiquitination of the insulin-like growth factor receptor regulates receptor internalization

(2008) Giada Monami et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The E3 Ubiquitin Ligase WWP1 Selectively Targets HER4 and Its Proteolytically Derived Signaling Isoforms for Degradation

(2008) S.-M. Feng et al.   MOLECULAR AND CELLULAR BIOLOGY

Ubiquitination of Fibroblast Growth Factor Receptor 1 Is Required for Its Intracellular Sorting but Not for Its Endocytosis

(2008) Ellen Margrethe Haugsten et al.   MOLECULAR BIOLOGY OF THE CELL

Gp78 Cooperates with RMA1 in Endoplasmic Reticulum-associated Degradation of CFTRΔF508

(2008) Daisuke Morito et al.   MOLECULAR BIOLOGY OF THE CELL

Different Ubiquitin Signals Act at the Golgi and Plasma Membrane to Direct GAP1 Trafficking

(2008) April L. Risinger et al.   MOLECULAR BIOLOGY OF THE CELL

The E3 Ubiquitin Ligase Atrophin Interacting Protein 4 Binds Directly To The Chemokine Receptor CXCR4 Via a Novel WW Domain-mediated Interaction

(2008) Deepali Bhandari et al.   MOLECULAR BIOLOGY OF THE CELL

AIP4/Itch Regulates Notch Receptor Degradation in the Absence of Ligand

(2008) Patricia Chastagner et al.   PLoS One

Nedd4 Controls Animal Growth by Regulating IGF-1 Signaling

(2008) X. R. Cao et al.   Science Signaling

The Ubiquitin E3 Ligase MARCH7 is Differentially Regulated by the Deubiquitylating Enzymes USP7 and USP9X

(2008) James A. Nathan et al.   TRAFFIC

Substrate- and Ubiquitin-Dependent Trafficking of the Yeast Siderophore Transporter Sit1

(2008) Zoi Erpapazoglou et al.   TRAFFIC

Johanson-Blizzard syndrome with mild phenotypic features confirmed by UBR1 gene testing

(2008) Naim Alkhouri et al.   WORLD JOURNAL OF GASTROENTEROLOGY