Ubiquitin and Membrane Protein Turnover: From Cradle to Grave

TORC1 Regulates Endocytosis via Npr1-Mediated Phosphoinhibition of a Ubiquitin Ligase Adaptor

(2011) Jason A. MacGurn et al.   CELL

The Arrestin Domain-Containing 3 Protein Regulates Body Mass and Energy Expenditure

(2011) Parth Patwari et al.   Cell Metabolism

Identification of a NBD1-Binding Pharmacological Chaperone that Corrects the Trafficking Defect of F508del-CFTR

(2011) Heidi M. Sampson et al.   CHEMISTRY & BIOLOGY

Protein folding and quality control in the endoplasmic reticulum: Recent lessons from yeast and mammalian cell systems

(2011) Jeffrey L Brodsky et al.   CURRENT OPINION IN CELL BIOLOGY

Structural regulation of cullin-RING ubiquitin ligase complexes

(2011) David M Duda et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The ESCRT Pathway

(2011) William M. Henne et al.   DEVELOPMENTAL CELL

Notch Ligand Ubiquitylation: What Is It Good For?

(2011) Gerry Weinmaster et al.   DEVELOPMENTAL CELL

Structural basis for endosomal recruitment of ESCRT-I by ESCRT-0 in yeast

(2011) Xuefeng Ren et al.   EMBO JOURNAL

The IDOL-UBE2D complex mediates sterol-dependent degradation of the LDL receptor

(2011) L. Zhang et al.   GENES & DEVELOPMENT

Proteome of ubiquitin/MVB pathway: possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation

(2011) Ryo Tachiyama et al.   GENES TO CELLS

Routing Misfolded Proteins through the Multivesicular Body (MVB) Pathway Protects against Proteotoxicity

(2011) Songyu Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Kinase C-dependent Ubiquitination and Clathrin-mediated Endocytosis of the Cationic Amino Acid Transporter CAT-1

(2011) Arnau Vina-Vilaseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A single ubiquitin is sufficient for cargo protein entry into MVBs in the absence of ESCRT ubiquitination

(2011) Daniel K. Stringer et al.   JOURNAL OF CELL BIOLOGY

Nedd4-mediated AMPA receptor ubiquitination regulates receptor turnover and trafficking

(2011) Amy Lin et al.   JOURNAL OF NEUROCHEMISTRY

Exposed hydrophobicity is a key determinant of nuclear quality control degradation

(2011) Eric K. Fredrickson et al.   MOLECULAR BIOLOGY OF THE CELL

Disorder Targets Misorder in Nuclear Quality Control Degradation: A Disordered Ubiquitin Ligase Directly Recognizes Its Misfolded Substrates

(2011) Joel C. Rosenbaum et al.   MOLECULAR CELL

Constructing and decoding unconventional ubiquitin chains

(2011) Christian Behrends et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Systematic Mutational Analysis of the Intracellular Regions of Yeast Gap1 Permease

(2011) Ahmad Merhi et al.   PLoS One

Hierarchical Binding of Cofactors to the AAA ATPase p97

(2011) Petra Hänzelmann et al.   STRUCTURE

How Ubiquitin Functions with ESCRTs

(2011) S. Brookhart Shields et al.   TRAFFIC

Protein quality control in the ER: balancing the ubiquitin checkbook

(2011) Jasper H.L. Claessen et al.   TRENDS IN CELL BIOLOGY

Ubiquitylation in ERAD: Reversing to Go Forward?

(2011) Yien Che Tsai et al.   PLOS BIOLOGY

Neurological Channelopathies

(2010) Dimitri M. Kullmann   Annual Review of Neuroscience

E2s: structurally economical and functionally replete

(2010) Dawn M. Wenzel et al.   BIOCHEMICAL JOURNAL

Protein dislocation from the ER

(2010) Katrin Bagola et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

The ESCRT complexes

(2010) James H. Hurley   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Protein misfolding disorders and macroautophagy

(2010) Fiona M Menzies et al.   CURRENT OPINION IN CELL BIOLOGY

VHS domains of ESCRT-0 cooperate in high-avidity binding to polyubiquitinated cargo

(2010) Xuefeng Ren et al.   EMBO JOURNAL

Arrestin domain-containing protein 3 recruits the NEDD4 E3 ligase to mediate ubiquitination of the β2-adrenergic receptor

(2010) Joseph F Nabhan et al.   EMBO REPORTS

Nedd4-1 and β-Arrestin-1 Are Key Regulators of Na+/H+Exchanger 1 Ubiquitylation, Endocytosis, and Function

(2010) Alexandre Simonin et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Hrs Controls Sorting of the Epithelial Na+Channel between Endosomal Degradation and Recycling Pathways

(2010) Ruifeng Zhou et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Lysine 63-linked Polyubiquitination of the Dopamine Transporter Requires WW3 and WW4 Domains of Nedd4-2 and UBE2D Ubiquitin-conjugating Enzymes

(2010) Arnau Vina-Vilaseca et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

ESCRT-0 Assembles as a Heterotetrameric Complex on Membranes and Binds Multiple Ubiquitinylated Cargoes Simultaneously

(2010) Jonathan R. Mayers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ubiquitylation and SUMOylation of Cardiac Ion Channels

(2010) Jean-Sébastien Rougier et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Multiple mechanisms collectively regulate clathrin-mediated endocytosis of the epidermal growth factor receptor

(2010) Lai Kuan Goh et al.   JOURNAL OF CELL BIOLOGY

Quality control for unfolded proteins at the plasma membrane

(2010) Pirjo M. Apaja et al.   JOURNAL OF CELL BIOLOGY

The regulation of autophagy - unanswered questions

(2010) Y. Chen et al.   JOURNAL OF CELL SCIENCE

Control of Notch-ligand endocytosis by ligand-receptor interaction

(2010) E. M. Hansson et al.   JOURNAL OF CELL SCIENCE

HECT E3 Ubiquitin Ligase Nedd4-1 Ubiquitinates ACK and Regulates Epidermal Growth Factor (EGF)-Induced Degradation of EGF Receptor and ACK

(2010) Q. Lin et al.   MOLECULAR AND CELLULAR BIOLOGY

Endocytosis of the Aspartic Acid/Glutamic Acid Transporter Dip5 Is Triggered by Substrate-Dependent Recruitment of the Rsp5 Ubiquitin Ligase via the Arrestin-Like Protein Aly2

(2010) R. Hatakeyama et al.   MOLECULAR AND CELLULAR BIOLOGY

Evasion of Endoplasmic Reticulum Surveillance Makes Wsc1p an Obligate Substrate of Golgi Quality Control

(2010) Songyu Wang et al.   MOLECULAR BIOLOGY OF THE CELL

Arrestin-2 Interacts with the Endosomal Sorting Complex Required for Transport Machinery to Modulate Endosomal Sorting of CXCR4

(2010) Rohit Malik et al.   MOLECULAR BIOLOGY OF THE CELL

Neuralized Promotes Basal to Apical Transcytosis of Delta in Epithelial Cells

(2010) Najate Benhra et al.   MOLECULAR BIOLOGY OF THE CELL

α-Arrestins Aly1 and Aly2 Regulate Intracellular Trafficking in Response to Nutrient Signaling

(2010) Allyson F. O'Donnell et al.   MOLECULAR BIOLOGY OF THE CELL

Molecular mechanism of multivesicular body biogenesis by ESCRT complexes

(2010) Thomas Wollert et al.   NATURE

Eaten alive: a history of macroautophagy

(2010) Zhifen Yang et al.   NATURE CELL BIOLOGY

ARRDC3 suppresses breast cancer progression by negatively regulating integrin β4

(2010) K M Draheim et al.   ONCOGENE

Insulin-induced gene: A new regulator in lipid metabolism

(2010) Xiao-Ying Dong et al.   PEPTIDES

Mutations in CHMP2B in Lower Motor Neuron Predominant Amyotrophic Lateral Sclerosis (ALS)

(2010) Laura E. Cox et al.   PLoS One

Peripheral Protein Quality Control Removes Unfolded CFTR from the Plasma Membrane

(2010) T. Okiyoneda et al.   SCIENCE

The ubiquitin code of yeast permease trafficking

(2010) Elsa Lauwers et al.   TRENDS IN CELL BIOLOGY

RING Domain E3 Ubiquitin Ligases

(2009) Raymond J. Deshaies et al.   Annual Review of Biochemistry

The role of CHMP2B in frontotemporal dementia

(2009) Hazel Urwin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The emerging complexity of protein ubiquitination

(2009) David Komander   BIOCHEMICAL SOCIETY TRANSACTIONS

Abnormal regulation of TSG101 in mice with spongiform neurodegeneration

(2009) Jian Jiao et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Ubiquitin ligase complexes: from substrate selectivity to conjugational specificity

(2009) Vanja Nagy et al.   BIOLOGICAL CHEMISTRY

Quantitative Proteomics Reveals the Function of Unconventional Ubiquitin Chains in Proteasomal Degradation

(2009) Ping Xu et al.   CELL

The Cell Biology of HIV-1 Virion Genesis

(2009) Paul D. Bieniasz   Cell Host & Microbe

The deubiquitinases USP33 and USP20 coordinate β2 adrenergic receptor recycling and resensitization

(2009) Magali Berthouze et al.   EMBO JOURNAL

Treating lysosomal storage diseases with pharmacological chaperones: from concept to clinics

(2009) Giancarlo Parenti   EMBO Molecular Medicine

The Deubiquitinating Enzyme USP10 Regulates the Post-endocytic Sorting of Cystic Fibrosis Transmembrane Conductance Regulator in Airway Epithelial Cells

(2009) Jennifer M. Bomberger et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucose-induced Ubiquitylation and Endocytosis of the Yeast Jen1 Transporter

(2009) Sandra Paiva et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

K63-linked ubiquitin chains as a specific signal for protein sorting into the multivesicular body pathway

(2009) Elsa Lauwers et al.   JOURNAL OF CELL BIOLOGY

ESCRT ubiquitin-binding domains function cooperatively during MVB cargo sorting

(2009) S. Brookhart Shields et al.   JOURNAL OF CELL BIOLOGY

The TRC8 E3 ligase ubiquitinates MHC class I molecules before dislocation from the ER

(2009) Helen R. Stagg et al.   JOURNAL OF CELL BIOLOGY

Derlin-dependent accumulation of integral membrane proteins at cell surfaces

(2009) B. Schaheen et al.   JOURNAL OF CELL SCIENCE

Building ubiquitin chains: E2 enzymes at work

(2009) Yihong Ye et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Breaking the chains: structure and function of the deubiquitinases

(2009) David Komander et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

WW domain containing E3 ubiquitin protein ligase 1 targets the full-length ErbB4 for ubiquitin-mediated degradation in breast cancer

(2009) Y Li et al.   ONCOGENE

Inefficient Quality Control of Thermosensitive Proteins on the Plasma Membrane

(2009) Michael J. Lewis et al.   PLoS One

Rescue of CF airway epithelial cell function in vitro by a CFTR potentiator, VX-770

(2009) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

LXR Regulates Cholesterol Uptake Through Idol-Dependent Ubiquitination of the LDL Receptor

(2009) Noam Zelcer et al.   SCIENCE

Hybrid Structural Model of the Complete Human ESCRT-0 Complex

(2009) Xuefeng Ren et al.   STRUCTURE

Arrestin-Mediated Endocytosis of Yeast Plasma Membrane Transporters

(2009) Elina Nikko et al.   TRAFFIC

Interactions between the Three CIN85 SH3 Domains and Ubiquitin: Implications for CIN85 Ubiquitination†

(2008) Irina Bezsonova et al.   BIOCHEMISTRY

The HECT Family of E3 Ubiquitin Ligases: Multiple Players in Cancer Development

(2008) Francesca Bernassola et al.   CANCER CELL

Arrestin-Related Ubiquitin-Ligase Adaptors Regulate Endocytosis and Protein Turnover at the Cell Surface

(2008) Charles H. Lin et al.   CELL

UBX domain proteins: major regulators of the AAA ATPase Cdc48/p97

(2008) C. Schuberth et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Clathrin-Mediated Internalization Is Essential for Sustained EGFR Signaling but Dispensable for Degradation

(2008) Sara Sigismund et al.   DEVELOPMENTAL CELL

Arrestin-like proteins mediate ubiquitination and endocytosis of the yeast metal transporter Smf1

(2008) Elina Nikko et al.   EMBO REPORTS

The Ubiquitin-Protein Ligase Nedd4-2 Differentially Interacts with and Regulates Members of the Tweety Family of Chloride Ion Channels

(2008) Yaowu He et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Multidimensional Chromatography Technology for In-depth Phosphoproteome Analysis

(2008) Claudio P. Albuquerque et al.   MOLECULAR & CELLULAR PROTEOMICS

The Clathrin Adaptor Gga2p Is a Phosphatidylinositol 4-phosphate Effector at the Golgi Exit

(2008) Lars Demmel et al.   MOLECULAR BIOLOGY OF THE CELL

Different Ubiquitin Signals Act at the Golgi and Plasma Membrane to Direct GAP1 Trafficking

(2008) April L. Risinger et al.   MOLECULAR BIOLOGY OF THE CELL

One step at a time: endoplasmic reticulum-associated degradation

(2008) Shruthi S. Vembar et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Substrate- and Ubiquitin-Dependent Trafficking of the Yeast Siderophore Transporter Sit1

(2008) Zoi Erpapazoglou et al.   TRAFFIC

Epsin 1 is Involved in Recruitment of Ubiquitinated EGF Receptors into Clathrin-Coated Pits

(2008) Maja Kazazic et al.   TRAFFIC

Regulation of Tsg101 Expression by the Steadiness Box: A Role of Tsg101-associated Ligase

(2007) Bethan McDonald et al.   MOLECULAR BIOLOGY OF THE CELL