Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

(2013) Akihito Ohta et al.   BIOCHEMICAL JOURNAL

Regulation of with-no-lysine kinase signaling by Kelch-like proteins

(2013) Shinichi Uchida et al.   BIOLOGY OF THE CELL

CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma

(2013) A. Ooi et al.   CANCER RESEARCH

Disease-causing mutations in KLHL3 impair its effect on WNK4 degradation

(2013) Guojin Wu et al.   FEBS LETTERS

Structural Basis for Cul3 Protein Assembly with the BTB-Kelch Family of E3 Ubiquitin Ligases

(2013) Peter Canning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SPAK Differentially Mediates Vasopressin Effects on Sodium Cotransporters

(2013) T. Saritas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

WNK1-related Familial Hyperkalemic Hypertension results from an increased expression of L-WNK1 specifically in the distal nephron

(2013) E. Vidal-Petiot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kelch-like 3 and Cullin 3 regulate electrolyte homeostasis via ubiquitination and degradation of WNK4

(2013) S. Shibata et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired KLHL3-Mediated Ubiquitination of WNK4 Causes Human Hypertension

(2013) Mai Wakabayashi et al.   Cell Reports

Cullin-3 Regulates Vascular Smooth Muscle Function and Arterial Blood Pressure via PPARγ and RhoA/Rho-Kinase

(2012) Christopher J. Pelham et al.   Cell Metabolism

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

(2012) Hélène Louis-Dit-Picard et al.   NATURE GENETICS

Activation of the renal Na+:Cl- cotransporter by angiotensin II is a WNK4-dependent process

(2012) M. Castaneda-Bueno et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A SPAK Isoform Switch Modulates Renal Salt Transport and Blood Pressure

(2011) James A. McCormick et al.   Cell Metabolism

The calcineurin inhibitor tacrolimus activates the renal sodium chloride cotransporter to cause hypertension

(2011) Ewout J Hoorn et al.   NATURE MEDICINE

The cyclin E regulator cullin 3 prevents mouse hepatic progenitor cells from becoming tumor-initiating cells

(2010) Uta Kossatz et al.   JOURNAL OF CLINICAL INVESTIGATION

SORLA/SORL1 Functionally Interacts with SPAK To Control Renal Activation of Na+-K+-Cl- Cotransporter 2

(2010) J. Reiche et al.   MOLECULAR AND CELLULAR BIOLOGY

The human Dcn1-like protein DCNL3 promotes Cul3 neddylation at membranes

(2009) N. Meyer-Schaller et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An efficient and versatile system for acute and chronic modulation of renal tubular function in transgenic mice

(2008) Milena Traykova-Brauch et al.   NATURE MEDICINE