Activation of 3-Phosphoinositide-dependent Kinase 1 (PDK1) and Serum- and Glucocorticoid-induced Protein Kinase 1 (SGK1) by Short-chain Sphingolipid C4-ceramide Rescues the Trafficking Defect of ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator (ΔF508-CFTR)

PIKfyve Sensitivity of hERG Channels

(2013) Tatsiana Pakladok et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

ARF6 Regulates Neuron Differentiation through Glucosylceramide Synthase

(2013) Lu Li et al.   PLoS One

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(2012) John Holleran et al.   MOLECULAR MEDICINE

Cystic Fibrosis and the Innate Immune System: Therapeutic Implications

(2012) Massimo Conese   Endocrine Metabolic & Immune Disorders-Drug Targets

Elevated miR-155 Promotes Inflammation in Cystic Fibrosis by Driving Hyperexpression of Interleukin-8

(2011) Sharmistha Bhattacharyya et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

(2011) F. Van Goor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of GSK2334470, a novel and highly specific inhibitor of PDK1

(2010) Ayaz Najafov et al.   BIOCHEMICAL JOURNAL

The V510D Suppressor Mutation Stabilizes ΔF508-CFTR at the Cell Surface

(2010) Tip W. Loo et al.   BIOCHEMISTRY

Modulation of endocytic trafficking and apical stability of CFTR in primary human airway epithelial cultures

(2009) Deborah M. Cholon et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Rescue of ΔF508-CFTR by the SGK1/Nedd4-2 Signaling Pathway

(2009) Hung Caohuy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cystic Fibrosis Fatty Acid Imbalance Is Linked to Ceramide Deficiency and Corrected by Fenretinide

(2008) Claudine Guilbault et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

A secondary assay for ceramide kinase inhibitors based on cell growth inhibition by short-chain ceramides

(2008) Christine Graf et al.   ANALYTICAL BIOCHEMISTRY

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Development of a Small-Molecule Serum- and Glucocorticoid-Regulated Kinase-1 Antagonist and Its Evaluation as a Prostate Cancer Therapeutic

(2008) A. B. Sherk et al.   CANCER RESEARCH

Long-chain Ceramide Is a Potent Inhibitor of the Mitochondrial Permeability Transition Pore

(2008) Sergei A. Novgorodov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Chain length specificity for activation of cPLA2α by C1P: use of the dodecane delivery system to determine lipid-specific effects

(2008) Dayanjan S. Wijesinghe et al.   JOURNAL OF LIPID RESEARCH

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis

(2008) Volker Teichgräber et al.   NATURE MEDICINE

Fenretinide Corrects Newly Found Ceramide Deficiency in Cystic Fibrosis

(2007) Claudine Guilbault et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY