Switching substitution groups on the in-tether chiral centre influences backbone peptides’ permeability and target binding affinity

An In-tether Chiral Center Modulates the Helicity, Cell Permeability, and Target Binding Affinity of a Peptide

(2016) Kuan Hu et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Stapled Peptides with γ-Methylated Hydrocarbon Chains for the Estrogen Receptor/Coactivator Interaction

(2016) Thomas E. Speltz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Crosslinked Aspartic Acids as Helix-Nucleating Templates

(2016) Hui Zhao et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

An in-tether sulfilimine chiral center induces helicity in short peptides

(2016) Huacan Lin et al.   CHEMICAL COMMUNICATIONS

A proline-derived transannular N-cap for nucleation of short α-helical peptides

(2016) Yuan Tian et al.   CHEMICAL COMMUNICATIONS

Stapling of unprotected helical peptides via photo-induced intramolecular thiol–yne hydrothiolation

(2016) Yuan Tian et al.   Chemical Science

A Thiol-Ene Coupling Approach to Native Peptide Stapling and Macrocyclization

(2015) Yuanxiang Wang et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Peptide stapling techniques based on different macrocyclisation chemistries

(2015) Yu Heng Lau et al.   CHEMICAL SOCIETY REVIEWS

Comparative α-Helicity of Cyclic Pentapeptides in Water

(2014) Aline D. de Araujo et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Controlling leucine-zipper partner recognition in cells through modification of a–g interactions

(2014) Yusuke Azuma et al.   CHEMICAL COMMUNICATIONS

Robust asymmetric synthesis of unnatural alkenyl amino acids for conformationally constrained α-helix peptides

(2014) Boris Aillard et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Functionalised staple linkages for modulating the cellular activity of stapled peptides

(2014) Yu Heng Lau et al.   Chemical Science

Stapled α−helical peptide drug development: A potent dual inhibitor of MDM2 and MDMX for p53-dependent cancer therapy

(2013) Yong S. Chang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction

(2012) Hyunil Jo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

(2011) Steven A. Kawamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the Stapled p53 Peptide Bound to Mdm2

(2011) Sohee Baek et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Structure of Stapled Peptides Binding to Estrogen Receptors

(2011) Chris Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Targeting protein–protein interactions for therapeutic intervention: a challenge for the future

(2010) Giovanna Zinzalla et al.   Future Medicinal Chemistry

Introduction of All-Hydrocarboni,i+3 Staples into α-Helices via Ring-Closing Olefin Metathesis

(2010) Young-Woo Kim et al.   ORGANIC LETTERS

Synthesis and Conformational Analysis of a Cyclic Peptide Obtained viaitoi+4 Intramolecular Side-Chain to Side-Chain Azide−Alkyne 1,3-Dipolar Cycloaddition

(2008) Sonia Cantel et al.   JOURNAL OF ORGANIC CHEMISTRY