4.7 Article

Controlling leucine-zipper partner recognition in cells through modification of a-g interactions

Journal

CHEMICAL COMMUNICATIONS
Volume 50, Issue 48, Pages 6364-6367

Publisher

ROYAL SOC CHEMISTRY
DOI: 10.1039/c4cc00555d

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Funding

  1. Ministry of Education, Culture, Sports, Science and Technology of Japan
  2. German Research Foundation (DFG) [Ar373/1-3]
  3. Grants-in-Aid for Scientific Research [25560401, 25293219, 22114003, 221S0001] Funding Source: KAKEN

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By focusing on the a-g interactions, successful design and selection were accomplished to obtain a leucine-zipper segment that discriminates the appropriate partner over another that provides very similar patterns of electrostatic interactions.

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