Targeting protein–protein interactions for therapeutic intervention: a challenge for the future

A Hydrogen Bond Surrogate Approach for Stabilization of Short Peptide Sequences in α-Helical Conformation

(2008) Anupam Patgiri et al.   ACCOUNTS OF CHEMICAL RESEARCH

Design and Applications of Bifunctional Small Molecules: Why Two Heads Are Better Than One

(2008) Timothy W. Corson et al.   ACS Chemical Biology

Natural Products as a Robust Source of New Drugs and Drug Leads: Past Successes and Present Day Issues

(2008) Gilbert M. Rishton   AMERICAN JOURNAL OF CARDIOLOGY

Monitoring Ligand Modulation of Protein−Protein Interactions by Mass Spectrometry: Estrogen Receptor α-SRC1

(2008) Cédric Bovet et al.   ANALYTICAL CHEMISTRY

Synthesis of Natural-Product-Like Molecules with Over Eighty Distinct Scaffolds

(2008) Daniel Morton et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Single-bead, Single-molecule, Single-cell Fluorescence

(2008) Martin Hintersteiner et al.   Annals of the New York Academy of Sciences

Computationally Designed Peptide Inhibitors of Protein−Protein Interactions in Membranes†

(2008) Gregory A. Caputo et al.   BIOCHEMISTRY

Sidechain-linked inhibitors of HIV-1 protease dimerization

(2008) Michael J. Bowman et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Allosteric inhibitors of Akt1 and Akt2: Discovery of [1,2,4]triazolo[3,4-f][1,6]naphthyridines with potent and balanced activity

(2008) Yiwei Li et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Efficacy, pharmacokinetics, tisssue distribution, and metabolism of the Myc–Max disruptor, 10058-F4 [Z,E]-5-[4-ethylbenzylidine]-2-thioxothiazolidin-4-one, in mice

(2008) Jianxia Guo et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Bcl-2 inhibitors: small molecules with a big impact on cancer therapy

(2008) M Vogler et al.   CELL DEATH AND DIFFERENTIATION

The magic of the hypoxia-signaling cascade

(2008) E. Benizri et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Wnt and beyond Wnt: Multiple mechanisms control the transcriptional property of β-catenin

(2008) Tianru Jin et al.   CELLULAR SIGNALLING

Exploiting domino enyne metathesis mechanisms for skeletal diversity generation

(2008) Richard J. Spandl et al.   CHEMICAL COMMUNICATIONS

Principles of Protein−Protein Interactions: What are the Preferred Ways For Proteins To Interact?

(2008) Ozlem Keskin et al.   CHEMICAL REVIEWS

Structural Rationale for the Coupled Binding and Unfolding of the c-Myc Oncoprotein by Small Molecules

(2008) Ariele Viacava Follis et al.   CHEMISTRY & BIOLOGY

Natural-Product-Like Spiroketals and Fused Bicyclic Acetals as Potential Therapeutic Agents for B-Cell Chronic Lymphocytic Leukaemia

(2008) Lech-Gustav Milroy et al.   ChemMedChem

Fluorescent biosensors of protein function

(2008) Schuyler B VanEngelenburg et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Peptidomimetics, a synthetic tool of drug discovery

(2008) Josef Vagner et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Small molecular weight protein–protein interaction antagonists—an insurmountable challenge?

(2008) Alexander Dömling   CURRENT OPINION IN CHEMICAL BIOLOGY

The impact of natural products upon modern drug discovery

(2008) A Ganesan   CURRENT OPINION IN CHEMICAL BIOLOGY

Role of Stat3 in suppressing anti-tumor immunity

(2008) Marcin Kortylewski et al.   CURRENT OPINION IN IMMUNOLOGY

The application of FAST-NMR for the identification of novel drug discovery targets

(2008) R POWERS et al.   DRUG DISCOVERY TODAY

Protein networks in disease

(2008) T. Ideker et al.   GENOME RESEARCH

Non-peptidic small molecule inhibitors against Bcl-2 for cancer therapy

(2008) Asfar S. Azmi et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Automated clustering of probe molecules from solvent mapping of protein surfaces: new algorithms applied to hot-spot mapping and structure-based drug design

(2008) Michael G. Lerner et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Strongylophorines: Natural Product Inhibitors of Hypoxia-Inducible Factor-1 Transcriptional Pathway

(2008) Kaleem A. Mohammed et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of an Orally Bioavailable Small Molecule Inhibitor of Prosurvival B-Cell Lymphoma 2 Proteins

(2008) Cheol-Min Park et al.   JOURNAL OF MEDICINAL CHEMISTRY

Natural Products as Leads to Potential Drugs: An Old Process or the New Hope for Drug Discovery?

(2008) David J. Newman   JOURNAL OF MEDICINAL CHEMISTRY

A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor

(2008) Hongtao Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Allostery: Absence of a Change in Shape Does Not Imply that Allostery Is Not at Play

(2008) Chung-Jung Tsai et al.   JOURNAL OF MOLECULAR BIOLOGY

Atomic Structure of a Short α-Helix Stabilized by a Main Chain Hydrogen-Bond Surrogate

(2008) Jie Liu et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Minimally Cationic Cell-Permeable Miniature Proteins via α-Helical Arginine Display

(2008) Betsy A. Smith et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Natural products as an inspiration in the diversity-oriented synthesis of bioactive compound libraries

(2008) Christopher Cordier et al.   NATURAL PRODUCT REPORTS

Allosteric regulation and catalysis emerge via a common route

(2008) Nina M Goodey et al.   Nature Chemical Biology

Displacement of protein-bound aptamers with small molecules screened by fluorescence polarization

(2008) Markus Hafner et al.   Nature Protocols

BCL-2 family antagonists for cancer therapy

(2008) Guillaume Lessene et al.   NATURE REVIEWS DRUG DISCOVERY

Drug development from marine natural products

(2008) Tadeusz F. Molinski et al.   NATURE REVIEWS DRUG DISCOVERY

Core Binding Factor Acute Myeloid Leukemia

(2008) Peter Paschka   SEMINARS IN ONCOLOGY

Initial testing (stage 1) of the BH3 mimetic ABT-263 by the pediatric preclinical testing program

(2007) Richard Lock et al.   PEDIATRIC BLOOD & CANCER