Comparative α-Helicity of Cyclic Pentapeptides in Water

Monosubstituted alkenyl amino acids for peptide “stapling”

(2013) David J. Yeo et al.   CHEMICAL COMMUNICATIONS

New modalities in conformationally constrained peptides for potency, selectivity and cell permeation

(2013) Ram Dharanipragada   Future Medicinal Chemistry

A Perfluoroaryl-Cysteine SNAr Chemistry Approach to Unprotected Peptide Stapling

(2013) Alexander M. Spokoyny et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Inhibition of α-helix-mediated protein–protein interactions using designed molecules

(2013) Valeria Azzarito et al.   Nature Chemistry

Truncated and Helix-Constrained Peptides with High Affinity and Specificity for the cFos Coiled-Coil of AP-1

(2013) Tara Rao et al.   PLoS One

Direct activation of full-length proapoptotic BAK

(2013) Elizaveta S. Leshchiner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Development of α-Helical Calpain Probes by Mimicking a Natural Protein–Protein Interaction

(2012) Hyunil Jo et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Helix stabilization of amphipathic peptides by hydrocarbon stapling increases cholesterol efflux by the ABCA1 transporter

(2011) D.O. Sviridov et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Stabilized helical peptides: overview of the technologies and therapeutic promises

(2011) Karine Estieu-Gionnet et al.   Expert Opinion on Drug Discovery

Design of Triazole-Stapled BCL9 α-Helical Peptides to Target the β-Catenin/B-Cell CLL/lymphoma 9 (BCL9) Protein–Protein Interaction

(2011) Steven A. Kawamoto et al.   JOURNAL OF MEDICINAL CHEMISTRY

Assessing Helical Protein Interfaces for Inhibitor Design

(2011) Brooke N. Bullock et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Design and Structure of Stapled Peptides Binding to Estrogen Receptors

(2011) Chris Phillips et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Stapled peptides in the p53 pathway: Computer simulations reveal novel interactions of the staples with the target protein

(2010) Thomas Leonard Joseph et al.   CELL CYCLE

Novel Helix-Constrained Nociceptin Derivatives Are Potent Agonists and Antagonists of ERK Phosphorylation and Thermal Analgesia in Mice

(2010) Rosemary S. Harrison et al.   JOURNAL OF MEDICINAL CHEMISTRY

Development of Potent Glucagon-like Peptide-1 Agonists with High Enzyme Stability via Introduction of Multiple Lactam Bridges

(2010) Eunice N. Murage et al.   JOURNAL OF MEDICINAL CHEMISTRY

The MCL-1 BH3 helix is an exclusive MCL-1 inhibitor and apoptosis sensitizer

(2010) Michelle L Stewart et al.   Nature Chemical Biology

Downsizing human, bacterial, and viral proteins to short water-stable alpha helices that maintain biological potency

(2010) R. S. Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stereochemical effects of all-hydrocarbon tethers in i,i+4 stapled peptides

(2009) Young-Woo Kim et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

From Peptides to Non-Peptide Alpha-Helix Inducers and Mimetics

(2009) V. Haridas   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

CuI-Catalyzed Azide–Alkyne Intramoleculari-to-(i+4) Side-Chain-to-Side-Chain Cyclization Promotes the Formation of Helix-Like Secondary Structures

(2009) Mario Scrima et al.   EUROPEAN JOURNAL OF ORGANIC CHEMISTRY

Left- and Right-Handed Alpha-Helical Turns in Homo- and Hetero-Chiral Helical Scaffolds

(2009) Nicholas E. Shepherd et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Direct inhibition of the NOTCH transcription factor complex

(2009) Raymond E. Moellering et al.   NATURE

A Hydrogen Bond Surrogate Approach for Stabilization of Short Peptide Sequences in α-Helical Conformation

(2008) Anupam Patgiri et al.   ACCOUNTS OF CHEMICAL RESEARCH

Contemporary strategies for the stabilization of peptides in the α-helical conformation

(2008) Laura K Henchey et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

A Cell-penetrating Helical Peptide as a Potential HIV-1 Inhibitor

(2008) Hongtao Zhang et al.   JOURNAL OF MOLECULAR BIOLOGY

Synthesis and Conformational Analysis of a Cyclic Peptide Obtained viaitoi+4 Intramolecular Side-Chain to Side-Chain Azide−Alkyne 1,3-Dipolar Cycloaddition

(2008) Sonia Cantel et al.   JOURNAL OF ORGANIC CHEMISTRY

BAX activation is initiated at a novel interaction site

(2008) Evripidis Gavathiotis et al.   NATURE