Playing polo during mitosis: PLK1 takes the lead

Bistability of mitotic entry and exit switches during open mitosis in mammalian cells

(2016) Nadia Hégarat et al.   BIOESSAYS

The hairpin region of Ndc80 is important for the kinetochore recruitment of Mph1/MPS1 in fission yeast

(2016) Aldona Ewa Chmielewska et al.   CELL CYCLE

Attachment issues: kinetochore transformations and spindle checkpoint silencing

(2016) Banafsheh Etemad et al.   CURRENT OPINION IN CELL BIOLOGY

ARHGEF17 is an essential spindle assembly checkpoint factor that targets Mps1 to kinetochores

(2016) Mayumi Isokane et al.   JOURNAL OF CELL BIOLOGY

A noncatalytic function of the topoisomerase II CTD in Aurora B recruitment to inner centromeres during mitosis

(2016) Heather Edgerton et al.   JOURNAL OF CELL BIOLOGY

SUMOylation of DNA topoisomerase IIα regulates histone H3 kinase Haspin and H3 phosphorylation in mitosis

(2016) Makoto M. Yoshida et al.   JOURNAL OF CELL BIOLOGY

A Conserved Motif Provides Binding Specificity to the PP2A-B56 Phosphatase

(2016) Emil Peter Thrane Hertz et al.   MOLECULAR CELL

Decoding Polo-like kinase 1 signaling along the kinetochore–centromere axis

(2016) Robert F Lera et al.   Nature Chemical Biology

The Bub1–Plk1 kinase complex promotes spindle checkpoint signalling through Cdc20 phosphorylation

(2016) Luying Jia et al.   Nature Communications

The Molecular Biology of Spindle Assembly Checkpoint Signaling Dynamics

(2015) Andrea Musacchio   CURRENT BIOLOGY

The ABBA Motif Binds APC/C Activators and Is Shared by APC/C Substrates and Regulators

(2015) Barbara Di Fiore et al.   DEVELOPMENTAL CELL

Sequential Multisite Phospho-Regulation of KNL1-BUB3 Interfaces at Mitotic Kinetochores

(2015) Mathijs Vleugel et al.   MOLECULAR CELL

Understanding the Polo Kinase machine

(2015) V Archambault et al.   ONCOGENE

Competition between MPS1 and microtubules at kinetochores regulates spindle checkpoint signaling

(2015) Y. Hiruma et al.   SCIENCE

Kinetochore attachment sensed by competitive Mps1 and microtubule binding to Ndc80C

(2015) Z. Ji et al.   SCIENCE

Bub1 autophosphorylation feeds back to regulate kinetochore docking and promote localized substrate phosphorylation

(2015) Adeel Asghar et al.   Nature Communications

Distinct domains in Bub1 localize RZZ and BubR1 to kinetochores to regulate the checkpoint

(2015) Gang Zhang et al.   Nature Communications

Natural Loss of Mps1 Kinase in Nematodes Uncovers a Role for Polo-like Kinase 1 in Spindle Checkpoint Initiation

(2015) Julien Espeut et al.   Cell Reports

Plk1 and Mps1 Cooperatively Regulate the Spindle Assembly Checkpoint in Human Cells

(2015) Conrad von Schubert et al.   Cell Reports

A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

(2015) Katharina Overlack et al.   eLife

Requirement for PLK1 kinase activity in the maintenance of a robust spindle assembly checkpoint

(2015) Aisling O'Connor et al.   Biology Open

Cross-Talk between AURKA and Plk1 in Mitotic Entry and Spindle Assembly

(2015) Italia Anna Asteriti et al.   Frontiers in Oncology

The Aurora B Kinase in Chromosome Bi-Orientation and Spindle Checkpoint Signaling

(2015) Veronica Krenn et al.   Frontiers in Oncology

Acetyl-lysine Binding Site of Bromodomain-Containing Protein 4 (BRD4) Interacts with Diverse Kinase Inhibitors

(2014) Stuart W. J. Ember et al.   ACS Chemical Biology

Plk1 puts a (Has)pin on the mitotic histone code

(2014) T. Moutinho-Santos et al.   EMBO REPORTS

The Cdc20-binding Phe Box of the Spindle Checkpoint Protein BubR1 Maintains the Mitotic Checkpoint Complex During Mitosis

(2014) Laura A. Diaz-Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

PP2A-B56 opposes Mps1 phosphorylation of Knl1 and thereby promotes spindle assembly checkpoint silencing

(2014) Antonio Espert et al.   JOURNAL OF CELL BIOLOGY

Kinetochore genes are coordinately up-regulated in human tumors as part of a FoxM1-related cell division program

(2014) Prathapan Thiru et al.   MOLECULAR BIOLOGY OF THE CELL

Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1

(2014) Monika Raab et al.   Molecular Oncology

A PP1–PP2A phosphatase relay controls mitotic progression

(2014) Agnes Grallert et al.   NATURE

Negative feedback at kinetochores underlies a responsive spindle checkpoint signal

(2014) Wilco Nijenhuis et al.   NATURE CELL BIOLOGY

Dual kinase-bromodomain inhibitors for rationally designed polypharmacology

(2014) Pietro Ciceri et al.   Nature Chemical Biology

Polo-like kinases: structural variations lead to multiple functions

(2014) Sihem Zitouni et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

PhosphoSitePlus, 2014: mutations, PTMs and recalibrations

(2014) Peter V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

Dynamic Autophosphorylation of Mps1 Kinase Is Required for Faithful Mitotic Progression

(2014) Xinghui Wang et al.   PLoS One

Regulation of Centromere Localization of the Drosophila Shugoshin MEI-S332 and Sister-Chromatid Cohesion in Meiosis

(2014) Cristina Nogueira et al.   G3-Genes Genomes Genetics

Polo kinase regulates the localization and activity of the chromosomal passenger complex in meiosis and mitosis in Drosophila melanogaster

(2014) M. Carmena et al.   Open Biology

Cell division: control of the chromosomal passenger complex in time and space

(2013) Armando van der Horst et al.   CHROMOSOMA

KI Motifs of Human Knl1 Enhance Assembly of Comprehensive Spindle Checkpoint Complexes around MELT Repeats

(2013) Veronica Krenn et al.   CURRENT BIOLOGY

Drosophila Polo regulates the spindle assembly checkpoint through Mps1-dependent BubR1 phosphorylation

(2013) Carlos Conde et al.   EMBO JOURNAL

A minimal number of MELT repeats supports all the functions of KNL1 in chromosome segregation

(2013) Gang Zhang et al.   JOURNAL OF CELL SCIENCE

Direct binding between BubR1 and B56-PP2A phosphatase complexes regulate mitotic progression

(2013) T. Kruse et al.   JOURNAL OF CELL SCIENCE

Universal Quantitative Kinase Assay Based on Diagonal SCX Chromatography and Stable Isotope Dimethyl Labeling Provides High-definition Kinase Consensus Motifs for PKA and Human Mps1

(2013) Marco L. Hennrich et al.   JOURNAL OF PROTEOME RESEARCH

Autoinhibition and Polo-Dependent Multisite Phosphorylation Restrict Activity of the Histone H3 Kinase Haspin to Mitosis

(2013) Cristina Ghenoiu et al.   MOLECULAR CELL

Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

(2013) Ivana Primorac et al.   eLife

BUBR1 recruits PP2A via the B56 family of targeting subunits to promote chromosome congression

(2013) P. Xu et al.   Biology Open

Enabling and Disabling Polo-like Kinase 1 Inhibition through Chemical Genetics

(2012) Mark E. Burkard et al.   ACS Chemical Biology

Phosphodependent Recruitment of Bub1 and Bub3 to Spc7/KNL1 by Mph1 Kinase Maintains the Spindle Checkpoint

(2012) Lindsey A. Shepperd et al.   CURRENT BIOLOGY

Phosphoregulation of Spc105 by Mps1 and PP1 Regulates Bub1 Localization to Kinetochores

(2012) Nitobe London et al.   CURRENT BIOLOGY

Evolution and Function of the Mitotic Checkpoint

(2012) Mathijs Vleugel et al.   DEVELOPMENTAL CELL

The Vertebrate Mitotic Checkpoint Protein BUBR1 Is an Unusual Pseudokinase

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Integration of Kinase and Phosphatase Activities by BUBR1 Ensures Formation of Stable Kinetochore-Microtubule Attachments

(2012) Saskia J.E. Suijkerbuijk et al.   DEVELOPMENTAL CELL

Polo-like kinase-1 regulates kinetochore–microtubule dynamics and spindle checkpoint silencing

(2012) Dan Liu et al.   JOURNAL OF CELL BIOLOGY

POLO ensures chromosome bi-orientation by preventing and correcting erroneous chromosome-spindle attachments

(2012) T. Moutinho-Santos et al.   JOURNAL OF CELL SCIENCE

Phosphorylation network dynamics in the control of cell cycle transitions

(2012) D. Fisher et al.   JOURNAL OF CELL SCIENCE

MPS1/Mph1 phosphorylates the kinetochore protein KNL1/Spc7 to recruit SAC components

(2012) Yuya Yamagishi et al.   NATURE CELL BIOLOGY

The chromosomal passenger complex (CPC): from easy rider to the godfather of mitosis

(2012) Mar Carmena et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Chromosomal Passenger Complex Activates Polo Kinase at Centromeres

(2012) Mar Carmena et al.   PLOS BIOLOGY

From Plk1 to Plk5

(2011) Guillermo de Cárcer et al.   CELL CYCLE

Plk1 Controls the Nek2A-PP1γ Antagonism in Centrosome Disjunction

(2011) Balca R. Mardin et al.   CURRENT BIOLOGY

Feedback Control in Sensing Chromosome Biorientation by the Aurora B Kinase

(2011) Kevan J. Salimian et al.   CURRENT BIOLOGY

A Positive Feedback Loop Involving Haspin and Aurora B Promotes CPC Accumulation at Centromeres in Mitosis

(2011) Fangwei Wang et al.   CURRENT BIOLOGY

PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis

(2011) Kwanwoo Lee et al.   JOURNAL OF CELL BIOLOGY

Combination of Chemical Genetics and Phosphoproteomics for Kinase Signaling Analysis Enables Confident Identification of Cellular Downstream Targets

(2011) Felix S. Oppermann et al.   MOLECULAR & CELLULAR PROTEOMICS

Bub1 and BubR1: at the Interface between Chromosome Attachment and the Spindle Checkpoint

(2011) S. Elowe   MOLECULAR AND CELLULAR BIOLOGY

Formation of stable attachments between kinetochores and microtubules depends on the B56-PP2A phosphatase

(2011) Emily A. Foley et al.   NATURE CELL BIOLOGY

Quantitative Mass Spectrometry Analysis Reveals Similar Substrate Consensus Motif for Human Mps1 Kinase and Plk1

(2011) Zhen Dou et al.   PLoS One

Quantitative Phosphoproteomics Identifies Substrates and Functional Modules of Aurora and Polo-Like Kinase Activities in Mitotic Cells

(2011) A. N. Kettenbach et al.   Science Signaling

Molecular Causes for BUBR1 Dysfunction in the Human Cancer Predisposition Syndrome Mosaic Variegated Aneuploidy

(2010) Saskia J.E. Suijkerbuijk et al.   CANCER RESEARCH

Regulated protein kinases and phosphatases in cell cycle decisions

(2010) Bela Novak et al.   CURRENT OPINION IN CELL BIOLOGY

Liaisons between Survivin and Plk1 during Cell Division and Cell Death

(2010) Rita Colnaghi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mps1 directs the assembly of Cdc20 inhibitory complexes during interphase and mitosis to control M phase timing and spindle checkpoint signaling

(2010) John Maciejowski et al.   JOURNAL OF CELL BIOLOGY

Release of Mps1 from kinetochores is crucial for timely anaphase onset

(2010) Nannette Jelluma et al.   JOURNAL OF CELL BIOLOGY

Dissecting the role of MPS1 in chromosome biorientation and the spindle checkpoint through the small molecule inhibitor reversine

(2010) Stefano Santaguida et al.   JOURNAL OF CELL BIOLOGY

Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1–C-Mad2 core complex

(2010) Laura Hewitt et al.   JOURNAL OF CELL BIOLOGY

The Plk1-dependent Phosphoproteome of the Early Mitotic Spindle

(2010) Anna Santamaria et al.   MOLECULAR & CELLULAR PROTEOMICS

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Two Histone Marks Establish the Inner Centromere and Chromosome Bi-Orientation

(2010) Yuya Yamagishi et al.   SCIENCE

Histone H3 Thr-3 Phosphorylation by Haspin Positions Aurora B at Centromeres in Mitosis

(2010) Fangwei Wang et al.   SCIENCE

Aurora B kinase activation requires survivin priming phosphorylation by PLK1

(2010) Youjun Chu et al.   Journal of Molecular Cell Biology

Haspin: a newly discovered regulator of mitotic chromosome behavior

(2009) Jonathan M. G. Higgins   CHROMOSOMA

BubR1 N Terminus Acts as a Soluble Inhibitor of Cyclin B Degradation by APC/CCdc20 in Interphase

(2009) Liviu A. Malureanu et al.   DEVELOPMENTAL CELL

Intrakinetochore localization and essential functional domains of Drosophila Spc105

(2009) Ralf B Schittenhelm et al.   EMBO JOURNAL

Bub1 regulates chromosome segregation in a kinetochore-independent manner

(2009) Christiane Klebig et al.   JOURNAL OF CELL BIOLOGY

Uncoupling of the spindle-checkpoint and chromosome-congression functions of BubR1

(2009) S. Elowe et al.   JOURNAL OF CELL SCIENCE

Studies of haspin-depleted cells reveal that spindle-pole integrity in mitosis requires chromosome cohesion

(2009) J. Dai et al.   JOURNAL OF CELL SCIENCE

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal structure of the catalytic domain of Haspin, an atypical kinase implicated in chromatin organization

(2009) F. Villa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure and functional characterization of the atypical human kinase haspin

(2009) J. Eswaran et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mps1 Phosphorylates Borealin to Control Aurora B Activity and Chromosome Alignment

(2008) Nannette Jelluma et al.   CELL

Polo on the Rise—from Mitotic Entry to Cytokinesis with Plk1

(2008) Mark Petronczki et al.   DEVELOPMENTAL CELL

Sequestration of Polo kinase to microtubules by phosphopriming-independent binding to Map205 is relieved by phosphorylation at a CDK site in mitosis

(2008) V. Archambault et al.   GENES & DEVELOPMENT

Phosphorylation sites in BubR1 that regulate kinetochore attachment, tension, and mitotic exit

(2008) Haomin Huang et al.   JOURNAL OF CELL BIOLOGY

Regulation of Kinetochore Recruitment of Two Essential Mitotic Spindle Checkpoint Proteins by Mps1 Phosphorylation

(2008) Quanbin Xu et al.   MOLECULAR BIOLOGY OF THE CELL

Structure and Substrate Recruitment of the Human Spindle Checkpoint Kinase Bub1

(2008) Jungseog Kang et al.   MOLECULAR CELL

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

(2008) Zheng Fu et al.   NATURE CELL BIOLOGY

Chromosomal Instability by Inefficient Mps1 Auto-Activation Due to a Weakened Mitotic Checkpoint and Lagging Chromosomes

(2008) Nannette Jelluma et al.   PLoS One

Bora and the Kinase Aurora A Cooperatively Activate the Kinase Plk1 and Control Mitotic Entry

(2008) A. Seki et al.   SCIENCE