Bistability of mitotic entry and exit switches during open mitosis in mammalian cells

Nutritional Control of Cell Size by the Greatwall-Endosulfine-PP2A·B55 Pathway

(2016) Nathalia Chica et al.   CURRENT BIOLOGY

PP1 initiates the dephosphorylation of MASTL, triggering mitotic exit and bistability in human cells

(2016) Samuel Rogers et al.   JOURNAL OF CELL SCIENCE

Greatwall dephosphorylation and inactivation upon mitotic exit is triggered by PP1

(2016) Sheng Ma et al.   JOURNAL OF CELL SCIENCE

Protein phosphatase 1 is essential for Greatwall inactivation at mitotic exit

(2015) A. Heim et al.   EMBO REPORTS

The selective inhibition of protein phosphatase-1 results in mitotic catastrophe and impaired tumor growth

(2015) C. Winkler et al.   JOURNAL OF CELL SCIENCE

Global Phosphoproteomic Mapping of Early Mitotic Exit in Human Cells Identifies Novel Substrate Dephosphorylation Motifs

(2015) Rachael A. McCloy et al.   MOLECULAR & CELLULAR PROTEOMICS

TORC1 controls G1–S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway

(2015) Marta Moreno-Torres et al.   Nature Communications

The lethal response to Cdk1 inhibition depends on sister chromatid alignment errors generated by KIF4 and isoform 1 of PRC1

(2015) Erik Voets et al.   Scientific Reports

Fcp1 phosphatase controls Greatwall kinase to promote PP2A-B55 activation and mitotic progression

(2015) Rosa Della Monica et al.   eLife

Preparing a cell for nuclear envelope breakdown: Spatio-temporal control of phosphorylation during mitotic entry

(2014) Mónica Álvarez-Fernández et al.   BIOESSAYS

Cyclin B–Cdk1 inhibits protein phosphatase PP2A-B55 via a Greatwall kinase–independent mechanism

(2014) Eiichi Okumura et al.   JOURNAL OF CELL BIOLOGY

Assessing Kinetics from Fixed Cells Reveals Activation of the Mitotic Entry Network at the S/G2 Transition

(2014) Karen Akopyan et al.   MOLECULAR CELL

A PP1–PP2A phosphatase relay controls mitotic progression

(2014) Agnes Grallert et al.   NATURE

Ultradeep Human Phosphoproteome Reveals a Distinct Regulatory Nature of Tyr and Ser/Thr-Based Signaling

(2014) Kirti Sharma et al.   Cell Reports

Changes in Oscillatory Dynamics in the Cell Cycle of Early Xenopus laevis Embryos

(2014) Tony Y.-C. Tsai et al.   PLOS BIOLOGY

PP2A/B55 and Fcp1 Regulate Greatwall and Ensa Dephosphorylation during Mitotic Exit

(2014) Nadia Hégarat et al.   PLoS Genetics

The Rim15-Endosulfine-PP2ACdc55 Signalling Module Regulates Entry into Gametogenesis and Quiescence via Distinct Mechanisms in Budding Yeast

(2014) Sourav Sarkar et al.   PLoS Genetics

Greatwall-phosphorylated Endosulfine is both an inhibitor and a substrate of PP2A-B55 heterotrimers

(2014) Byron C Williams et al.   eLife

Structural characterization of the cyclin-dependent protein kinase family

(2013) Jane A. Endicott et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Breaking down the wall: the nuclear envelope during mitosis

(2013) Christine J Smoyer et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of α-endosulfine, an inhibitor of protein phosphatase 2A, by multisite phosphorylation

(2013) Satoru Mochida   FEBS Journal

Chemical genetic analyses of quantitative changes in Cdk1 activity during the human cell cycle

(2013) Polly Gravells et al.   HUMAN MOLECULAR GENETICS

Loss of centrioles causes chromosomal instability in vertebrate somatic cells

(2013) Joo-Hee Sir et al.   JOURNAL OF CELL BIOLOGY

Panta rhei: The APC/C at steady state

(2013) Ivana Primorac et al.   JOURNAL OF CELL BIOLOGY

The BEG (PP2A-B55/ENSA/Greatwall) Pathway Ensures Cytokinesis follows Chromosome Separation

(2013) Michael J. Cundell et al.   MOLECULAR CELL

Mitotic trigger waves and the spatial coordination of the Xenopus cell cycle

(2013) Jeremy B. Chang et al.   NATURE

Greatwall is essential to prevent mitotic collapse after nuclear envelope breakdown in mammals

(2013) M. Alvarez-Fernandez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Robust mitotic entry is ensured by a latching switch

(2013) Chloe Tuck et al.   Biology Open

Spatial Positive Feedback at the Onset of Mitosis

(2012) Silvia D.M. Santos et al.   CELL

Protein phosphatases and their regulation in the control of mitosis

(2012) Satoru Mochida et al.   EMBO REPORTS

Determinants for Activation of the Atypical AGC Kinase Greatwall during M Phase Entry

(2012) K. A. Blake-Hodek et al.   MOLECULAR AND CELLULAR BIOLOGY

The CDK1 inhibitory kinase MYT1 in DNA damage checkpoint recovery

(2012) J P H Chow et al.   ONCOGENE

Fcp1-dependent dephosphorylation is required for M-phase-promoting factor inactivation at mitosis exit

(2012) Roberta Visconti et al.   Nature Communications

Spindle Checkpoint Silencing: PP1 Tips the Balance

(2011) Bart Lesage et al.   CURRENT BIOLOGY

Protein phosphatases and the regulation of mitosis

(2011) F. A. Barr et al.   JOURNAL OF CELL SCIENCE

Characterization of the Mechanisms Controlling Greatwall Activity

(2011) S. Vigneron et al.   MOLECULAR AND CELLULAR BIOLOGY

Mitotic progression becomes irreversible in prometaphase and collapses when Wee1 and Cdc25 are inhibited

(2011) Tamara A. Potapova et al.   MOLECULAR BIOLOGY OF THE CELL

Switches and latches: a biochemical tug-of-war between the kinases and phosphatases that control mitosis

(2011) M. R. Domingo-Sananes et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Cdc14b regulates mammalian RNA polymerase II and represses cell cycle transcription

(2011) María Guillamot et al.   Scientific Reports

Targeting Mitotic Exit Leads to Tumor Regression In Vivo: Modulation by Cdk1, Mastl, and the PP2A/B55α,δ Phosphatase

(2010) Eusebio Manchado et al.   CANCER CELL

MASTL is the human ortholog of Greatwall kinase that facilitates mitotic entry, anaphase and cytokinesis

(2010) Erik Voets et al.   CELL CYCLE

Mitosis in vertebrates: the G2/M and M/A transitions and their associated checkpoints

(2010) Conly L. Rieder   CHROMOSOME RESEARCH

Progressive Activation of CyclinB1-Cdk1 Coordinates Entry to Mitosis

(2010) Olivier Gavet et al.   DEVELOPMENTAL CELL

Activation of cyclin B1–Cdk1 synchronizes events in the nucleus and the cytoplasm at mitosis

(2010) Olivier Gavet et al.   JOURNAL OF CELL BIOLOGY

Vertebrate cells genetically deficient for Cdc14A or Cdc14B retain DNA damage checkpoint proficiency but are impaired in DNA repair

(2010) Annamaria Mocciaro et al.   JOURNAL OF CELL BIOLOGY

Constant regulation of both the MPF amplification loop and the Greatwall-PP2A pathway is required for metaphase II arrest and correct entry into the first embryonic cell cycle

(2010) T. Lorca et al.   JOURNAL OF CELL SCIENCE

Phenotypic profiling of the human genome by time-lapse microscopy reveals cell division genes

(2010) Beate Neumann et al.   NATURE

Loss of human Greatwall results in G2 arrest and multiple mitotic defects due to deregulation of the cyclin B-Cdc2/PP2A balance

(2010) Andrew Burgess et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure, function and mechanism of the anaphase promoting complex (APC/C)

(2010) David Barford   QUARTERLY REVIEWS OF BIOPHYSICS

The Substrate of Greatwall Kinase, Arpp19, Controls Mitosis by Inhibiting Protein Phosphatase 2A

(2010) A. Gharbi-Ayachi et al.   SCIENCE

Greatwall Phosphorylates an Inhibitor of Protein Phosphatase 2A That Is Essential for Mitosis

(2010) S. Mochida et al.   SCIENCE

The extended PP1 toolkit: designed to create specificity

(2010) Mathieu Bollen et al.   TRENDS IN BIOCHEMICAL SCIENCES

Serine/Threonine Phosphatases: Mechanism through Structure

(2009) Yigong Shi   CELL

Greatwall maintains mitosis through regulation of PP2A

(2009) Suzanne Vigneron et al.   EMBO JOURNAL

Regulated activity of PP2A–B55δ is crucial for controlling entry into and exit from mitosis in Xenopus egg extracts

(2009) Satoru Mochida et al.   EMBO JOURNAL

The decision to enter mitosis: feedback and redundancy in the mitotic entry network

(2009) Arne Lindqvist et al.   JOURNAL OF CELL BIOLOGY

The M Phase Kinase Greatwall (Gwl) Promotes Inactivation of PP2A/B55δ, a Phosphatase Directed Against CDK Phosphosites

(2009) Priscila V. Castilho et al.   MOLECULAR BIOLOGY OF THE CELL

PP1-mediated dephosphorylation of phosphoproteins at mitotic exit is controlled by inhibitor-1 and PP1 phosphorylation

(2009) Judy Qiju Wu et al.   NATURE CELL BIOLOGY

Orchestrating nuclear envelope disassembly and reassembly during mitosis

(2009) Stephan Güttinger et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mitotic phosphatases: from entry guards to exit guides

(2009) Mathieu Bollen et al.   TRENDS IN CELL BIOLOGY

Roles of Greatwall Kinase in the Regulation of Cdc25 Phosphatase

(2008) Yong Zhao et al.   MOLECULAR BIOLOGY OF THE CELL

Rapid Cycling and Precocious Termination of G1 Phase in Cells Expressing CDK1AF

(2008) Joseph R. Pomerening et al.   MOLECULAR BIOLOGY OF THE CELL

A quantitative atlas of mitotic phosphorylation

(2008) N. Dephoure et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA