Mitotic arrest and slippage induced by pharmacological inhibition of Polo-like kinase 1

p53 deficiency enhances mitotic arrest and slippage induced by pharmacological inhibition of Aurora kinases

(2013) M Marxer et al.   ONCOGENE

Enabling and Disabling Polo-like Kinase 1 Inhibition through Chemical Genetics

(2012) Mark E. Burkard et al.   ACS Chemical Biology

Killing cells by targeting mitosis

(2012) E Manchado et al.   CELL DEATH AND DIFFERENTIATION

Polo-like kinases in AML

(2012) Tobias Berg et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Targeting FAK Radiosensitizes 3-Dimensional Grown Human HNSCC Cells Through Reduced Akt1 and MEK1/2 Signaling

(2012) Stephanie Hehlgans et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Cyclin-dependent Kinase-1 (Cdk1)/Cyclin B1 Dictates Cell Fate after Mitotic Arrest via Phosphoregulation of Antiapoptotic Bcl-2 Proteins

(2012) Nandini Sakurikar et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polo-Box Domain Inhibitor Poloxin Activates the Spindle Assembly Checkpoint and Inhibits Tumor Growth in Vivo

(2011) Juping Yuan et al.   AMERICAN JOURNAL OF PATHOLOGY

Sensitivity to antitubulin chemotherapeutics is regulated by MCL1 and FBW7

(2011) Ingrid E. Wertz et al.   NATURE

Serendipitous alkylation of a Plk1 ligand uncovers a new binding channel

(2011) Fa Liu et al.   Nature Chemical Biology

Toxicity modelling of Plk1-targeted therapies in genetically engineered mice and cultured primary mammalian cells

(2011) Monika Raab et al.   Nature Communications

Cdk1/Cyclin B1 Controls Fas-Mediated Apoptosis by Regulating Caspase-8 Activity

(2010) Y. Matthess et al.   MOLECULAR AND CELLULAR BIOLOGY

Multifaceted polo-like kinases: drug targets and antitargets for cancer therapy

(2010) Klaus Strebhardt   NATURE REVIEWS DRUG DISCOVERY

Aurora B kinase activation requires survivin priming phosphorylation by PLK1

(2010) Youjun Chu et al.   Journal of Molecular Cell Biology

BI 6727, A Polo-like Kinase Inhibitor with Improved Pharmacokinetic Profile and Broad Antitumor Activity

(2009) D. Rudolph et al.   CLINICAL CANCER RESEARCH

A Comparison of Labeling and Label-Free Mass Spectrometry-Based Proteomics Approaches

(2009) Vibhuti J. Patel et al.   JOURNAL OF PROTEOME RESEARCH

Cyclin-Dependent Kinase 1-Mediated Bcl-xL/Bcl-2 Phosphorylation Acts as a Functional Link Coupling Mitotic Arrest and Apoptosis

(2009) D. T. Terrano et al.   MOLECULAR AND CELLULAR BIOLOGY

Polo-like kinases: conservation and divergence in their functions and regulation

(2009) Vincent Archambault et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Polo-Like Kinase (PLK) Inhibitors in Preclinical and Early Clinical Development in Oncology

(2009) P. Schoffski   ONCOLOGIST

Caveolin-1 mediated radioresistance of 3D grown pancreatic cancer cells

(2009) Stephanie Hehlgans et al.   RADIOTHERAPY AND ONCOLOGY

A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1

(2008) Wolfgang Reindl et al.   ANALYTICAL BIOCHEMISTRY

Cancer Cells Display Profound Intra- and Interline Variation following Prolonged Exposure to Antimitotic Drugs

(2008) Karen E. Gascoigne et al.   CANCER CELL

Inhibition of Polo-like Kinase 1 by Blocking Polo-Box Domain-Dependent Protein-Protein Interactions

(2008) Wolfgang Reindl et al.   CHEMISTRY & BIOLOGY

Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression

(2008) Zheng Fu et al.   NATURE CELL BIOLOGY

Centromeric Aurora-B Activation Requires TD-60, Microtubules, and Substrate Priming Phosphorylation

(2008) S. E. Rosasco-Nitcher et al.   SCIENCE