Biomarkers of Epileptogenesis: The Focus on Glia and Cognitive Dysfunctions

Molecular isoforms of high-mobility group box 1 are mechanistic biomarkers for epilepsy

(2017) Lauren Elizabeth Walker et al.   JOURNAL OF CLINICAL INVESTIGATION

WONOEP appraisal: Imaging biomarkers in epilepsy

(2016) Erwin A. van Vliet et al.   EPILEPSIA

Transient and chronic seizure-induced inflammation in human focal epilepsy

(2016) Tracy Butler et al.   EPILEPSIA

The genetic absence epilepsy rat from Strasbourg as a model to decipher the neuronal and network mechanisms of generalized idiopathic epilepsies

(2016) Antoine Depaulis et al.   JOURNAL OF NEUROSCIENCE METHODS

Insight into Pre-Clinical Models of Traumatic Brain Injury Using Circulating Brain Damage Biomarkers: Operation Brain Trauma Therapy

(2016) Stefania Mondello et al.   JOURNAL OF NEUROTRAUMA

Serial Quantitative TSPO-Targeted PET Reveals Peak Microglial Activation up to 2 Weeks After an Epileptogenic Brain Insult

(2016) M. Brackhan et al.   JOURNAL OF NUCLEAR MEDICINE

Development of epilepsy after ischaemic stroke

(2016) Asla Pitkänen et al.   LANCET NEUROLOGY

MicroRNAs in epilepsy: pathophysiology and clinical utility

(2016) David C Henshall et al.   LANCET NEUROLOGY

Matrix Metalloproteinase 9 in Epilepsy: The Role of Neuroinflammation in Seizure Development

(2016) Elżbieta Bronisz et al.   MEDIATORS OF INFLAMMATION

Cognitive deficits and brain myo-Inositol are early biomarkers of epileptogenesis in a rat model of epilepsy

(2016) Rosaria Pascente et al.   NEUROBIOLOGY OF DISEASE

Subtle alterations in memory systems and normal visual attention in the GAERS model of absence epilepsy

(2016) J.E. Marques-Carneiro et al.   NEUROSCIENCE

Novel combinations of phenotypic biomarkers predict development of epilepsy in the lithium–pilocarpine model of temporal lobe epilepsy in rats

(2015) Sonja Bröer et al.   EPILEPSY & BEHAVIOR

Metabolic Changes in Early Poststatus Epilepticus Measured by MR Spectroscopy in Rats

(2015) Yijen Wu et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Reactive Astrogliosis Causes the Development of Spontaneous Seizures

(2015) S. Robel et al.   JOURNAL OF NEUROSCIENCE

An astrocyte-dependent mechanism for neuronal rhythmogenesis

(2015) Philippe Morquette et al.   NATURE NEUROSCIENCE

Albumin induces excitatory synaptogenesis through astrocytic TGF-β/ALK5 signaling in a model of acquired epilepsy following blood–brain barrier dysfunction

(2015) Itai Weissberg et al.   NEUROBIOLOGY OF DISEASE

Brain inflammation in a chronic epilepsy model: Evolving pattern of the translocator protein during epileptogenesis

(2015) Halima Amhaoul et al.   NEUROBIOLOGY OF DISEASE

Minocycline inhibits brain inflammation and attenuates spontaneous recurrent seizures following pilocarpine-induced status epilepticus

(2015) N. Wang et al.   NEUROSCIENCE

Cognition in the early stages of adult epilepsy

(2015) Juri-Alexander Witt et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Neuroinflammation in Temporal Lobe Epilepsy Measured Using Positron Emission Tomographic Imaging of Translocator Protein

(2015) Leah D. Gershen et al.   JAMA Neurology

Past and Present Definitions of Epileptogenesis and Its Biomarkers

(2014) Asla Pitkänen et al.   Neurotherapeutics

Disulfide-Containing High Mobility Group Box-1 Promotes N-Methyl-d-Aspartate Receptor Function and Excitotoxicity by Activating Toll-Like Receptor 4-Dependent Signaling in Hippocampal Neurons

(2013) Silvia Balosso et al.   ANTIOXIDANTS & REDOX SIGNALING

Postictal psychosis in temporal lobe epilepsy: Risk factors and postsurgical outcome?

(2013) Rebecca A. Cleary et al.   EPILEPSY RESEARCH

The many faces of HMGB1: molecular structure-functional activity in inflammation, apoptosis, and chemotaxis

(2013) Huan Yang et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Receptor for Advanced Glycation Endproducts is upregulated in temporal lobe epilepsy and contributes to experimental seizures

(2013) Valentina Iori et al.   NEUROBIOLOGY OF DISEASE

Microglia: A new frontier for synaptic plasticity, learning and memory, and neurodegenerative disease research

(2013) Gary P. Morris et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Correlation of Circulating MMP-9 with White Blood Cell Count in Humans: Effect of Smoking

(2013) Soren Snitker et al.   PLoS One

S100B as a Marker for Brain Damage and Blood–Brain Barrier Disruption Following Exercise

(2013) Serene X. T. Koh et al.   SPORTS MEDICINE

Glia and epilepsy: excitability and inflammation

(2013) Orrin Devinsky et al.   TRENDS IN NEUROSCIENCES

Homeostatic control of brain function – new approaches to understand epileptogenesis

(2013) Detlev Boison et al.   Frontiers in Cellular Neuroscience

Fluoxetine restores spatial learning but not accelerated forgetting in mesial temporal lobe epilepsy

(2012) Lisa Barkas et al.   BRAIN

In vivo imaging of glia activation using1H-magnetic resonance spectroscopy to detect putative biomarkers of tissue epileptogenicity

(2012) Marta Filibian et al.   EPILEPSIA

Microglia as modulators of cognition and neuropsychiatric disorders

(2012) Thomas Blank et al.   GLIA

Astrocyte immune responses in epilepsy

(2012) Eleonora Aronica et al.   GLIA

Increased In Vivo Expression of an Inflammatory Marker in Temporal Lobe Epilepsy

(2012) J. Hirvonen et al.   JOURNAL OF NUCLEAR MEDICINE

Unknown

(2012) Huan Yang et al.   MOLECULAR MEDICINE

Mouse with Nav1.1 haploinsufficiency, a model for Dravet syndrome, exhibits lowered sociability and learning impairment

(2012) Susumu Ito et al.   NEUROBIOLOGY OF DISEASE

Major depressive disorder as a predictor of a worse seizure outcome one year after surgery in patients with temporal lobe epilepsy and mesial temporal sclerosis

(2012) Gerardo Maria de Araújo Filho et al.   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Molecular biomarkers of epileptogenesis

(2011) Asla Pitkänen et al.   Biomarkers in Medicine

Activation of toll-like receptor, RAGE and HMGB1 signalling in malformations of cortical development

(2011) E. Zurolo et al.   BRAIN

Insights into pathophysiology and therapy from a mouse model of Dravet syndrome

(2011) John C. Oakley et al.   EPILEPSIA

High-mobility group box-1 impairs memory in mice through both toll-like receptor 4 and Receptor for Advanced Glycation End Products

(2011) Andréy Mazarati et al.   EXPERIMENTAL NEUROLOGY

Mechanisms of epileptogenesis and potential treatment targets

(2011) Asla Pitkänen et al.   LANCET NEUROLOGY

Temporal changes in mRNA expression of the brain nutrient transporters in the lithium–pilocarpine model of epilepsy in the immature and adult rat

(2011) Claire Leroy et al.   NEUROBIOLOGY OF DISEASE

Critical review of current animal models of seizures and epilepsy used in the discovery and development of new antiepileptic drugs

(2011) Wolfgang Löscher   SEIZURE-EUROPEAN JOURNAL OF EPILEPSY

Rapid astrocyte and microglial activation following pilocarpine-induced seizures in rats

(2010) Lee A. Shapiro et al.   EPILEPSIA

Inflammasome-Dependent Release of the Alarmin HMGB1 in Endotoxemia

(2010) M. Lamkanfi et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 4 and high-mobility group box-1 are involved in ictogenesis and can be targeted to reduce seizures

(2010) Mattia Maroso et al.   NATURE MEDICINE

Selective induction of astrocytic gliosis generates deficits in neuronal inhibition

(2010) Pavel I Ortinski et al.   NATURE NEUROSCIENCE

Glia: The many ways to modulate synaptic plasticity

(2010) S. Ben Achour et al.   NEUROCHEMISTRY INTERNATIONAL

Astrocytes: biology and pathology

(2009) Michael V. Sofroniew et al.   ACTA NEUROPATHOLOGICA

Blood–brain barrier breakdown-inducing astrocytic transformation: Novel targets for the prevention of epilepsy

(2009) Alon Friedman et al.   EPILEPSY RESEARCH

Early Deficits in Spatial Memory and Theta Rhythm in Experimental Temporal Lobe Epilepsy

(2009) L. Chauviere et al.   JOURNAL OF NEUROSCIENCE

A lifetime psychiatric history predicts a worse seizure outcome following temporal lobectomy

(2009) A. M. Kanner et al.   NEUROLOGY

In Vivo Detection of Thalamic Gliosis

(2008) Stéphane Haïk et al.   ARCHIVES OF NEUROLOGY

S100B's double life: Intracellular regulator and extracellular signal

(2008) Rosario Donato et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Predictors of pharmacoresistant epilepsy: Pharmacoresistant rats differ from pharmacoresponsive rats in behavioral and cognitive abnormalities associated with experimentally induced epilepsy

(2008) Alexandra M. Gastens et al.   EPILEPSIA

1H MR spectroscopy of inflammation, infection and ischemia of the brain

(2008) Irina Mader et al.   EUROPEAN JOURNAL OF RADIOLOGY

Neural-Activity-Dependent Release of S100B from Astrocytes Enhances Kainate-Induced Gamma Oscillations In Vivo

(2008) S. Sakatani et al.   JOURNAL OF NEUROSCIENCE

Innate and adaptive immunity during epileptogenesis and spontaneous seizures: Evidence from experimental models and human temporal lobe epilepsy

(2007) Teresa Ravizza et al.   NEUROBIOLOGY OF DISEASE

Non‐invasive detection of hippocampal sclerosis: correlation between metabolite alterations detected by1H‐MRS and neuropathology

(2007) Thilo Hammen et al.   NMR IN BIOMEDICINE