Review
Cell Biology
Gerardo Cazzato, Anna Colagrande, Antonietta Cimmino, Caterina Abbatepaolo, Emilio Bellitti, Paolo Romita, Lucia Lospalluti, Caterina Foti, Francesca Arezzo, Vera Loizzi, Teresa Lettini, Sara Sablone, Leonardo Resta, Gennaro Cormio, Giuseppe Ingravallo, Roberta Rossi
Summary: The study on how melanoma cells survive and proliferate by consuming glucose is still ongoing, with results on the role and expression of glucose transporters in melanoma far from definitive. While some progress has been made, further research is needed to fully understand and potentially block this mechanism.
Article
Biochemistry & Molecular Biology
Anna A. Kovalenko, Maria V. Zakharova, Alexander P. Schwarz, Alexandra V. Dyomina, Olga E. Zubareva, Aleksey V. Zaitsev
Summary: This study analyzed the changes in gene expression of mGluR subtypes in different brain regions during the latent and chronic phases of a lithium-pilocarpine model of epilepsy. The results showed region- and phase-specific changes in expression, with increased mGluR5 mRNA levels and decreased expression of group III genes during the latent phase. Most of the changes in expression detected in the latent stage were absent in the chronic stage, except for reduced mGluR8 mRNA production in the hippocampus. The study suggested that agonists of group III mGluRs are the most promising targets for preventing epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Clinical Neurology
Supriya Sharma, Meetal Sharma, Anil Kumar Rana, Robin Joshi, Mohit Kumar Swarnkar, Vishal Acharya, Damanpreet Singh
Summary: This study identified STAT3, Mapk8, and Erbb as key regulators involved in seizure-associated cardiac changes using an integrated approach of RNA-Seq, proteomics, and system biology analysis in a rat model of temporal lobe epilepsy. The study also supported the activation of the transforming growth factor beta (TGF-beta) pathway in the heart of epileptic animals. Gene and protein expression studies further established a key role of STAT3, Erbb, and Mapk8 in the development of cardiac changes linked with recurrent seizures.
Article
Biochemistry & Molecular Biology
Iran M. Cumbres-Vargas, Sergio R. Zamudio, Luz A. Pichardo-Macias, Eduardo Ramirez-San Juan
Summary: Thalidomide has potential therapeutic effects in neurological diseases such as epilepsy and may act as an antiepileptic drug and treatment against disease development. This study evaluated the antiepileptogenic and anti-inflammatory effects of Thalidomide, showing promising results in terms of reducing seizure frequency and neuroinflammation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Kai Zhong, Chengyu Qian, Rui Lyu, Xinyi Wang, Zhe Hu, Jie Yu, Jing Ma, Yilu Ye
Summary: Crocin has shown anti-epileptic effects in models of temporal lobe epilepsy, reducing seizure stages and duration, as well as suppressing generalized and spontaneous recurrent seizures. These effects may be mediated by its neuroprotective properties and modulation of inflammatory and neurotrophic factors.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Olga E. Zubareva, Denis S. Sinyak, Alisa D. Kalita, Alexandra V. Griflyuk, Georgy P. Diespirov, Tatiana Y. Postnikova, Aleksey V. Zaitsev
Summary: This study evaluated the effects of anakinra, lamotrigine, and their combination on epileptogenesis using a rat model. The treatment showed significant reductions in the severity of seizures and neuronal loss in the CA1 hippocampus. However, the combination treatment was less effective in preventing neuron loss in the hippocampal CA3 field compared to monotherapy. The findings suggest that anakinra and lamotrigine, either alone or in combination, may be clinically useful in preventing histopathological and behavioral abnormalities associated with epilepsy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Pharmacology & Pharmacy
Sarah S. El-Sayed, Mohammed F. El-Yamany, Hesham A. Salem, Ayman E. El-Sahar
Summary: The study investigated the modulatory effects of Vinpocetine (VNP) on neurobehavioral comorbidities via the mTOR signaling pathway in a lithium-pilocarpine (Li-Pil) rat model of seizures. VNP demonstrated a protective effect against Li-Pil-induced seizures and improved locomotor and cognitive abilities, while also exerting a neuroprotective action through inhibitory effects on hippocampal glutamate excitotoxicity, mTOR pathway, and inflammatory and apoptotic parameters.
JOURNAL OF PHARMACY AND PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Etsay Weldekidan Tsegay, Rajkapoor Balasubramanian, Kald Beshir Tuem, Abadi Kahsu Gebre
Summary: The study aimed to investigate the effect of Moringa stenopetala crude extract on the development of lithium-pilocarpine-induced temporal lobe epilepsy model in rats. The results showed that the extract exhibited antidepressant and anxiolytic activity in the rats with epilepsy.
PHARMACOGNOSY MAGAZINE
(2021)
Article
Plant Sciences
Chih-Sheng Yang, Sheng-Chun Chiu, Ping-Yen Liu, Sheng-Nan Wu, Ming-Chi Lai, Chin-Wei Huang
Summary: The study aimed to investigate the effects of gastrodin on reducing seizure severity and neuronal excitotoxicity induced by lithium-pilocarpine, and explore the underlying mechanism. Results showed that gastrodin significantly reduced acute seizure severity and provided neuroprotective effects against seizure-related hippocampal neuronal damage. Additionally, gastrodin reversed the degradation of the GABA(A) receptor after pilocarpine-induced seizures, indicating its potential as a new antiepileptic drug from traditional Chinese medicine.
JOURNAL OF ETHNOPHARMACOLOGY
(2021)
Review
Behavioral Sciences
Maxime Levesque, Giuseppe Biagini, Marco de Curtis, Vadym Gnatkovsky, Julika Pitsch, Siyan Wang, Massimo Avoli
Summary: Research on the mechanisms of focal epileptic discharges in mesial temporal lobe epilepsy (MTLE) often utilizes rodent models induced by pilocarpine, revealing specific neuronal events during latent and chronic states, as well as the effects of optogenetic activation on spontaneous seizures.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Chemistry, Medicinal
Thiago S. Charret, Mariana T. M. Pereira, Vinicius D. B. Pascoal, Iscia Lopes-Cendes, Aislan Cristina Rheder Fagundes Pascoal
Summary: Research has shown that citral has inhibitory effects on status epilepticus in a rat model, increasing latency for seizure development, reducing neuronal death, and inhibiting overexpression of proinflammatory genes.
JOURNAL OF MEDICINAL FOOD
(2021)
Article
Behavioral Sciences
Alexandra Dyomina, Ilya Smolensky, Aleksey Zaitsev
Summary: This study optimized the procedures of Morris water maze and Barnes maze for assessing spatial learning and memory in rats with TLE. It was found that the Barnes maze may be a better choice due to the risk of unexpected seizure occurrence during Morris water maze tests.
EPILEPSY & BEHAVIOR
(2023)
Article
Neurosciences
Maxime Levesque, Siyan Wang, Guillaume Etter, Sylvain Williams, Massimo Avoli
Summary: Bilateral activation of PV interneurons in the hippocampus promotes seizures and high-frequency oscillations in a mouse model of mesial temporal lobe epilepsy.
NEUROBIOLOGY OF DISEASE
(2022)
Article
Clinical Neurology
Ali Izadi, Amber Schedlbauer, Katelynn Ondek, Gregory Disse, Arne D. Ekstrom, Stephen L. Cowen, Kiarash Shahlaie, Gene G. Gurkoff
Summary: In this study, theta stimulation of the septohippocampal circuit in rodents following exposure to pilocarpine was found to alter the progression of epilepsy, resulting in increased seizure thresholds, reduced spikes, and improved cognitive outcomes. The findings suggest that early intervention with septal theta stimulation may serve as a potential alternative or adjunct to high frequency thalamic stimulation in refractory cases, emphasizing the critical importance of further research in this area.
FRONTIERS IN NEUROLOGY
(2021)
Article
Plant Sciences
Supriya Sharma, Anil Kumar Rana, Shubham Nilkanth Rahmatkar, Vikram Patial, Damanpreet Singh
Summary: This study aimed to investigate the efficacy of Nardostachys jatamansi extract in the treatment of lithium-pilocarpine-induced seizures and associated cardiac irregularities. The results showed that the extract reduced seizure severity and cardiac abnormalities by inhibiting the mTOR signaling pathway. The chemical composition and interactions of Nardostachys jatamansi provide important insights for further research on this plant.
JOURNAL OF ETHNOPHARMACOLOGY
(2023)
Article
Cardiac & Cardiovascular Systems
Hiran A. Prag, Anja Gruszczyk, Margaret M. Huang, Timothy E. Beach, Timothy Young, Laura Tronci, Efterpi Nikitopoulou, John F. Mulvey, Raimondo Ascione, Anna Hadjihambi, Michael J. Shattock, Luc Pellerin, Kourosh Saeb-Parsy, Christian Frezza, Andrew M. James, Thomas Krieg, Michael P. Murphy, Dunja Aksentijevic
Summary: Release of accumulated succinate in the ischaemic heart upon reperfusion is mediated by MCT1 and is facilitated by acidification of the myocardium during ischaemia.
CARDIOVASCULAR RESEARCH
(2021)
Article
Neurosciences
Filipa Boucanova, Gill Pollmeier, Katalin Sandor, Carlos Morado Urbina, Jik Nijssen, Jean-Jacques Medard, Luca Bartesaghi, Luc Pellerin, Camilla Svensson, Eva Hedlund, Roman Chrast
Summary: Recent studies have shown that MCT1 in Schwann cells is necessary for maintaining the integrity of motor end-plates, while MCT4 appears largely dispensable for supporting motor neurons. Structural alterations and transcriptional changes in lumbar motor neurons from MCT1 cKO mice provide further insight into the biology of axon-glia metabolic crosstalk.
Article
Neurosciences
Roxane Pasquettaz, Irina Kolotuev, Antoine Rohrbach, Cathy Gouelle, Luc Pellerin, Fanny Langlet
Summary: The study investigates the neuroanatomical associations between tanycytes and neural cells, particularly in the arcuate nucleus. Tanycytes were found to have subcellular protrusions contacting different neural cells, including NPY and POMC neurons in the arcuate nucleus. The protrusions were observed to contain ribosomes, mitochondria, vesicles, and transporters, indicating dense communications between tanycytes, neurons, and blood vessels.
JOURNAL OF COMPARATIVE NEUROLOGY
(2021)
Article
Neurosciences
Ursule Dumont, Stephane Sanchez, Cendrine Repond, Marie-Christine Beauvieux, Jean-Francois Chateil, Luc Pellerin, Anne-Karine Bouzier-Sore, Helene Roumes
Summary: Neonatal hypoxia-ischemia (nHI) is a major cause of death or disabilities in infants, with no pharmacological treatment currently available. Research has shown that supplementation of trans-resveratrol in pregnant rat females can significantly reduce brain lesions caused by nHI and alleviate long-term consequences.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Biochemistry & Molecular Biology
Sanja Ramljak, Matthias Schmitz, Cendrine Repond, Inga Zerr, Luc Pellerin
Summary: This study investigated the impact of cellular prion protein deficiency on neuroenergetics by analyzing the expression of genes involved in lactate/pyruvate metabolism. The results show that the absence of PrP(C) leads to altered MCT1 and MCT4 expression levels in different brain regions, indicating a potential role of PrP(C) in the regulation of monocarboxylate transport.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Review
Neurosciences
Carole Escartin, Elena Galea, Andras Lakatos, James P. O'Callaghan, Gabor C. Petzold, Alberto Serrano-Pozo, Christian Steinhauser, Andrea Volterra, Giorgio Carmignoto, Amit Agarwal, Nicola J. Allen, Alfonso Araque, Luis Barbeito, Ari Barzilai, Dwight E. Bergles, Gilles Bonvento, Arthur M. Butt, Wei-Ting Chen, Martine Cohen-Salmon, Colm Cunningham, Benjamin Deneen, Bart De Strooper, Blanca Diaz-Castro, Cinthia Farina, Marc Freeman, Vittorio Gallo, James E. Goldman, Steven A. Goldman, Magdalena Gotz, Antonia Gutierrez, Philip G. Haydon, Dieter H. Heiland, Elly M. Hol, Matthew G. Holt, Masamitsu Iino, Ksenia V. Kastanenka, Helmut Kettenmann, Baljit S. Khakh, Schuichi Koizumi, C. Justin Lee, Shane A. Liddelow, Brian A. MacVicar, Pierre Magistretti, Albee Messing, Anusha Mishra, Anna V. Molofsky, Keith K. Murai, Christopher M. Norris, Seiji Okada, Stephane H. R. Oliet, Joao F. Oliveira, Aude Panatier, Vladimir Parpura, Marcela Pekna, Milos Pekny, Luc Pellerin, Gertrudis Perea, Beatriz G. Perez-Nievas, Frank W. Pfrieger, Kira E. Poskanzer, Francisco J. Quintana, Richard M. Ransohoff, Miriam Riquelme-Perez, Stefanie Robel, Christine R. Rose, Jeffrey D. Rothstein, Nathalie Rouach, David H. Rowitch, Alexey Semyanov, Swetlana Sirko, Harald Sontheimer, Raymond A. Swanson, Javier Vitorica, Ina-Beate Wanner, Levi B. Wood, Jiaqian Wu, Binhai Zheng, Eduardo R. Zimmer, Robert Zorec, Michael V. Sofroniew, Alexei Verkhratsky
Summary: The article highlights the challenges and uncertainties surrounding reactive astrocytes, advocating for comprehensive research that includes assessment of multiple molecular and functional parameters, preferably in vivo, along with multivariate statistics and determination of impact on pathological hallmarks in relevant models.
NATURE NEUROSCIENCE
(2021)
Letter
Radiology, Nuclear Medicine & Medical Imaging
Igor C. Fontana, Debora Guerini Souza, Luc Pellerin, Diogo O. Souza, Eduardo R. Zimmer
EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING
(2021)
Article
Biochemistry & Molecular Biology
David Pamies, Chiara Sartori, Domitille Schvartz, Victor Gonzalez-Ruiz, Luc Pellerin, Carolina Nunes, Denise Tavel, Vanille Maillard, Julien Boccard, Serge Rudaz, Jean-Charles Sanchez, Marie-Gabrielle Zurich
Summary: This study aimed to explore the metabolic changes occurring in activated human astrocytes. Results showed that activated astrocytes exhibited significant changes in inflammation response, cytoskeleton, and energy metabolism.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Clinical Neurology
Bruna Bellaver, Joao Pedro Ferrari-Souza, Lucas Uglione da Ros, Stephen F. Carter, Elena Rodriguez-Vieitez, Agneta Nordberg, Luc Pellerin, Pedro Rosa-Neto, Douglas Teixeira Leffa, Eduardo R. Zimmer
Summary: This meta-analysis found that levels of GFAP and YKL-40 in the CSF, as well as S100B in the blood, were significantly increased in patients with AD. Despite significant progress, applications of astrocyte biomarkers in AD are still in the early stages.
Article
Cell Biology
Marc Cougnon, Romain Carcy, Nicolas Melis, Isabelle Rubera, Christophe Duranton, Karine Dumas, Jean-Francois Tanti, Catherine Pons, Nicolas Soubeiran, Marina Shkreli, Thierry Hauet, Luc Pellerin, Sebastien Giraud, Nicolas Blondeau, Michel Tauc, Didier F. Pisani
Summary: Inhibition of eukaryotic initiation factor 5A activation by GC7 protects kidney cells from ischemic damage by altering their energy source and oxygen dependence, making them independent of oxygen supply.
CELL DEATH & DISEASE
(2021)
Article
Physiology
Tomaz Martini, Jurgen A. Ripperger, Rohit Chavan, Michael Stumpe, Citlalli Netzahualcoyotzi, Luc Pellerin, Urs Albrecht
Summary: Animals can predict daily recurring events through their internal circadian timing system, and food restriction to a specific time can induce food anticipatory activity (FAA). Research has shown that the role of Mct1 in the liver has a significant impact on FAA in mice, which is associated with blood levels of beta OHB.
FRONTIERS IN PHYSIOLOGY
(2021)
Article
Cell Biology
Bessem Mornagui, Raja Rezg, Cendrine Repond, Luc Pellerin
Summary: Bisphenol S (BPS), a substitute for bisphenol A (BPA), may act as an obesogenic endocrine disruptor and affect monocarboxylate transporters and mitochondrial respiratory system in the liver, leading to the development of hepatic steatosis.
JOURNAL OF CELLULAR PHYSIOLOGY
(2022)
Editorial Material
Cell Biology
Eduardo R. Zimmer, Tharick A. Pascoal, Pedro Rosa-Neto, Agneta Nordberg, Luc Pellerin
Summary: This statement suggests that astrocytes play a major role in the microglia-dependent modulation of FDG-PET.
SCIENCE TRANSLATIONAL MEDICINE
(2022)
Letter
Gastroenterology & Hepatology
Anna Hadjihambi, Luc Pellerin
JOURNAL OF HEPATOLOGY
(2023)
Article
Biochemistry & Molecular Biology
Damien Lagarde, Yannick Jeanson, Corinne Barreau, Cedric Moro, Lindsay Peyriga, Edern Cahoreau, Christophe Guissard, Emmanuelle Arnaud, Anne Galinier, Anne-Karine Bouzier-Sore, Luc Pellerin, Edward T. Chouchani, Luc Penicaud, Isabelle Ader, Jean-Charles Portais, Louis Casteilla, Audrey Carriere
Summary: Activation of brown/beige adipocytes through MCT1-mediated lactate fluxes plays a crucial role in regulating glucose utilization and oxidative metabolism, highlighting the importance of lactate metabolism in controlling the metabolic activity of beige adipocytes according to extracellular metabolic conditions.
JOURNAL OF BIOLOGICAL CHEMISTRY
(2021)
Article
Neurosciences
Nihal A. Salem, Lawrence Manzano, Michael W. Keist, Olga Ponomareva, Amanda J. Roberts, Marisa Roberto, R. Dayne Mayfield
Summary: This study identified cell-type specific gene expression changes associated with alcohol dependence in the medial prefrontal cortex of mice. The results revealed dysregulated gene co-expression networks and differentially expressed genes in multiple cell types, highlighting the involvement of inhibitory neurons and astrocytes in alcohol dependence. Novel targets for studying molecular mechanisms contributing to alcohol dependence were also identified.
NEUROBIOLOGY OF DISEASE
(2024)
Article
Neurosciences
Laura E. Hawley, Megan Stringer, Abigail J. Deal, Andrew Folz, Charles R. Goodlett, Randall J. Roper
Summary: This study found that the overexpression of DYRK1A protein in Down syndrome mice varies with age, sex, and brain region, and reducing the copy number of Dyrk1a can decrease the expression of DYRK1A. These sex-specific patterns of DYRK1A overexpression may provide mechanistic targets for therapeutic intervention in Down syndrome.
NEUROBIOLOGY OF DISEASE
(2024)