Article
Neurosciences
Theresa A. Lusardi, Ursula S. Sandau, Nikita A. Sakhanenko, Sarah Catherine B. Baker, Jack T. Wiedrick, Jodi A. Lapidus, Murray A. Raskind, Ge Li, Elaine R. Peskind, David J. Galas, Joseph F. Quinn, Julie A. Saugstad
Summary: The study revealed that both traumatic brain injury (TBI) and deployment can result in persistent changes in cerebrospinal fluid (CSF) miRNA levels that are relevant to known miRNA-mediated Alzheimer's disease (AD) pathology, which may reflect early events in AD.
FRONTIERS IN NEUROSCIENCE
(2021)
Review
Critical Care Medicine
Carlos A. Santacruz, Jean-Louis Vincent, Andres Bader, Luis A. Rincon-Gutierrez, Claudia Dominguez-Curell, David Communi, Fabio S. Taccone
Summary: Studies suggest that altered CSF concentrations of protein biomarkers related to cytoskeletal damage, inflammation, apoptosis, and oxidative stress may predict worse neurological outcomes in patients with acute brain injuries.
Article
Behavioral Sciences
Megan E. Huibregtse, Jeffrey J. Bazarian, Sandy R. Shultz, Keisuke Kawata
Summary: Blood biomarkers can provide objective measures in traumatic brain injury (TBI) assessment and predict recovery duration. Proteomic markers, often examined in research, have short half-lives due to degradation, while emerging biomarkers like microRNA and extracellular vesicles can better reflect the genetic and metabolic alterations following TBI.
NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS
(2021)
Article
Biochemistry & Molecular Biology
Johann Zwirner, Sven Anders, Simone Bohnert, Ralph Burkhardt, Ugo Da Broi, Niels Hammer, Dirk Pohlers, Rexson Tse, Enjamin Ondruschka
Summary: The study suggests that using creatine kinase (CK) immunoassays in postmortem cerebrospinal fluid can serve as an adjunct quantitative test aid in diagnosing acute TBI-related fatalities. TBI cases showed a significant increase in CK and CK-MB, with moderate to high diagnostic accuracy.
Article
Surgery
Dewen Ru, Yufeng Yan, Bing Li, Xiao Shen, Ri Tang, Ersong Wang
Summary: This study found that CSF BNP and NT-proBNP levels peaked on day 3 after TBI, and were significantly higher in TBI patients compared to the control group. CSF BNP may originate from the brain and could potentially serve as a biomarker for TBI.
JOURNAL OF SURGICAL RESEARCH
(2021)
Article
Engineering, Biomedical
Tiange Chen, Yuguo Xia, Liyang Zhang, Tao Xu, Yan Yi, Jianwei Chen, Ziyuan Liu, Liting Yang, Siming Chen, Xiaoxi Zhou, Xin Chen, Haiyu Wu, Jinfang Liu
Summary: Neural stem cells (NSCs) have potential therapeutic effects in treating traumatic brain injury (TBI) due to their ability to replenish dysfunctional neurons and stimulate neurorestorative processes. However, their efficacy is hindered by low cell retention rates after transplantation into the brain. This study found that cerebrospinal fluid (CSF) flow after TBI is a crucial factor in NSC loss post-transplantation. Hydrogel scaffolds, particularly the GelMA/Alg scaffold, can promote NSC adherence, growth, and differentiation while preventing CSF flow-induced cell loss.
MATERIALS TODAY BIO
(2023)
Review
Neurosciences
Suna Huang, Su Li, Hua Feng, Yujie Chen
Summary: Traumatic brain injury (TBI) is a severe form of acute brain injury predicted to become one of the top three neurological diseases causing disabilities by 2030. Mild TBI (mTBI), often overlooked, accounts for 80% of all TBIs and can lead to long-term cognitive dysfunction due to iron deposition and its effects on neural pathways. Iron overload and dysfunction in metabolism play a crucial role in the pathophysiology of mTBI.
FRONTIERS IN NEUROSCIENCE
(2021)
Article
Oncology
Jan Remsik, Jessica A. Wilcox, N. Esther Babady, Tracy A. McMillen, Behroze A. Vachha, Neil A. Halpern, Vikram Dhawan, Marc Rosenblum, Christine A. Iacobuzio-Donahue, Edward K. Avila, Bianca Santomasso, Adrienne Boire
Summary: Cancer patients with neurologic sequelae of COVID-19 have meningeal inflammatory cytokines without viral neuroinvasion, mainly driven by type II interferon and correlated with the degree of neurological dysfunction. The neuroinflammatory process persists weeks after recovery from acute respiratory infection, leading to long-term neurocognitive dysfunction. Anti-inflammatory treatments may play a role in managing neurological complications of COVID-19 infection.
Review
Neurosciences
Diana G. G. Nelles, Lili-Naz Hazrati
Summary: Mild traumatic brain injury (mTBI) is a common neurological condition. Ependymal cells have potential in studying the pathogenesis of mTBI. Research has shown DNA damage and cellular senescence in ependymal cells following mTBI, as well as dysfunction in cerebrospinal fluid homeostasis. This review explores the molecular and structural alterations in ependymal cells, the potential pathological mechanisms, and possible therapeutic approaches.
FRONTIERS IN CELLULAR NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Lara Valencic Sersic, Vedrana Krusic Alic, Masa Biberic, Sinisa Zrna, Tin Jagoic, Janja Tarcukovic, Kristina Grabusic
Summary: Severe traumatic brain injury (sTBI) is caused by external force and can lead to intracranial damage. The study analyzed the effect of sTBI on extracellular microRNAs (miRNAs). The results suggest that miRNAs may provide information about brain tissue damage and recovery after sTBI.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Review
Biochemistry & Molecular Biology
Anastasia A. Vasilieva, Elena E. Timechko, Kristina D. Lysova, Anastasia I. Paramonova, Alexey M. Yakimov, Elena A. Kantimirova, Diana V. Dmitrenko
Summary: Structural or post-traumatic epilepsy often develops after brain tissue damage caused by traumatic brain injury, stroke, infections of the brain, etc. MicroRNAs, such as miR-21, miR-181a, and miR-155, show potential as biomarkers for predicting epileptogenesis. However, more in-depth and prolonged studies are needed to understand the process of epileptogenesis.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Xintao Huang, Xinjuan Xu, Ce Wang, Yi Wang, Yajun Yang, Tianle Yao, Rui Bai, Xile Pei, Feirong Bai, Panpan Li
Summary: Traumatic brain injury (TBI) is a common neurological disease with high mortality and long-term complications. The study explores the use of serum exosomal microRNA (ExomiR) as a potential biomarker for TBI diagnosis and evaluation. The results suggest that serum ExomiRs may provide a new research direction for the diagnosis and treatment of TBI.
FRONTIERS IN NEUROSCIENCE
(2023)
Article
Biochemistry & Molecular Biology
Rany Vorn, Maiko Suarez, Jacob C. White, Carina A. Martin, Hyung-Suk Kim, Chen Lai, Si-Jung Yun, Jessica M. Gill, Hyunhwa Lee
Summary: In chronic mild traumatic brain injury (mTBI), dysregulation of exosomal microRNAs in plasma may indicate long-lasting neuronal inflammation, resulting in persistent post-injury symptoms.
Article
Infectious Diseases
Navpreet K. Dhillon, Saad Sahi, Galinos Barmparas, Nikhil T. Linaval, Ting Lung Lin, Shouri Lahiri, Carlos V. R. Brown, Eric J. Ley
Summary: This study reviewed CSF culture results of 145 TBI patients and found a low positivity rate, especially in patients without prior external ventricular drain placement. Other sources of infectious etiologies should be considered in this patient population.
SURGICAL INFECTIONS
(2021)
Article
Multidisciplinary Sciences
Xiaobo Wang, Na Xie, Yi Zhang, Xianli Meng, Ya Hou, Sanyin Zhang
Summary: The study demonstrates an efficient and dynamic method to obtain hippocampal extracellular fluid (HECF) in awake rats using brain microdialysis technology. This technique allows for continuous sampling and monitoring of changes in the composition of the extracellular fluid, providing unlimited possibilities for exploring the pathogenesis of CNS-related diseases and evaluating drug efficacy.
JOVE-JOURNAL OF VISUALIZED EXPERIMENTS
(2022)
Article
Neurosciences
Diana Miszczuk, Konrad J. Debski, Heikki Tanila, Katarzyna Lukasiuk, Asla Pitkanen
MOLECULAR NEUROBIOLOGY
(2016)
Review
Clinical Neurology
Asla Pitkanen, Reina Roivainen, Katarzyna Lukasiuk
Article
Multidisciplinary Sciences
Joanna Bednarczyk, Konrad J. Debski, Anna M. Bot, Katarzyna Lukasiuk
SCIENTIFIC REPORTS
(2016)
Review
Clinical Neurology
Erwin A. van Vliet, Noora Puhakka, James D. Mills, Prashant K. Srivastava, Michael R. Johnson, Paolo Roncon, Shalini Das Gupta, Jenni Karttunen, Michele Simonato, Katarzyna Lukasiuk, Jan A. Gorter, Eleonora Aronica, Asla Pitkanen
Article
Clinical Neurology
Niina Lapinlampi, Esbjorn Melin, Eleonora Aronica, Jens P. Bankstahl, Albert Becker, Cristophe Bernard, Jan A. Gorter, Olli Grohn, Anu Lipsanen, Katarzyna Lukasiuk, Wolfgang Loescher, Jussi Paananen, Teresa Ravizza, Paolo Roncon, Michele Simonato, Annamaria Vezzani, Merab Kokaia, Asla Pitkanen
Article
Biochemical Research Methods
Justyna Sobocinska, Paula Roszczenko-Jasinska, Monika Zareba-Koziol, Aneta Hromada-Judycka, Orest V. Matveichuk, Gabriela Traczyk, Katarzyna Lukasiuk, Katarzyna Kwiatkowska
MOLECULAR & CELLULAR PROTEOMICS
(2018)
Article
Biochemistry & Molecular Biology
Niina Vuokila, Katarzyna Lukasiuk, Anna Maria Bot, Erwin A. van Vliet, Eleonora Aronica, Asla Pitkanen, Noora Puhakka
CELLULAR AND MOLECULAR LIFE SCIENCES
(2018)
Article
Multidisciplinary Sciences
Noora Puhakka, Anna Maria Bot, Niina Vuokila, Konrad Jozef Debski, Katarzyna Lukasiuk, Asla Pitkanen
Article
Multidisciplinary Sciences
Avgoustinos Vouros, Tiago Gehring, Kinga Szydlowska, Artur Janusz, Zehai Tu, Mike Croucher, Katarzyna Lukasiuk, Witold Konopka, Carmen Sandi, Eleni Vasilaki
SCIENTIFIC REPORTS
(2018)
Article
Cell Biology
Anna R. Malik, Kinga Szydlowska, Karolina Nizinska, Antonino Asaro, Erwin A. van Vliet, Oliver Popp, Gunnar Dittmar, Raphaela Fritsche-Guenther, Jennifer A. Kirwan, Anders Nykjaer, Katarzyna Lukasiuk, Eleonora Aronica, Thomas E. Willnow
Article
Multidisciplinary Sciences
K. J. Debski, N. Ceglia, A. Ghestem, A. I. Ivanov, G. E. Brancati, S. Broeer, A. M. Bot, J. A. Mueller, S. Schoch, A. Becker, W. Loescher, M. Guye, P. Sassone-Corsi, K. Lukasiuk, P. Baldi, C. Bernard
Article
Multidisciplinary Sciences
Karolina Nizinska, Kinga Szydlowska, Avgoustinos Vouros, Anna Kiryk, Aleksandra Stepniak, Eleni Vasilaki, Katarzyna Lukasiuk
Summary: The study analyzed behavior in a rat model of epilepsy, identifying differences in behavioral impairments between animals with short versus long latency to seizures and low versus high number of seizures. Results suggest that epilepsy intensity and seizure frequency may affect animal behavior, with mild behavioral changes observed overall.
SCIENTIFIC REPORTS
(2021)
Article
Biochemistry & Molecular Biology
Malgorzata Gorniak-Walas, Karolina Nizinska, Katarzyna Lukasiuk
Summary: The study identified a 592 bp rat Ttyh1 promoter sequence and found that Ascl1, Sp1, and responsive cis-regulatory elements may be involved in the transcriptional regulation of Ttyh1 expression in rat dissociated hippocampal neurons in vitro, providing novel information about Ttyh1 gene regulation in neurons.
NEUROCHEMICAL RESEARCH
(2021)
Review
Biochemistry & Molecular Biology
Katarzyna Lukasiuk, Wladyslaw Lason
Summary: The pharmacological treatment of epilepsy is only aimed at relieving symptoms. Despite years of research, a causal treatment for this common neurological disorder is still unavailable. Advances in neuroscience and molecular biology tools, as well as improved animal models, may accelerate the development of antiepileptogenic and epilepsy-modifying drugs. Epileptogenesis triggers various changes in the genome, epigenome, and transcriptome, leading to the transformation of neuronal circuits and the occurrence of seizures.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Neurosciences
Prashant K. Srivastava, Paolo Roncon, Katarzyna Lukasiuk, Jan A. Gorter, Eleonora Aronica, Asla Pitkanen, Enrico Petretto, Michael R. Johnson, Michele Simonato