Synovium and the Innate Inflammatory Network in Osteoarthritis Progression

The growing array of innate inflammatory ignition switches in osteoarthritis

(2012) Ru Liu-Bryan et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritis: A disease of the joint as an organ

(2012) Richard F. Loeser et al.   ARTHRITIS AND RHEUMATISM

Synovial fluid from patients with early osteoarthritis modulates fibroblast-like synoviocyte responses to Toll-like receptor 4 and Toll-like receptor 2 ligands via soluble CD14

(2012) Anjali Nair et al.   ARTHRITIS AND RHEUMATISM

Mitochondrial dysfunction in osteoarthritis is associated with down-regulation of superoxide dismutase 2

(2012) Christos Gavriilidis et al.   ARTHRITIS AND RHEUMATISM

Role of S100A12 in the pathogenesis of osteoarthritis

(2012) Motoshige Nakashima et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

The receptor for advanced glycation end-products: A complex signaling scenario for a promiscuous receptor

(2012) Armando Rojas et al.   CELLULAR SIGNALLING

Plasma proteins present in osteoarthritic synovial fluid can stimulate cytokine production via Toll-like receptor 4

(2012) Dong Sohn et al.   ARTHRITIS RESEARCH & THERAPY

Complement in health and disease

(2011) Maria V. Carroll et al.   ADVANCED DRUG DELIVERY REVIEWS

Destructive role of myeloid differentiation factor 88 and protective role of TRIF in interleukin-17-dependent arthritis in mice

(2011) Shahla Abdollahi-Roodsaz et al.   ARTHRITIS AND RHEUMATISM

Active involvement of alarmins S100A8 and S100A9 in the regulation of synovial activation and joint destruction during mouse and human osteoarthritis

(2011) Peter L. E. M. van Lent et al.   ARTHRITIS AND RHEUMATISM

Alarmins S100A8 and S100A9 elicit a catabolic effect in human osteoarthritic chondrocytes that is dependent on Toll-like receptor 4

(2011) Rik F. P. Schelbergen et al.   ARTHRITIS AND RHEUMATISM

Role of the complement system in rheumatoid arthritis and psoriatic arthritis: Relationship with anti-TNF inhibitors

(2011) Eleonora Ballanti et al.   AUTOIMMUNITY REVIEWS

Tenascin-C induces inflammatory mediators and matrix degradation in osteoarthritic cartilage

(2011) Lisha Patel et al.   BMC MUSCULOSKELETAL DISORDERS

The NLRP3 inflammasome in health and disease: the good, the bad and the ugly

(2011) P. Menu et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Inflammation in osteoarthritis

(2011) Mary B. Goldring et al.   CURRENT OPINION IN RHEUMATOLOGY

Identification of a central role for complement in osteoarthritis

(2011) Qian Wang et al.   NATURE MEDICINE

NLRP3 inflammasome plays a critical role in the pathogenesis of hydroxyapatite-associated arthropathy

(2011) C. Jin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tenascin-C fragments are endogenous inducers of cartilage matrix degradation

(2011) Nidhi Sofat et al.   RHEUMATOLOGY INTERNATIONAL

Crosstalk between Complement and Toll-Like Receptors

(2011) Wen-Chao Song   TOXICOLOGIC PATHOLOGY

Superoxide dismutase downregulation in osteoarthritis progression and end-stage disease

(2010) J. L. Scott et al.   ANNALS OF THE RHEUMATIC DISEASES

Regulation of complement by cartilage oligomeric matrix protein allows for a novel molecular diagnostic principle in rheumatoid arthritis

(2010) Kaisa E. Happonen et al.   ARTHRITIS AND RHEUMATISM

The role of HMGB1 in the pathogenesis of rheumatic disease

(2010) Ulf Andersson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

RAGE: A Multi-Ligand Receptor Unveiling Novel Insights in Health and Disease

(2010) P. Alexiou et al.   CURRENT MEDICINAL CHEMISTRY

Anaphylatoxin C5a-induced toll-like receptor 4 signaling in bovine neutrophils

(2010) M.G.H. Stevens et al.   JOURNAL OF DAIRY SCIENCE

The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors

(2010) Taro Kawai et al.   NATURE IMMUNOLOGY

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Crosstalk pathways between Toll-like receptors and the complement system

(2010) George Hajishengallis et al.   TRENDS IN IMMUNOLOGY

S100A8 and S100A9 in experimental osteoarthritis

(2010) Hala Zreiqat et al.   ARTHRITIS RESEARCH & THERAPY

Analysing the role of endogenous matrix molecules in the development of osteoarthritis

(2009) Nidhi Sofat   INTERNATIONAL JOURNAL OF EXPERIMENTAL PATHOLOGY

The Pattern Recognition Receptor CD36 Is a Chondrocyte Hypertrophy Marker Associated with Suppression of Catabolic Responses and Promotion of Repair Responses to Inflammatory Stimuli

(2009) D. L. Cecil et al.   JOURNAL OF IMMUNOLOGY

Tenascin-C is an endogenous activator of Toll-like receptor 4 that is essential for maintaining inflammation in arthritic joint disease

(2009) Kim Midwood et al.   NATURE MEDICINE

Deficiency of tenascin-C delays articular cartilage repair in mice

(2009) N. Okamura et al.   OSTEOARTHRITIS AND CARTILAGE

Human genetic deficiencies reveal the roles of complement in the inflammatory network: Lessons from nature

(2009) K. T. Lappegard et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Convergence and amplification of toll-like receptor (TLR) and receptor for advanced glycation end products (RAGE) signaling pathways via high mobility group B1 (HMGB1)

(2008) Judy R. van Beijnum et al.   ANGIOGENESIS

Mitochondrial Dysregulation of Osteoarthritic Human Articular Chondrocytes Analyzed by Proteomics

(2008) Cristina Ruiz-Romero et al.   MOLECULAR & CELLULAR PROTEOMICS