Transcription regulation by the Mediator complex

Core Mediator structure at 3.4 Å extends model of transcription initiation complex

(2017) Kayo Nozawa et al.   NATURE

Mediator structure and rearrangements required for holoenzyme formation

(2017) Kuang-Lei Tsai et al.   NATURE

Understanding nucleosome dynamics and their links to gene expression and DNA replication

(2017) William K. M. Lai et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Chromatin potentiates transcription

(2017) Shigeki Nagai et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex

(2016) Philip J. Robinson et al.   CELL

Epigenetic transcriptional memory

(2016) Agustina D’Urso et al.   CURRENT GENETICS

Mediator binding to UASs is broadly uncoupled from transcription and cooperative with TFIID recruitment to promoters

(2016) Sebastian Grünberg et al.   EMBO JOURNAL

Functional interplay between Mediator and TFIIB in preinitiation complex assembly in relation to promoter architecture

(2016) Thomas Eychenne et al.   GENES & DEVELOPMENT

Role for the MED21-MED7 Hinge in Assembly of the Mediator-RNA Polymerase II Holoenzyme

(2016) Shigeo Sato et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eukaryotic Transcription Regulation: Getting to the Heart of the Matter: Commentary on Mediator Architecture and RNA Polymerase II Function by Plaschka et al

(2016) Sohail Malik   JOURNAL OF MOLECULAR BIOLOGY

Mediator Undergoes a Compositional Change during Transcriptional Activation

(2016) Natalia Petrenko et al.   MOLECULAR CELL

Tail and Kinase Modules Differently Regulate Core Mediator Recruitment and Function In Vivo

(2016) Célia Jeronimo et al.   MOLECULAR CELL

Inhibiting fungal multidrug resistance by disrupting an activator–Mediator interaction

(2016) Joy L. Nishikawa et al.   NATURE

Opposing effects of Elk-1 multisite phosphorylation shape its response to ERK activation

(2016) A. Mylona et al.   SCIENCE

Dynamic Encounters of Genes and Transcripts with the Nuclear Pore

(2016) Rakefet Ben-Yishay et al.   TRENDS IN GENETICS

A single-molecule view of transcription reveals convoys of RNA polymerases and multi-scale bursting

(2016) Katjana Tantale et al.   Nature Communications

Identification of Mediator Kinase Substrates in Human Cells using Cortistatin A and Quantitative Phosphoproteomics

(2016) Zachary C. Poss et al.   Cell Reports

Set1/COMPASS and Mediator are repurposed to promote epigenetic transcriptional memory

(2016) Agustina D'Urso et al.   eLife

The Nuclear Pore-Associated TREX-2 Complex Employs Mediator to Regulate Gene Expression

(2015) Maren Schneider et al.   CELL

Mapping Nucleosome Resolution Chromosome Folding in Yeast by Micro-C

(2015) Tsung-Han S. Hsieh et al.   CELL

The S. cerevisiae SUMO stress response is a conjugation–deconjugation cycle that targets the transcription machinery

(2015) Megan C. Lewicki et al.   Journal of Proteomics

Mediator kinase inhibition further activates super-enhancer-associated genes in AML

(2015) Henry E. Pelish et al.   NATURE

Architecture of the RNA polymerase II–Mediator core initiation complex

(2015) C. Plaschka et al.   NATURE

The Mediator complex: a central integrator of transcription

(2015) Benjamin L. Allen et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Evolution of disorder in Mediator complex and its functional relevance

(2015) Malini Nagulapalli et al.   NUCLEIC ACIDS RESEARCH

Mediator independently orchestrates multiple steps of preinitiation complex assemblyin vivo

(2015) Fanny Eyboulet et al.   NUCLEIC ACIDS RESEARCH

Molecular architecture of the yeast Mediator complex

(2015) Philip J Robinson et al.   eLife

Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex

(2014) Kuang-Lei Tsai et al.   CELL

Redefining the modular organization of the core Mediator complex

(2014) Xuejuan Wang et al.   CELL RESEARCH

Mediator, TATA-binding Protein, and RNA Polymerase II Contribute to Low Histone Occupancy at Active Gene Promoters in Yeast

(2014) Suraiya A. Ansari et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TFIIH Phosphorylation of the Pol II CTD Stimulates Mediator Dissociation from the Preinitiation Complex and Promoter Escape

(2014) Koon Ho Wong et al.   MOLECULAR CELL

Coupling mRNA processing with transcription in time and space

(2014) David L. Bentley   NATURE REVIEWS GENETICS

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit

(2014) Murat A Cevher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Kin28 regulates the transient association of Mediator with core promoters

(2014) Célia Jeronimo et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structural basis for binding the TREX2 complex to nuclear pores, GAL1 localisation and mRNA export

(2014) Divyang Jani et al.   NUCLEIC ACIDS RESEARCH

Suppression of Mediator is regulated by Cdk8-dependent Grr1 turnover of the Med3 coactivator

(2014) D. Gonzalez et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A sequence-specific transcription activator motif and powerful synthetic variants that bind Mediator using a fuzzy protein interface

(2014) L. Warfield et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanisms of epigenetic memory

(2014) Agustina D’Urso et al.   TRENDS IN GENETICS

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Super-Enhancers in the Control of Cell Identity and Disease

(2013) Denes Hnisz et al.   CELL

The Mediator complex and transcription regulation

(2013) Zachary C. Poss et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

Mediator links transcription and DNA repair by facilitating Rad2/XPG recruitment

(2013) F. Eyboulet et al.   GENES & DEVELOPMENT

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator

(2013) M. A. Davis et al.   GENES & DEVELOPMENT

Proteomic Analysis of Coregulators Bound to ERα on DNA and Nucleosomes Reveals Coregulator Dynamics

(2013) Charles E. Foulds et al.   MOLECULAR CELL

Functional roles of enhancer RNAs for oestrogen-dependent transcriptional activation

(2013) Wenbo Li et al.   NATURE

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

(2013) Fan Lai et al.   NATURE

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

(2013) Kuang-Lei Tsai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Model of the Mediator middle module based on protein cross-linking

(2013) Laurent Larivière et al.   NUCLEIC ACIDS RESEARCH

A structural perspective on Mediator function

(2012) Laurent Larivière et al.   CURRENT OPINION IN CELL BIOLOGY

The RNA polymerase II CTD coordinates transcription and RNA processing

(2012) J.-P. Hsin et al.   GENES & DEVELOPMENT

Role of Mediator in Regulating Pol II Elongation and Nucleosome Displacement in Saccharomyces cerevisiae

(2012) S. B. Kremer et al.   GENETICS

Proteomic Analysis Demonstrates Activator- and Chromatin-specific Recruitment to Promoters

(2012) Timothy W. Sikorski et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediator Phosphorylation Prevents Stress Response Transcription During Non-stress Conditions

(2012) Christian Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediator-Regulated Transcription through the +1 Nucleosome

(2012) Adam Nock et al.   MOLECULAR CELL

Structure of the Mediator head module

(2012) Laurent Larivière et al.   NATURE

Genome-wide structure and organization of eukaryotic pre-initiation complexes

(2012) Ho Sung Rhee et al.   NATURE

Med5(Nut1) and Med17(Srb4) Are Direct Targets of Mediator Histone H4 Tail Interactions

(2012) Zhongle Liu et al.   PLoS One

Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II

(2012) P. J. J. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

(2011) Hidehisa Takahashi et al.   CELL

The Cyc8-Tup1 complex inhibits transcription primarily by masking the activation domain of the recruiting protein

(2011) K. H. Wong et al.   GENES & DEVELOPMENT

MED29, a component of the mediator complex, possesses both oncogenic and tumor suppressive characteristics in pancreatic cancer

(2011) Riina Kuuselo et al.   INTERNATIONAL JOURNAL OF CANCER

The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

(2011) Peter S. Brzovic et al.   MOLECULAR CELL

A Comprehensive Genomic Binding Map of Gene and Chromatin Regulatory Proteins in Saccharomyces

(2011) Bryan J. Venters et al.   MOLECULAR CELL

Architecture of the Mediator head module

(2011) Tsuyoshi Imasaki et al.   NATURE

Structure and VP16 binding of the Mediator Med25 activator interaction domain

(2011) Erika Vojnic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the VP16 transactivator target in the Mediator

(2011) Alexander G Milbradt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization

(2011) Martin Seizl et al.   NUCLEIC ACIDS RESEARCH

Histone modifications influence mediator interactions with chromatin

(2011) Xuefeng Zhu et al.   NUCLEIC ACIDS RESEARCH

MED23 Mutation Links Intellectual Disability to Dysregulation of Immediate Early Gene Expression

(2011) S. Hashimoto et al.   SCIENCE

Direct Interaction of RNA Polymerase II and Mediator Required for Transcription in Vivo

(2011) J. Soutourina et al.   SCIENCE

Mediator and human disease

(2011) Jason M. Spaeth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular Architecture of the Human Mediator–RNA Polymerase II–TFIIF Assembly

(2011) Carrie Bernecky et al.   PLOS BIOLOGY

Infantile Cerebral and Cerebellar Atrophy Is Associated with a Mutation in the MED17 Subunit of the Transcription Preinitiation Mediator Complex

(2010) Rami Kaufmann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Lentivirus-mediated inhibition of Med19 suppresses growth of breast cancer cells in vitro

(2010) Li-Hua Li et al.   CANCER CHEMOTHERAPY AND PHARMACOLOGY

Interaction of a DNA Zip Code with the Nuclear Pore Complex Promotes H2A.Z Incorporation and INO1 Transcriptional Memory

(2010) William H. Light et al.   MOLECULAR CELL

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

Mediator Head module structure and functional interactions

(2010) Gang Cai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

(2009) M. T. Knuesel et al.   GENES & DEVELOPMENT

Nucleosome positioning and gene regulation: advances through genomics

(2009) Cizhong Jiang et al.   NATURE REVIEWS GENETICS

Mediator complex association with constitutively transcribed genes in yeast

(2009) S. A. Ansari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

(2009) Frederic D. Bushman et al.   PLoS Pathogens

Mediator-Dependent Recruitment of TFIIH Modules in Preinitiation Complex

(2008) Cyril Esnault et al.   MOLECULAR CELL

A nuclear receptor-like pathway regulating multidrug resistance in fungi

(2008) Jitendra K. Thakur et al.   NATURE

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

(2008) Henri-Marc Bourbon   NUCLEIC ACIDS RESEARCH

Identification of Host Proteins Required for HIV Infection Through a Functional Genomic Screen

(2008) Abraham L. Brass et al.   SCIENCE

Malleable Machines in Transcription Regulation: The Mediator Complex

(2008) Ágnes Tóth-Petróczy et al.   PLoS Computational Biology