Evolution of disorder in Mediator complex and its functional relevance

Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex

(2014) Kuang-Lei Tsai et al.   CELL

Liver Med23 ablation improves glucose and lipid metabolism through modulating FOXO1 activity

(2014) Yajing Chu et al.   CELL RESEARCH

Redefining the modular organization of the core Mediator complex

(2014) Xuejuan Wang et al.   CELL RESEARCH

The Mediator complex: a master coordinator of transcription and cell lineage development

(2014) J.-w. Yin et al.   DEVELOPMENT

The Metazoan-Specific Mediator Subunit 26 (Med26) Is Essential for Viability and Is Found at both Active Genes and Pericentric Heterochromatin in Drosophila melanogaster

(2014) S. K. Marr et al.   MOLECULAR AND CELLULAR BIOLOGY

The Arabidopsis Mediator Complex Subunits MED16, MED14, and MED2 Regulate Mediator and RNA Polymerase II Recruitment to CBF-Responsive Cold-Regulated Genes

(2014) P. A. Hemsley et al.   PLANT CELL

Prepaying the entropic cost for allosteric regulation in KIX

(2014) S. M. Law et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Drosophila melanogaster Hox Transcription Factors Access the RNA Polymerase II Machinery through Direct Homeodomain Binding to a Conserved Motif of Mediator Subunit Med19

(2014) Muriel Boube et al.   PLoS Genetics

The Evolutionarily Conserved Mediator Subunit MDT-15/MED15 Links Protective Innate Immune Responses and Xenobiotic Detoxification

(2014) Read Pukkila-Worley et al.   PLoS Pathogens

Analysis of Molecular Recognition Features (MoRFs) in membrane proteins

(2013) Ioly Kotta-Loizou et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

The Mediator complex and transcription regulation

(2013) Zachary C. Poss et al.   CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY

The most important thing is the tail: Multitudinous functionalities of intrinsically disordered protein termini

(2013) Vladimir N. Uversky   FEBS LETTERS

The role of disordered protein regions in the assembly of decapping complexes and RNP granules

(2013) S. Jonas et al.   GENES & DEVELOPMENT

Mediator complex subunit 12 exon 2 mutation analysis in different subtypes of smooth muscle tumors confirms genetic heterogeneity

(2013) Marieke A. de Graaff et al.   HUMAN PATHOLOGY

Mediator Complex Recruits Epigenetic Regulators via Its Two Cyclin-dependent Kinase Subunits to Repress Transcription of Immune Response Genes

(2013) Taiki Tsutsui et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MAFFT Multiple Sequence Alignment Software Version 7: Improvements in Performance and Usability

(2013) K. Katoh et al.   MOLECULAR BIOLOGY AND EVOLUTION

Sequence and expression analyses of KIX domain proteins suggest their importance in seed development and determination of seed size in rice, and genome stability in Arabidopsis

(2013) Jitendra Kumar Thakur et al.   MOLECULAR GENETICS AND GENOMICS

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

(2013) Kuang-Lei Tsai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Molecular recognition by the KIX domain and its role in gene regulation

(2013) J. K. Thakur et al.   NUCLEIC ACIDS RESEARCH

Intrinsic Disorder in PTEN and its Interactome Confers Structural Plasticity and Functional Versatility

(2013) Prerna Malaney et al.   Scientific Reports

Structural flexibility and functional interaction of mediator Cdk8 module

(2013) Xuejuan Wang et al.   Protein & Cell

GRAS proteins: the versatile roles of intrinsically disordered proteins in plant signalling

(2012) Xiaolin Sun et al.   BIOCHEMICAL JOURNAL

MoRFpred, a computational tool for sequence-based prediction and characterization of short disorder-to-order transitioning binding regions in proteins

(2012) Fatemeh Miri Disfani et al.   BIOINFORMATICS

Med1 plays a critical role in the development of tamoxifen resistance

(2012) Arumugam Nagalingam et al.   CARCINOGENESIS

A structural perspective on Mediator function

(2012) Laurent Larivière et al.   CURRENT OPINION IN CELL BIOLOGY

Mediator Phosphorylation Prevents Stress Response Transcription During Non-stress Conditions

(2012) Christian Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structure of the Mediator head module

(2012) Laurent Larivière et al.   NATURE

Non-Recognition-of-BTH4, anArabidopsisMediator Subunit Homolog, Is Necessary for Development and Response to Salicylic Acid

(2012) Juan Vicente Canet et al.   PLANT CELL

MEDIATOR25 Acts as an Integrative Hub for the Regulation of Jasmonate-Responsive Gene Expression in Arabidopsis

(2012) V. Cevik et al.   PLANT PHYSIOLOGY

PMeS: Prediction of Methylation Sites Based on Enhanced Feature Encoding Scheme

(2012) Shao-Ping Shi et al.   PLoS One

Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II

(2012) P. J. J. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recognition Pliability Is Coupled to Structural Heterogeneity: A Calmodulin Intrinsically Disordered Binding Region Complex

(2012) Malini Nagulapalli et al.   STRUCTURE

Control of final organ size by Mediator complex subunit 25 in Arabidopsis thaliana

(2011) R. Xu et al.   DEVELOPMENT

The role of Mediator in small and long noncoding RNA production inArabidopsis thaliana

(2011) Yun Ju Kim et al.   EMBO JOURNAL

HTLV-1 HBZ Protein Deregulates Interactions between Cellular Factors and the KIX Domain of p300/CBP

(2011) Pamela R. Cook et al.   JOURNAL OF MOLECULAR BIOLOGY

The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder

(2011) E.V. Schneider et al.   JOURNAL OF MOLECULAR BIOLOGY

The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

(2011) Peter S. Brzovic et al.   MOLECULAR CELL

A High-Throughput Screening System for Arabidopsis Transcription Factors and Its Application to Med25-Dependent Transcriptional Regulation

(2011) Bin Ou et al.   Molecular Plant

Architecture of the Mediator head module

(2011) Tsuyoshi Imasaki et al.   NATURE

Structure and VP16 binding of the Mediator Med25 activator interaction domain

(2011) Erika Vojnic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization

(2011) Martin Seizl et al.   NUCLEIC ACIDS RESEARCH

PhosphoSitePlus: a comprehensive resource for investigating the structure and function of experimentally determined post-translational modifications in man and mouse

(2011) P. V. Hornbeck et al.   NUCLEIC ACIDS RESEARCH

MACCHI-BOU 2 is Required for Early Embryo Patterning and Cotyledon Organogenesis in Arabidopsis

(2011) Jun Ito et al.   PLANT AND CELL PHYSIOLOGY

The Mediator Complex in Plants: Structure, Phylogeny, and Expression Profiling of Representative Genes in a Dicot (Arabidopsis) and a Monocot (Rice) during Reproduction and Abiotic Stress

(2011) S. Mathur et al.   PLANT PHYSIOLOGY

Differences in the Number of Intrinsically Disordered Regions between Yeast Duplicated Proteins, and Their Relationship with Functional Divergence

(2011) Floriane Montanari et al.   PLoS One

The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development

(2011) N. Elfving et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Diverse roles of the Mediator complex in plants

(2011) Brendan N. Kidd et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

iRefWeb: interactive analysis of consolidated protein interaction data and their supporting evidence

(2011) B. Turner et al.   Database-The Journal of Biological Databases and Curation

PTOV1 antagonizes MED25 in RAR transcriptional activation

(2010) Hye-Sook Youn et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Cytoscape Web: an interactive web-based network browser

(2010) Christian T. Lopes et al.   BIOINFORMATICS

Differential Roles of Transcriptional Mediator Subunits in Regulation of Multidrug Resistance Gene Expression in Saccharomyces cerevisiae

(2010) Puja Shahi et al.   MOLECULAR BIOLOGY OF THE CELL

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

Preparation and topology of the Mediator middle module

(2010) Tobias Koschubs et al.   NUCLEIC ACIDS RESEARCH

BiP-mediated polar nuclei fusion is essential for the regulation of endosperm nuclei proliferation in Arabidopsis thaliana

(2010) D. Maruyama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Library of Disordered Patterns in 3D Protein Structures

(2010) Michail Yu. Lobanov et al.   PLoS Computational Biology

Quantifying the mechanisms of domain gain in animal proteins

(2010) Marija Buljan et al.   GENOME BIOLOGY

How do proteins gain new domains?

(2010) Joseph A Marsh et al.   GENOME BIOLOGY

Linking folding and binding

(2009) Peter E Wright et al.   CURRENT OPINION IN STRUCTURAL BIOLOGY

The MED12-MED13 module of Mediator regulates the timing of embryo patterning in Arabidopsis

(2009) C. S. Gillmor et al.   DEVELOPMENT

Shifted Transversal Design smart-pooling for high coverage interactome mapping

(2009) X. Xin et al.   GENOME RESEARCH

Comparing Models of Evolution for Ordered and Disordered Proteins

(2009) C. J. Brown et al.   MOLECULAR BIOLOGY AND EVOLUTION

Protein structure prediction on the Web: a case study using the Phyre server

(2009) Lawrence A Kelley et al.   Nature Protocols

HISTONE MONOUBIQUITINATION1 Interacts with a Subunit of the Mediator Complex and Regulates Defense against Necrotrophic Fungal Pathogens in Arabidopsis

(2009) R. Dhawan et al.   PLANT CELL

The Mediator Complex Subunit PFT1 Is a Key Regulator of Jasmonate-Dependent Defense in Arabidopsis

(2009) B. N. Kidd et al.   PLANT CELL

Biochemical Characterization of AtRECQ3 Reveals Significant Differences Relative to Other RecQ Helicases

(2009) D. Kobbe et al.   PLANT PHYSIOLOGY

Mediator Structural Conservation and Implications for the Regulation Mechanism

(2009) Gang Cai et al.   STRUCTURE

Structure-system correlation identifies a gene regulatory Mediator submodule

(2008) L. Lariviere et al.   GENES & DEVELOPMENT

Saccharomyces cerevisiaeMed9 comprises two functionally distinct domains that play different roles in transcriptional regulation

(2008) Hiroyuki Takahashi et al.   GENES TO CELLS

Semidominant Mutations in Reduced Epidermal Fluorescence 4 Reduce Phenylpropanoid Content in Arabidopsis

(2008) J. Stout et al.   GENETICS

Mediator Subunit Gal11p/MED15 Is Required for Fatty Acid-dependent Gene Activation by Yeast Transcription Factor Oaf1p

(2008) Jitendra K. Thakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Myofibrillar Protein, Projectin, is Highly Conserved Across Insect Evolution Except for Its PEVK Domain

(2008) Agnes J. Ayme-Southgate et al.   JOURNAL OF MOLECULAR EVOLUTION

A nuclear receptor-like pathway regulating multidrug resistance in fungi

(2008) Jitendra K. Thakur et al.   NATURE

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II

(2008) Linfeng Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

(2008) Henri-Marc Bourbon   NUCLEIC ACIDS RESEARCH

Multiple Mechanism-Mediated Retention of a Defective Brassinosteroid Receptor in the Endoplasmic Reticulum of Arabidopsis

(2008) Z. Hong et al.   PLANT CELL

Malleable Machines in Transcription Regulation: The Mediator Complex

(2008) Ágnes Tóth-Petróczy et al.   PLoS Computational Biology