The Mediator complex and transcription regulation

Selective Inhibition of Tumor Oncogenes by Disruption of Super-Enhancers

(2013) Jakob Lovén et al.   CELL

Transcriptional Regulation and Its Misregulation in Disease

(2013) Tong Ihn Lee et al.   CELL

Master Transcription Factors and Mediator Establish Super-Enhancers at Key Cell Identity Genes

(2013) Warren A. Whyte et al.   CELL

Human TFIID Binds to Core Promoter DNA in a Reorganized Structural State

(2013) Michael A. Cianfrocco et al.   CELL

Architectural Protein Subclasses Shape 3D Organization of Genomes during Lineage Commitment

(2013) Jennifer E. Phillips-Cremins et al.   CELL

HIF1A Employs CDK8-Mediator to Stimulate RNAPII Elongation in Response to Hypoxia

(2013) Matthew D. Galbraith et al.   CELL

The SCF-Fbw7 ubiquitin ligase degrades MED13 and MED13L and regulates CDK8 module association with Mediator

(2013) M. A. Davis et al.   GENES & DEVELOPMENT

A genome-wide RNA interference screen identifies new regulators of androgen receptor function in prostate cancer cells

(2013) K. Imberg-Kazdan et al.   GENOME RESEARCH

CDK8 Kinase Phosphorylates Transcription Factor STAT1 to Selectively Regulate the Interferon Response

(2013) Joanna Bancerek et al.   IMMUNITY

Small-Molecule Probes to Target the Human Mediator Complex

(2013) Andrew J. Phillips et al.   ISRAEL JOURNAL OF CHEMISTRY

Srb5/Med18-mediated Termination of Transcription Is Dependent on Gene Looping

(2013) Banupriya Mukundan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Role for Human Mediator Subunit MED25 in Recruitment of Mediator to Promoters by Endoplasmic Reticulum Stress-responsive Transcription Factor ATF6α

(2013) Dotan Sela et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediator Recruitment to Heat Shock Genes Requires Dual Hsf1 Activation Domains and Mediator Tail Subunits Med15 and Med16

(2013) Sunyoung Kim et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Adenovirus L-E1A Activates Transcription through Mediator Complex-Dependent Recruitment of the Super Elongation Complex

(2013) S. Vijayalingam et al.   JOURNAL OF VIROLOGY

Establishment of a Cell-Type-Specific Genetic Network by the Mediator Complex Component Med1

(2013) N. J. Pope et al.   MOLECULAR AND CELLULAR BIOLOGY

Proteomic Analysis of Coregulators Bound to ERα on DNA and Nucleosomes Reveals Coregulator Dynamics

(2013) Charles E. Foulds et al.   MOLECULAR CELL

Structural visualization of key steps in human transcription initiation

(2013) Yuan He et al.   NATURE

Activating RNAs associate with Mediator to enhance chromatin architecture and transcription

(2013) Fan Lai et al.   NATURE

Alternative splicing: a pivotal step between eukaryotic transcription and translation

(2013) Alberto R. Kornblihtt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

(2013) Kuang-Lei Tsai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Mediator complex subunit MED25 is targeted by the N-terminal transactivation domain of the PEA3 group members

(2013) Alexis Verger et al.   NUCLEIC ACIDS RESEARCH

The Arabidopsis Mediator complex subunits MED14/SWP and MED16/SFR6/IEN1 differentially regulate defense gene expression in plant immune responses

(2013) Xudong Zhang et al.   PLANT JOURNAL

Mediator Subunit18 Controls Flowering Time and Floral Organ Identity in Arabidopsis

(2013) Zhengui Zheng et al.   PLoS One

Reflections on the history of pre-mRNA processing and highlights of current knowledge: A unified picture

(2013) J. E. Darnell   RNA

Mediator regulates non-coding RNA transcription at fission yeast centromeres

(2013) Michael Thorsen et al.   Epigenetics & Chromatin

Genome-Wide Control of RNA Polymerase II Activity by Cohesin

(2013) Cheri A. Schaaf et al.   PLoS Genetics

A Systematic Analysis of Host Factors Reveals a Med23-Interferon-λ Regulatory Axis against Herpes Simplex Virus Type 1 Replication

(2013) Samantha J. Griffiths et al.   PLoS Pathogens

RNA Polymerase II Elongation Control

(2012) Qiang Zhou et al.   Annual Review of Biochemistry

The Mediator complex and transcription elongation

(2012) Ronald C. Conaway et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

The Mediator complex in thyroid hormone receptor action

(2012) Joseph D. Fondell   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

CDK8 Maintains Tumor Dedifferentiation and Embryonic Stem Cell Pluripotency

(2012) A. S. Adler et al.   CANCER RESEARCH

Med1 plays a critical role in the development of tamoxifen resistance

(2012) Arumugam Nagalingam et al.   CARCINOGENESIS

MED12 Controls the Response to Multiple Cancer Drugs through Regulation of TGF-β Receptor Signaling

(2012) Sidong Huang et al.   CELL

Roles for MicroRNAs in Conferring Robustness to Biological Processes

(2012) Margaret S. Ebert et al.   CELL

A Sterol-Binding Protein Integrates Endosomal Lipid Metabolism with TOR Signaling and Nitrogen Sensing

(2012) Carl J. Mousley et al.   CELL

A Cardiac MicroRNA Governs Systemic Energy Homeostasis by Regulation of MED13

(2012) Chad E. Grueter et al.   CELL

Regulation of mammalian transcription by Gdown1 through a novel steric crosstalk revealed by cryo-EM

(2012) Yi-Min Wu et al.   EMBO JOURNAL

Regulation of mammalian cell differentiation by long non-coding RNAs

(2012) Wenqian Hu et al.   EMBO REPORTS

Mediator MED23 plays opposing roles in directing smooth muscle cell and adipocyte differentiation

(2012) J.-w. Yin et al.   GENES & DEVELOPMENT

Role of Mediator in Regulating Pol II Elongation and Nucleosome Displacement in Saccharomyces cerevisiae

(2012) S. B. Kremer et al.   GENETICS

Mediator CDK subunits are platforms for interactions with various chromatin regulatory complexes

(2012) R. Fukasawa et al.   JOURNAL OF BIOCHEMISTRY

Mediator Phosphorylation Prevents Stress Response Transcription During Non-stress Conditions

(2012) Christian Miller et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polycomb Repressive Complex 1 (PRC1) Disassembles RNA Polymerase II Preinitiation Complexes

(2012) Lynn Lehmann et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of lipogenesis by cyclin-dependent kinase 8–mediated control of SREBP-1

(2012) Xiaoping Zhao et al.   JOURNAL OF CLINICAL INVESTIGATION

Activator–Mediator Binding Stabilizes RNA Polymerase II Orientation within the Human Mediator–RNA Polymerase II–TFIIF Assembly

(2012) Carrie Bernecky et al.   JOURNAL OF MOLECULAR BIOLOGY

Mediator Subunits MED1 and MED24 Cooperatively Contribute to Pubertal Mammary Gland Development and Growth of Breast Carcinoma Cells

(2012) N. Hasegawa et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclin-Dependent Kinase 8 Regulates Mitotic Commitment in Fission Yeast

(2012) Z. Szilagyi et al.   MOLECULAR AND CELLULAR BIOLOGY

Mediator Promotes CENP-A Incorporation at Fission Yeast Centromeres

(2012) J. O. Carlsten et al.   MOLECULAR AND CELLULAR BIOLOGY

The Super Elongation Complex Family of RNA Polymerase II Elongation Factors: Gene Target Specificity and Transcriptional Output

(2012) Z. Luo et al.   MOLECULAR AND CELLULAR BIOLOGY

Mediator-Regulated Transcription through the +1 Nucleosome

(2012) Adam Nock et al.   MOLECULAR CELL

Mediator Complex Regulates Alternative mRNA Processing via the MED23 Subunit

(2012) Yan Huang et al.   MOLECULAR CELL

Transcriptional Regulation by Pol II(G) Involving Mediator and Competitive Interactions of Gdown1 and TFIIF with Pol II

(2012) Miki Jishage et al.   MOLECULAR CELL

Functional Association of Gdown1 with RNA Polymerase II Poised on Human Genes

(2012) Bo Cheng et al.   MOLECULAR CELL

Structure of the Mediator head module

(2012) Laurent Larivière et al.   NATURE

Modular regulatory principles of large non-coding RNAs

(2012) Mitchell Guttman et al.   NATURE

TFIIH: when transcription met DNA repair

(2012) Emmanuel Compe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The super elongation complex (SEC) family in transcriptional control

(2012) Zhuojuan Luo et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

(2012) Stéphane Larochelle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CDK8 regulates E2F1 transcriptional activity through S375 phosphorylation

(2012) J Zhao et al.   ONCOGENE

MEDIATOR25 Acts as an Integrative Hub for the Regulation of Jasmonate-Responsive Gene Expression in Arabidopsis

(2012) V. Cevik et al.   PLANT PHYSIOLOGY

Med5(Nut1) and Med17(Srb4) Are Direct Targets of Mediator Histone H4 Tail Interactions

(2012) Zhongle Liu et al.   PLoS One

Selective requirement for Mediator MED23 in Ras-active lung cancer

(2012) X. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MED12 mutations link intellectual disability syndromes with dysregulated GLI3-dependent Sonic Hedgehog signaling

(2012) H. Zhou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II

(2012) P. J. J. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclin-dependent kinase 8 mediates chemotherapy-induced tumor-promoting paracrine activities

(2012) D. C. Porter et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Control of mitochondrial metabolism and systemic energy homeostasis by microRNAs 378 and 378

(2012) M. Carrer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An RNAi screen identifies additional members of the Drosophila Integrator complex and a requirement for cyclin C/Cdk8 in snRNA 3'-end formation

(2012) J. Chen et al.   RNA

Interaction of the Mediator Head Module with RNA Polymerase II

(2012) Gang Cai et al.   STRUCTURE

Mediator and SAGA Have Distinct Roles in Pol II Preinitiation Complex Assembly and Function

(2012) Xiao-Fen Chen et al.   Cell Reports

Cdk11-CyclinL Controls the Assembly of the RNA Polymerase II Mediator Complex

(2012) Julie Drogat et al.   Cell Reports

The Functions of Mediator in Candida albicans Support a Role in Shaping Species-Specific Gene Expression

(2012) Nathalie Uwamahoro et al.   PLoS Genetics

Unraveling framework of the ancestral Mediator complex in human diseases

(2011) Claudio Napoli et al.   BIOCHIMIE

GPS-Prot: A web-based visualization platform for integrating host-pathogen interaction data

(2011) Marie E Fahey et al.   BMC BIOINFORMATICS

Human Mediator Subunit MED26 Functions as a Docking Site for Transcription Elongation Factors

(2011) Hidehisa Takahashi et al.   CELL

Master Transcription Factors Determine Cell-Type-Specific Responses to TGF-β Signaling

(2011) Alan C. Mullen et al.   CELL

Analysis of the Human Endogenous Coregulator Complexome

(2011) Anna Malovannaya et al.   CELL

Lineage Regulators Direct BMP and Wnt Pathways to Cell-Specific Programs during Differentiation and Regeneration

(2011) Eirini Trompouki et al.   CELL

Cohesin Selectively Binds and Regulates Genes with Paused RNA Polymerase

(2011) Avery Fay et al.   CURRENT BIOLOGY

Requirements for mediator complex subunits distinguish three classes of notch target genes at the Drosophila wing margin

(2011) Florence Janody et al.   DEVELOPMENTAL DYNAMICS

The role of Mediator in small and long noncoding RNA production inArabidopsis thaliana

(2011) Yun Ju Kim et al.   EMBO JOURNAL

Distinct role of Mediator tail module in regulation of SAGA-dependent, TATA-containing genes in yeast

(2011) Suraiya A Ansari et al.   EMBO JOURNAL

Phospho-MED1-enhanced UBE2C locus looping drives castration-resistant prostate cancer growth

(2011) Zhong Chen et al.   EMBO JOURNAL

Mediator is a transducer of amyloid-precursor-protein-dependent nuclear signalling

(2011) Xuan Xu et al.   EMBO REPORTS

Core promoter-selective function of HMGA1 and Mediator in Initiator-dependent transcription

(2011) M. Xu et al.   GENES & DEVELOPMENT

Mediator coordinates PIC assembly with recruitment of CHD1

(2011) J. J. Lin et al.   GENES & DEVELOPMENT

Identification of target genes for the CDK subunits of the Mediator complex

(2011) Taiki Tsutsui et al.   GENES TO CELLS

Novel Role for Mediator Complex Subunit Srb5/Med18 in Termination of Transcription

(2011) Banupriya Mukundan et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

REF4 and RFR1, Subunits of the Transcriptional Coregulatory Complex Mediator, Are Required for Phenylpropanoid Homeostasis inArabidopsis

(2011) Nicholas D. Bonawitz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Dysregulation of CDK8 and Cyclin C in tumorigenesis

(2011) Wu Xu et al.   Journal of Genetics and Genomics

The Structure of CDK8/CycC Implicates Specificity in the CDK/Cyclin Family and Reveals Interaction with a Deep Pocket Binder

(2011) E.V. Schneider et al.   JOURNAL OF MOLECULAR BIOLOGY

Cdk8 Regulates Stability of the Transcription Factor Phd1 To Control Pseudohyphal Differentiation of Saccharomyces cerevisiae

(2011) S. Raithatha et al.   MOLECULAR AND CELLULAR BIOLOGY

Mediator Influences Telomeric Silencing and Cellular Life Span

(2011) X. Zhu et al.   MOLECULAR AND CELLULAR BIOLOGY

The Acidic Transcription Activator Gcn4 Binds the Mediator Subunit Gal11/Med15 Using a Simple Protein Interface Forming a Fuzzy Complex

(2011) Peter S. Brzovic et al.   MOLECULAR CELL

Molecular Mechanisms of Long Noncoding RNAs

(2011) Kevin C. Wang et al.   MOLECULAR CELL

Architecture of the Mediator head module

(2011) Tsuyoshi Imasaki et al.   NATURE

Reprogramming transcription by distinct classes of enhancers functionally defined by eRNA

(2011) Dong Wang et al.   NATURE

Structure and VP16 binding of the Mediator Med25 activator interaction domain

(2011) Erika Vojnic et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the VP16 transactivator target in the Mediator

(2011) Alexander G Milbradt et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization

(2011) Martin Seizl et al.   NUCLEIC ACIDS RESEARCH

The tail-module of yeast Mediator complex is required for telomere heterochromatin maintenance

(2011) Jing Peng et al.   NUCLEIC ACIDS RESEARCH

Histone modifications influence mediator interactions with chromatin

(2011) Xuefeng Zhu et al.   NUCLEIC ACIDS RESEARCH

MACCHI-BOU 2 is Required for Early Embryo Patterning and Cotyledon Organogenesis in Arabidopsis

(2011) Jun Ito et al.   PLANT AND CELL PHYSIOLOGY

The Mediator Complex in Plants: Structure, Phylogeny, and Expression Profiling of Representative Genes in a Dicot (Arabidopsis) and a Monocot (Rice) during Reproduction and Abiotic Stress

(2011) S. Mathur et al.   PLANT PHYSIOLOGY

The Arabidopsis thaliana Med25 mediator subunit integrates environmental cues to control plant development

(2011) N. Elfving et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Core promoter recognition complex changes accompany liver development

(2011) J. A. D'Alessio et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Direct Interaction of RNA Polymerase II and Mediator Required for Transcription in Vivo

(2011) J. Soutourina et al.   SCIENCE

Diverse roles of the Mediator complex in plants

(2011) Brendan N. Kidd et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Interactions between subunits of the Mediator complex with gene-specific transcription factors

(2011) Tilman Borggrefe et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Origins and activity of the Mediator complex

(2011) Ronald C. Conaway et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Mediator and human disease

(2011) Jason M. Spaeth et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Wwp2 is essential for palatogenesis mediated by the interaction between Sox9 and mediator subunit 25

(2011) Yukio Nakamura et al.   Nature Communications

Molecular Architecture of the Human Mediator–RNA Polymerase II–TFIIF Assembly

(2011) Carrie Bernecky et al.   PLOS BIOLOGY

Pol II waiting in the starting gates: Regulating the transition from transcription initiation into productive elongation

(2010) Sergei Nechaev et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Long Noncoding RNAs with Enhancer-like Function in Human Cells

(2010) Ulf Andersson Ørom et al.   CELL

Architecture of the RNA polymerase II–TFIIF complex revealed by cross-linking and mass spectrometry

(2010) Zhuo Angel Chen et al.   EMBO JOURNAL

ATAC and Mediator coactivators form a stable complex and regulate a set of non-coding RNA genes

(2010) Arnaud R Krebs et al.   EMBO REPORTS

MiR-205 silences MED1 in hypoxic primary human trophoblasts

(2010) Jean-Francois Mouillet et al.   FASEB JOURNAL

Activation of a Poised RNAPII-Dependent Promoter Requires Both SAGA and Mediator

(2010) S. K. Lee et al.   GENETICS

CDK19 is disrupted in a female patient with bilateral congenital retinal folds, microcephaly and mild mental retardation

(2010) Arijit Mukhopadhyay et al.   HUMAN GENETICS

A Chromatin-remodeling Protein Is a Component of Fission Yeast Mediator

(2010) Olga Khorosjutina et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Understanding large multiprotein complexes: applying a multiple allosteric networks model to explain the function of the Mediator transcription complex

(2010) B. A. Lewis   JOURNAL OF CELL SCIENCE

MED14 Tethers Mediator to the N-Terminal Domain of Peroxisome Proliferator-Activated Receptor   and Is Required for Full Transcriptional Activity and Adipogenesis

(2010) L. Grontved et al.   MOLECULAR AND CELLULAR BIOLOGY

Med25 Is Required for RNA Polymerase II Recruitment to Specific Promoters, Thus Regulating Xenobiotic and Lipid Metabolism in Human Liver

(2010) R. Rana et al.   MOLECULAR AND CELLULAR BIOLOGY

A Genome-Wide RNA Interference Screen Identifies a Differential Role of the Mediator CDK8 Module Subunits for GATA/ RUNX-Activated Transcription in Drosophila

(2010) Vanessa Gobert et al.   MOLECULAR AND CELLULAR BIOLOGY

Cyclin-Dependent Kinase 8 Positively Cooperates with Mediator To Promote Thyroid Hormone Receptor-Dependent Transcriptional Activation

(2010) M. Belakavadi et al.   MOLECULAR AND CELLULAR BIOLOGY

A TFIIH-Associated Mediator Head Is a Basal Factor of Small Nuclear Spliced Leader RNA Gene Transcription in Early-Diverged Trypanosomes

(2010) J. H. Lee et al.   MOLECULAR AND CELLULAR BIOLOGY

AFF4, a Component of the ELL/P-TEFb Elongation Complex and a Shared Subunit of MLL Chimeras, Can Link Transcription Elongation to Leukemia

(2010) Chengqi Lin et al.   MOLECULAR CELL

The histone variant macroH2A suppresses melanoma progression through regulation of CDK8

(2010) Avnish Kapoor et al.   NATURE

Mediator and cohesin connect gene expression and chromatin architecture

(2010) Michael H. Kagey et al.   NATURE

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

p53 activates transcription by directing structural shifts in Mediator

(2010) Krista D Meyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

CDK8 is a positive regulator of transcriptional elongation within the serum response network

(2010) Aaron J Donner et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Mediator Head module structure and functional interactions

(2010) Gang Cai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The distribution of active RNA polymerase II along the transcribed region is gene-specific and controlled by elongation factors

(2010) Alfonso Rodríguez-Gil et al.   NUCLEIC ACIDS RESEARCH

Preparation and topology of the Mediator middle module

(2010) Tobias Koschubs et al.   NUCLEIC ACIDS RESEARCH

Activator-Mediator binding regulates Mediator-cofactor interactions

(2010) C. C. Ebmeier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific erythroid-lineage defect in mice conditionally deficient for Mediator subunit Med1

(2010) M. Stumpf et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A muscle-specific knockout implicates nuclear receptor coactivator MED1 in the regulation of glucose and energy metabolism

(2010) W. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Key roles for MED1 LxxLL motifs in pubertal mammary gland development and luminal-cell differentiation

(2010) P. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Active RNA Polymerases: Mobile or Immobile Molecular Machines?

(2010) Argyris Papantonis et al.   PLOS BIOLOGY

Cortistatin A is a High-Affinity Ligand of Protein Kinases ROCK, CDK8, and CDK11

(2009) Victor J. Cee et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Nuclear CDKs Drive Smad Transcriptional Activation and Turnover in BMP and TGF-β Pathways

(2009) Claudio Alarcón et al.   CELL

Profiling the Human Protein-DNA Interactome Reveals ERK2 as a Transcriptional Repressor of Interferon Signaling

(2009) Shaohui Hu et al.   CELL

The MED12-MED13 module of Mediator regulates the timing of embryo patterning in Arabidopsis

(2009) C. S. Gillmor et al.   DEVELOPMENT

Position of the general transcription factor TFIIF within the RNA polymerase II transcription preinitiation complex

(2009) Jesse Eichner et al.   EMBO JOURNAL

The Med8 mediator subunit interacts with the Rpb4 subunit of RNA polymerase II and Ace2 transcriptional activator inSchizosaccharomyces pombe

(2009) Surbhi Mehta et al.   FEBS LETTERS

The human CDK8 subcomplex is a molecular switch that controls Mediator coactivator function

(2009) M. T. Knuesel et al.   GENES & DEVELOPMENT

Long noncoding RNAs: functional surprises from the RNA world

(2009) J. E. Wilusz et al.   GENES & DEVELOPMENT

Ubiquitin Ligase Nedd4L Targets Activated Smad2/3 to Limit TGF-β Signaling

(2009) Sheng Gao et al.   MOLECULAR CELL

“Cotranscriptionality”: The Transcription Elongation Complex as a Nexus for Nuclear Transactions

(2009) Roberto Perales et al.   MOLECULAR CELL

Histone H4 lysine 16 acetylation regulates cellular lifespan

(2009) Weiwei Dang et al.   NATURE

Cyclin-dependent kinases: a family portrait

(2009) Marcos Malumbres et al.   NATURE CELL BIOLOGY

The Mediator Complex Subunit PFT1 Is a Key Regulator of Jasmonate-Dependent Defense in Arabidopsis

(2009) B. N. Kidd et al.   PLANT CELL

Where Does Mediator Bind In Vivo?

(2009) Xiaochun Fan et al.   PLoS One

Mediator complex association with constitutively transcribed genes in yeast

(2009) S. A. Ansari et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mediator Structural Conservation and Implications for the Regulation Mechanism

(2009) Gang Cai et al.   STRUCTURE

Two Modes of Transcriptional Activation at Native Promoters by NF-κB p65

(2009) Dominic van Essen et al.   PLOS BIOLOGY

Genome-Wide Analysis of Factors Affecting Transcription Elongation and DNA Repair: A New Role for PAF and Ccr4-Not in Transcription-Coupled Repair

(2009) Hélène Gaillard et al.   PLoS Genetics

Host Cell Factors in HIV Replication: Meta-Analysis of Genome-Wide Studies

(2009) Frederic D. Bushman et al.   PLoS Pathogens

Global Analysis of Host-Pathogen Interactions that Regulate Early-Stage HIV-1 Replication

(2008) Renate König et al.   CELL

Genome-Scale RNAi Screen for Host Factors Required for HIV Replication

(2008) Honglin Zhou et al.   Cell Host & Microbe

Promoter proximal pausing on genes in metazoans

(2008) David S. Gilmour   CHROMOSOMA

Identification, structure, and functional requirement of the Mediator submodule Med7N/31

(2008) Tobias Koschubs et al.   EMBO JOURNAL

Human mediator kinase subunit CDK11 plays a negative role in viral activator VP16-dependent transcriptional regulation

(2008) Taiki Tsutsui et al.   GENES TO CELLS

Saccharomyces cerevisiaeMed9 comprises two functionally distinct domains that play different roles in transcriptional regulation

(2008) Hiroyuki Takahashi et al.   GENES TO CELLS

Most mammalian mRNAs are conserved targets of microRNAs

(2008) R. C. Friedman et al.   GENOME RESEARCH

Role for Med12 in Regulation ofNanogand Nanog Target Genes

(2008) Antonin V. Tutter et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MED19 and MED26 Are Synergistic Functional Targets of the RE1 Silencing Transcription Factor in Epigenetic Silencing of Neuronal Gene Expression

(2008) Ning Ding et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mediator Subunit Gal11p/MED15 Is Required for Fatty Acid-dependent Gene Activation by Yeast Transcription Factor Oaf1p

(2008) Jitendra K. Thakur et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Med1 Subunit of Transcriptional Mediator Plays a Central Role in Regulating CCAAT/Enhancer-binding Protein-β-driven Transcription in Response to Interferon-γ

(2008) Hui Li et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artificial Recruitment of Mediator by the DNA-Binding Domain of Adr1 Overcomes Glucose Repression of ADH2 Expression

(2008) E. T. Young et al.   MOLECULAR AND CELLULAR BIOLOGY

Multiple Yeast Genes, Including Paf1 Complex Genes, Affect Telomere Length via Telomerase RNA Abundance

(2008) A. D. Mozdy et al.   MOLECULAR AND CELLULAR BIOLOGY

The Human CDK8 Subcomplex Is a Histone Kinase That Requires Med12 for Activity and Can Function Independently of Mediator

(2008) M. T. Knuesel et al.   MOLECULAR AND CELLULAR BIOLOGY

MED1 Phosphorylation Promotes Its Association with Mediator: Implications for Nuclear Receptor Signaling

(2008) M. Belakavadi et al.   MOLECULAR AND CELLULAR BIOLOGY

MyoD Targets TAF3/TRF3 to Activate Myogenin Transcription

(2008) Maria Divina E. Deato et al.   MOLECULAR CELL

Mediator Links Epigenetic Silencing of Neuronal Gene Expression with X-Linked Mental Retardation

(2008) Ning Ding et al.   MOLECULAR CELL

Mediator-Dependent Recruitment of TFIIH Modules in Preinitiation Complex

(2008) Cyril Esnault et al.   MOLECULAR CELL

CCAR1, a Key Regulator of Mediator Complex Recruitment to Nuclear Receptor Transcription Complexes

(2008) Jeong Hoon Kim et al.   MOLECULAR CELL

A nuclear receptor-like pathway regulating multidrug resistance in fungi

(2008) Jitendra K. Thakur et al.   NATURE

E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8

(2008) Erick J. Morris et al.   NATURE

CDK8 is a colorectal cancer oncogene that regulates β-catenin activity

(2008) Ron Firestein et al.   NATURE

HP1-mediated silencing targets Pol II coactivator complexes

(2008) Andrea Smallwood et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Erratum: Fungal Rtt109 histone acetyltransferase is an unexpected structural homolog of metazoan p300/CBP

(2008) Yong Tang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

An atypical RNA polymerase involved in RNA silencing shares small subunits with RNA polymerase II

(2008) Linfeng Huang et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

(2008) Henri-Marc Bourbon   NUCLEIC ACIDS RESEARCH

Two conserved modules of Schizosaccharomyces pombe Mediator regulate distinct cellular pathways

(2008) Tomas Linder et al.   NUCLEIC ACIDS RESEARCH

AtRECQ2, a RecQ helicase homologue fromArabidopsis thaliana, is able to disrupt various recombinogenic DNA structuresin vitro

(2008) Daniela Kobbe et al.   PLANT JOURNAL

Pygopus activates Wingless target gene transcription through the mediator complex subunits Med12 and Med13

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