Architecture of the RNA polymerase II–Mediator core initiation complex

Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex

(2014) Kuang-Lei Tsai et al.   CELL

Redefining the modular organization of the core Mediator complex

(2014) Xuejuan Wang et al.   CELL RESEARCH

Rpb4 Subunit Functions Mainly in mRNA Synthesis by RNA Polymerase II

(2014) Daniel Schulz et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit

(2014) Murat A Cevher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Fast and accurate reference-free alignment of subtomograms

(2013) Yuxiang Chen et al.   JOURNAL OF STRUCTURAL BIOLOGY

One number does not fit all: Mapping local variations in resolution in cryo-EM reconstructions

(2013) Giovanni Cardone et al.   JOURNAL OF STRUCTURAL BIOLOGY

Global Analysis of Eukaryotic mRNA Degradation Reveals Xrn1-Dependent Buffering of Transcript Levels

(2013) Mai Sun et al.   MOLECULAR CELL

RNA polymerase I structure and transcription regulation

(2013) Christoph Engel et al.   NATURE

Structural visualization of key steps in human transcription initiation

(2013) Yuan He et al.   NATURE

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

Lysine-specific chemical cross-linking of protein complexes and identification of cross-linking sites using LC-MS/MS and the xQuest/xProphet software pipeline

(2013) Alexander Leitner et al.   Nature Protocols

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

(2013) Kuang-Lei Tsai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Model of the Mediator middle module based on protein cross-linking

(2013) Laurent Larivière et al.   NUCLEIC ACIDS RESEARCH

Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex

(2013) K. Murakami et al.   SCIENCE

A structural perspective on Mediator function

(2012) Laurent Larivière et al.   CURRENT OPINION IN CELL BIOLOGY

Comparative dynamic transcriptome analysis (cDTA) reveals mutual feedback between mRNA synthesis and degradation

(2012) M. Sun et al.   GENOME RESEARCH

Unraveling the structure of membrane proteins in situ by transfer function corrected cryo-electron tomography

(2012) Matthias Eibauer et al.   JOURNAL OF STRUCTURAL BIOLOGY

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Mediator-Regulated Transcription through the +1 Nucleosome

(2012) Adam Nock et al.   MOLECULAR CELL

Structure of the Mediator head module

(2012) Laurent Larivière et al.   NATURE

Structure and function of the initially transcribing RNA polymerase II–TFIIB complex

(2012) Sarah Sainsbury et al.   NATURE

Architecture of the RNA polymerase II preinitiation complex and mechanism of ATP-dependent promoter opening

(2012) Sebastian Grünberg et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II

(2012) P. J. J. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Probing of a Protein Phosphatase 2A Network by Chemical Cross-Linking and Mass Spectrometry

(2012) F. Herzog et al.   SCIENCE

Structural Basis of Transcription Initiation

(2012) Y. Zhang et al.   SCIENCE

Interaction of the Mediator Head Module with RNA Polymerase II

(2012) Gang Cai et al.   STRUCTURE

Structural basis of initial RNA polymerase II transcription

(2011) Alan C M Cheung et al.   EMBO JOURNAL

Transcriptional Regulation inSaccharomyces cerevisiae: Transcription Factor Regulation and Function, Mechanisms of Initiation, and Roles of Activators and Coactivators

(2011) Steven Hahn et al.   GENETICS

Computer controlled cryo-electron microscopy – TOM2 a software package for high-throughput applications

(2011) Andreas Korinek et al.   JOURNAL OF STRUCTURAL BIOLOGY

PyTom: A python-based toolbox for localization of macromolecules in cryo-electron tomograms and subtomogram analysis

(2011) Thomas Hrabe et al.   JOURNAL OF STRUCTURAL BIOLOGY

Architecture of the Yeast RNA Polymerase II Open Complex and Regulation of Activity by TFIIF

(2011) J. Fishburn et al.   MOLECULAR AND CELLULAR BIOLOGY

Architecture of the Mediator head module

(2011) Tsuyoshi Imasaki et al.   NATURE

Mediator head subcomplex Med11/22 contains a common helix bundle building block with a specific function in transcription initiation complex stabilization

(2011) Martin Seizl et al.   NUCLEIC ACIDS RESEARCH

Direct Interaction of RNA Polymerase II and Mediator Required for Transcription in Vivo

(2011) J. Soutourina et al.   SCIENCE

Origins and activity of the Mediator complex

(2011) Ronald C. Conaway et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Molecular Architecture of the Human Mediator–RNA Polymerase II–TFIIF Assembly

(2011) Carrie Bernecky et al.   PLOS BIOLOGY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

ICC-CLASS: isotopically-coded cleavable crosslinking analysis software suite

(2010) Evgeniy V Petrotchenko et al.   BMC BIOINFORMATICS

Architecture of the RNA polymerase II–TFIIF complex revealed by cross-linking and mass spectrometry

(2010) Zhuo Angel Chen et al.   EMBO JOURNAL

Probing Native Protein Structures by Chemical Cross-linking, Mass Spectrometry, and Bioinformatics

(2010) Alexander Leitner et al.   MOLECULAR & CELLULAR PROTEOMICS

Preparation and topology of the Mediator middle module

(2010) Tobias Koschubs et al.   NUCLEIC ACIDS RESEARCH

Position of the general transcription factor TFIIF within the RNA polymerase II transcription preinitiation complex

(2009) Jesse Eichner et al.   EMBO JOURNAL

Structural Basis of Transcription: Mismatch-Specific Fidelity Mechanisms and Paused RNA Polymerase II with Frayed RNA

(2009) Jasmin F. Sydow et al.   MOLECULAR CELL

RNA polymerase II–TFIIB structure and mechanism of transcription initiation

(2009) Dirk Kostrewa et al.   NATURE

SPIDER image processing for single-particle reconstruction of biological macromolecules from electron micrographs

(2009) Tanvir R Shaikh et al.   Nature Protocols

Structure of an RNA Polymerase II-TFIIB Complex and the Transcription Initiation Mechanism

(2009) X. Liu et al.   SCIENCE

Mediator Structural Conservation and Implications for the Regulation Mechanism

(2009) Gang Cai et al.   STRUCTURE

Identification, structure, and functional requirement of the Mediator submodule Med7N/31

(2008) Tobias Koschubs et al.   EMBO JOURNAL

Mediator-Dependent Recruitment of TFIIH Modules in Preinitiation Complex

(2008) Cyril Esnault et al.   MOLECULAR CELL

Comparative genomics supports a deep evolutionary origin for the large, four-module transcriptional mediator complex

(2008) Henri-Marc Bourbon   NUCLEIC ACIDS RESEARCH