Mediator structure and rearrangements required for holoenzyme formation

Structure of a Complete Mediator-RNA Polymerase II Pre-Initiation Complex

(2016) Philip J. Robinson et al.   CELL

Near-atomic resolution visualization of human transcription promoter opening

(2016) Yuan He et al.   NATURE

Transcription initiation complex structures elucidate DNA opening

(2016) C. Plaschka et al.   NATURE

Structure of promoter-bound TFIID and model of human pre-initiation complex assembly

(2016) Robert K. Louder et al.   NATURE

Architecture of the RNA polymerase II–Mediator core initiation complex

(2015) C. Plaschka et al.   NATURE

Structure of an RNA polymerase II preinitiation complex

(2015) Kenji Murakami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular architecture of the yeast Mediator complex

(2015) Philip J Robinson et al.   eLife

Subunit Architecture and Functional Modular Rearrangements of the Transcriptional Mediator Complex

(2014) Kuang-Lei Tsai et al.   CELL

Redefining the modular organization of the core Mediator complex

(2014) Xuejuan Wang et al.   CELL RESEARCH

Reconstitution of active human core Mediator complex reveals a critical role of the MED14 subunit

(2014) Murat A Cevher et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Electron counting and beam-induced motion correction enable near-atomic-resolution single-particle cryo-EM

(2013) Xueming Li et al.   NATURE METHODS

A conserved Mediator–CDK8 kinase module association regulates Mediator–RNA polymerase II interaction

(2013) Kuang-Lei Tsai et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Model of the Mediator middle module based on protein cross-linking

(2013) Laurent Larivière et al.   NUCLEIC ACIDS RESEARCH

Architecture of an RNA Polymerase II Transcription Pre-Initiation Complex

(2013) K. Murakami et al.   SCIENCE

RELION: Implementation of a Bayesian approach to cryo-EM structure determination

(2012) Sjors H.W. Scheres   JOURNAL OF STRUCTURAL BIOLOGY

Structure of the Mediator head module

(2012) Laurent Larivière et al.   NATURE

Structure of the Mediator Head module bound to the carboxy-terminal domain of RNA polymerase II

(2012) P. J. J. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subunit architecture of general transcription factor TFIIH

(2012) B. J. Gibbons et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Outcome of the First Electron Microscopy Validation Task Force Meeting

(2012) Richard Henderson et al.   STRUCTURE

Architecture of the Mediator head module

(2011) Tsuyoshi Imasaki et al.   NATURE

Features and development ofCoot

(2010) P. Emsley et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

PHENIX: a comprehensive Python-based system for macromolecular structure solution

(2010) Paul D. Adams et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Refinements to Label Free Proteome Quantitation: How to Deal with Peptides Shared by Multiple Proteins

(2010) Ying Zhang et al.   ANALYTICAL CHEMISTRY

The metazoan Mediator co-activator complex as an integrative hub for transcriptional regulation

(2010) Sohail Malik et al.   NATURE REVIEWS GENETICS

p53 activates transcription by directing structural shifts in Mediator

(2010) Krista D Meyer et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Preparation and topology of the Mediator middle module

(2010) Tobias Koschubs et al.   NUCLEIC ACIDS RESEARCH

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Appion: An integrated, database-driven pipeline to facilitate EM image processing

(2009) Gabriel C. Lander et al.   JOURNAL OF STRUCTURAL BIOLOGY

Schizosacharomyces pombe RNA polymerase II at 3.6-A resolution

(2009) H. Spahr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mediator Structural Conservation and Implications for the Regulation Mechanism

(2009) Gang Cai et al.   STRUCTURE

Identification, structure, and functional requirement of the Mediator submodule Med7N/31

(2008) Tobias Koschubs et al.   EMBO JOURNAL

Saccharomyces cerevisiaeMed9 comprises two functionally distinct domains that play different roles in transcriptional regulation

(2008) Hiroyuki Takahashi et al.   GENES TO CELLS

Mediator-Dependent Recruitment of TFIIH Modules in Preinitiation Complex

(2008) Cyril Esnault et al.   MOLECULAR CELL